Seithikurippu R. Pandi-Perumal

• Master of Science in Botany
• Centre for Research and Development, Chandigarh University, Mohali, 140413, Punjab, India.

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans, melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light/dark cycle via the suprachiasmatic nucleus. Pinealocyte...

Background: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine t...

Migraine and restless legs syndrome (RLS) are common medical disorders that often co-occur. Various hypotheses have suggested that the co-occurrence of these distinct disorders could be related to shared genetic, neurobiological, or environmental factors. In this article, we review the available evidence regarding hypotheses concerning the possible...

We aimed to assess the effect of Islamic intermittent fasting, during and outside of Ramadan, on plasma levels of leptin and ghrelin while controlling for several potential confounding variables. Eight healthy male volunteers with a mean age of 26.6±4.9 years reported to the sleep disorders center (SDC) at King Saud University on four occasions: 1)...

Sleep is a universally conserved behavior whose origin and evolutionary purpose are uncertain. Using phylogenomics, this article investigates the evolutionary foundations of sleep from a never before used perspective. More specifically, it identifies orthologs of human sleep-related genes in the Lokiarchaeota of the Asgard superphylum and examines...

The current study employed phylogenomic methods to examine sleep-related genes’ evolutionary role and significance in Sulfurimonas paralvinellae of the Epsilonproteobacteria class. This has facilitated the identification of conserved sleep orthologs, including DnaK (Hsp70), serine hydroxymethyltransferase (SHMT), and potassium channel family protei...

Sleep is a widespread and evolutionarily conserved process observed in diverse organisms, from jellyfish to mammals, hinting at its origin as a life-supporting mechanism over 500 million years ago. Although its fundamental purpose and mechanisms remain unclear, sleep's evolution and adaptive significance continue to be debated. This study explores...

In common with most physiological activities, sleep is a highly evolutionarily conserved function. Nevertheless, the purpose of sleep remains inadequately investigated. One possible cause of this deficiency is the limitations of the traditional methods used for examining sleep. Up to this time, the mainstay tool used to look at the evolutionary bas...

Asthma and atopic dermatitis are common allergic conditions that contribute to substantial health loss, economic burden, and pain across individuals of all ages worldwide. Therefore, as a component of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, we present updated estimates of the prevalence, disability-adjusted life-...

Summary Background: Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future traje...

Background Despite the well documented consequences of obesity during childhood and adolescence and future risks of excess body mass on non-communicable diseases in adulthood, coordinated global action on excess body mass in early life is still insufficient. Inconsistent measurement and reporting are a barrier to specific targets, resource allocati...

Background Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future trajectories t...

The current study employed phylogenomic methods to examine the evolutionary role and significance of sleep-related genes in Sulfurimonas paralvinellae of the Epsilonproteobacteria class. This has facilitated the identification of conserved sleep orthologs, including DnaK, serine hydroxymethyltransferase, and potassium channel family proteins, exhib...

Background Pulmonary arterial hypertension (PAH) is a vascular disease characterised by restricted flow and high pressure through the pulmonary arteries, leading to progressive right heart failure and death. This study reports the global burden of PAH, leveraging all available data and using methodology of the Global Burden of Diseases, Injuries, a...

Food addiction (FA) is linked to eating disorders and obesity. The Yale Food Addiction Scale (YFAS), which has various versions in different languages, is widely used to assess FA worldwide. This meta‐analysis aimed to assess the YFAS through reliability generalization meta‐analysis (REGEMA). From their inception until April 2024, a comprehensive s...

A circadian disruption, manifested by disturbed sleep and low-grade inflammation, is commonly seen in noncommunicable diseases (NCDs). Cardiovascular, respiratory and renal disorders, diabetes and the metabolic syndrome, cancer, and neurodegenerative diseases are among the most common NCDs prevalent in today’s 24-h/7 days Society. The decline in pl...

