Sebastian Podlipnik

Sebastian Podlipnik
Hospital Clínic de Barcelona · Servicio de Dermatología

MD PhD

About

105
Publications
16,875
Reads
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436
Citations
Introduction
I’m a board-certified dermatologist from Barcelona, Spain, currently working at Hospital Clínic of Barcelona. My main area of interest is in Dermato-Oncology. Other areas of interests include melanoma screening, prevention, dermoscopy medical and surgical therapy and follow-up. I’m also interested in conducting clinical and basic science research.
Additional affiliations
May 2013 - present
Hospital Clínic de Barcelona
Position
  • Medical Doctor
Education
March 2005 - December 2011
Universidad Mayor
Field of study

Publications

Publications (105)
Article
Background: There is no international consensus on optimal follow-up schedules and which supplementary tests should be used after resection of a primary melanoma. Objective: We sought to analyze the performance of the follow-up components and identify procedures that detect melanoma metastasis earlier. Methods: This was a prospective cohort fr...
Article
Background Many follow‐up guidelines for high‐risk melanoma patients include expensive imaging studies, serum biomarkers, and regular visits to the dermatologist with little attention to cost‐effectiveness. Objectives To establish the cost‐effectiveness of chest‐abdomen‐pelvis CT‐scan and brain MRI in a follow‐up protocol for patients at high risk...
Article
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Background The clinical and pathological features of primary melanoma are not sufficiently sensitive to accurately predict which patients are at a greater risk of relapse. Recently, a 31‐gene expression profile (DecisionDx‐Melanoma) test has shown promising results. Objectives To evaluate the early prognostic performance of a genetic signature in...
Article
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Background Females have a better melanoma prognosis and fairer skin and hair colour. The presence of inherited MC1R variants has been associated with a better melanoma prognosis, but its interaction with sex is unknown. Objectives To evaluate the relationship between germline MC1R status and survival and determine any association with gender. Met...
Article
Background The 8th edition of the AJCC manual for melanoma includes many changes leading to major substage migrations, which could lead to important clinical reassessments. Objectives To evaluate the differences and prognostic value of the 8th AJCC classification in comparison with the 7th edition. Methods Clinical and histopathological data were...
Article
Background Many patients with low-stage cutaneous melanoma will experience tumor recurrence, metastasis, or death, and many higher-staged patients will not. Objective Develop an algorithm by integrating the 31-gene expression profile test with clinicopathologic data for an optimized, personalized risk of recurrence (i31-ROR) or death and use i31-R...
Article
Background: Cutaneous immune-related adverse events (irAEs) represent the most frequent toxicities induced by immune checkpoint inhibitors (ICI). Objectives: To investigate clinical associations of cutaneous toxicities induced by different ICI therapies. Methods: Multi-centric retrospective international cohort study of cancer patients, who de...
Article
Background: Around 0.5% cutaneous melanoma (CM) patients will present with synchronous melanomas when first seen. Moreover, 26%-40% of patients with multiple primary melanomas present with synchronous lesions. Objectives: To assess the prevalence, clinical and histopathological characteristics, germline mutations and outcome in patients with syn...
Article
Background: Sinonasal mucosal melanoma is an aggressive malignancy with a 5-year survival rate ranging from 20% to 39%. Despite the evolving surgical and radiotherapy techniques, and introduction of immune-checkpoint inhibitor therapy, overall survival rates remain poor. Methodology: A retrospective cohort study was conducted at the Hospital Clínic...
Article
Background: Hypomorphic MC1R variants are the most prevalent genetic determinants of melanoma risk in the Caucasian population. However, the genetic background of wild-type (WT) MC1R melanoma patients is poorly studied. Objectives: To analyse the role of candidate common genetic variants on the melanoma risk and the naevi count in Spanish wild-t...
Article
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Background Previous studies of artificial intelligence (AI) applied to dermatology have shown AI to have higher diagnostic classification accuracy than expert dermatologists; however, these studies did not adequately assess clinically realistic scenarios, such as how AI systems behave when presented with images of disease categories that are not in...
Article
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Linked Article: Wei et al. Br J Dermatol 2022; 186:977–987.
Article
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Resumen La escabiosis afecta a más de 200 millones de personas en el mundo, y ocasiona un importante impacto socioeconómico. El mecanismo de contagio es por contacto directo prolongado. El contagio por fómites es infrecuente, aunque puede ser importante en la sarna noruega. La terapia con permetrina tópica al 5% es recomendada como tratamiento de p...
Article
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Immune-related adverse events (irAEs) are frequent and could be associated with improved response to immune checkpoint inhibitors (ICIs). A prospective cohort of advanced melanoma patients receiving ICI as first-line therapy was retrospectively reviewed (January 2011–February 2019). A total of 116 of 153 patients presented with at least one irAE (7...
Article
