Seema Patel- PhD Biotech (IITG-India); MS Bioinformatics (SDSU-USA)
- Researcher at Reprogene, USA
Seema Patel
- PhD Biotech (IITG-India); MS Bioinformatics (SDSU-USA)
- Researcher at Reprogene, USA
About
190
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Introduction
A microbiologist - molecular biologist - bioinformatician - medical writer.......I want to take a break from collaborations.....seems like I am spending much time and effort, and gaining nothing out of it......I am done with editing on random topics.....Henceforth, I will be focussing on Immunology- Endocrinology - Neurobiology.....not mere publishing but diving deep into these areas...
Current institution
Reprogene, USA
Current position
- Researcher
Additional affiliations
November 2017 - present
Reprogene, USA
Position
- Researcher
August 2013 - June 2016
Position
- Research Assistant
Description
- In-silico investigation of mutation and drug resistance in Mycobacterium tuberculosis.
August 2010 - May 2011
Education
August 2013 - May 2016
August 2007 - June 2010
Publications
Publications (190)
Kelch is a conserved domain found in a widespread variety of proteins of pathogenic and allergenic relevance. Due to its suspected role in immune manipulation, it holds considerable interest. This in silico study examines the distribution of kelch domains in the SMART database of bacterial proteins. The data was interpreted using custom programmes....
Kelch is a conserved domain found in a widespread variety of proteins of pathogenic and allergenic relevance. Due to its suspected role in immune manipulation, it holds considerable interest. This in silico study examines the distribution of kelch domains in the SMART database of bacterial proteins. The data was interpreted using custom programmes....
Pistacia integerrima grows in some areas of Pakistan and some other south Asian countries such as
Afghanistan, India, Nepal, and Myanmar. It is an important medicinal plant which has been traditionally
used for the treatment of asthma, cough, and dysentery. In the present study, we intend to re-isolate bioactive
compounds (I–III) from P. integerrim...
Synthetic fragrance compounds have become a ubiquitous part of household cleaning products and personal care agents. To improve aesthetics, fragrances are added, but the current research has unveiled detrimental effects of these odorous compounds. The exposure to the synthetic fragrances and musks, which are produced in quantities of thousands of t...
Cuscuta reflexa (dodder) of the family Convolvulaceae has many ethno-medicinal uses such as antidiarrheal and antiemetic. The antidiarrheal use of this plant is well established in different communities around the world without many scientific bases. One of the uses of this plant is the alleviation of diarrhea. The antibacterial, anthelmintic, anti...
Published studies indicate that virtually any kind of botanical material can be exploited to make biocompatible, safe, and cost-effective silver nanoparticles. This hypothesis is supported by the fact that plants possess active bio-ingredients that function as powerful reducing and coating agents for Ag+. In this respect, a phytomediation method pr...
The bioactive triterpenoid 3-oxo-6-β-hydroxy-β-amyrin (1) has been isolated from multiple plant sources. In this study, chloroform fraction of Pistacia integerrima extract was processed for the isolation of the compound. The compound identity was confirmed by advanced spectroscopy technique. X-ray crystallography was applied for molecular structure...
Aim: The current study focused on anticancer potential of two known dimeric napthoquiones, diospyrin (1) and 8-hydroxydiospyrin (2) isolated from the roots of Diospyros lotus.
Background: Cancer being a genetically heterogenous and complex disease, the available therapies for it are not very effective, rendering them the predominant cause of morta...
Food security is a global concern, and it is a substantial challenge to feed the ever-increasing population. The anthropological operations, abiotic and biotic stresses, have limited the crop productivity to a great extent. Phytopathogens are the major biotic constraints and pose a significant threat to food production. The extensive utility of haz...
This chapter deals with the emerging potential of microbial-based biocontrol agents for the management of Phytopathogens in agricultural
In this work, the extract of Callicarpa macrophylla (family Lamiaceae) was evaluated as
an antidiarrheal agent. BALB/c mice were subjected to castor oil-induced diarrhea and
charcoal meal gastrointestinal transit time assay. The antidiarrheal effect of the methanol extracts of the leaves and bark of C. macrophylla on the animals was evaluated. The...