Rhythmicity is a characteristic feature of the inanimate universe. The organization of biological rhythms in time is an adaptation to the cyclical environmental changes brought on by the earth's rotation on its axis and around the sun. Circadian (L. Circa = "around or approximately"; diem = "a day") rhythms are biological responses to the geophysic...

Background The six global nutrition targets (GNTs) related to low birthweight, exclusive breastfeeding, child growth (ie, wasting, stunting, and overweight), and anaemia among females of reproductive age were chosen by the World Health Assembly in 2012 as key indicators of maternal and child health, but there has yet to be a comprehensive report o...

Background The capacity to anticipate future health issues is important for both policy makers and practitioners in the USA, as such insights can facilitate effective planning, investment, and implementation strategies. Forecasting trends in disease and injury burden is not only crucial for policy makers but also garners substantial interest from...

Biphasic sleep, characterized by nighttime sleep plus daytime napping, has demonstrated some cognitive, health and performance impacts when compared with consolidated monophasic sleep. This motivated the development and validation of the Biphasic Sleep Scale, reported in this paper. Scale development involved a literature review, expert input and i...

Whether it involves human subjects or non-human animals, basic, translational, or clinical sleep research poses significant ethical challenges for researchers and ethical committees alike. Sleep research greatly benefits from using diverse animal models, each offering unique insights into sleep control mechanisms. The fruit fly (Drosophila melanoga...

Background/Objectives: Orthosomnia has become a concern in the field of sleep medicine. The purpose of this cross-sectional study was to estimate the prevalence of orthosomnia in the general population. Methods: We collected data from 523 participants via the Generalized Anxiety Disorder Scale, Anxiety and Preoccupation about Sleep Questionnaire, a...

Sleep is a widespread and evolutionarily conserved process observed in diverse organisms, from jellyfish to mammals, hinting at its origin as a life-supporting mechanism over 500 million years ago. Although its fundamental purpose and mechanisms remain unclear, the evolution and adaptive significance of sleep continue to be debated. This study expl...

Sleep is a universally conserved behavior with an elusive origin and an uncertain evolutionary purpose. Leveraging phylogenomics, we investigate the evolutionary foundations of sleep by identifying orthologs of Human sleep-related genes in the Lokiarchaeota of the Asgard superphylum. Our findings indicate a conserved suite of genes associated with...

Background Ghosting refers to the sudden cessation of communication in interpersonal relationships. Ghosting has gained attention as a phenomenon commonly encountered in the context of digital communication. Earlier studies on ghosting mostly focused on Western societies while, in Arab societies, research into this practice has yet to be initiated....

Mental disorders have been rising on a global scale. The number of existing psychiatrists and other mental health professionals is far lower than the number of psychiatric patients world-wide. Social stigmatization worsens this situation, whereby almost one-third of those who need mental health services do not opt for professional treatment due to...

Objectives: In this study, the trends and current situation of the injury burden as well as attributable burden to injury risk factors at global, regional, and national levels based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 are presented. Study design: To assess the attributable burden of injury risk factors, th...

Purpose The Pre-Sleep Arousal Scale (PSAS) is a well-recognized instrument utilized for measuring cognitive and somatic arousal before sleep. Although the PSAS is useful, an Arabic version of the scale has not yet been developed and validated. The current study aimed to translate the PSAS into Arabic language and evaluate its psychometric propertie...

Background Hoarding disorder (HD) is characterized by a compulsion to collect belongings, and to experience significant distress when parting from them. HD is often misdiagnosed for several reasons. These include patient and family lack of recognition that it is a psychiatric disorder and professionals’ lack of relevant expertise with it. This stud...

Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. We estimated incidence, prevalence, death, and disability-adjusted life-year (...

Background: Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. Methods: We estimated incidence, prevalence, death, and disabilit...

Background: The coronavirus disease 2019 (COVID‑19) pandemic has had a significant influence on the general population’s and students’ sleep quality and mental health. However, few studies have looked into sleep, perceived changes in everyday living, and mental health issues among Saudi medical students during the pandemic. Objectives: The objectiv...

