Selcuk Erdem

Istanbul University · Department of Urology (Istanbul Medical Faculty)

Renal cell carcinoma (RCC) is characterized by its diverse histopathological features, which pose possible challenges to accurate diagnosis and prognosis. A comprehensive literature review was conducted to explore recent advancements in the field of artificial intelligence (AI) in RCC pathology. The aim of this paper is to assess whether these adva...

Background: Further stratification of the risk of recurrence of clear-cell renal cell carcinoma (ccRCC) with venous tumor thrombus (VTT) will facilitate selection of candidates for adjuvant therapy. Objective: To assess the impact of tumor grade discrepancy (GD) between the primary tumor (PT) and VTT in nonmetastatic ccRCC on disease-free surviv...

Renal cell carcinoma (RCC) incidence has doubled over the past few decades. However, death rates have remained stable as the number of incidental renal mass diagnoses peaked. RCC has been recognized as a European health care issue, but to date, no screening programmes have been introduced. Well-known modifiable risk factors for RCC are smoking, obe...

Single-port (SP) robotic surgery is a novel technology and is at the beginning of its adoption curve in urology. The goal of this narrative review is to provide an overview of SP-robotic partial nephrectomy (PN) 4 years after the introduction of the da Vinci SP dedicated platform, focusing on perioperative outcomes, length of stay, and surgical tec...

Renal medullary carcinoma (RMC) is a rare form of renal cell carcinoma that has a poor prognosis. It is known to be associated with sickle cell trait or disease, although the exact underlying mechanisms are still unclear. The diagnosis is made through immunochemical staining for SMARCB1 (INI1). In this report, we present a case of a 31-year-old mal...

Introduction: Kidney transplant (KT) recipients have a four-times higher risk of renal malignancies compared to general population. As these patients frequently harbor bilateral or multifocal tumors, the management of renal masses is still under debate. Objective: To explore the current management of the native kidney masses in KT patients. Acq...

Ablative techniques have been increasing as an alternative to surgical approaches, especially in patients who are unfit for surgery or with the low probability of aggressive malignancy in renal cancer. This chapter covers ablative therapies in renal cancer.KeywordsAblation therapyRenal cancer

Partial nephrectomy (PN) is recommended as standard treatment for technically feasible all clinical T1 renal tumors, by the guidelines. This chapter covers open partial nephrectomy.KeywordsOpen partial nephrectomyRenal cancer

Radical nephrectomy is an established surgical procedure with evolving indications. This chapter covers indications, technological advances and technique in robotic radical nephrectomy.KeywordRobotic radical nephrectomy

Renal cell carcinoma (RCC) represents approximately 2% of all diagnosed cancers and is the third most common genitourinary malignancy following prostate and bladder cancer (Chandrasekar et al. in Eur Urol S0302–2838:00060–69, 2021, [1]). This chapter reviews decision making for patients with localized renal masses.KeywordsLocalised diseaseRenal can...

Partial nephrectomy (PN) is nowadays considered as the gold standard treatment for the management of clinical T1 renal masses. This chapter covers robotic partial nephrectomy.KeywordsRobotic surgeryRenal cancerPartial nephrectomy

According to the European Association of Urology (EAU), American Urology Association (AUA) and American Society of Clinical Oncology (ASCO) Guidelines, the contemporary management options for patients with localized renal masses include: active surveillance, partial nephrectomy, radical nephrectomy, and thermal ablation. This chapter covers those m...

Due to the diffusion and large use of abdominal imaging small renal masses are more frequently diagnosed in the last few years (Sohlberg et al. in Eur Urol Focus 5(6):943–945, 2019, [1]). However, a not negligible proportion of these lesions represent pathologically benign tumors (up to 30%) or tumors with low malignant potential (Sohlberg et al. i...

Nitric oxide (NO), plays a significant part in biological processes. Endothelial nitric oxide synthase (eNOS), the enzyme that catalyzes the generation of NO in endothelium, contains genetic polymorphisms that have been linked to an increased risk of developing cancer. The purpose of this investigation was to ascertain whether there is any connecti...

Introduction The updated European Association of Urology (EAU) Guidelines issued a weak recommendation for adjuvant pembrolizumab for patients with high-risk operable clear cell Renal Cell Carcinoma (ccRCC) until final overall survival data are available. High risk of recurrence was defined, as per protocol-criteria, as tumor stage II with nuclear...

