Seema Patel

Seema Patel
Reprogene, USA

PhD Biotech (IITG-India); MS Bioinformatics (SDSU-USA)

About

189
Publications
265,377
Reads
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6,788
Citations
Introduction
A microbiologist - molecular biologist - bioinformatician - medical writer.......I want to take a break from collaborations.....seems like I am spending much time and effort, and gaining nothing out of it......I am done with editing on random topics.....Henceforth, I will be focussing on Immunology- Endocrinology - Neurobiology.....not mere publishing but diving deep into these areas...
Additional affiliations
November 2017 - present
Reprogene, USA
Position
  • Researcher
August 2013 - June 2016
San Diego State University
Position
  • Research Assistant
Description
  • In-silico investigation of mutation and drug resistance in Mycobacterium tuberculosis.
August 2010 - May 2011
Lovely Professional University
Position
  • Professor (Assistant)
Education
August 2013 - May 2016
San Diego State University
Field of study
  • Bioinformatics
August 2007 - June 2010
Indian Institute of Technology Guwahati
Field of study
  • Applied Microbiology

Publications

Publications (189)
Article
Full-text available
Pistacia integerrima grows in some areas of Pakistan and some other south Asian countries such as Afghanistan, India, Nepal, and Myanmar. It is an important medicinal plant which has been traditionally used for the treatment of asthma, cough, and dysentery. In the present study, we intend to re-isolate bioactive compounds (I–III) from P. integerrim...
Article
Full-text available
Synthetic fragrance compounds have become a ubiquitous part of household cleaning products and personal care agents. To improve aesthetics, fragrances are added, but the current research has unveiled detrimental effects of these odorous compounds. The exposure to the synthetic fragrances and musks, which are produced in quantities of thousands of t...
Article
Full-text available
Cuscuta reflexa (dodder) of the family Convolvulaceae has many ethno-medicinal uses such as antidiarrheal and antiemetic. The antidiarrheal use of this plant is well established in different communities around the world without many scientific bases. One of the uses of this plant is the alleviation of diarrhea. The antibacterial, anthelmintic, anti...
Article
Aim: The current study focused on anticancer potential of two known dimeric napthoquiones, diospyrin (1) and 8-hydroxydiospyrin (2) isolated from the roots of Diospyros lotus. Background: Cancer being a genetically heterogenous and complex disease, the available therapies for it are not very effective, rendering them the predominant cause of morta...
Article
Full-text available
The bioactive triterpenoid 3-oxo-6-β-hydroxy-β-amyrin (1) has been isolated from multiple plant sources. In this study, chloroform fraction of Pistacia integerrima extract was processed for the isolation of the compound. The compound identity was confirmed by advanced spectroscopy technique. X-ray crystallography was applied for molecular structure...
Article
Full-text available
Published studies indicate that virtually any kind of botanical material can be exploited to make biocompatible, safe, and cost-effective silver nanoparticles. This hypothesis is supported by the fact that plants possess active bio-ingredients that function as powerful reducing and coating agents for Ag+. In this respect, a phytomediation method pr...
Chapter
Food security is a global concern, and it is a substantial challenge to feed the ever-increasing population. The anthropological operations, abiotic and biotic stresses, have limited the crop productivity to a great extent. Phytopathogens are the major biotic constraints and pose a significant threat to food production. The extensive utility of haz...
Chapter
This chapter deals with the emerging potential of microbial-based biocontrol agents for the management of Phytopathogens in agricultural
Article
Full-text available
In this work, the extract of Callicarpa macrophylla (family Lamiaceae) was evaluated as an antidiarrheal agent. BALB/c mice were subjected to castor oil-induced diarrhea and charcoal meal gastrointestinal transit time assay. The antidiarrheal effect of the methanol extracts of the leaves and bark of C. macrophylla on the animals was evaluated. The...
Article
Full-text available
Ebola virus (EBOV) was discovered for the first time in 1976. It belongs to the family Filoviridae, which causes hemorrhagic fever that could lead to death in a few days. West Africa faced a major outbreak where symptoms appeared in the form of chills, myalgia, fever, diarrhea, and vomiting, and the disease finally reached a severe state as a resul...
