Selvaraj Karthick Raja Namasivayam

• M.Sc., Ph.D
• Professor (Associate) at Sathyabama Institute of Science and Technology

In the present study, the metabolites consortium was formulated from solvent extract of Acorus calamus Tinospora cordifolia, Coscinium fenestratum, Terminalia chebula, Smilax china using green science principles followed by screening of biological activities like anti-oxidant, anti-inflammatory, anti-diabetic and anti-microbial activities. The meta...

A promising environmentally friendly bioenergy device called a microbial fuel cell (MFC) uses bacterial biofilms as biocatalysts to convert organic matter into power.Because MFCs provide potentially new prospects for sustainable energy production from biodegradable and reusable waste materials, their design and use have drawn significant attention....

Dyes which are used in textile and leather industries, commercial goods, and laboratories play a crucial role in accumulating lethal components in the water bodies, thereby affecting the environment. Though various physicochemical methods have been adopted for eradication of dyes, adsorption using biomass has gained more attention due to their high...

Cyclic dimeric guanosine monophosphate (c-di-GMP) plays a vital role within the nucleotide signaling network of bacteria, participating in various biological processes such as biofilm formation and toxin production, among others. Substantial evidence demonstrates its critical involvement in the progression of chronic infections. Treating chronic in...

This study delves into the nanotechnology idea for the formulation of natural-based anti-quorum-sensing agents, particularly Candida albicans, a significant fungal pathogen. This research highlights how they may be generated and improved over traditional anti-quorum-sensing agents. The development of a metallic or green anti-quorum-sensing agent en...

Among the diverse nanomaterials, polymeric nanocomposites incorporating metallic nanoparticles have recently garnered significant attention due to their high efficacy, biocompatibility, and biodegradability. This study presents a novel approach to synthesizing a nano-selenium polymeric bionanocomposite, created from biocompatible polymers using in...

Alzheimer’s disease, a progressive neurodegenerative disorder marked by cognitive decline, affects millions worldwide. The presence of amyloid plaques and neurofibrillary tangles in the brain is the key pathological feature, leading to neuronal dysfunction and cell death. Current treatment options include pharmacological approaches such as cholines...

Treatment of wastewater or effluent using nanotechnology principles has gained more attention recently due to high removal efficacy of toxic pollutants with notable biosafety. In this study, chemogenic and biogenic nano zero valent iron (nZVI) particles were screened for wastewater treatment efficacy of domestic sewage water adapting green science...

Contamination of agroecosystems by metallic ions on various scales significantly reduces crop productivity and yield due to their toxic effects on beneficial soil microbiota. This study investigates the toxic effects of heavy metals chromium (Cr), lead (Pb), nickel (Ni) and metallic nanoparticles silver (AgNPs) and zinc oxide (ZnONPs), both individ...

While various physicochemical methods are available for wastewater treatment, lignocellulosic biomass stands out as a highly valued adsorbent due to its excellent adsorption efficiency, cost-effectiveness, and environmental advantages. This study investigates the removal of methylene blue from aqueous solutions using lignocellulosic biomass through...

Aquatic environments, including marine and freshwater ecosystems, are vital for ecological balance and biodiversity. The rising global demand for aquaculture products necessitates increased production, with intensified aquaculture practices posing significant environmental risks. This review explores the pathways through which chemical pollutants,...

Aim: The present investigation evaluated the effect of various formulations on the viability, pesticide compatibility and biocontrol potential of fungal biopesticidal agent Metarhizium anisopliae under laboratory conditions. Methodology: Soil isolate of M. anisopliae biomass was formulated with different oils like sunflower, groundnut, neem oil, wa...

Liver damage and metabolic dysfunctions, the defining features of non‐alcoholic fatty liver disease (NAFLD), are marked by inflammation, oxidative stress, and excessive hepatic fat accumulation. The current therapeutic approaches for NAFLD are limited, necessitating exploring novel treatment strategies. Dioxopiperidinamide derivatives, particularly...

Solid waste management using biological methods, particularly microorganisms is widely used in many parts of the world because of their high degradation efficacy, environmentally friendly and less cost effective. In this present study, keratinase producing fungal strains were isolated from local soil samples using human hair as the substrate. A tot...