Ebola virus (EBOV) was discovered for the first time in 1976. It belongs to the family Filoviridae, which causes hemorrhagic fever that could lead to death in a few days. West Africa faced a major outbreak where symptoms appeared in the form of chills, myalgia, fever, diarrhea, and vomiting, and the disease finally reached a severe state as a resul...
The monooxygenase enzymes, cytochrome P450s (CYPs), are ubiquitous in their presence and versatile in their functions. They are indispensable for hormone synthesis, dietary metabolism, and detoxification among other roles. CYPs from marine organisms are interesting candidates for recruitment in drug biotransformation, synthesis of therapeutics, bio...
Abstract
Keywords: Ethno-Veterinary; Frequency of citation; Relative Frequency of Citation; Informant’s Consensus Factor; Direct Matrix
Ranking
Introduction
Medicinal plants are a good natural resource and safe drugs
and have been used for the treatment of health disorders in human
and livestock from time immemorable [1]. Approximately 85% of
all m...
Study Objective: In order to analyze the local importance of medicinal plants and their availability status, a quantitative ethno-veterinary study has been carried out in the outskirts of district Malakand from March 2014 to February 2016.
Materials and Methods: The plant resources with ethno-veterinary usages were evaluated via a semi-structured a...
Bawazeer et al.: Molecular Binding Mode of Diospyrin against PTP1B The present study was designed to evaluate the antidiabetic potential of diospyrin isolated from Diospyros lotus, using protein tyrosine phosphatase 1B enzyme as the target. Molecular binding mode of diospyrin to protein tyrosine phosphatase 1B was essential to explore its molecular...
Background
Many years back, during Islamic civilization, truffle (Kama'ah) was mentioned by Prophet Muhammed (PBUH) to be well recognized as a therapeutic for eye diseases. (“In the Sahihain, it is narrated that the Prophet said: “The Kama'ah (truffle) is among the manna (which is a food mentioned in the Qura'n, Surah al-Baqarah), and its water (ex...
A diverse range of agents, from biological and chemical to mechanical, can be perceived as stressors by the immune system. Even the diet, depending on its components and dosage, can provoke the immune system. Processed foods are acidogenic which lower the pH of the extracellular matrix (ECM), causing an aberrant enzyme activity. The consequent agit...
Proanthocyanidins are condensed tannins with various pharmacological properties. These phytochemicals are considered as 'offense and defense molecules because of their human health benefits. The validation of their diverse health aspects, namely, antioxidant, anticancer, antidiabetic, neuroprotective, and antimicrobial has earned them repute in the...
Mushrooms, the macrofungi, are enigmatic in their composition, which renders some of them umami-flavored edible, some medicinal, some hallucinogenic/psychoactive, while some lethal. In current times, appreciation and demand of the medicinal mushrooms is rising, with the validation of their efficacy as antioxidant, anti-inflammatory, immunomodulator...
α-glucosidase inhibition is a rational approach in the effective management of type 2 diabetes. Several inhibitors of this enzyme class are in clinical use, but are riddled with efficacy, potency and safety challenges. For this reason, new effective α-glucosidase inhibitors are under investigation. Compounds with 1, 3, 4-oxadiazole nucleus have sho...
Antiplatelet drugs reduce the risks associated with atherothrombotic events and show various applications in diverse cardiovascular diseases including myocardial infarctions. Efficacy of the current antiplatelet medicines including aspirin, clopidogrel, prasugrel and ticagrelor, and the glycoprotein IIb/IIIa antagonists, are limited due to their in...
Huge demand of safe and natural preservatives has opened new area for intensive research on bacteriocins to unravel the novel range of antimicrobial compounds that could efficiently fight off the food-borne pathogens. Since food safety has become an increasingly important international concern, the application of bacteriocins from lactic acid bacte...
