Seher yılmaz

• PhD
• Professor (Associate) at Bozok University

Tartrazine finds widespread application in the realms of alimentation, pharmaceuticals, cosmetic formulations, and textile manufacturing. Tartrazine has a negative effect on human health such as hyperactivity, allergies and asthma in children. Substances such as tartrazine might effect the embryo in a kind of aspects, containing physical or mental...

Fetal alcohol syndrome (FAS) can occur because of high amount of alcohol intake during pregnancy and is characterized by both physical and neurological problems. Children diagnosed with FAS have difficulties in learning, memory, and coordination. Hippocampus has a major role in memory and learning. We aimed to determine whether alcohol exposure dur...

Alcohol use disorder has negative effects on the reproductive system through the development of oxidative stress and its genotoxic effects on DNA integrity. Acute and chronic alcohol use adversely affects the male reproductive system. Phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) levels, which are involved in oxidati...

Tartrazine, an azo dye prevalent in pharmaceuticals and food items, was investigated for its impact on fetal development, specifically examining visceral and skeletal abnormalities in rat offspring exposed to daily oral doses throughout pregnancy. Fourteen pregnant rats were randomly assigned to control and tartrazine groups (seven animals each), w...

Objective: Fenugreek paste, which contains fenugreek and some spices, is a widely consumed food in Kayseri and the surrounding region of Turkey. In this study, the antitumor effect of an extract obtained from fenugreek paste was investigated in Balb/C mice bearing Ehrlich ascites tumor (EAT). Materials and Methods: The concentration of fenugreek pa...

Background Studies for new treatment strategies on cancer continue, and new searches continue in the diagnosis and evaluation of cancer. This study examined the possible anticarcinogenic effect of Rutin on the brain tissues of male mice with Ehrlich ascites carcinoma (EAC). Material and methods We used micro‐computed tomography (micro‐CT) and hist...

In recent years, seminal studies have been devoted to unraveling the puzzling mysteries associated with the cancer preventive/inhibitory role of melatonin. Our current knowledge of the translational mechanisms and the detailed structural insights have highlighted the characteristically exclusive role of melatonin in the inhibition of carcinogenesis...

Epileptic seizures are seen as a result of changing excitability balance depending on the deterioration in synaptic plasticity in the brain. Neuroplastin, and its related molecules which are known to play a role in synaptic plasticity, neurotransmitter activities that provide balance of excitability and, different neurological diseases, have not be...

OBJECTIVE: In this study the antioxidant effect of carob plant, ıt's effects of nicotine-induced oxidative stress and the number of pyramidal cells in the rat hippocampus in cornu ammonis (CA) were investigated. MATERIAL AND METHODS: In the study, 28 adult Wistar Albino male rats were used. Rats are divided into four groups as control group, carob...

Amaç: Bu çalışmada, gıdalarda yaygın olarak kullanılan Tartrazinin, önemli sitokinlerden olan ve tümör büyümesi ile yakından ilişkili olan IL-6’nın ve hücre farklılaşması, apoptoz ile otofajide önemli rol oynayan Beklin-1 proteininin rat plasenta dokusundaki ekspresyon yoğunluğu araştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmada, 10 adet...

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling pathway. Melatonin has many benefits, such as organizing circadian rhythms and acting as a powerful hormone. We aimed to show the antitumor effects of melatonin in both in vivo an...

Radiation has been widely used in many business sectors over the last century. Our study investigated the possible teratogenic effects of radiation on the bones of rat fetuses and the protective effect of melatonin against these effects. In this study, 15 pregnant female Wistar albino rats were used. These rats were divided into four groups: the co...

Background Gabapentin is a drug commonly prescribed to adult pregnant women with neuropathic pain and epilepsy. Since the effect of antiepileptic drugs used in pregnant women with epilepsy on prenatal bone development is controversial, this study was conducted to demonstrate the toxic effects of gabapentin use during pregnancy on the skeletal syste...

Inflammation and hypoxia have an effect on the molecular mechanism of cardiovascular and respiratory pathologies accompanying seizures. Against this, Tauroursodeoxycholic Acid (TUDCA) can regulate oxidative stress, inflammation and cellular survival by suppressing endoplasmic reticulum (ER) stress. We evaluated the expression changes of NF-κB p65,...

