Sebastian Wolf

Sebastian Wolf
Technische Universität München | TUM · Research Group Systems Biotechnology

Master of Science

About

6
Publications
800
Reads
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47
Citations
Additional affiliations
February 2015 - April 2015
Technische Universität München
Position
  • Researcher
Description
  • Dynamical process optimization in biotechnology . Using dynamical modeling strategies for a strain and process optimization for the production of a special chemical with a biotechnologycal process
August 2014 - February 2015
Technische Universität München
Position
  • Master's Student
Description
  • Implementation of a computer model describing the regulatory influence of the nitrogen-phosphotransferase branch (PTS Ntr ) on the transcription of the high affinity potassium transporter KdpFABC
June 2012 - September 2012
Ludwig-Maximilians-University of Munich
Position
  • Intern
Description
  • control of beta-secretase 5′-untranslated region by Unr, complex between Nck1 and Unr
Education
October 2012 - February 2015
Technische Universität München
Field of study
  • Molekulare Biotechnologie
October 2008 - March 2012
Otto-von-Guericke-Universität Magdeburg
Field of study
  • Biosystemtechnik

Publications

Publications (6)
Article
Advances in Machine Learning and availability of state-of-the-art computational resources, along with digitized healthcare data, have set the stage for extensive application of artificial intelligence in the realm of diagnosis, prognosis, clinical decision support, personalized treatment options, drug development, and the field of biomedicine. Here...
Article
The study of biological systems at a system level has become a reality due to the increasing powerful computational approaches able to handle increasingly larger datasets. Uncovering the dynamic nature of gene regulatory networks in order to attain a system level understanding and improve the predictive power of biological models is an important re...
Article
Full-text available
Cancer is a group of diseases that involves abnormal cell growth, resulting from genetic perturbations in signaling mechanisms. High resolution RNAseq and microarray assays enable the evaluation of the transcriptional activity of high number of signaling molecules. Furthermore, many signaling pathways are described in publically available databases...
Article
Full-text available
Computational methods have enabled the discovery of non-intuitive strategies to enhance the production of a variety of target molecules. In the case of succinate production, reviews covering the topic have not yet analyzed the impact and future potential that such methods may have. In this work, we review the application of computational methods to...
Article
Full-text available
The nitrogen phosphotransferase system (PTS(Ntr)) of Pseudomonas putida is a key regulatory device that participates in controlling many physiological processes in a posttranscriptional fashion. One of the target functions of the PTS(Ntr) is the regulation of potassium transport. This is mediated by the direct interaction of one of its components w...
Article
Oligomerization of protein complexes has been involved in various mechanisms that play a major role in endoplasmic reticulum (ER) functions. In particular, in response to the accumulation of misfolded proteins in the ER, an adaptive response is activated and named the unfolded protein response (UPR). To facilitate recovery of ER homeostasis, both t...

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