Article
The monooxygenase enzymes, cytochrome P450s (CYPs), are ubiquitous in their presence and versatile in their functions. They are indispensable for hormone synthesis, dietary metabolism, and detoxification among other roles. CYPs from marine organisms are interesting candidates for recruitment in drug biotransformation, synthesis of therapeutics, bio...
Article
Full-text available
Abstract Keywords: Ethno-Veterinary; Frequency of citation; Relative Frequency of Citation; Informant’s Consensus Factor; Direct Matrix Ranking Introduction Medicinal plants are a good natural resource and safe drugs and have been used for the treatment of health disorders in human and livestock from time immemorable [1]. Approximately 85% of all m...
Article
Full-text available
Study Objective: In order to analyze the local importance of medicinal plants and their availability status, a quantitative ethno-veterinary study has been carried out in the outskirts of district Malakand from March 2014 to February 2016. Materials and Methods: The plant resources with ethno-veterinary usages were evaluated via a semi-structured a...
Article
Full-text available
Bawazeer et al.: Molecular Binding Mode of Diospyrin against PTP1B The present study was designed to evaluate the antidiabetic potential of diospyrin isolated from Diospyros lotus, using protein tyrosine phosphatase 1B enzyme as the target. Molecular binding mode of diospyrin to protein tyrosine phosphatase 1B was essential to explore its molecular...
Article
Background Many years back, during Islamic civilization, truffle (Kama'ah) was mentioned by Prophet Muhammed (PBUH) to be well recognized as a therapeutic for eye diseases. (“In the Sahihain, it is narrated that the Prophet said: “The Kama'ah (truffle) is among the manna (which is a food mentioned in the Qura'n, Surah al-Baqarah), and its water (ex...
Chapter
A diverse range of agents, from biological and chemical to mechanical, can be perceived as stressors by the immune system. Even the diet, depending on its components and dosage, can provoke the immune system. Processed foods are acidogenic which lower the pH of the extracellular matrix (ECM), causing an aberrant enzyme activity. The consequent agit...
Article
Proanthocyanidins are condensed tannins with various pharmacological properties. These phytochemicals are considered as 'offense and defense molecules because of their human health benefits. The validation of their diverse health aspects, namely, antioxidant, anticancer, antidiabetic, neuroprotective, and antimicrobial has earned them repute in the...
Chapter
Mushrooms, the macrofungi, are enigmatic in their composition, which renders some of them umami-flavored edible, some medicinal, some hallucinogenic/psychoactive, while some lethal. In current times, appreciation and demand of the medicinal mushrooms is rising, with the validation of their efficacy as antioxidant, anti-inflammatory, immunomodulator...
Article
α-glucosidase inhibition is a rational approach in the effective management of type 2 diabetes. Several inhibitors of this enzyme class are in clinical use, but are riddled with efficacy, potency and safety challenges. For this reason, new effective α-glucosidase inhibitors are under investigation. Compounds with 1, 3, 4-oxadiazole nucleus have sho...
Article
Antiplatelet drugs reduce the risks associated with atherothrombotic events and show various applications in diverse cardiovascular diseases including myocardial infarctions. Efficacy of the current antiplatelet medicines including aspirin, clopidogrel, prasugrel and ticagrelor, and the glycoprotein IIb/IIIa antagonists, are limited due to their in...
Article
Huge demand of safe and natural preservatives has opened new area for intensive research on bacteriocins to unravel the novel range of antimicrobial compounds that could efficiently fight off the food-borne pathogens. Since food safety has become an increasingly important international concern, the application of bacteriocins from lactic acid bacte...
Conference Paper
The fatal dengue virus (DENV) endured by Aedes sp. mosquito roots huge morbidity and mortality in subtropical and tropical sections of the world. There are four antigenically related but diverse serotypes of dengue virus, labelled as DENV-1, DENV-2, DENV-3, and DENV-4. With no drugs or vaccines to control this pathogen, that exists in four differen...