The development and progression of sepsis are multifactorial and influence the immunological, endocrine, and cardiovascular systems of the body. Our knowledge of the key mechanisms involved in the pathogenesis of sepsis has expanded exponentially, yet this still needs to be translated into effective targeted therapeutic regimes. In the present stud...

Rutin is one of the flavonoids found in fruits and vegetables. The PI3K/AKT/mTOR signaling pathway is critical for the life cycle at the cellular level. In current study, we purposed to demonstrate the antitumoral effect of rutin at different doses through the mTOR-signaling pathway and argyrophilic nucleolar regulatory region. EAC cells were injec...

Rhamnetin is a flavonoid which contained in especially clove, such as apple, tea, and onion plant. Rhamnetin has been used in cancer research due to its antitumor and antioxidant properties. In this study, effects of rhamnetin administration at different doses on ascites and solid tumors were investigated in Balb/C mice bearing EAT model that origi...

Aims: Demyelination affects the propogation of neuronal action potential by slowing down the progression. This process results in a neuro-impairment like Multiple Sclerosis (MS). Evidence show that MS also contributes to involvement of the autonomic system. In the molecular approach to this involvement, we aimed to observe muscarinic ACh receptor...

Background and aim: Rhamnetin is a flavonoid which contained in especially clove, such as apple, tea, onion plant. Rhamnetin has been used in cancer research due to its antitumor and antioxidant properties. In this study, effects of rhamnetin administration at different doses on ascites and solid tumors were investigated in Balb/C mice bearing EAT...

In this study, the protective effect of melatonin was investigated in lipopolysaccharide induced sepsis model. 28 rats were randomly divided; Control, Melatonin, LPS and LPS + Melatonin. After LPS application, surgically remove kidney and liver tissues. The level of malondialdehyde (MDA) an oxidative stress marker and the immunoreactivity of Toll‐l...

Introduction One of the most important health problems today is cancer. The aim of this study was to investigate the in vitro effect of yarrow (Y) with known anticarcinogenic effect on Ehrlich ascites tumor (EAT). Materials and Methods The above-ground part (300 g) of Y was macerated with water and extracted three times for 24 hours at 37°C in a s...

Objective This study was carried out to determine the effect of intrauterine carbamazepine (CBZ) exposure on fetal bone development during pregnancy. Methods In the study, 24 female Wistar pregnant rats were used. Rats were 20 weeks old. They had an average body weight of 150–200 g. Pregnant rats were randomly selected and divided (n = 6) into a c...

Aim: Vestibular neuritis is one of the most common causes of acute spontaneous vertigo. In our study, we aimed to analyze the cerebellum volume and cerebellum connections in patients diagnosed with vestibular neuritis using the VolBrain program. Materials and Methods: 10 patients and 9 healthy (control) persons were included in the study. Automatic...

Cerebral ischemia/reperfusion injury has emerged as an intricate mechanism. However, identification of wide-ranging mechanisms which mechanistically regulate reperfusion injuries have significantly improved our understanding. Recent advancements in our knowledge about the molecular consequences of ischemia and reperfusion might be advantageous in t...

Introduction Mistletoe has been used alone or as a complementary therapy in the treatment of different diseases for years. In this study, the antitumoral effect of mistletoe fruit extract on Ehrlich ascites tumor (EAT) cells was evaluated. Materials and Methods EAT cells from preformed stock mice were transferred to culture dishes containing 5-flu...

Discovery of kisspeptin signaling has paradigmatically shifted our understanding about the instrumental role of transduction cascades in myriad of biological activities. Moreover, rapidly emerging evidence about central role of kisspeptin signaling in carcinogenesis and metastasis has attracted widespread attention. However, kisspeptin-driven signa...

Background: Sometimes seen distal to humerus foramen supratrochleare and supracondylar process are rare variations. Supracondylar process is a variations observed on the distal side of humerus. The supracondylar process is a variant located 1/3 distal side of the humerus. The supratrochlear foramen may appear between the coronoid fossa and olecra-n...

The toxicological effects of paracetamol on lung

Paracetamol (PAR) is an analgesic and antipyretic drug that is frequently used during pregnancy in many countries of the world. Although the fetal and maternal effects of toxic or long-term therapeutic doses used during pregnancy are known, the data on fetal effects during trimesters are insufficient. In this study, the possible effects of PAR expo...

