Seithikurippu R. Pandi-Perumal

Seithikurippu R. Pandi-Perumal
Saveetha University ·  Department of Psychiatry

Master of Science in Botany

About

793
Publications
643,059
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13,703
Citations
Additional affiliations
January 2009 - present
University of Toronto
January 2006 - December 2007
Mount Sinai School of Medicine
January 2004 - December 2005
Education
April 1988 - April 1990
Madurai Kamaraj University
Field of study
  • Botany

Publications

Publications (793)
Article
Full-text available
Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans, melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light/dark cycle via the suprachiasmatic nucleus. Pinealocyte...
Article
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Melatonin, an endogenous signal of darkness, is an important component of the body's internal time-keeping system. As such it regulates major physiological processes including the sleep wake cycle, pubertal development and seasonal adaptation. In addition to its relevant antioxidant activity, melatonin exerts many of its physiological actions by in...
Article
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We aimed to assess the effect of Islamic intermittent fasting, during and outside of Ramadan, on plasma levels of leptin and ghrelin while controlling for several potential confounding variables. Eight healthy male volunteers with a mean age of 26.6±4.9 years reported to the sleep disorders center (SDC) at King Saud University on four occasions: 1)...
Article
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Migraine and restless legs syndrome (RLS) are common medical disorders that often co-occur. Various hypotheses have suggested that the co-occurrence of these distinct disorders could be related to shared genetic, neurobiological, or environmental factors. In this article, we review the available evidence regarding hypotheses concerning the possible...
Article
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Background: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine t...
Article
Introduction There have been no previous meta-analytic studies that have looked at the prevalence of insomnia symptoms in different COVID-19 groups using a single assessment instrument to evaluate insomnia symptoms while maintaining data homogeneity. The current review's associated goal is to undertake an individual participant data (IPD) analysis...
Article
Introduction NOMOPHOBIA is a term used to describe an anxiety disorder in which people fear being disconnected from their mobile phones. Strong associations between nomophobia and insomnia have previously been documented. However, there is no clear explanation for this relationship between the two disorders. The present study was designed to first...
Article
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Background: Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10-24 years during the past three decades. Methods: Using the Global Burden of Disease, Injuries, and...
Preprint
Introduction: There have been no previous meta-analytic studies that have looked at the prevalence of insomnia symptoms in different COVID-19 groups using a single assessment instrument to evaluate insomnia symptoms while maintaining data homogeneity. The current review's associated goal is to undertake an individual participant data (IPD) analysis...
Article
Full-text available
Sleep deprivation (SD) interferes with long-term memory and cognitive functions by overactivation of phosphodiesterase (PDEs) enzymes. PDE4, a nonredundant regulator of the cyclic nucleotides (cAMP), is densely expressed in the hippocampus and is involved in learning and memory processes. In the present study, we investigated the effects of Roflumi...
Article
Full-text available
Background Sleep disturbances are highly prevalent in collegiate adults. Although different forms of treatments for sleep disturbances exist, the treatments remain unsatisfactory. Exercises are one of the mainstays of the treatment but there is an ambiguity as far as the timing and type of the exercises are concerned. Aims This study aims to inves...
Article
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Yoga nidra, also known as ‘yogic sleep’, is a simplified form of an ancient tantric relaxation technique. The most general description of the practice is that it combines guided mental imagery with a specific yoga posture called Shavasana (or “corpse pose”). The goal of yoga nidra is to promote a profound state of relaxation, which differs from sle...
Article
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Sleep deprivation (SD) is emulating an epidemic imparting detrimental effects ranging from immediate repercussions like vehicle accidents to very serious neurological disorders. All age groups are vulnerable to SD either because of lifestyle or illness. This imposes a significant burden on public health and safety. SD triggers an array of inflammat...