Nanoscale materials derived from natural polymers have attracted considerable attention in various scientific and technological fields due to their impressive qualities such as high efficacy, biodegradability, and particularly, biocompatibility. Chitosan, among these biopolymer-based nanomaterials, plays a crucial role owing to its unique structura...

The Earth’s atmosphere contains ultrafine particles known as aerosols, which can be either liquid or solid par- ticles suspended in gas. These aerosols originate from both natural sources and human activities, termed primary and secondary sources respectively. They have significant impacts on the environment, particularly when they transform into...

This study assessed the anti‐biofouling potential of Acalypha indica ethanolic extract against biofouling communities associated with Chembarambakkam Lake water under in vitro conditions. Water samples from the lake were collected at various seasons, and changes in various physicochemical parameters and microbial status were evaluated. Most signifi...

The significance of microorganisms occurring in foods is predominantly targeted due to their application for identifying a novel range of the bacterial spectrum. Diverse microbial species are capable of exhibiting potential pharmacological activities like antimicrobial and anticancer. Microbial strains capable of reducing obesity-related syndromes...

The present study was undertaken to screen the pesticidal activity of extra cellular metabolites derived from entomopathogenic fungus Metarhizium anisopliae against Spodoptera litura and Aphis crassivora an important aphid pest under laboratory and pot culture condition. Fungal strain used in the study was isolated from the soil by serial dilution...

Mucilage derived from the various plant species has gained more attention in biomedicine field as its high potential bioactivities. However, the peer solubility and bioavailability limits the desired biological activities. Nanotechnology principles can be effectively utilized in the formulation of various plant-based products which enhance the desi...

The role of food additives is to preserve food by extending shelf life and limiting harmful microorganism proliferation. They prevent spoilage by enhancing the taste and safety of food by utilizing beneficial microorganisms and their antimicrobial metabolites. Current advances in food preservation and processing utilize green technology principles...

Chemical pesticides in crop protection pose long‐term threats to living beings due to their harmful side effects. Plant consortium, a mixture of diverse plant extracts and biomedicine, has gained attention for integrated pest management. Developmental formulations increase bioavailability of bioactive constituents, enhancing desired biological acti...

Azo dye degradation utilizing microorganisms has acquired significance over the last decades, owing to its beneficial properties such as rapid degradation, economic feasibility, and eco‐friendly. In this work, azo dyes (Methyl red and methylene blue) degradation efficacy using indigenous bacterial strains Pseudomonas sp. and Bacillus sp. as free an...

The present study is undertaken to evaluate the potential biological activities of bacteriocin produced by the Lactic acid bacteria Bifidobacterium sp. adopting solid state fermentation. Bifidobacterium was isolated from cooked fermented rice water. Isolated bacterial strain was identified by morphological, biochemical, and molecular characteristic...

Since prehistoric times till the present and most probably in the future, medicinal plants will take the spotlight in the pharmaceutical industry because of their rich important natural sources of antioxidants for novel drugs discovery and development. Plants synthesise several bioactive compounds that exhibit a high antioxidant capacity. Furthermo...

In the present study, rhizobacterial strains associated with paddy rhizosphere were screened for plant growth promotion efficacy against Vigna radiata. Plant growth promotion effect was determined by measuring indole acetic acid (IAA) phosphate solubilisation efficacy and antagonistic activity. Among the isolates, Azosprillum strain AZOSP -V1 strai...

The review provides an essential insight into the nanotechnology principles for nano-selenium based materials mainly selenium nanoparticles (SeNPs), selenium nanocomposite (SeNC) and how they can be synthesized, utilized in biomedicine. Various methods of synthesis of nano selenium have revealed extensively in this study. Applications in biomedicin...

Currently adopted methods that are used for diagnosis and treatment are not effective in the successful management of CRC. Nanotechnology has explored a new beginning to the development of nanoscale materials that are having distinct properties which aid in the effective diagnosis and treatment of cancers including CRC. These nanostructural systems...

Effective microorganism (EM) – a mixture of beneficial microbial formulation are extensively utilized worldwide in agriculture as plant growth promotor and biocontrol agent. Because of their wide spectrum usage, it is necessary to study the non‐target effect against the beneficial organisms used in crop production. Though, the wider applications of...