Background: Gerascophobia, or excessive fear of aging, is thought to be caused by a mixture of cognitive, experiential, and physiological factors acting on a person at particular time points. Measurement tools for evaluating geraschophobia remain insufficiently developed, despite this commonplace fear’s distress. Objective: The objective of the c...

This mini-meta-analysis evaluated the internal consistency of the Anxiety and Preoccupation about Sleep Questionnaire (APSQ) across existing studies to assess its potential as an orthosomnia (an obsessive preoccupation with achieving perfect sleep) screening tool. A systematic literature search identified four studies with 2,506 participants using...

Objective: The current study evaluates the therapeutic efficacy of Jasminum sambac Linn. essential oil (JEO) by investigating its pharmacological potentials, specifically its anticancer (using MCF-7 cells), anti-inflammatory, antioxidant and antimicrobial activity. Methods: With the anti-inflammatory activity assessed as red blood cell membrane sta...

Sleep is an essential component of a healthy lifespan, influencing both physical and mental well-being along with good quality of life. Adequate sleep quality and quantity are associated with a host of health advantages, including enhanced immune function, learning and memory, emotional well-being, and cardiovascular health. Chronic sleep deprivati...

Background Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensiv...

Background Sleep effort refers to the cognitive and behavioral exertion involved in initiating and maintaining sleep. High sleep effort is increasingly recognized as perpetuating insomnia and poor sleep quality. Validated sleep effort scales enable the quantification of this construct in clinical and research settings. However, no Arabic version ha...

Sleep is essential for athletes' physical performance as well as their general health, well-being, and quality of life. To assess athletes' sleep behaviors, the Athlete Sleep Behavior Questionnaire (ASBQ) was developed in the Eng-lish language. However, a validated Arabic-version of the ASBQ is lacking. This study aimed to translate the ASBQ into A...

Objective: To prevent eating disorders in future physicians, this umbrella review and meta-analysis of previous meta-analyses estimates the prevalence of disordered eating (DE) among medical students worldwide and identifies key risk factors. Methods: Four databases were searched electronically between their inception and February 1, 2023. The sear...

Background Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-base...

Objective Monitoring trends in key population health indicators is important for informing health policies. The aim of this study was to examine population health trends in Canada over the past 30 years in relation to other countries. Methods We used data on disability-adjusted life years (DALYs) Methods We used data on disability-adjusted life yea...

Sleep is an essential component of a healthy lifespan, influencing both physical and mental well-being along with good quality of life. Adequate sleep quality and quantity are associated with a host of health advantages, including enhanced immune function, learning and memory, emotional well-being, and cardiovascular health. Chronic sleep deprivati...

Background Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important follow...

General food frequency questionnaires (FFQs) have not been tailored for or validated in individuals with psychiatric disorders. Given the unique eating behaviors of patients with serious mental illnesses (SMIs), custom-made tools are needed. Therefore, we developed and validated an FFQ customized to individuals with SMIs. A total of 150 adults with...

Purpose of Review The Jenkins Sleep Scale (JSS) is a widely used self-report measure for assessing sleep difficulties. While the original English version of the JSS has demonstrated sound psychometric properties, research on translated versions is limited. We conducted a reliability generalization meta-analysis to systematically review and quantify...

Background The ORTO scale was developed in 2004 as a self-report questionnaire to assess symptoms of orthorexia nervosa (ON). ON is an unhealthy preoccupation with eating healthy food. The scale aims to measure obsessive attitudes and behaviors related to the selection, purchase, preparation, and consumption of pure, healthy food. Since its develop...

Background The ORTO scale was developed in 2004 as a self-report questionnaire to assess symptoms of orthorexia nervosa (ON). ON is an unhealthy preoccupation with eating healthy food. The scale aims to measure obsessive attitudes and behaviors related to the selection, purchase, preparation, and consumption of pure, healthy food. Since its develop...

Background Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of D...

Background: “Ghosting” refers to the practice of abruptly cutting off all contact with a person with whom you have been in constant correspondence. The break comes without warning and without understandable provocation. The term most commonly applies to online romantic relationships. The motives for and effects of ghosting have been studied, and va...

