Seema Dharni

Seema Dharni
Hong Kong Baptist University · Institute of Bioresource and Agriculture (IBA)

Ph.D. (Biological Science)

About

22
Publications
6,347
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291
Citations
Introduction
My research area is dedicated to the discovery, isolation, and structure elucidation of novel biologically active secondary metabolites from microbes . The process of discovering and isolating biologically active natural products is guided by different microbiological assays that have pharmaceutical relevance, including antifungal, antibacterial and anticancer.
Additional affiliations
October 2020 - present
Hong Kong Baptist University
Position
  • PostDoc Position
March 2012 - December 2015
Central Institute of Medicinal and Aromatic Plants
Position
  • SEEMA DHARNI
Education
January 2011 - December 2015

Publications

Publications (22)
Article
Full-text available
We have investigated in vitro antifungal efficiency of nitrogen doped carbon nanohorn (NCNH) against Rhizoctonia solani (R. solani) plant pathogenic fungi. NCNH with size of 50-60 nm and concentrations of 10, 50, 100 and 150µg mL-1 were used. The results showed that growth of fungi in the presence of NCNH was significantly (p>0.05) inhibited at 150...
Article
Full-text available
Beta-site APP cleaving enzyme1 (BACE1) catalyzes the rate determining step in the generation of Aβ peptide and is widely considered as a potential therapeutic drug target for Alzheimer’s disease (AD). Active site of BACE1 contains catalytic aspartic (Asp) dyad and flap. Asp dyad cleaves the substrate amyloid precursor protein with the help of flap....
Article
Full-text available
A novel strain of Pseudomonas monteilii, PsF84 was isolated from tannery waste soil, Jajmau, Kanpur, India. 16S rRNA gene sequence phylogenetic analysis confirmed the taxonomic affiliation of PsF84 as P. monteilii. An antifungal volatile organic compound (VOC) was active against hyphal growth of Fusarium oxysporum (CIMAP-IMI-357464) in vitro was is...
Article
Full-text available
1-Hydroxyphenazine (1-OH-PHZ), a natural product from Pseudomonas aeruginosa strain SD12, was earlier reported to have potent antifungal activity against Rhizoctonia solani. In the present work, the antifungal activity of 1-OH-PHZ on 40S ribosomal S9 protein was validated by molecular docking approach. 1-OH-PHZ showed interaction with two polar con...
Article
Full-text available
A new strain of Streptomyces was isolated from heavy metal polluted soil of industrial (tannery) area of Jajmau, Kanpur, India. The strain was designated as Streptomyces sp. CIMAP A2 based on cultural, morphological and physiological studies. Further, molecular characterization of the strain was carried out based on sequencing 1520 bp fragment of 1...
Article
Full-text available
A bacterial strain, Streptomyces sp. CIMAP- A1 was isolated from Geranium rhizosphere and identified by morphological, physiological, biochemical and molecular characters (16S rDNA gene sequence). Phylogenetically, it was found most closely related to S. vinacendrappus, strain NRRL-2363 with 99% sequence similarity. The strain had potential antagon...
Article
Full-text available
A new strain, SD12, was isolated from tannery waste polluted soil and identified as Pseudomonas aeruginosa on the basis of phenotypic traits and by comparison of 16S rRNA sequences. This bacterium exhibited broad-spectrum antagonistic activity against phytopathogenic fungi. The strain produced phosphatases, cellulases, proteases, pectinases, and HC...
Article
Full-text available
A new strain, SD12, was isolated from tannery waste polluted soil and identified as Pseudomonas aeruginosa on the basis of phenotypic traits and by comparison of 16S rRNA sequences. This bacterium exhibited broad-spectrum antagonistic activity against phytopathogenic fungi. The strain produced phosphatases, cellulases, proteases, pectinases, and HC...
Article
Full-text available
Stevia rebaudiana Bertoni (Asteraceae) is one of the most important commercial crops in the world (4). It is known to produce glycosides that are up to 300 times sweeter than sucrose and do not affect blood sugar levels. Unlike artificial sweeteners like saccharin, they are non-carcinogenic and safe for diabetics. An unknown disease emerged during...
Article
Full-text available
Four different arbuscular mycorrhizal (AM) fungi, Glomus aggregatum, Glomus fasciculatum, Glomus intraradices and Glomus mosseae, were used alone and in combinations with Bacillus subtilis to evaluate their capability to increase the productivity of geranium. Mycorrhizal treatment increased the growth and total biomass invariably over non-mycorrhiz...

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Projects

Project (1)
Project
Contributing to the quest for potential biofertilizer and biocontrol agent for agriculture.