Preprint
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Background: Sterlite Copper in Thoothukudi was shuttered after complaints were received about air contamination, and an increased rate of disease in the community, especially cancer. Political leaders, activists, and non-governmental organizations (NGOs) in the state of Tamil Nadu subsequently lodged petitions against its reopening. Aim: Because St...
Article
Exposure to an adequate light-dark cycle is important for the speedy recovery of hospitalized and institutionalized patients. Light exposure, including natural light, offers several health benefits to both patients and nursing staff. This includes physical (e.g., decreased confusion and disorientation) and mental health benefits (e.g., prevention o...
Article
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Purpose Poor sleep and cognitive deficits are often associated with increased drug use. However, no study has addressed the relationship between poor sleep, substance dependence, and metacognitive deficit in polysubstance users. Methods This was a cross-sectional study with a simple random sampling involving community-dwelling polysubstance users...
Article
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Purpose: This article focuses on recent evidence linking Rapid eye movement (REM) obstructive sleep apnea (OSA) (REMOSA) to neurocognitive dysfunction and mood changes, the proposed mechanisms for increased risk of neurocognitive dysfunction in REMOSA, and future research prospects. Methods: PubMed and Google Scholar records were examined for art...
Article
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The current Russian war against Ukraine is of global concern. It builds on the annexation of Crimea in 2014 and subsequently the war in the Donbas region of Ukraine, and has become a large-scale Russian invasion of Ukraine from three directions, Crimea in the south, Russia in the east, and Belarus in the north. Despite the geopolitical background t...
Article
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Purpose: Few studies have investigated the validity of the Athens Insomnia Scale (AIS) using a robust approach of both classical theory and the Rating Scale Model. Therefore, in this study, we investigated psychometric validation of the AIS using both of these approaches in nurses. Methods: Nurses (n= 563, age= 33.2±7.1 years) working in health fa...
Article
Full-text available
Purpose: Poor sleep and cognitive deficits are often associated with drug use. However, no study has addressed the relationship between poor sleep, substance dependence, and metacognitive deficit in polysubstance users. Methods: This was a cross-sectional study with a simple random sampling involving community-dwelling polysubstance users (n=326,...
Article
Full-text available
Some research suggests that distress, secondary to isolation and fear following COVID-19 infection, can negatively affect the long-term more than the COVID-19 infection itself. This narrative review aims to provide a global view on the neuropsychiatric consequences of COVID-19 that can be ascribed to several factors, ranging from the direct effect...
Article
This systematic review and meta-analysis evaluated the extent of sleep disturbances during the COVID-19 pandemic. Eleven databases (Cochrane, CINAHL, EBSCOhost, EMBASE, Google Scholar, MEDLINE, ProQuest Medical, PsycINFO, ScienceDirect, Scopus, and Web of Science) and six preprint repositories were searched for the period From November 1, 2019, to...
Article
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Background Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.
Chapter
In patients with unipolar (depressive) disorder, sleep disturbance generally takes the form of insomnia, whereas patients with bipolar disorder typically show a reduced need for sleep. Sleep impairment in these patients increases the risk for a major depressive episode and suicidal behavior. Insomnia is also a common trait in schizophrenia, with to...
Chapter
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Several neurotransmitter systems and circulating factors regulate rapid eye move-5 ment (REM) sleep, non-REM (NREM) sleep, and wakefulness (W). The nuclei involved in the occurrence of W are located in the brainstem, hypothalamus, and the basal forebrain (BFB). These corresponding to the brainstem include the dorsal raphe nucleus (serotonergic neur...
Article
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Background: Implications from accumulated bodies of commentaries and media/social-media reports highlight the drug shortage during the COVID-19 pandemic. In this special report, the relation between drug shortage and response measures is discussed in the light of a preliminary data construct. Materials and Methods: Media reports and social media p...
Article
Various lines of evidence suggest that a bidirectional relationship exists between poor sleep quality and chronic pain, with each condition tending to promote and exacerbate the other. Inadequate sleep and chronic pain may share neurophysiological and molecular pathways that are similar or overlapping. The present evidence reported that chronic nec...