Background There are relatively few data about the association between locus of control and weight loss in Arabic populations. A tool does exist, the Dieting Belief Scale (DBS), that was designed to measure individuals’ beliefs regarding their ability to control their body weight. The aim of this study was to translate this tool into Arabic and to...

Understanding Post-stroke fatigue (PSF) and its associated factors is crucial for effective therapy and rehabilitation. This study aimed to assess the mediating role of excessive daytime sleepness-related functional status (SFS) on the relationship between sleep and severity of fatigue in sub-acute stroke survivors. Methods: Subacute stroke survivo...

Central sleep apnea (CSA) is characterized by recurrent apneic episodes with absent respiratory effort. This is not a common clinical condition like obstructive sleep apnea. Central sleep apnea is diagnosed when more than 50% of the events are central types. Cheyne–Stokes respiration (CSR) is a breathing pattern characterized by cycles of crescendo...

The incidence and prevalence of obstructive sleep apnea (OSA) continue to rise in the United States and the world. The prevalence of OSA is conservatively estimated to be 3% among women and 10% among men 30 to 49 years of age and 9% among women and 17% among men 50 to 70 years of age, including an estimated 24 million persons in the United States w...

Sleep is a complex process characterized by different stages, including rapid eye movement (REM) and non-rapid eye movement (NREM) sleep. Throughout the night, the body cycles through these stages, with REM sleep episodes increasing in duration. REM sleep is associated with active dreaming, while the body experiences muscle atonia and impaired brea...

Every year, a substantial number of people are killed or injured due to motor vehicle accidents (MVAs). A large number of these collisions are caused by driving errors. Vehicles travel at fast speeds, necessitating the driver’s constant attention and alertness. However, scientific evidence suggests that tired drivers or drivers who drive at unusual...

Positive pressure therapy (PAP) is widely recognized as the gold standard treatment for OSA. Long-term adherence to PAP therapy, on the other hand, is typically low, ranging from 40 to 60%. Lifestyle modifications (weight loss, avoidance of alcohol or other drugs that reduce upper airway patency), positional therapy, continuous or bi-level positive...

Wearable devices [consumer sleep technologies (CSTs)] have disrupted sleep disorders management in the world today. In the USA, sleep disorders are managed in sleep disorders centers, usually accredited by AASM. The delivery of sleep health care is usually done by clinical evaluation by a sleep medicine physician after a referral from a primary car...

Background The purpose of this meta-analysis was to provide a pooled prevalence estimate of self-reported disordered eating (SRDE) in athletes based on the available literature, and to identify risk factors for their occurrence. Methods Across ten academic databases, an electronic search was conducted from inception to 7th January 2024. The propor...

Sleep genetics is an intriguing, as yet less understood, understudied, emerging area of biological and medical discipline. A generalist may not be aware of the current status of the field given the variety of journals that have published studies on the genetics of sleep and the circadian clock over the years. For researchers venturing into this fas...

The ongoing wars in many regions—such as the conflict between Israel and Hamas—as well as the effects of war on communities, social services, and mental health are covered in this special editorial. This article emphasizes the need for international efforts to promote peace, offer humanitarian aid, and address the mental health challenges faced by...

https://pubmed.ncbi.nlm.nih.gov/38092509/#full-view-affiliation-41

The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) is a multinational collaborative research study with >10,000 collaborators around the world. GBD generates a time series of summary measures of health, including prevalence, cause-specific mortality (CSMR), years of life lost (YLLs), years lived with disability (YLDs), and disabi...

Background and Aims: There has been no previous investigation into the relationship between serum β-carotene levels and metabolic syndrome in patients with schizophrenia. This research aims to explore the association between schizophrenia, metabolic syndrome, and serum β-carotene levels. Specifically, this study addresses this knowledge gap and ex...