Chapter
Consumption of medicinal plants exert a promising role in drug discovery and have been proven very effective against various human syndromes. Diallyl trisulfide (DATS) suppresses naphthalene-induced oxidative injury and inhibits inflammatory responses such as TNF-α, IL-6, IL-8, and nuclear factor-kappa B (NF-κB). It also suppresses the production o...
Article
In the face of rising population, food insecurity is emerging as a global challenge. Nutritious sources of food are frantically being searched for and so far underutilized food candidates are being assessed. In this regard, Arthropoda, the largest phylum in the animal kingdom fits the bill. Especially, the Class Insecta holds tremendous promise, wi...
Article
Last few decades have witnessed the unprecedented growth in the application of probiotics for promoting the general gut health as well as their inception as biotherapeutics to alleviate certain clinical disorders related to dysbiosis. While numerous studies have substantiated the health-restoring potentials for a restricted group of microbial speci...
Chapter
The detrimental impacts of conventional building materials on environmental health have raised global concerns. While the fast-depleting fossil-derived materials are adding to global warming, chemically-synthesized materials are polluting the air, water, and soil. To promote health and to meet sustainability target, the importance of eco-friendly g...
Article
Full-text available
Spillage of fossil-based oils during their conveyance through water conduits are sporadic, but significant environmental disasters. As the viscous hydrocarbons of the crude oils spread on water surface and choke aquatic life to death, their effective degradation is crucial for ecological balance. Though chemical and mechanical means are conventiona...
Article
Full-text available
The need to maximize agricultural productivity has made pesticides an indispensable part of current times. Farmers are unaware of the lurking consequences of the pesticide exposure, which endanger their health. It also puts the unsuspecting consumers in peril. The pesticides (from organophosphates, organochlorine, and carbamate class) disrupt the i...
Article
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Article
Full-text available
The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance. The chemical structure of compound 7 (methyl 3-O-phospo- α -D-glucopyranuronic acid was elucidated by physical and advance spectral technique. Also, this compound was assessed for various in vitro biological screening. The results showed...
Article
Full-text available
Purpose of Review Allergen is an umbrella term for irritants of diverse origin. Along with other offenders such as pathogens, mutagens, xenobiotics, and pollutants, allergens can be grouped as inflammatory agents. Danger-associated molecular patterns (DAMPs) are altered metabolism products of necrotic or stressed cells, which are deemed as alarm si...
Chapter
The kingdom fungi, including the genus Monascus, is a trove of potential pharmaceuticals. This mold Monascus holds paradoxical stature in the realm of healthcare. On one hand, it has been an ubiquitous ingredient of Oriental medication such as Traditional Chinese Medicine (TCM), since ages. Monascus-fermented product red yeast rice (RYR) is being u...
Chapter
AIDS (Acquired Immuno-Deficiency Syndrome) has been a major epidemic bothering mankind for last decades. UNAIDS estimate displays the existence of millions of AIDS patients at the end of 2016, though remarkable progress against AIDS over the past 15 years has stirred a global obligation to end the epidemic by 2030. All the FDA (Food and Drug Admini...
Article
Full-text available
The development of reliable and green methods for the fabrication of metallic nanoparticles has many advantages in the field of nanotechnology. In this direction, the present work describes eco-friendly and costeffective protocol for the production of silver nanoparticles (AgNPs) using aqueous extract of Quercus semecarpifolia leaves. Different tec...
Article
Background: Honokiol ((3',5-di-(2-propenyl)-1,1'-biphenyl-2,2'-diol), a lignan, is a promising antitumor compound, having exerted activity against a number of human cancer cell lines. Honokiol has inhibitory role on the proliferation, invasion and survival of cancer cells in in vitro as well as in vivo studies. It interferes with signaling pathway...
Article
Urease inhibition potential of Hypochoeris glucoside (1), guaiane-type sequiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughput mechanism-based assay. These compounds were isolated from Hypochaeris radicata L, an Asteraceae family member. The pure compounds were screened for their urease and carbonic anhydrase inhibit...