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Background: Fifteen to forty percent of patients with localized cutaneous melanoma (CM) (stages I-II) will experience disease relapse. The 31-gene expression profile (31-GEP) uses gene expression data from the primary tumor in conjunction with clinicopathologic features to refine patient prognosis. The study's objective was to evaluate 31-GEP risk...
Article
Introduction The incidence of cutaneous melanoma is rising fast, and its prevalence has doubled in the past 3 decades. Detailed local epidemiological information is essential for informing community-based prevention strategies and optimizing hospital resources. Material and methods We included all patients diagnosed with cutaneous melanoma at Hosp...
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The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observ...
Article
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Introduction The incidence of cutaneous melanoma is rising fast, and its prevalence has doubled in the past 3 decades. Detailed local epidemiological information is essential for informing community-based prevention strategies and optimizing hospital resources. Material and methods We included all patients diagnosed with cutaneous melanoma at Hosp...
Article
Full-text available
Background Multiple studies have compared the performance of artificial intelligence (AI)–based models for automated skin cancer classification to human experts, thus setting the cornerstone for a successful translation of AI-based tools into clinicopathological practice. Objective The objective of the study was to systematically analyse the curre...
Article
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Determining disease activity from clinical signs in patients with connective tissue panniculitis (CTP) is often challenging but is essential for therapeutic decision making, which largely relies on immunosuppressant treatment. High-frequency ultrasound (HFUS) may be useful in supporting such decisions by accurately determining CTP activity. This st...
Article
Background Monitoring of sclerosing dermatoses (SD) disease activity can be challenging and tools to support clinical decision-making are lacking. Objectives To analyze the impact of high-frequency ultrasound (HFUS) on the clinical management of SD and to describe their ultrasonographic characteristics of disease activity. Methods Cohort study in...
Article
The aim of this study was to compare tumour burden in patients who underwent surgery for melanoma and cutaneous squamous cell carcinoma during nationwide lockdown in Spain due to COVID-19 (for the period 14 March to 13 June 2020) and during the same dates in 2019 before the COVID-19 pandemic. In addition, associations between median tumour burden (...
Article
Resumen Introducción: La incidencia del melanoma cutáneo está aumentando rápidamente y ha duplicado su prevalencia durante las últimas tres décadas. Tener un conocimiento detallado de la epidemiología local es fundamental para el desarrollo de estrategias de prevención comunitaria y optimizar los recursos hospitalarios. Material y métodos: Se inclu...
Article
Given recent developments in the treatment of metastatic melanoma, early detection of disease recurrence is crucial. The aim of this single-centre retrospective cohort study was to investigate the impact of the initial stage of primary melanoma on the pattern and timing of disease recurrence and post-recurrence survival. Patients diagnosed with cut...
Article
In this article we examine the most important genetic markers involved in melanoma susceptibility, initiation and progression, and their impact on the prognosis of the disease. Current knowledge in melanoma genetics identifies distinct pathways to the development of different melanoma subtypes characterized by specific clinico-pathological features...
Article
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Several studies have suggested that naevus-associated melanomas differ from de novo melanomas, being thinner and with less ulceration; however, the prognostic implication is unclear. The objective of this study was to describe clinicopathological, genetic and survival characteristics of de novo and naevus-associated melanomas in a cohort of primary...
Article
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Sclerodermoid chronic graft-versus-host disease (scGVHD) is a severe complication of allogeneic haema-- topoietic stem cell transplantation. The aim of this study was to investigate the usefulness of high-frequency ultrasound of the skin in assessing the inflammatory patterns and prognosis of patients with scGVHD. A prospective study was carried ou...
Article
Nevus count is highly determined by inherited variants and has been associated with the origin of melanoma. De novo melanomas (DNMMs) are more prevalent in patients with a low nevus count and have distinctive dermoscopic features than nevus‐associated melanomas. We evaluated the impact of 9 Single Nucleotide Polymorphisms (SNPs) of MTAP (rs10811629...
Article
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The incidence of melanoma has been increasing worldwide during recent decades. The objective of the study was to analyse the trends in incidence for in situ and invasive melanoma in the Spanish region of Catalonia during the period of 2008-2017. We designed a cross-sectional study with an age-period-cohort analysis of melanoma patient data from the...
Article
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Background: Data on the clinical patterns and histopathology of SARS-CoV-2 related skin lesions, as well as on their relationship with the severity of COVID-19 are limited. Methods and materials: Retrospective analysis of a prospectively collected cohort of patients with SARS-CoV-2 infection in a teaching hospital in Barcelona, Spain, from 1 Apr...
Article
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Background and objectives Spain is in a situation of indefinite lockdown due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. One of the consequences of this lockdown is delays in medical and surgical procedures for common diseases. The aim of this study was to model the impact on survival of tumor growth caused by such delays in patien...