Clear cell Renal Cell Carcinoma (ccRCC) is among the 10 most common cancers in both men and women and causes more than 140,000 deaths worldwide every year. In order to elucidate the underlying molecular mechanisms orchestrated by phosphorylation modifications, we performed a comprehensive quantitative phosphoproteomics characterization of ccRCC tum...

Background: The aim of this study is to assess the extent of the increased intracranial pressure resulting from lateral decubitus and 45° downward positioning using sonographic optic nerve sheath diameter (ONSD) in patients undergoing laparoscopic transperitoneal nephrectomy. In addition, we evaluated the effect of the carbon dioxide pneumoperitone...

Quadratus lumborum block (QLB) is a new fascial plane block that may be helpful for laparoscopic surgeries. In this present study, we aim to evaluate the analgesic efficacy of QLB in laparoscopic living related donor nephrectomy (LLRDN) applied continuously via a catheter that was placed under laparoscopic vision by the surgeon. Following the appro...

Objective No standard strategy for diagnosis and management of positive surgical margin (PSM) and local recurrence after partial nephrectomy PN are reported in literature. This review aims to provide an overview of the current strategies and further perspectives on this patient setting. Methods A non-systematic review of the literature was complet...

Standard-of-care management of renal cell carcinoma (RCC) indisputably relies on surgery for low-risk localized tumours and systemic treatment for poor-prognosis metastatic disease, but a grey area remains, encompassing high-risk localized tumours and patients with metastatic disease with a good-to-intermediate prognosis. Over the past few years, r...

Objective The role of lymph node dissection (LND) is still controversial in patients with renal cell carcinoma undergoing surgery. We aimed to provide a comprehensive review of the literature about the effect of LND on survival, prognosis, surgical outcomes, as well as patient selection and available LND templates. Methods Recent literature (from...

Purpose To systematically review studies focused on screening programs for renal cell carcinoma (RCC) and provide an exhaustive overview on their clinical impact, potential benefits, and harms. Methods A systematic review of the recent English-language literature was conducted according to the European Association of Urology guidelines and the PRI...

Although the vast majority of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging occurs in the field of prostate cancer, PSMA is also highly expressed on the cell surface of the microvasculature of several other solid tumors, including renal cell carcinoma (RCC). This makes it a potentially interesting imaging targ...

Background Distinguishing hydronephrosis that requires surgical intervention is a clinical challenge. The aim of this study is to determine the level of urinary heat shock protein 70 (HSP70) in children who required surgery for ureteropelvic junction obstruction and its potential use as a biomarker for prediction of surgery in children with isolate...

The incidental detection of renal masses has been steadily rising. As a significant proportion of renal masses that are surgically treated are benign or indolent in nature, there is a clear need for better presurgical characterization of renal masses to minimize unnecessary harm. Ultrasound is a widely available and relatively inexpensive real-time...

Objective Recently, VENUSS (VEnous extension, NUclear Grade, Size, Stage), as a prognostic model, was defined to predict disease recurrence (DR) after curative surgery of non-metastatic papillary renal cell carcinoma (papRCC). This study aimed to validate the VENUSS prognostic model in a large multi-institutional European cohort of patients with hi...

Objective To present a multidisciplinary open surgical treatment under cardiopulmonary bypass (CPB) for a renal cell carcinoma (RCC) with Mayo level 4 inferior vena cava (IVC) thrombus extending into the right atrium. Patient and Surgical Procedure A 57 years old man with macrohematuria was diagnosed 8.5 cm left kidney tumor with venous tumor thro...

Introduction We aimed to evaluate the impact of the resection technique (tumor enucleation (TE) or standard partial nephrectomy (SPN)) on trifecta outcomes in patients having undergone partial nephrectomy (PN). Materials and Methods We retrospectively analyzed the clinical and pathologic parameters in patients with localized renal cell carcinoma (...

Background: Frailty has been recognized as a major risk factor for adverse perioperative and oncological outcomes in patients with genitourinary malignancies. Yet, the evidence supporting such an association in patients with renal cell carcinoma (RCC) is still sparse. Herein we provide an updated comprehensive overview of the impact of frailty on...

Objective To document and analyze diagnostic accuracy of renal core biopsy (RCB), its diagnostic correlation with resection specimens, and to question the need for immunohistochemistry (IHC) in the preoperative diagnosis of renal masses. Material and method RCBs performed at a reference center between 2007 and 2017 were included. Pathological, cli...

PurposeTo investigate the natural history and follow-up after kidney tumor treatment of Von Hippel-Lindau (VHL) patients.Materials and methodsA multi-institutional European consortium of patients with VHL syndrome included 96 non-metastatic patients treated at 9 urological departments (1987–2018). Descriptive and survival analyses were performed.Re...