The present study is aimed to evaluate pesticidal activity and biocompatibility including ecotoxicity of functionalized silica nanoparticles that synthesized by simple, in vitro, green technology principles. Sol-gel method was adopted for the synthesis of silica nanoparticles and was functionalized by Aminopropyltriethoxysilane (APS), characterized...

Microplastics are small plastic particles (<5mm) linked by hydrocarbon atoms. Microplastics are of two types: primary microplastics, which are inadvertently released into the ecosystem as microbeads, plastic pellets and plastic fibres and secondary microplastics, derived from primary microplastics, when macroplastics get decomposed in the presence...

Synthetic agrochemicals, including herbicides, cause diverse environmental and health effects that lead to searching for herbicide formulations with high biocompatibility, biosafety, and biodegradability. Developmental formulations of herbicides from biological sources, mainly microorganisms, are considered suitable alternative due to their high ef...

Formulation of effective, biocompatible therapeutic agents against diabetes is an important need in biomedicine as conventional therapy is known to cause poor efficacy and side effects. Plant-based medicinal principles against diabetes have been utilized for years. However, various limitations exist in plant-based herbal medicine that are used for...

Biocompatible, eco-friendly, highly economical packaging methods should be needed as conventional packaging is known to cause undesirable effects. As food packaging is the major determining factor of food safety, the selection or methods of packaging materials plays a pioneering role. With this scope, modern food technology seeks unique sustainable...

Metabolites derived from herbal plants like Azadirachta indica, Curcuma longa, and Allium sativum have shown noteworthy healing activity against various skin infection disease like cellulitis, erysipelas, impetigo, folliculitis, furuncles, and carbuncles. Although, the healing properties of medicinal plants have been utilized ,scientific validation...

The present investigation was aimed to explore the cadmium removal efficiency, mechanism and characterization of Chitosan biopolymers from cephalopods waste. The extracted chitosan has showed good yield of 32% and with high minerals, ash and moisture content. In the Fourier-transform infrared spectroscopy (FT-IR) analysis multiple active functional...

Bioactive metabolites derived from the medicinal plant or herbs biomass have gained more attention in recent biomedicine and pharmacotherapy. Formulation of plant-based medicine as polyherbal forms are thought to have greater pharmacological effects than single herbs; they are presently used in the majority of herbal-based products rather than sing...

The present study evaluates the biocompatibility of silver and zinc oxide nanoparticles with various effective microorganisms (EM), like beneficial microbial formulations. The respective nanoparticle was synthesised by chemical reduction of metal precursor with reducer via simple route green technology principles. The synthesised nanoparticles were...

Obesity is linked to the development of major metabolic disorders such as type 2 diabetes, cardiovascular disease, and cancer. Recent research has focused on the molecular link between obesity and oxidative stress. Obesity impairs antioxidant function, resulting in dramatically increased reactive oxygen levels and apoptosis. In this study, we inves...

In the current investigation, the enhanced cytotoxic impact of gold nanoparticle–loaded camptothecin—a bioactive metabolite produced by a soil isolate of Aspergillus niger against breast cancer cell line (MCF 7)—was studied. Camptothecin (CPT) was isolated from Aspergillus niger biomass followed by loading with chemogenic gold nanoparticles, and th...

The combination of nanotechnology principles and membrane technology has gained more attention in waste water remediation owing to the high efficiency of toxicants removal, unique physico chemical properties and biodegradability. This current work offers a wide and accurate overview of nanocellulose acetate membrane technology for waste water treat...

Aim: Methodology: Results: Interpretation: The present study aimed to evaluate the antinociceptive effect of Triphala extract coated with marine derived chitosan against the formalin-induced adult zebrafish (Danio rerio) model. Marine derived chitosan was extracted from Aspergillus niger and the extracted chitosan was coated witha commercial formul...

The study was aimed to remove the fluoride from aqueous solution by plant materials through batch experiment. The bio-adsorbents (Manilkara zapota and peels of Solanum tuberosum) were thermally activated and converted into ash. The batch study was performed in a laboratory and optimized by dose and time. The maximum removal of fluoride was observed...

Using natural and synthetic polymers as the components for the core–shell nanocomposite preparation has received recent attention in biomedicine due to their high biocompatibility, high efficacy, and biodegradability. In this present investigation, chitosan-polyvinyl alcohol core–shell gold nanocomposite was synthesised adopting green science princ...