The aim of this study is to investigate the protective effect of 70% methanolic extract of Myrtus communis L. leaves (300 mg/kg) against the kidney stone modeling created by (0.75%) ethylene glycole. Twenty-eight, 10 week’s Sprague Dawley male rats were divided into four groups (n = 7) as the control group, ethylene glycol (EG) group, M. communis (...

HSP90 (heat shock protein 90) chaperone machinery is a versatile regulator of diverse client repertoire under normal physiological as well as in stress conditions. Overwhelmingly, increasing list of high-impact research reports has significantly improved our knowledge about regulation of HSP90 by noncoding RNAs. In this chapter we have gathered new...

A fundamental goal in molecular oncology is to unravel the underlying mechanisms which cause the cell transformation. In line with this approach, genome-wide functional screening approaches have revealed exciting insights into heterogeneous nature of cancer. Rapidly expanding horizons of research have unraveled myriad of pathways which play instrum...

Aim: According to World Health Organization data, around 1.5 billion people in the world use tobacco products. Nicotine, the most common use of tobacco, is the main psychoactive substance that causes addiction. Exposure to nicotine during pregnancy increases the risk of low placenta weight, stillbirth, congenital heart disease, musculoskeletal defe...

Discovery of non-coding RNAs has paradigmatically shifted our understanding of the multifaceted nature of cancer. It is becoming progressively more understandable that long non-coding RNAs play fundamental role in regulation of cell signaling pathways in different cancers. DANCR has started to gain remarkable appreciation because of its central rol...

Quercetin is a natural flavonoid with potential anticancer properties without significant cytotoxicity in normal tissues. However, the effects of quercetin on Ehrlich Ascites carcinoma (EAC) have not yet been clarified. The study aimed to show the antitumoral effect of quercetin through argyrophilic-NOR (AgNOR) protein synthesis in mice carrying EA...

Cancer is a therapeutically challenging disease because of its heterogeneous and multifaceted nature. Decades of research have sequentially and systematically enabled us to develop a sharper and better understanding of the heterogeneous nature of cancer. Genetic, genomic and proteomic studies have unraveled wide-ranging signaling cascades which pla...

Objective: Cerebellum plays quite important in our balance by coordinating the control and synergistic movements of the skeletal muscles. There are many studies in which the volume of the cerebellum is measured and different methods are used. Manual measurements are accepted as the gold standard in these studies, but these measurements are not comm...

In the current work, the effects of curcumin on testicular tissues in Ehrlich Ascites Tumor (EAT) model developed in Balb/C mice. EAT cells (1x10 6) received from stock of animals were injected intraperitoneally to animals. 25 mg/kg and 50 mg/kg of curcumin were administered intraperitoneally. Testicular tissues obtained after all the experiment we...

Nicotine plays an important role in oxidative stress formation. For this purpose, to reveal the antioxidant effect of cornelian cherry plant, the effects of nicotine-induced oxidative stress. 28 adult Wistar Albino (180-220 g) male rats were used in the study. Rats were divided into four groups as control group (n=6)

Oxidative stress plays an important role in fetus development. In this study, the role of nicotine in skeletal system changes were investigated with double staining 6 mg/kg nicotine; and the protective role of 50 and 100 mg/kg curcumin was also investigated. Pregnant rats were divided into 6 groups with 5 rats in each. Nicotine was applied to the e...

Backround: Cornelian Cherry (Cornus Mas L) has widespread use due to its anti-inflammatory, anti-carcinogenic and anti-oxidant properties. In this study, the effects of Cornus Mas L (C. mas L) in different dosages on the biochemical values of mice organs were investigated in the Ehrlich Ascites tumor model, which originated from mice breast adenoca...

Aim: Cerebellum plays quite important in our balance by coordinating the control and synergistic movements of the skeletal muscles. There are numerous studies in which the volume of the cerebellum is measured and different methods are used. Manual measurements are accepted as the gold standard in these studies, but these measurements are not common...

Skeletal system and some organs development changes in rat fetuses with 30 and 60 mg/kg caffeine and melatonin’s (10 mg/kg) protective role against rat fetuses were investigated. Groups (n = 4) were formed as Control, LDC, HDC, LDC+melatonin, HDC+melatonin and melatonin. Fetuses were taken by cesarean section and stained using dual skeletal stainin...