Background and aim Gallium-68 (68Ga)-Prostate Membrane Specific Antigen Positron Emission Tomography/Computed Tomography (68Ga-PSMA PET/CT) is an emerging diagnostic modality which is gaining importance in individualized prostate cancer (PCa) management era. This study aimed to investigate the diagnostic accuracy of ⁶⁸Ga-PSMA PET/CT on primary LN s...

Introduction: Behçet's disease (BD) is a chronic inflammatory disease which can be limited to only mucocutaneous tissues or can affect different systems of the body. Aim: To investigate the association of endothelial and erectile dysfunctions with BD, on the basis of comparative analysis between mucocutaneous and systemic BD. Material and metho...

Background Differential diagnosis can be a challenge for eosinophilic subtypes of renal cell tumors due to their overlapping histomorphological and immunohistochemical features. We aimed to investigate the frequency of rare variants of renal cell carcinomas (RCCs) such as succinate dehydrogenase-deficient RCC (SDDRCC), hereditary leiomyomatosis and...

Background Transcription factor E3 (TFE3) related renal cell carcinomas constitute a very small percent of all renal tumors in adults. Prognosis mainly depends on the stage of the disease at the time of diagnosis which is often poor. There is yet to be a standardized treatment protocol. Treatment options include agents identical to TFE3(–) cell ren...

Purpose To evaluate the impact of delay in cystoscopic surveillance on recurrence and progression rates in non-muscle-invasive bladder cancer (NMIBC). Materials and Methods A total of 407 patients from four high-volume centers with NMIBC that applied for follow-up cystoscopy were included in our study prospectively. Patients’ demographics and prev...

Clear cell renal cell carcinoma (ccRCC) is the third most common and most malignant urological cancer, with a 5-year survival rate of 10% for patients with advanced tumors. Here, we identified 10,160 unique proteins by in-depth quantitative proteomics, of which 955 proteins were significantly regulated between tumor and normal adjacent tissues. We...

PurposeWe aimed to investigate the diagnostic power of 68Ga-PSMA PET/CT in the detection of metastatic spread of newly diagnosed PCa, and evaluate the relationship with modified D’Amico risk classification.Methods We evaluated newly diagnosed PCa patients who underwent 68Ga-PSMA PET/CT prior to therapy. All images were interpreted retrospectively a...

A Correction to this paper has been published: https://doi.org/10.1007/s00259-021-05286-3

Introduction Matrix metalloproteinase‐9 (MMP‐9) has a role in the destruction of lamina propria (LP) of the bladder wall and SMAD‐2 promotes cell‐to‐cell adhesion. This study aimed to investigate the association between LP invasion and serum protein and mRNA expression levels of MMP‐9 and SMAD‐2 in bladder cancer (BC) patients. Methods Serum sampl...

We present a case of clear cell renal cell carcinoma, which demonstrates complementary FDG and prostate-specific membrane antigen (PSMA) uptake on metastases in PET/CT, as an example of tumor heterogeneity. The patient had non-FDG-avid lung and bone metastases with PSMA uptake, whereas metastatic cervical and axillary lymph nodes showed vice versa,...

Clear cell Renal Cell Carcinoma (ccRCC) is the third most common and most malignant urological cancer, with a 5-year survival rate of 10% for patients with advanced tumors. Here, we identified 10,160 unique proteins by in-depth quantitative proteomics, of which 955 proteins were significantly regulated between tumor and normal adjacent tissues. We...

Aim: To determine the general tendencies of urology patients and effect of COVID-19 pandemic on daily urological practice at tertiary centers located in the most affected area in Turkey. Methods: We retrospectively analyzed the data of 39,677 patients (group 1) that applied to 6 different large-volume tertiary centers in Istanbul for outpatient co...

Background Selection of patients for upfront cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) has to be improved. Objective To evaluate a new scoring system for the prediction of overall mortality (OM) in mRCC patients undergoing CN. Design, setting, and participants We identified a total of 519 patients with synchronous m...

AMAÇ: Bu çalışmada gebelikte akut flank ağrının gebelik sayısı ve hidronefroz ile ilişkisini araştırmayı amaçladık. GEREÇ-YÖNTEM: Çalışmaya akut flank ağrı ile başvuran 48 hasta dahil edildi. Enfeksiyon bulgusu olan, idrar analizi anormal, üreter veya böbrek taşı olan hastalar çalışmaya dahil edilmedi. Gebelerin ağrı dışında herhangi bir semptomu y...