Article
This systematic review and meta-analysis evaluated the extent of sleep disturbances during the COVID�19 pandemic. Eleven databases and six preprint repositories were searched for the period from November 1, 2019, to July 15, 2021. The DerSimonian and Laird method was used to develop random-effect meta�analyses. Two hundred and fifty studies compri...
Article
Research suggests that distress secondary to the isolation and fear associated with COVID-19 infection can have more negative effects than the COVID-19 infection itself. This narrative review provides a global view of neuropsychiatric consequences. Several factors are responsible, ranging from the direct effects of infection, to the body’s response...
Preprint
Full-text available
Some research suggested that distress secondary to isolation and fear can negatively affect the long-term than COVID-19 infection itself. This narrative review aims to provide a global view on the neuropsychiatric consequences of COVID-19 that can be ascribed to several factors ranging from the direct effect of infection to the body's responses aga...
Article
Full-text available
Sleep and the circadian clock are intertwined and have persisted throughout history. The suprachiasmatic nucleus (SCN) orchestrates sleep by controlling circadian (Process C) and homeostatic (Process S) activities. As a "hand" on the endogenous circadian clock, melatonin is critical for sleep regulation. Light serves as a cue for sleep/wake control...
Article
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Phytocannabinoid derivatives are among the several compounds found in the cannabis plant. The phytocannabinoid chemicals Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are mostly responsible for the drug's behavioural effects. Chronic cannabis administration has been shown to disrupt circadian rhythms and reduce the duration of the deepest pha...
Article
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Precision medicine (PM) is an emerging approach for disease prevention, diagnosis, treatment, and management that holds promise for improving the future of sleep healthcare. This concept of PM is guided by evidence-based medicine for treatment decisions by taking into account individual variability in genes, environment, and lifestyle factors. Chro...
Article
BACKGROUND: Over the next 20 yr, international market expansion will necessitate the production of new commercial airplanes and the recruitment of additional crewmembers and technicians. Research has proven that fatigue and lack of sleep are risk factors for impaired cognitive performance and human error. Pilots frequently report fatigue to their e...
Article
Full-text available
BACKGROUND: Over the next 20 yr, international market expansion will necessitate the production of new commercial airplanes and the recruitment of additional crewmembers and technicians. Research has proven that fatigue and lack of sleep are risk factors for impaired cognitive performance and human error. Pilots frequently report fatigue to their e...
Preprint
Full-text available
Sleep deprivation interferes with long-term memory and cognitive functions by over-activation of phosphodiesterase (PDE) enzymes. PDE4 is a non-redundant regulator of the cyclic nucleotides (cAMP), is densely expressed in the hippocampus, and is involved in learning and memory processes. In the present study, we investigated the effects of Roflumil...
Article
Aims: The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced PCOS rats. Material and Methods: Assessment of gravimetric, hormonal profile and thyroid histology and relative expression...
Article
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Introduction: The present study was designed to evaluate the therapeutic efficacy of melatonin and insulin coadministration in diabetes-induced renal injury in rats. Research design and methods: Diabetes was achieved by giving streptozotocin (15 mg/kg) for 6 consecutive days. The diabetic condition was confirmed by assessing the blood glucose le...
Article
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Physiological processes and behaviours in many mammals are rhythmic. Recently there is increasing interest in the role of circadian rhythmicity in the control of reproductive function. The circadian rhythm of the pineal hormone melatonin plays a role in synchronizing the reproductive responses of animals to environmental light conditions. There is...
Article
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Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate res...
Article
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Despite the passage of more than 60 years since its discovery and much evidence to the contrary, there has been great reluctance to conceive of melatonin as anything other than a hormone. Many other body chemicals are known to have multiple roles. Melatonin was first shown to be a hormone derived from the pineal gland, to be actively synthesized th...
Article
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Background Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential traject...