Objective: The primary aim was to investigate whether any association exists between poor sleep quality and deterioration in postural control among university student population. Materials and Methods: A case-control study was conducted in which sleep quality of 119 university students from different departments of Jamia Millia Islamia University,...

Introduction: As the prevalence of ASD (autism spectrum disorder) continues to rise, so does the need to evaluate the impact of associated difficulties on both the diagnosed child and the immediate family. Objectives: The aim of the present study was to assess reports of sleep disturbance or abnormal sleep behaviours (sleep profiles) in the siblin...

Sleep is an essential physiological process that profoundly affects a wide range of biological activities. It is now known that sleep supports myriad vital functions in the central nervous system. This includes neural plasticity, learning, memory, cognition, and emotional regulation. Additionally, it affects basic processes such as cardiovascular,...

Epidemiological studies since 1980 have shown significant increases in the incidence of type 2 diabetes mellitus (T2DM). The public health burden generated by the growing prevalence of T2DM, which, in its fully developed form, is a lifelong illness, has been associated with further social and economic costs in affected countries. Recent studies hav...

Nomophobia, often known as a 21st-century disorder, is a recent condition that has received considerable attention, with numerous studies conducted to better understand it since it was first introduced in 2008. To better understand the present research status and prospects to assist practitioners, policymakers, and funding agencies in protecting th...

Over the last three to four decades, it has been observed that the average total number of hours of sleep obtained per night by normal individuals has decreased. Concomitantly, global figures indicate that insufficient sleep is associated with serious adverse health and social outcomes. Moreover, insufficient sleep has been linked to seven of the f...

Objectives: To assess the prevalence and types of arrhythmias in Saudi OSA patients and to identify predictors of arrhythmia in this group of patients. Methods: This case-control study included all patients who underwent level I attended overnight polysomnography between 2009 and 2012. Electrocardiographic data collected during sleep studies of pat...

Human immunodeficiency virus (HIV) infection, and the anti-retroviral therapy (ART) associated complications necessitate that the medical care system keeps evolving for proper management of this group of patients. Electrolyte imbalance and sleep problems are common in patients on ART. Both of these conditions are associated with increased morbidity...

The pineal hormone Melatonin plays an important role in the regulation of the circadian sleep/wake cycle, mood, and perhaps immune functions, carcinogensis and reproduction. The human circadian rhythm of melatonin release from the pineal gland is tightly synchronized with the habitual hours of sleep. Peri- and postmenopausal women often complain of...

The current development in the field of artificial intelligence and its applications has advantages and disadvantages in the digital age that we now live in. The state of the use of AI for mental health has to be assessed by stakeholders, which includes all of us. We must comprehend the trends, gaps, opportunities, challenges, and shortcomings of t...

Objective: Medical students frequently experience a range of stressors, such as demanding academic requirements, competition and rivalry, self-doubt, and financial distress. As a result, they are at risk for psychological and behavioral symptoms (PBS) including: depression, anxiety, and sleep difficulties as well as maladaptive substance use. Metho...

Background and Aims: There has been no previous investigation into the relationship between serum β-carotene levels and metabolic syndrome in patients with schizophrenia. This research aims to explore the association between schizophrenia, metabolic syndrome, and serum β-carotene levels. Specifically, this study addresses the knowledge gap and exam...

Faith healing is a traditional healing method involving spiritual and faith-based practices performed by a religious medicine man, referred to here as a faith healer. The practice of faith healing is widespread in the Arab World for treating a range of mental disorders. This research aims to review the literature concerned with faith healing practi...

Objective: Medical students frequently experience a range of stressors, such as demanding academic requirements, competition and rivalry, self-doubt, and financial distress. As a result, they are at risk for psycho- logical and behavioral symptoms (PBS) including: depression, anxiety, and sleep difficulties as well as maladaptive substance use. Met...

This article examines the advantages and disadvantages of Large Language Models (LLMs) and Artificial Intelligence (AI) in research and education and proposes the urgent need for an international statement to guide their responsible use. LLMs and AI demonstrate remarkable natural language processing, data analysis, and decision-making capabilities,...