The fatal dengue virus (DENV) endured by Aedes sp. mosquito roots huge morbidity and mortality in subtropical and tropical sections of the world. There are four antigenically related but diverse serotypes of dengue virus, labelled as DENV-1, DENV-2, DENV-3, and DENV-4. With no drugs or vaccines to control this pathogen, that exists in four differen...
Consumption of medicinal plants exert a promising role in drug discovery and have been proven very effective against various human syndromes. Diallyl trisulfide (DATS) suppresses naphthalene-induced oxidative injury and inhibits inflammatory responses such as TNF-α, IL-6, IL-8, and nuclear factor-kappa B (NF-κB). It also suppresses the production o...
In the face of rising population, food insecurity is emerging as a global challenge. Nutritious sources of food are frantically being searched for and so far underutilized food candidates are being assessed. In this regard, Arthropoda, the largest phylum in the animal kingdom fits the bill. Especially, the Class Insecta holds tremendous promise, wi...
Last few decades have witnessed the unprecedented growth in the application of probiotics for promoting the general gut health as well as their inception as biotherapeutics to alleviate certain clinical disorders related to dysbiosis. While numerous studies have substantiated the health-restoring potentials for a restricted group of microbial speci...
The detrimental impacts of conventional building materials on environmental health have raised global concerns. While the fast-depleting fossil-derived materials are adding to global warming, chemically-synthesized materials are polluting the air, water, and soil. To promote health and to meet sustainability target, the importance of eco-friendly g...
Spillage of fossil-based oils during their conveyance through water conduits are sporadic, but significant environmental disasters. As the viscous hydrocarbons of the crude oils spread on water surface and choke aquatic life to death, their effective degradation is crucial for ecological balance. Though chemical and mechanical means are conventiona...
The need to maximize agricultural productivity has made pesticides an indispensable part of current times. Farmers are unaware of the lurking consequences of the pesticide exposure, which endanger their health. It also puts the unsuspecting consumers in peril. The pesticides (from organophosphates, organochlorine, and carbamate class) disrupt the i...
Your article is protected by copyright and all rights are held exclusively by Springer-Verlag GmbH Germany, part of Springer Nature. This e-offprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website....
The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance. The chemical structure of compound 7 (methyl 3-O-phospo- α -D-glucopyranuronic acid was elucidated by physical and advance spectral technique. Also, this compound was assessed for various in vitro biological screening. The results showed...
The development of reliable and green methods for the fabrication of metallic nanoparticles has many
advantages in the field of nanotechnology. In this direction, the present work describes eco-friendly and costeffective
protocol for the production of silver nanoparticles (AgNPs) using aqueous extract of Quercus
semecarpifolia leaves. Different tec...
Purpose of Review
Allergen is an umbrella term for irritants of diverse origin. Along with other offenders such as pathogens, mutagens, xenobiotics, and pollutants, allergens can be grouped as inflammatory agents. Danger-associated molecular patterns (DAMPs) are altered metabolism products of necrotic or stressed cells, which are deemed as alarm si...
The kingdom fungi, including the genus Monascus, is a trove of potential pharmaceuticals. This mold Monascus holds paradoxical stature in the realm of healthcare. On one hand, it has been an ubiquitous ingredient of Oriental medication such as Traditional Chinese Medicine (TCM), since ages. Monascus-fermented product red yeast rice (RYR) is being u...
AIDS (Acquired Immuno-Deficiency Syndrome) has been a major epidemic bothering mankind for last decades. UNAIDS estimate displays the existence of millions of AIDS patients at the end of 2016, though remarkable progress against AIDS over the past 15 years has stirred a global obligation to end the epidemic by 2030. All the FDA (Food and Drug Admini...
Background:
Honokiol ((3',5-di-(2-propenyl)-1,1'-biphenyl-2,2'-diol), a lignan, is a promising antitumor compound, having exerted activity against a number of human cancer cell lines. Honokiol has inhibitory role on the proliferation, invasion and survival of cancer cells in in vitro as well as in vivo studies. It interferes with signaling pathway...