Article
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The author contends that politicians and the media (local and foreign) are both to culpable for playing a risky game during the COVID-19 outbreak and during vaccination in India during its second wave. Several journalists found to be engaged in unethical behaviour, such as disseminating misinformation, disinformation, mal-information, and alternati...
Article
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Objective – There are diverse results on the association between physical activity and sleep. So this study investigated the association of level and type of physical activity with short-term insomnia among college students. Methods - A cross-sectional study was conducted among college students in India. The sample was 662 students with 359 males...
Article
Exclusive breastfeeding (EBF)—giving infants only breast-milk for the first 6 months of life—is a component of optimal breast- feeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries...
Article
Full-text available
Exclusive breastfeeding (EBF)—giving infants only breast-milk for the first 6 months of life—is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries (L...
Article
Full-text available
This paper centers around blockchain-based health services frameworks and presents an extensive review on current work, distinguishing existing and arising difficulties in sleep medicine. We attempt to combine health care, especially sleep medicine, allied with blockchain technology. It addresses the capability of blockchain innovation and how it c...
Article
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Background High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across...
Article
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Social distancing, also referred to as physical distancing, means creating a safe distance of at least two metres (six feet) between yourself and others. This is a term popularized during the COVID-19 pandemic, as it is one of the most important measures to prevent the spread of this virus. However, the term “social distancing” can be misleading, a...
Article
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Background: Anxiety symptoms, stress, poor sleep, and inadequate sleep hygiene are common in university students and these affect their learning and increase attrition. However, limited knowledge exists about the inter-relationship between these factors among university students in low-middle income countries. Therefore, this study aimed to investi...
Article
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Purpose: To evaluate the presence of obstructive sleep apnea (OSA), using home sleep testing in pilots and first officers in Saudi-based airlines. This will allow for proper diagnosis and management of OSA in that group which can help in minimizing any possible aviation accidents related to sleep disturbances secondary to OSA. Materials and Method...
Article
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Free vaccination against COVID-19 commenced in India on January 16, 2021, and the government is urging all of its citizens to be immunized, in what is expected to be the largest vaccination program in the world. Out of the eight COVID-19 vaccines that are currently under various stages of clinical trials in India, four were developed in the country...
Article
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Abstract Background: Prevalence of anxiety and its associated factors in Ethiopians necessitates the availability of a valid questionnaire tool to screen this disorder. Therefore, this study aimed to assess the factor structure, its stability, and psychometric measures of the GAD-7 scale in Ethiopian university students. Methods: A cross-sectional...
Article
Background and objective People with substance use disorder (SUD) may be easily vulnerable to COVID-19. Given that impaired lung function caused by COVID-19 may exacerbate the symptoms of patients already having preexisting opioids or CNS stimulants use disorder. This narrative review highlights the risks of interactions between COVID-19 and SUD....
Article
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Chronic disruption of circadian rhythms which include intricate molecular transcription–translation feedback loops of evolutionarily conserved clock genes has serious health consequences and negatively affects cardiovascular physiology. Sirtuins (SIRTs) are nuclear, cytoplasmic and mitochondrial histone deacetylases that influence the circadian clo...
Article
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According to the Lancet Commission Report on Global Surgery, it was estimated that in 2010 about 16.9 million lives were lost due to the unavailability of surgical. It was further calculated that 77.2 million DALYs could simply have been averted by providing basic surgical inspection and triage. Aiding Universal Health Coverage (UHC) through Humani...
Article
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Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop COVID-19. An unusual extended course of COVID-19 disease illness has been reported in one ASD patient and a group of patients have COVID-19 disease in a neurodevelopmental facility. It has been widely reported that many of those with ASD have substantial sleep disorde...
Article
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Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality worldwide. The coronary atherosclerotic process involves different pathological mechanisms; inflammation is one of the major triggers for the development of atherosclerotic plaque. Although several studies showed the favorable effects of melatonin on the cardiovas...