Sebastin Varghese

Kerala University of Health Sciences

In developing nations' primary healthcare systems, medicinal plants and their mimetics are thought to be the most significant element. The objective of research was to execute identification & characterization of the bio-active compounds present in whole plant extract of Crotalaria biflora using Gas Chromatography-Mass Spectrum (GC-MS). The prelimi...

In developing nations' primary healthcare systems, medicinal plants and their mimetics are thought to be the most significant element. The objective of research was to execute identification & characterization of the bio-active compounds present in whole plant extract of Crotalaria biflora using Gas Chromatography-Mass Spectrum (GC-MS). The prelimi...

A chronic skin condition called psoriasis causes patches of skin to thicken and become covered in silvery scales. Though less successful, topical chemical treatments are used to treat psoriasis; nevertheless, medicinal plants can offer an alternative. One significant and distinctive source of medications is medicinal plants. The three most often us...

Quercetin is a plant derived aglycone form of flavonoid glycosides. It has nutritional value and well known for its diverse biological activities such as anticancer, antiulcer, antihypertensive, anti-allergy, anti-infective, immunomodulatory, anti-diabetic, anti-obesity, anti-hypercholesterolemic anti-atherosclerotic anti-inflammatory and vasodilat...

ARTICLE INFO ABSTRACT Topoisomerases are ubiquitous enzymes have significant roles in several critical DNA processes. Over the past few years, there has been considerable interest in DNA topoisomerases, as they were shown to be the cellular targets for several anticancer drugs. The functions of various topoisomerase enzymes related to the maintenan...

Hydrotropy is a solubilization process whereby addition of a large amount of second solute results in an increase in the aqueous solubility of another solute. Hydrotropic agents are ionic organic salts. Additives or salts that increase the solubility in a given solvent are said to salt in the solute and those salts that decrease the solubility are...

ABSRACT The cosmetic used to colourize the lips is lipstick. It improves the lips' visual appeal. Lipstick is intended to protect the lips from many forms of harmful UV rays, enhance beauty, and make them appear more attractive. In addition to pigments, oils, scent, preservatives, colours, and textures, herbal lipstick also provides protection for...

Lipstickisacosmeticproductcontainingpigments,oils,fragrance,preservatives,colors,textureandprotection to the lips. This review paper is about the overview on herbal lipstick which includes advantages, ideal characters, defect in lipstick, approaches to minimize defect in lipstick formulation and evaluation. Lipsticks are gaining popularity because...

The majority of cosmetic products on the market are synthetic in nature and have a variety of negative side effects when used for an extended length of time. Use of herbal cosmetics is one remedy for this issue. Herbal cosmetics are thought to be generally safe with little adverse effects. Some of the main skin problems are acne, redness, wrinkles,...

Sunscreens aid in reducing facial blotchiness and red veins, as well as other harmful sun effects like erythema development and early photoaging. The colour, aroma, pH, viscosity, and spreadability of manufactured creams as well as other physical and chemical qualities were evaluated. The sun protection efficacy of lotion was evaluated in terms of...

Talinum fruticosum.L (Talinaceae) is a erect, stout, fleshy, perennial herb. It is used as a leaf vegetable. It contain rich in vitamins including vitamin A and C and minerals such as iron and calcium. The present work highlights phytochemical and antimicrobial studies of Talinum fruticosum. The whole plant were collected from Kasaragod district an...

Pyrimidine derivatives are important heterocyclic molecules employed in the field of research and development of newer therapeutic agents. Pyrimidine is a six membered heterocyclic aromatic compound containing two nitrogen atoms at c 1 and c 2 position. Their derivatives are prevalent in nucleobases and numerous natural products. Most of the agents...

ABSTARCT Oxazine derivative is prevalent in numerous natural products and is extremely important in medicinal chemistry. Derivatives of 1,3-oxazine show interesting reactivity and can be used as chemotherapeutic agents and constitute an important class of various natural and synthetic product which possess antimicrobial, antioxidant activities. Var...

The work include the synthesis of four Derivatives of Ethyl-4-(4-alkylphenyl)-6-methylsulfanyldiene-1,2,3,4-tetrahydropyrimidine-5-carboxylate by one pot multicomponent reaction, involving reaction of Aromatic aldehyde, β keto ester, Thiourea in presence of concHCl and ethanol. The structure of synthesised compound was confirmed by IR spectroscopic...

Purines and pyrimidine derivatives are the important class of compounds in medicinal chemistry. Pyrimidine-a totally unsaturated six membered ring containing nitrogen at 1,3-position. They represent the diazine family with urazil and thymine being the constituents of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) and with cytosine. The work...

One of the most prevalent skin problems is acne. Nearly all teenagers are affected, and up to 41% of adults may still have the condition. Regardless of skin tone, pigmentary consequences are significant cosmetic concerns for all patients, and they may cause the patient greater problems than the primary skin disorder did. Darker skinned people appea...

Plants of the genus Argyreia posses’ ethno medicinal importance and various pharmacological activities are also reported. In this study, phenolic content, anti-oxidant potential of different extracts of Argyreia imbricata was evaluated. Extraction of powdered whole plant material was done with different solvents viz., petroleum ether, chloroform, e...

Various biological activities of the genus "Crotalaria" was reported in several studies. In this study, the antioxidant and anthelmintic activity of the whole plant Crotalaria biflora was evaluated. The plant material was collected, identified and authenticated and extracted with different solvents such as petroleum ether, chloroform, ethyl acetate...

Several drugs currently available today for a variety of ailments are developed directly or indirectly from plant source. With this view, the plant Crotalaria biflora was selected for our research and initially it was decided to evaluate the phytochemical compositions and their characterization by different spectral methods. The whole plant Crotala...

Plants of the genus Argyreia have ethnomedicinal importance, and several pharmacological activities are also reported. In this study, the anti-inflammatory activity of different extracts of Argyreia imbricata was evaluated by in vitro and in vivo methods. In both evaluations, standard, Diclofenac sodium was used for comparative evaluation. In this...

Objective: The present study was designed with the aim of preliminary phytochemical evaluation and spectral characterization phytochemicals present in the extracts of whole plant Argyreia imbricata (Rox) Sant and Patel. Methods: The whole plant A. imbricata was collected, authenticated, and dried in the shade for powdering in mechanical grinder. Th...

Dosage forms for topical drug delivery systems are applied directly to the skin in order to treat a variety of illnesses. The most recent and widely used drug delivery technology for hydrophobic medications is emulgels. Different polymers are used to prepare emulgel, which serves as both an emulsifying and thickening agent. The gelling capacity red...