Urease inhibition potential of Hypochoeris glucoside (1), guaiane-type sequiterpene (2), confertin (3) and
scopoletin (4) was carried out with high throughput mechanism-based assay. These compounds were
isolated from Hypochaeris radicata L, an Asteraceae family member. The pure compounds were screened
for their urease and carbonic anhydrase inhibit...
Vitamin D (25(OH)D3 and 1,25-dihydroxycholecalciferol), is known to play role in calcium uptake, bone metabolism, mineral homeostasis, modulation of the innate and adaptive immune systems and the regulation of cell proliferation, among a litany of other functions. If serum level of this vitamin falls below 30-40 ng/mL, its deficiency can occur, pre...
The state of enzymes in the human body determines the normal physiology or pathology, so all the six classes of
enzymes are crucial. Proteases, the hydrolases, can be of several types based on the nucleophilic amino acid or
the metal cofactor needed for their activity. Cathepsins are proteases with serine, cysteine, or aspartic acid
residues as the...
Background
Hypochaeris radicata (flatweed) from the family Asteraceae is a medicinal plant found in Europe, Middle East, and India. In folkloric medication, it is used to heal jaundice, dyspepsia, constipation, rheumatism, and hypoglycemia as well as renal problems. Leaves and roots of the plant have antioxidant and antibacterial properties. The pl...
Graphical abstract of this paper is given as a supplementary material. Supplementary material represents in vivo study on analgesic, muscle-relaxant, sedative activity of extracts of Hypochaeris radicata.
The pathogenicity of microbes in the rhizosphere is influenced by the change in climatic conditions. The modification in climate factors as temperature, CO2, moisture, etc. enhances the abundance and virulence of soilborne pathogens residing in the rhizosphere. Among, microbial communities, fungi such as Fusarium and Rhizoctonia infect a wide range...
Citrus aurantium L. (Rutaceae), commonly known as bitter orange, possesses multiple therapeutic potentials. These biological credentials include anticancer, antianxiety, antiobesity, antibacterial, antioxidant, pesticidal, and antidiabetic activities. The essential oil of C. aurantium was reported to display marked pharmacological effects and great...
Thermostable proteases are important in biotechnological and industrial sectors, due to their stability against denaturing agents and chemicals. The feature that gives them such unique applicability is their reaction at high temperatures, which affords a high concentration of substrate, and less risk of microbial contamination. Nearly 65% of indust...
Background:
Acetylcholinesterase (AChE), a serine hydrolase, is primarily responsible for the termination of signal transmission in the cholinergic system, owing to its outstanding hydrolyzing potential. Its substrate acetylcholine (ACh), is a neurotransmitter of the cholinergic system, with a predominant effect on motor neurons involved in memory...
Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, apart from a gamut of other metabolic co-morbidities such as insulin resistance, obesity, cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammator...
Superoxide dismutase (SOD) is the pivotal antioxidant enzyme that defends organisms against the oxidative stresses of superoxide radicals. In this experimental study, purification of SOD from the leaves of Avicennia marina (grey mangrove or white mangrove) from the family Acanthaceae, located in Sirik mangrove forest on the shore of the Gulf of Oma...
Current therapies in clinical practice face strong criticism regarding their efficacy, and side effects, which forced the neuro-researchers to discover novel agents with different mechanistic insights. Glycosides are naturally-occurring plant secondary metabolites with significant medicinal potential and clinical scope as antidepressant. The aim of...
Background:
Blood platelets are crucial for maintaining hemostasis and several events in the woundhealing. However, platelet up-regulation leads to the development and the complications of several cardiovascular diseases. For the effective management of these complications, several synthetic drugs are in clinical practice such as aspirin, warfarin...
Breast cancer is the most common cancer in females. The deteriorating environment, and lifestyle flaws are raising the frequency of this cancer. Existing therapies are not universally-effective, and they cause side effects, relapses, and high mortality rate. Alternative medications may be milder, but are less effective or are inadequate for a compl...
Pistacia genus belong to family Anacardiaceae and it is versatile in that its member species have food (P. vera), medicinal (P. lentiscus) and ornamental (P. chinensis) values. Various species of this genus have folkloric uses with credible mention in diverse pharmacopeia. As a trove of phenolic compounds, terpenoids, monoterpenes, flavonoids, alka...