Article
Vitamin D (25(OH)D3 and 1,25-dihydroxycholecalciferol), is known to play role in calcium uptake, bone metabolism, mineral homeostasis, modulation of the innate and adaptive immune systems and the regulation of cell proliferation, among a litany of other functions. If serum level of this vitamin falls below 30-40 ng/mL, its deficiency can occur, pre...
Article
The state of enzymes in the human body determines the normal physiology or pathology, so all the six classes of enzymes are crucial. Proteases, the hydrolases, can be of several types based on the nucleophilic amino acid or the metal cofactor needed for their activity. Cathepsins are proteases with serine, cysteine, or aspartic acid residues as the...
Data
Graphical abstract of this paper is given as a supplementary material. Supplementary material represents in vivo study on analgesic, muscle-relaxant, sedative activity of extracts of Hypochaeris radicata.
Article
Full-text available
Background Hypochaeris radicata (flatweed) from the family Asteraceae is a medicinal plant found in Europe, Middle East, and India. In folkloric medication, it is used to heal jaundice, dyspepsia, constipation, rheumatism, and hypoglycemia as well as renal problems. Leaves and roots of the plant have antioxidant and antibacterial properties. The pl...
Chapter
The pathogenicity of microbes in the rhizosphere is influenced by the change in climatic conditions. The modification in climate factors as temperature, CO2, moisture, etc. enhances the abundance and virulence of soilborne pathogens residing in the rhizosphere. Among, microbial communities, fungi such as Fusarium and Rhizoctonia infect a wide range...
Article
Full-text available
Citrus aurantium L. (Rutaceae), commonly known as bitter orange, possesses multiple therapeutic potentials. These biological credentials include anticancer, antianxiety, antiobesity, antibacterial, antioxidant, pesticidal, and antidiabetic activities. The essential oil of C. aurantium was reported to display marked pharmacological effects and great...
Article
Full-text available
Thermostable proteases are important in biotechnological and industrial sectors, due to their stability against denaturing agents and chemicals. The feature that gives them such unique applicability is their reaction at high temperatures, which affords a high concentration of substrate, and less risk of microbial contamination. Nearly 65% of indust...
Article
Background: Acetylcholinesterase (AChE), a serine hydrolase, is primarily responsible for the termination of signal transmission in the cholinergic system, owing to its outstanding hydrolyzing potential. Its substrate acetylcholine (ACh), is a neurotransmitter of the cholinergic system, with a predominant effect on motor neurons involved in memory...
Article
Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, apart from a gamut of other metabolic co-morbidities such as insulin resistance, obesity, cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammator...
Article
Superoxide dismutase (SOD) is the pivotal antioxidant enzyme that defends organisms against the oxidative stresses of superoxide radicals. In this experimental study, purification of SOD from the leaves of Avicennia marina (grey mangrove or white mangrove) from the family Acanthaceae, located in Sirik mangrove forest on the shore of the Gulf of Oma...
Article
Current therapies in clinical practice face strong criticism regarding their efficacy, and side effects, which forced the neuro-researchers to discover novel agents with different mechanistic insights. Glycosides are naturally-occurring plant secondary metabolites with significant medicinal potential and clinical scope as antidepressant. The aim of...
Article
Full-text available
Background: Blood platelets are crucial for maintaining hemostasis and several events in the woundhealing. However, platelet up-regulation leads to the development and the complications of several cardiovascular diseases. For the effective management of these complications, several synthetic drugs are in clinical practice such as aspirin, warfarin...
Article
Breast cancer is the most common cancer in females. The deteriorating environment, and lifestyle flaws are raising the frequency of this cancer. Existing therapies are not universally-effective, and they cause side effects, relapses, and high mortality rate. Alternative medications may be milder, but are less effective or are inadequate for a compl...
Article
Pistacia genus belong to family Anacardiaceae and it is versatile in that its member species have food (P. vera), medicinal (P. lentiscus) and ornamental (P. chinensis) values. Various species of this genus have folkloric uses with credible mention in diverse pharmacopeia. As a trove of phenolic compounds, terpenoids, monoterpenes, flavonoids, alka...