In this current work, the herbicidal activity of fungal metabolites stacked chitosan nanocomposite against significant aquatic invasive weed Eichhornia crassipes (water hyacinth) was examined. Herbicidal metabolites from the fungal strain Allophoma oligotrophica were extracted and purified under standard condition. Altered ionic gelation technique...

In this present study, phytotoxicity of high strength distillery industry discharge wastewater and methyl orange dye in aqueous solution that treated by chemically modified fungal biomass Penicillium on Arachis hypogaea was investigated. The biomass of Penicillium strain was subjected to a simple eco-friendly acid treatment which brought about high...

In recent times, great prominence is moved towards reusing or recycling organic waste into various products with noteworthy applications. In this study, mixed vegetable wastes were decomposed by a microbial consortium composed of bacteria Pseudomonas stutzeri, Bacillus polymyxa, Lactococcus lactis, actinomycetes Streptomyces albus, filamentous fung...

Food preservation using biopreservative agents mainly microbial based metabolites have gained more attention in the modern food sector due to their broad spectrum anti-microbial efficacy with high biocompatibility. However, the effectiveness of these biopreservatives is highly dependent on suitable formulation which will enhance the desired efficac...

Nanomaterials mainly nanocomposites possess unique physical and chemical properties which makes them superior and indispensable. Though much research has been focused on the properties and application of nanocomposites, the eco-toxicity assessment is one among top priority, which aims to protect the population of concerned biological component and...

In this present work, microwave-mediated physical structural modification (PSM) of water hyacinth biomass and its impact on methylene blue biosorption kinetics and gold nanoparticle synthesis potential were studied. Microwaves with the strength of 750 W for 60 min brought about a notable impact on the morphology of the biomass by the formation of p...

In this present study, quorum quenching activity (QQ) of chitosan–selenium bionanocomposite with high biocompatibility was investigated. QQ activity was studied in Pseudomonas aeruginosa by measuring the expression level of Las B and RhII genes. Impact of gene expression on the major virulence factors production was also evaluated. Relative gene ex...

Consumers have been consistently concerned about possible adverse health effects from the presence of chemical additives in their foods. As a result, consumers are drawn to natural and fresher foods with no chemical preservatives added. This perception has stimulated research interest in finding natural but effective preservatives. Use of natural o...

In this present study, a highly stable gum acacia -gold nanocomposite fabricated with food preservative agent natamycin (GA-AuNC–NT) was prepared via green science principles under in vitro conditions. Various characterisation techniques reveal highly stable structural, functional properties of the synthesised nanocomposite with marked antifungal a...

Among the diverse nanomaterials, gold nanoparticles (AuNps) are utilised for various therapeutic application due to the distinct physical, chemical properties and biocompatibility. Synthesis of gold nanoparticles using plants is the promising route. This method is low cost, eco-friendly and higher biological activities. In this present study, Gold...

Among the diverse nanomaterials, polymer-based nanocomposites are gained more attention due to their high efficacy, target biological activities, biodegradability and biocompatibility—gum acacia (GA) - a polymer obtained from acacia trees-is considering the multifunctional nanocomposite synthesis. Distinctive Physico-chemical and biocompatibility p...

In the present study, optimization of parameters for the preparation of nano formulated whole attenuated rabies vaccine with high immune potency and biocompatibility was synthesised. Response Surface Methodology (RSM) was adapted to study the influence of factors such as the concentration of chitosan (mg/mL), PEG (mg), acetic acid (%), sodium tripo...

In the present study, calcium oxide supported on activated carbon ([email protected]) nanocomposite was synthesized using Basil leaf extract as a promoter and used to remove phenanthrene, an environmental pollutant, from aqueous solution. The activated carbon (AC) was prepared by the carbonization of Palm shells under pyrolytic conditions. The [ema...

Hydroxyapatite nanoparticles have been demonstrated as eminent nanomaterials because of their upgraded bioactivity, non-toxicity and biocompatibility properties. In this current examination, an upgraded wound healing activity of bioactive metabolites of medicinal polyherbal formulation Triphala fabricated hydroxyapatite nanocomposite was explored u...

In the present investigation, the enhanced pesticidal activity of fungal-based pesticidal metabolites extracted from a well-known fungal biocontrol agent biogenic silver nanoparticles–fungal-based insecticidal metabolite (AgNp–FM) was evaluated against major lepidopteron pest Spodoptera litura (Fab.). Nanoconjugate was prepared from silver nanopart...