The current paper summarizes the evaluation of the alcoholic extract of Sarcococca saligna (D. Don) Mull. fruits for acute toxicity, analgesic, GIT motility modulation, and anti-termite properties. The extract was evaluated for analgesic activity using acetic acid-induced writhing model while charcoal meal model was adopted for GIT motility estimat...
Galls, the abnormal growths in plants, induced by virus, bacteria, fungi, nematodes, arthropods, or even other plants, are akin to cancers in fauna. The galls which occur in a myriad of forms are phytochemically-distinct from the normal plant tissues, for these are the sites of tug-of-war, just like the granuloma in animals. To counter the stressor...
Renin-angiotensin-aldosterone system (RAAS) is a vital system of human body, as it maintains plasma sodium concentration, arterial blood pressure and extracellular volume. Kidney-secreted renin enzyme acts on its substrate to form angiotensin II, a versatile effector peptide hormone. Every organ is affected by RAAS activation and the resultant hype...
The current food options, especially in the Western countries, are acidogenic, which reduce extracellular pH and perturb ionic homeostasis. The acidity-activated enzymes mediate a large panel of chronic and acute diseases.
To quell the morbidities and mortalities associated with the metabolic syndromes, nonpharmacologic approaches are preferred. Di...
A new dimeric naphthoquinone, named 5,8,5′-trihydroxy-8′-methoxy-6,6′-dimethyl-7,3-binaphthyl-1,4,1′,4′-tetraone (1), was isolated from Diospyros lotus stem. The structure of the compound was elucidated by advance spectroscopic analysis including 1D and 2D experiments such as HMBC, NOESY, and J-resolved (JRES). Compound1was assessed for antioxidant...
Antimicrobial peptides (AMPs) are cationic amphiphilic molecules with α-helix or β-sheet linear motifs and linear or cyclic configurations. For their role in 'defense and offense', they are present in all living organisms. AMPs are named so, as they inhibit a wide array of microbes by membrane pore formation and subsequent perturbation of mitochond...
Background:
Inula viscosa L. (Asteraceae) is a medicinal plant widely used as a folk medicine in oriental Morocco, to treat hypertension. The antihypertensive effect of the methanolic extract obtained from I. viscosa leaves was evaluated in hypertensive L-NAME rats. Systolic blood pressure (SBP) was measured using a non-invasive indirect tail-cuff...
Adhesins are bacterial proteins with host cell adhesive properties. These proteins occur in diverse architectures, ranging from capsules, vesicles, pili, fimbri, to enzymes. These proteins interact with host cell surface receptor proteins, for cross-membrane- trafficking and the invasion of host cells. Thus, they lead to inflammation and pathogenes...
Rutin is a naturally-occurring bioactive compound of flavonoid family, exhibiting a multitude of health-endorsing effects such as anti-oxidative, anticancer, antidiabetic, cardio-protective, vaso-protective, neuroprotective, cyto-protective etc. The ameliorative properties emerge from its antioxidant attributes. Induction of TNF-α apoptosis; regula...
Mangiferin, a natural xanthone glycoside, isolated from variousparts of plant families such as Mangiferaceae, Zingiberaceae,Celastraceae, Gentianaceae, and Aphloiaceae, is known to modu-late several biological targets in inflammation and oxidative stress.It resolves oxidative stress by inhibiting enzymatic systems such asHMG-CoA reductase, the prot...
Ebola virus (EBOV) was discovered for the first time in 1976. It belongs to the family Filoviridae, which causes hemorrhagic fever that could lead to death in a few days. West Africa faced a major outbreak where symptoms appeared in the form of chills, myalgia, fever, diarrhea, and vomiting, and the disease finally reached a severe state as a resul...
Vitiligo is an idiopathic systemic autoimmune disease affecting skin, hair and oral mucosa. This genetic yet acquired disease characterized by melanin loss is a cause of morbidity across all races. Though thyroid disturbance has been recognized as a key trigger of this pathology, an array of other factors plays critical role in its manifestation. M...