Aim: Paracetamol is widely used by important societal groups such as pregnant women and the elderly. Paracetamol, taken in high doses especially during pregnancy, causes liver failure. The aim of our study is to investigate the effects of paracetamol, which is widely used during pregnancy, on the fetal liver. Methods: In our study, five groups of r...

Since the development of the neuroimaging sciences, the posterior cranial fossa (PCF) has been anatomically evaluated and measured volumetrically. Radiologically, the PCF volume is an important neuroimaging finding in Chiari malformation type I (CM I), but recent neuroimaging studies have revealed conflicting volumetric changes in the PCF in CM I p...

Epilepsy is a group of neurological disorders characterized by abnormal electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation. Sudden unexpected death in epilepsy (SUDEP) is the predominant cause of death in young epileptic patients. SUDEP patients displayed an increased car...

Introduction: Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study was performed to investigate effects of curcumin on lipid peroxidation and ant...

Introduction: Humerus it is located between the scapula, radius and ulna bones and is the longest and thickest bone of the upper extremity. Anatomical structures on the humerus are used for sex discrimination in morphology and anthropology. Materials and methods: This study was carried out using digital calipers with sensitivity of 0.01 millimeters...

Purpose: This study was designed to investigate the effect of apilarnil on neuronal damage and related mechanisms in a sepsis model in order to demonstrate whether or not apilarnil has neuroprotective effect. Methods: In this study, 64 adult male Sprague-Dawley species rats were randomly divided into eight groups. The rats were administered apil...

Experimental and clinical studies of cardiac pathology associated with epilepsy have demonstrated an impact on the autonomic nervous system (ANS). However, the underlying molecular mechanism has not been fully elucidated. Molecular investigation of the neurotransmitters related receptor and ion channel directing ANS might help in understanding the...

In this study, we aimed to evaluate the effect of carob extract against intratesticular histological, apoptotic, biochemical and spermatogenic changes in rats exposed to nicotine. Twenty‐eight rats were divided into four groups and were administered saline, nicotine, carob, or nicotine + carob once a day for 35 days. Superoxide dismutase (SOD), cat...

Background: Oxidative stress plays an important role in fetus brain development. The aim of this study was to investigate the protective role of melatonin against the effect of caffeine (given 30 mg/kg and 60 mg/kg) in embryo brain. Material and Methods: For this purpose, 35 adult female Sprague-Dawley rats were used in the study. Pregnant rats wer...

Introduction: The skeletal system is examined as upper and lower bones (skeleton appendiculare) and bones from the head to the pelvis (Skeleton axiale). Due to its complex structure and important functions, it is a common area where problems such as instability, pain and dysfunction are caused by both degenerative processes increasing with age and...

Situs Inversus is a rare congenital anomaly caused by the displacement of the organs in the chest and abdomen. Situs inversus totalis known as the displacement of all organs according to the mirror image. Dextrocardia is used to describe the position of the heart which tip is pointing to the right instead of left side of the chest. People having si...

Treatment options for effective treatment of cancer with minimum off-target effects and maximum clinical outcome have remained overarching goals in the clinical oncology. Vitamin C has remained in the shadows of controversy in the past few decades however, burgeoning evidence has started to shed light on wide-ranging anticancer effects exerted by V...

Objectives: In this study, we aimed to effect of extract that derived from fenugreek on total antioxidant/oxidant status at Ehrlich ascites tumor bearing Balb/C mice. Methods: The phenolic of Fenugreek extract was calculated as gallic acid equivalent using Folin-Ciocalteu method. Fenugreek extract concentration determined 200–400 mg/kg. In the end...

There has always been a quest to search for synthetic and natural compounds having premium pharmacological properties and minimum off-target and/or side effects. Therefore, in accordance with this approach, scientists have given special attention to the molecules having remarkable ability to target oncogenic protein network, restore drug sensitivit...

Background: Osteoarthritis is non-inflammatory, degenerative, and chronic disease observed especially as progressive in load-bearing joints. There are several studies that measure the volume and surface area of the knee joint cartilage in osteoarthritis patients. However, different methods were used in these studies. Methods: Our study population c...

