Sebastian Pleško

Jožef Stefan Institute | IJS · Reactor Physics

SARS-CoV-2 belongs to the family of coronaviruses, which are characterized by spikes that sit densely on the surface of the virus. The spike protein (Spro) is responsible for the attachment of the virus to the host cell via the ACE2 receptor on the surface of the host cell. The strength of the interaction between the receptor-binding domain (RBD) o...

COVID-19 represents a new potentially life-threatening illness caused by severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 pathogen. In 2021, new variants of the virus with multiple key mutations have emerged, such as B.1.1.7, B.1.351, P.1 and B.1.617, and are threatening to render available vaccines or potential drugs ineffective. In t...

M edicine and especially pharmaceuticals have improved dramatically in the last century. If isolation of natural compounds was the norm a hundred years ago, now it’s targeted design. Yet when we discover a new biochemical pathway to act on, we almost always start to seek novel classes of drugs out of natural compounds. Be it the later or the former...

The Zaire Ebola viral protein VP24 selectively inhibits nuclear import of STAT1 and as such blocks interferon-induced antiviral responses vital for cell's emergency. Inhibition of VP24 with small molecule inhibitor may neutralize the threatening action of Ebola virus. We performed molecular docking of compounds from a selected small library of plan...

Medicine and especially pharmaceuticals have improved dramatically in the last century. If isolation of natural compounds was the norm a hundred years ago, now it's targeted design. Yet when we discover a new biochemical pathway to act on, we almost always start to seek novel classes of drugs out of natural compounds. Be it the later or the former,...

The Zaire Ebola viral protein VP24 selectively inhibits nuclear import of STAT1 and as such blocks interferon-induced antiviral responses vital for cell's emergency. Inhibition of VP24 with small molecule inhibitor may neutralize the threatening action of Ebola virus. We performed molecular docking of compounds from a selected small library of plan...

The thesis shows cryoscopically determined osmotic coefficients of aqueous solu- tions of NaCl, CsCl, NaI, KI and CsI at various molalities (up to 1 mol kg^−1 ). Out of the all the salts, NaCl was used to test if a simple method frequently described in laboratory textbooks of physical chemistry gives comparable results to the more sophisticated tec...

Načrtov za pH metre obstaja že malo morje. Vseeno pa takšnega, kot je opisan tukaj, še nisem zasledil. Moja shema se od preostalih razlikuje po tem, da je zelo enostavna, a hkrati uporabna za vhod na mikrokontroler, saj večina enostavnih shem daje izhod, ki gre tudi v negativne napetosti in potrebuje negativno napajalno napetost. To sem enostavno r...