Glioblastoma multiforme (GBM) is the deadliest form of heterogeneous brain cancer. It affects an enormous number of patients every year and the survival is approximately 8 to 15 months. GBM has driven by complex signaling pathways and considered as a most challenging to treat. Standard treatment of GBM includes surgery, radiation therapy, chemother...
Inflammation is a pivotal defense system of body. Unfortunately, when homeostasis falters, the same inflammatory mechanism acts as a double-edged sword, and turns offensive, paving the path for a broad array of pathologies. A multi-protein complex termed as inflammasome perceives the PAMPs (pathogen associated molecular patterns) and DAMPs (danger...
Cucurbitaceae family members such as pumpkin and watermelon have seeds that are discarded as the by-products of food processing. However, they have been discovered to contain a rich repertoire of nutrients such as proteins, unsaturated fatty acids, phenolic acids, carotenoids, tocopherol, phytosterol, squalene etc. Biological assays have proven the...
Homeostasis of immune-endocrine-neural axis is paramount for human health. If this axis gets agitated due to age, genetic variations, environmental exposures or lifestyle assaults, a cascade of adverse reactions occurs in human body. Cytokines, hormones and neurotransmitters, the effector molecules of this axis behave erratically, leading to a gamu...
Chitin binding domain 3, known by the acronym ChtBD3, is a domain in the enzymes and proteins of several pathogenic virus, bacteria and fungi. As this domain is evolutionarily-conserved in virulence factors of these infectious agents, its detailed investigation is of clinical interest. In this regard, this in silico study analyzed ChtBD3 domain dis...
Plant pollens are airborne allergens, as their inhalation causes immune activation, leading to rhinitis, conjunctivitis, sinusitis and oral allergy syndrome. A myriad of pollen proteins belonging to profilin, expansin, polygalacturonase, glucan endoglucosidase, pectin esterase, and lipid transfer protein class have been identified. In the present i...
Background:
The plant secondary metabolites have an outstanding therapeutic potential and success over the years. In fact, it is the foundation of numerous clinically used drugs. Similarly, these is a general perception that these products are inherent safety. However, such products might have toxic/unwanted lethal effects therefore, along with bi...
The genus Diospyros from family Ebenaceae has versatile uses including edible fruits, valuable timber, and ornamental uses. The plant parts of numerous species have been in use as remedies in various folk healing practices, which include therapy for hemorrhage, incontinence, insomnia, hiccough, diarrhea etc. Phytochemical constituents such as terpe...
Zoonotic diseases are a subset of infectious diseases, which account for enormous morbidity and mortality. Pathologies like malaria, rabies, Lyme disease, leptospirosis, avian flu etc. are microbes- and parasite-caused ailments but are introduced into or on the human body via ticks, mosquitoes, birds, rodents, bats, deer, among other members of kin...
When the extracellular pH of the human body vacillates in either direction, tissue homeostasis is compromised. Fluctuations in acidosis have been linked to a wide variety of pathological conditions, including bone loss, cancer, allergies, and auto-immune diseases. Stress conditions may affect oxygen tension and hypoxia modulates the expression and/...
Proteins have highly conserved domains that determine their functionality. Out of the thousands of domains discovered so far across all living forms, some of the predominant clinically-relevant domains include IENR1, HNHc, HELICc, Pro-kuma_activ, Tryp_SPc, Lactamase_B, PbH1, ChtBD3, CBM49, acidPPc, G3P_acyltransf, RPOL8c, KbaA, HAMP, HisKA, Hr1, Da...
Pathogens and allergens are deemed as two contrasting facets of host immune status, deficiency and exuberant. In silico domain analysis of a diverse panel of pathogen and allergen proteins has revealed the shortcoming of this notion. Both the pathogen and allergen proteins elicit immune activation, with the outcome of immune agitation depending on...
The search for nutrient-dense food source is a top-priority in today’s food-challenged world of multi-billion population. Food insecurity has become especially critical in developing countries, though potential sources of functional foods are being wasted right before our eyes. Rose hips, the fruits of rose plants (Rosa sp.) have been discovered to...