Objective: The aim of this study was to contribute to the literature by making measurements on the dimensions of the dry radii. Methods: This study was carried out on 28 dry and radius bones. Bones were measured a total of 14 variables at the proximal end, trunk and distal end. Results: The mean radius length was 228.93 mm on the left side and 232....

AIM: Cornus mas L is commonly used due to its anti-infl ammatory, anti-carcinogenic and anti-oxidant properties. In the study, the effects of C. mas L extract on a solid tumor were examined in the Ehrlich solid tumor model developed in Balb/C type mice. METHODS: Ehrlich acid tumor (EAT) cells (1x106 EAT cell) from the stock animal were injected sub...

Aim: Teratogenic substances such as nicotine, alcohol, caffeine, and derivatives, which pregnant women may get exposed to unconsciously or use consciously can harm the mother and directly or indirectly damage embryonal and fetal tissues. Melatonin has been shown to exert direct free radical trapping and indirect antioxidant effects in different org...

Abstract: Introduction and purpose: The sacrum is an important bone structure involved in the field of fusion and stabilization in the treatment of sacral bone, lumbosacral and sacroiliac deformities or injuries. The aim of this study is to determine the mean index values of some parameters in the sacrum according to age and gender in certain age g...

Dextrocardia with situs inversus is an uncommon anomaly affecting about 1 to 2 per 10,000 in the general population. This report describes an adult male patient with dextrocardia and in a Turkish subject. The photographic illustrations revealed transposition of some of the visceral organs such as the spleen was located right and the liver and gall...

Dextrocardia with situs inversus is an uncommon anomaly affecting about 1 to 2 per 10,000 in the general population. This report describes an adult male patient with dextrocardia and in a Turkish subject. The photographic illustrations revealed transposition of some of the visceral organs such as the spleen was located right and the liver and gall...

Abstract Introduction: Different doses of C. Mas concentrated syrup on ascitic tumors was investigated in the Ehrlich Ascites Tumor model (EAT). Material and Methods: A total of 46 Balb/C mice were used in our study, 6 of which were stock animals and the other were in ascitic tumor groups. EAT cells (1x106 EAT cells) were injected intraperitoneally...

The double skeleton staining method is among the methods which are particularly used on rats. In the literature, studies take place titled as the examination of the effects on fetus bones by giving various substances on pregnant rats. Two different types of ossification are described in the embryonic period called as intramembranous ossification an...

Amaç: Os sacrum; sacral, lumbosacral ve sacroiliak şekil bozuklukları veya yaralanmalarının tedavisinde füzyon ve stabilizasyon alanına dahil edilen önemli bir kemiktir. Bu çalışmada os sacrum örnekleri üzerinde detaylı morfometrik ölçümler yapılması amaçlandı. Materyal ve Metot: Çalışma Erciyes Üniversitesi Anatomi Anabilim dalında bulunan 47 os s...

Objective(s) This study investigated the possible effects of low (3 mg/kg) and high (6 mg/kg) doses of nicotine on the skeletal development of rat fetuses by the double staining method and the protective role of melatonin (10 mg/kg) against these effects. Materials and Methods Eighteen adult female Wistar-Albino rats were divided into six groups (...

Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study was performed to investigate effects of curcumin on lipid peroxidation and antioxidant enzym...

Background: Curcumin is a polyphenol compound that has antioxidant, anticancer, anti-inflammatory, anti-hyperlipidemic and antimicrobial effects. Nucleolar-organizing regions are the sites of the gene on chromosomes. The present study was aimed to show the antitumoral effect of curcumin via AgNOR protein synthesis in Ehrlich's ascitic carcinoma (E...

This study was carried out to measure the volume of the palatine tonsil in otorhinolaryngology outpatients with complaints of adenotonsillar hypertrophy and chronic tonsillitis who had undergone tonsillectomy. To date, no study has investigated palatine tonsil volume using different methods and compared with subjective tonsil size in the literature...

Background: Spine is a column that consists of consecutively lined up vertebras. It includes medulla spinalis. It contributes the motions of head, neck and body. Spine is not a straight column. There is a convexity towards the front of the spine (lordosis) at cervical and lumbar areas in adults and a convexity towards the back of the spine (kyphosi...