Thesis
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El melanoma representa solo un 5% de los cánceres de piel, sin embargo es responsable de más del 90% de las muertes asociadas a neoplasias cutáneas. Lo que es más preocupantes es que su incidencia continua en aumento pese a las grandes campañas de prevención poblacional. En consecuencia, el aumento de casos prevalentes ha supuesto una sobrecarga as...
Article
Since December 2019, coronavirus disease 2019 (COVID‐19) has spread worldwide to become a pandemic. Multiple skin manifestations related to the infection have been described progressively. Recalcati1 asserted that 20.4% of infected patients developed cutaneous manifestations and Galván‐Casas et al2 have recently proposed 5 clinical patterns (pseudo...
Article
e22094 Background: The success of adjuvant therapy for patients with AJCC stage III melanomas coupled with the increased risk of mortality for patients with AJCC stage IIB compared to IIIA tumours has paved the way to adjuvant immunotherapy trials for patients with sentinel lymph node (SLNB) –ve AJCC stage II disease. However, the lack of biomarker...
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Resumen Antecedentes y objetivos: La pandemia del coronavirus COVID-19 ha provocado un confinamiento indefinido. Una posible consecuencia de esta situación es un retraso en los procedimientos asistenciales de las patologías comunes. El objetivo de este estudio es estimar el hipotético impacto en la supervivencia que tendría el aumento del tamaño ta...
Article
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Resumen Antecedentes La clasificación automática de imágenes es una rama prometedora del aprendizaje automático (de sus siglas en inglés Machine Learning [ML]), y es una herramienta útil en el diagnóstico de cáncer de piel. Sin embargo, poco se ha estudiado acerca de las limitaciones de su uso en la práctica clínica diaria. Objetivo Determinar la...
Article
The presence of regional metastasis is a predictor of worse survival in thick melanoma1 and is currently an indication for adjuvant therapy. Few studies have analyzed the prognostic role of clinical and pathologic variables in thick melanoma without metastatic lymph node involvement2‐4. The aim of this study was to identify them.
Article
Background Automated image classification is a promising branch of machine learning (ML) useful for skin cancer diagnosis, but little has been determined about its limitations for general usability in current clinical practice. Objective To determine limitations in the selection of skin cancer images for ML analysis, particularly in melanoma. Met...
Article
Numerous dermoscopic structures for the early detection of melanoma have been described. The aim of this study was to illustrate the characteristics of dermoscopic structures that are similar to blotches, but smaller (termed microblotches), and to evaluate their association with other well-known dermoscopic structures. A transversal study design, i...
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Blood plasma contains DNA fragments from dying cells, called cell‐free circulating DNA (cfDNA). In cancer patients, a fraction of their blood cfDNA comes from dying tumour cells. Therefore, key genetic alterations (mutations) from tumours might be detected in plasma from cancer patients. The analysis of cfDNA is a promising tool for the treating ca...
Article
血浆中含有垂死细胞的 DNA 片段,称为无细胞循环 DNA (cfDNA)。在癌症患者中,他们的血液 cfDNA 的一部分来自垂死的肿瘤细胞。因此,可以在癌症患者的血浆中检测到肿瘤的关键基因变异(突变)。 cfDNA 分析对于治疗癌症患者是一种有前景的工具,因为来自肿瘤的信息可能是从血液样本中获得的,从而避免了使用“侵入性”方法,例如组织活检(例如,通过手术采集样本)。 黑色素瘤是一种侵袭性皮肤癌。全世界每年有超过 250,000 例新确诊病例。在大约 50% 的黑色素瘤中检测到了 BRAF 基因 (BRAFV600E) 中的 p.V600E 突变。目前,对黑色素瘤患者血浆中 BRAFV600E 突变的分析可用于监测其疾病进展。 除肿瘤外,经常在皮肤上的痣中检测到 BRAFV600E 突变,...
Article
Background: The role of S100B protein in detecting early melanoma relapses is controversial, since most metastasis occur within normal values of S100B. Objective: The aim of this study was to assess the performance of S100B in detecting early disease progression in high-risk melanoma patients. Methods: Retrospective cohort study including pati...
Conference Paper
Full-text available
Background Melanoma is the most aggressive of common skin cancers. We aimed to create a polygenic risk score (PRS) and evaluate its capability to predict melanoma prognosis better than staging. Methods The cohort included 1126 melanoma patients (567 males, 559 females); 57%, 24% and 19% patients stage I, II and III at diagnosis, respectively. The...
Article
Introduction: Sentinel lymph node (SLN) biopsy is useful for the prognostic stratification of patients with thick melanoma. Identifying which variables are associated with SLN involvement and establishing risk in different subgroups of patients could be useful for guiding the indication of SLN biopsy. The value of complete lymph node dissection (C...
Article
Background: There is no consensus on the imaging tests that should be performed at the initial staging of melanoma patients. Objective: To evaluate the diagnostic accuracy of 4 imaging studies for the initial staging of melanoma patients. Methods: Cross-sectional study with prospectively collected data, from January 2011 to April 2017, includi...
Article
Background The p.V600E mutation in the BRAF gene (BRAFV600E) is the most frequent mutation in cutaneous melanoma and is a recurrent alteration found in common benign naevi. The analysis of cell‐free BRAFV600E mutation (cfBRAFV600E) in plasma has emerged as a biomarker for monitoring prognosis and treatment response in melanoma patients. Objectives...
Article
Introduction Alopecia areata (AA) is a high-prevalence immuno-mediated hair loss disorder. Extra follicular affections, including nail and ocular abnormalities, are classically related to a worse prognosis of the disease, and previous studies have suggested that the presence of a persistent nuchal nevus flammeus (NNF) also indicates a greater sever...