In the past few decades, synthetic fragrance compounds have become ubiquitous components of personal care and household cleaning products. Overwhelming consumerism trends have led to the excess usage of these chemicals. It has been observed that this fragrance-laden unhealthy lifestyle runs parallel with the unprecedented rates of diabetes, cancer,...
Proteolytic activity is fundamental to survival, so it is not surprising that all living organisms have proteases, especially seine protease. This enzyme in its numerous isoforms and homologues, constitutes the quintessential offence and defence factors, in the form of surface proteins, secreted molecules, gut digestive enzymes, venom in specialise...
Human health is beset with a legion of ailments, which is exacerbated by the lifestyle errors. Out of the numerous enzymes in human body, aromatase, a cytochromes P450 enzyme is particularly very critical. Occurring at the crossroads of multiple signalling pathways, its homeostasis is vital. Unfortunately, medications, hormone therapy, chemical add...
Chitin, a polysaccharide with particular abundance in fungi, nematodes and arthropods is immunogenic. It acts as a threat to other organisms, to tackle which they have been endowed with chitinase enzyme. Even if this enzyme is not present in all organisms, they possess proteins having chitin-binding domain(s) (ChtBD). Many lethal viruses like Ebola...
The results obtained from the different fractions of metabolites were selected for in vivo acute toxicity studies. The toxicological study revealed that the test samples are safe for animal use up to 800 mg/kg. The test sample showed dose dependent anti-nociceptive potentials, the significant effect was observed with 500 and 800 mg/kg b.w dose. The...
Questions
Questions (21)
In the last one month I must have more than 20 rejections from various Elsevier journals. And this experience makes me (an author of 80+ articles) think, if the journals are favoring those submissions going for open access choices. I never agree for open access options. It is extremely frustrating to have novel works and critical reviews written with so much thought getting rejected continuously.
I find the requirement to submit copyright form at submission stage unnecessary. Most of the Indian journals (some international too) ask for it as part of paper submission criteria. You have to print, sign and scan, only to find the manuscript rejected in screening stage. If a paper is accepted, the authors will anyway sign it in order to be published. I suggest publishers to lift this criteria, to make the submission process user-friendly and eco-friendly (paper-less).
I have submitted a review article depicting serine protease as a central inflammatory driver in most health issues, like infectious diseases, allergy etc. The editor requires me to add some core inflammatory mechanisms. I can do it on my on, but a professional in this field can do a better job with it. Is anybody interested???
Domain of unknown function (DUFs) form a substantial part of protein domain databases like pfam (about 3,500 DUF families). Many of the DUFs are shared across bacteria, archaea and eukaryota kingdom. Yet, they have not been characterized. What could be the reason? Any insights on them will be helpful.
Much of in silico pathogen studies involve culture of the clinical isolates, NGS sequencing followed by SNP calling . The novel polymorphisms are associated with drug resistance.
But, the genomic impact of the shift from host milieu to culture medium hardly gets attention. Would not the the change in growth conditions be causing acquisition of SNPs, indels and the chromosomal aberrations in the pathogen?
If drug stressor causes resistance development in the pathogens, the host immune pressure determines adaptation of pathogens too. In culture medium, the immune pressure and other competing microbes are lacking. Also the nutrient composition is much much different than host bio-fluid.
I will be surprised if not, for most of us are aware how mere optimization of growth medium substantially improves industrially-important microbial metabolite production.
Discussions and expert opinions are appreciated.
A half of my articles (from my beginner years), though in Elsevier and Springer journals, don't have any IF. I regard some of them highly, for the frequent rejections and rigorous revisions they have put me though. Also, with their high downloaded numbers, I think they deserve IF.
E.g. my manuscripts on established areas like probotics, cereal brans, oligosaccharides, antioxidants etc. get easily accepted, while manuscripts on lesser-known, underutilized candidates get rejected in the screening itself. If we block them from publication, how will they attract further research attention? I think,it very much violates the aim of bioprospecting.