Abstract A laboratory experiment was conducted to evaluate enhanced pesticidal activity of silica nanoparticles‐doped chitinase nano enzyme conjugate against an economically important insect pest Spodoptera litura (Fab.) (Lepidoptera; Noctuidae). Silica nanoparticles were synthesized by hydrolysis and condensation of precursor tetraethylorthosilica...

Principles of nanoscience and nanotechnology principles has received recent attention in biofilm inhibition strategy. Biofilm-notable microbial growth as cell aggregates on a solid surface is found to be highly susceptible to nanoparticles treatment, which leads to the development of nanoparticles as an effective antimicrobial. In this present stud...

Eichhornia crassipes (Water hyacinth) is considered a hazardous weed in numerous places in the world. Notwithstanding its natural disintegrating impacts, the weed, despite everything, offers the potential to be utilized as a substrate for the production of industrially important products. In this study, biological activities of water hyacinth bioma...

In this study, an eco-friendly green route strategy was adopted for the synthesis of highly stable, biocompatible polymer-polymer-metal-based composite with high potential anti-bacterial applications. The composite was prepared by modified ionic gelation of Chitosan-gum acacia copolymer with gold nanoparticles (Cs-GA-AuNC). Structural, functional c...

Pseudomonas aeruginosa– major group of an aerobic bacteria associated with nosocomial and other life threatening infections. Diverse virulence factors produced by P. aeruginosa is due to distinct molecular cell signaling mechanism termed as quorum sensing (QS). Interfering with normal QS mechanism by active biomolecules is an effective strategy for...

Antigen delivery framework utilising polymer-based nanomaterial is broadly used in biomedicine because of their high efficacy, antigenicity and biocompatibility. In this study, hepatitis B surface antigen fabricated chitosan-polyethylene glycol nanocomposite (HBsAg-CS-PEG NC) was prepared by in situ ionic gelation method which brought about highly...

The logical research on fundamentally adjusted iron oxide nanoparticles has turned out to expanded in biomedicine because of the improved activity and best biocompatibility. In this present work upgraded bio-restorative and pharmacotherapeutic property of chitosan iron oxide nanocomposite, which was set up by eco-friendly in situ substance techniqu...

Phycocyanin (PC), a photosynthetic pigment produced by cyanobacteria has been gained attention due to its distinct properties such as antioxidant and anti-proliferative. Acute and sub acute toxicity studies were carried out to determine the biocompatibility of the extracted phycocyanin on Wistar rat model. PC was extracted from Spirulina platensis...

In the present study, enhanced pesticidal activity and biocompatibility of chitosan nanocomposite prepared with biocompatible polymer chitosan - insecticidal metabolites derived from potential fungal biopesticidal agent Nomuraea rileyi were studied. Insecticidal metabolites were isolated from the culture filtrate of fungal strain grown in sabouraud...

Recently, principles of nanoscience and nanotechnology has being embraced in the field of agriculture rather than medicine and health care which has the potential to revolutionize modern day agriculture by effectively controlling insect pests and disease causing phytopathogenic microorganisms. In the present study, biocontrol potential of bovine se...

The production of reactive oxygen species is also prevalent in the world's oceans, and oxidative stress is an important component of the stress response in marine organisms exposed to a variety of insults as a result of changes in environmental conditions such as thermal stress, exposure to ultraviolet radiation, or exposure to pollution. Aquatic o...

Biopesticidal agents like microorganism, plant extracts and predators are now extensively utilized in the agriculture sector to overcome the harmful non target effects of synthetic chemical pesticides. Success of biopestcicidal agents is primarily based on effective formulation with the various materials which improves the viability and persistence...

Bioethanol conversion from lignocellulosic wastes play a major role due to the widespread availability,abundance and relatively low cost of cellulosic materials In the present study, effective microorganism (EM) like microbial consortia was constructed with seven different cellulose degrading microbial strains and production of ethanol was carried...

Biocontrol agents based on fungi play a pivotal role in insect pest management against economic imperative pests. Microbial control which makes use of naturally occurring microbes to control weeds, pathogens and pests, is less detrimental to non-target organisms and the environment than the chemical pesticides. Among the fungi, Nomuraea rileyi (Far...