Article
The current paper summarizes the evaluation of the alcoholic extract of Sarcococca saligna (D. Don) Mull. fruits for acute toxicity, analgesic, GIT motility modulation, and anti-termite properties. The extract was evaluated for analgesic activity using acetic acid-induced writhing model while charcoal meal model was adopted for GIT motility estimat...
Article
Galls, the abnormal growths in plants, induced by virus, bacteria, fungi, nematodes, arthropods, or even other plants, are akin to cancers in fauna. The galls which occur in a myriad of forms are phytochemically-distinct from the normal plant tissues, for these are the sites of tug-of-war, just like the granuloma in animals. To counter the stressor...
Article
Renin-angiotensin-aldosterone system (RAAS) is a vital system of human body, as it maintains plasma sodium concentration, arterial blood pressure and extracellular volume. Kidney-secreted renin enzyme acts on its substrate to form angiotensin II, a versatile effector peptide hormone. Every organ is affected by RAAS activation and the resultant hype...
Article
The current food options, especially in the Western countries, are acidogenic, which reduce extracellular pH and perturb ionic homeostasis. The acidity-activated enzymes mediate a large panel of chronic and acute diseases. To quell the morbidities and mortalities associated with the metabolic syndromes, nonpharmacologic approaches are preferred. Di...
Article
A new dimeric naphthoquinone, named 5,8,5′-trihydroxy-8′-methoxy-6,6′-dimethyl-7,3-binaphthyl-1,4,1′,4′-tetraone (1), was isolated from Diospyros lotus stem. The structure of the compound was elucidated by advance spectroscopic analysis including 1D and 2D experiments such as HMBC, NOESY, and J-resolved (JRES). Compound1was assessed for antioxidant...
Article
Antimicrobial peptides (AMPs) are cationic amphiphilic molecules with α-helix or β-sheet linear motifs and linear or cyclic configurations. For their role in 'defense and offense', they are present in all living organisms. AMPs are named so, as they inhibit a wide array of microbes by membrane pore formation and subsequent perturbation of mitochond...
Article
Background: Inula viscosa L. (Asteraceae) is a medicinal plant widely used as a folk medicine in oriental Morocco, to treat hypertension. The antihypertensive effect of the methanolic extract obtained from I. viscosa leaves was evaluated in hypertensive L-NAME rats. Systolic blood pressure (SBP) was measured using a non-invasive indirect tail-cuff...
Article
Adhesins are bacterial proteins with host cell adhesive properties. These proteins occur in diverse architectures, ranging from capsules, vesicles, pili, fimbri, to enzymes. These proteins interact with host cell surface receptor proteins, for cross-membrane- trafficking and the invasion of host cells. Thus, they lead to inflammation and pathogenes...
Article
Rutin is a naturally-occurring bioactive compound of flavonoid family, exhibiting a multitude of health-endorsing effects such as anti-oxidative, anticancer, antidiabetic, cardio-protective, vaso-protective, neuroprotective, cyto-protective etc. The ameliorative properties emerge from its antioxidant attributes. Induction of TNF-α apoptosis; regula...
Article
Full-text available
Mangiferin, a natural xanthone glycoside, isolated from variousparts of plant families such as Mangiferaceae, Zingiberaceae,Celastraceae, Gentianaceae, and Aphloiaceae, is known to modu-late several biological targets in inflammation and oxidative stress.It resolves oxidative stress by inhibiting enzymatic systems such asHMG-CoA reductase, the prot...
Article
Full-text available
Ebola virus (EBOV) was discovered for the first time in 1976. It belongs to the family Filoviridae, which causes hemorrhagic fever that could lead to death in a few days. West Africa faced a major outbreak where symptoms appeared in the form of chills, myalgia, fever, diarrhea, and vomiting, and the disease finally reached a severe state as a resul...
Article
Vitiligo is an idiopathic systemic autoimmune disease affecting skin, hair and oral mucosa. This genetic yet acquired disease characterized by melanin loss is a cause of morbidity across all races. Though thyroid disturbance has been recognized as a key trigger of this pathology, an array of other factors plays critical role in its manifestation. M...