Sebastiaan Overeem

Sebastiaan Overeem
Eindhoven University of Technology | TUE · Department of Industrial Design

MD, PhD

About

304
Publications
56,319
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16,599
Citations
Citations since 2016
104 Research Items
7525 Citations
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Introduction

Publications

Publications (304)
Article
Objective: To evaluate the impact of solriamfetol, a dopamine and norepinephrine reuptake inhibitor, on on-the-road driving performance in participants with narcolepsy. Methods: In this randomised, double-blind, placebo-controlled, crossover study, driving performance during a 1 h on-road driving test was assessed at 2 and 6 h post-dose followin...
Conference Paper
Nowadays, high amounts of data can be acquired in various applications, spurring the need for interpretable data representations that provide actionable insights. Algorithms that yield such representations ideally require as little a priori knowledge about the data or corresponding annotations as possible. To this end, we here investigate the use o...
Article
Sleep stage classification is an important tool for the diagnosis of sleep disorders. Because sleep staging has such a high impact on clinical outcome, it is important that it is done reliably. However, it is known that uncertainty exists in both expert scorers and automated models. On average, agreement between human scorers is only 82.6%. In this...
Preprint
Full-text available
Continuous monitoring with an ever-increasing number of sensors has become ubiquitous across many application domains. Acquired data are typically high-dimensional and difficult to interpret, but they are also hypothesized to lie on a lower-dimensional manifold. Many deep learning (DL) models aim to identify this manifold, but do not promote struct...
Article
Objective: To evaluate the impact of solriamfetol, a dopamine and norepinephrine reuptake inhibitor, on on-the-road driving in participants with excessive daytime sleepiness (EDS) associated with obstructive sleep apnoea (OSA). Methods: Eligible participants were aged 21-75 years with OSA and EDS (Maintenance of Wakefulness Test mean sleep laten...
Article
Full-text available
Study objectives The most sensitive and specific investigative method for the diagnosis of narcolepsy type 1 (NT1) is the determination of hypocretin-1 (orexin A) deficiency (≤110 pg/mL) in cerebrospinal fluid using a radioimmunoassay (RIA). We aimed to assess the reliability of the Phoenix Pharmaceuticals hypocretin-1 RIA, by determining the lower...
Article
Full-text available
Purpose: Narcolepsy type-1 (NT1) is a rare chronic neurological sleep disorder with excessive daytime sleepiness (EDS) as usual first and cataplexy as pathognomonic symptom. Shortening the NT1 diagnostic delay is the key to reduce disease burden and related low quality of life. Here we investigated the changes of diagnostic delay over the diagnost...
Article
Full-text available
Background and Objectives Recent studies fueled doubts as to whether all currently defined central disorders of hypersomnolence are stable entities, especially narcolepsy type 2 and idiopathic hypersomnia. New reliable biomarkers are needed and the question arises whether current diagnostic criteria of hypersomnolence disorders should be reassessed...
Article
Study objectives To review the Maintenance of Wakefulness Test (MWT) as assessment of daytime sleepiness in the evaluation of treatment effects and driving fitness in central disorders of hypersomnolence (CDH). Methods We performed a scoping review of studies using the MWT in patients with CDH (i.e. narcolepsy types 1 and 2, and idiopathic hyperso...
Preprint
div> Objective : Data acquired during a sleep recording is typically compressed into a hypnogram ; a visual representation of manually annotated sleep stages over the night. Recently, a richer hypnodensity representation was proposed that provides a probability distribution over these stages at each point in time. In this work we investigate how to...
Article
Full-text available
Study Objectives The diagnosis of narcolepsy type 1 (NT1) is based upon the presence of cataplexy and/or a cerebrospinal fluid (CSF) hypocretin-1/orexin-A level ≤110 pg/mL. We determined the clinical and diagnostic characteristics of patients with intermediate hypocretin-1 levels (111-200 pg/mL) and the diagnostic value of cataplexy characteristics...
Article
Sleep is characterized by an intricate variation of brain activity over time. Measuring these temporal sleep dynamics is relevant for elucidating healthy and pathological sleep mechanisms. The rapidly increasing possibilities for obtaining and processing sleep registrations have led to an abundance of data, which can be challenging to analyze and i...
Article
Study objectives: We created a Dutch version of the Paris Arousal Disorders Severity Scale, which assesses non-rapid eye movement (NREM) parasomnia symptoms over the past year (PADSS-year). This questionnaire was previously validated in patients with sleep walking and/or sleep terrors ('SW/ST'). We validated the questionnaire in SW/ST patients, an...
Article
Background The reported prevalence of insomnia symptoms in people with intellectual disabilities varies greatly, possibly due to the lack of a common definition. This article provides an overview of the different definitions used and formulates key points for a general definition. Methods A literature search was performed. An overview of the defin...
Article
Full-text available
Patients with narcolepsy or idiopathic hypersomnia (IH) are at increased risk of driving accidents. Both excessive daytime sleepiness, i.e. unwanted sleep episodes during the day, and disturbed vigilance are core features of these disorders. We tested on‐the‐road driving performance of patients with narcolepsy or IH coming in for a routine driving...
Preprint
div> Objective : Data acquired during a sleep recording is typically compressed into a hypnogram ; a visual representation of manually annotated sleep stages over the night. Recently, a richer hypnodensity representation was proposed that provides a probability distribution over these stages at each point in time. In this work we investigate how to...
Preprint
div>We used a dataset of nocturnal PSG recordings, collected as part of the Healthbed study, which main aim was development of technologies for sleep analyses. The dataset includes one clinical video-PSG recording for each subject, made according to the AASM recommendations in Sleep Medicine Center Kempenhaeghe Heeze, the Netherlands. The study inc...
Article
Full-text available
PurposeObstructive sleep apnea (OSA) is common in people with intellectual disabilities (ID), but in practice continuous positive airway pressure (CPAP) is often deemed unfeasible. We investigated adherence to and effect of CPAP in patients with ID and OSA.Methods Patients with ID were started on CPAP using an intensive training program. Acceptable...
Article
Full-text available
Objective: Parkinson's disease is a common, age-related, neurodegenerative disease, affecting gait and other motor functions. Technological developments in consumer imaging are starting to provide high-quality, affordable tools for home-based diagnosis and monitoring. This pilot study aims to investigate whether a consumer depth camera can capture...
Article
Full-text available
Laury Quaedackers,1 Sigrid Pillen,1 Sebastiaan Overeem2 1Sleep Medicine Center Kempenhaeghe, Heeze, the Netherlands; 2Biomedical Diagnostics Laboratory, Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the NetherlandsCorrespondence: Sebastiaan OvereemSleep Medicine Center Kempenhaeghe, Sterkselseweg 65, Heeze, VE...
Article
Full-text available
Purpose: There is great interest in unobtrusive long-term sleep measurements using wearable devices based on reflective photoplethysmography (PPG). Unfortunately, consumer devices are not validated in patient populations and therefore not suitable for clinical use. Several sleep staging algorithms have been developed and validated based on ECG-sig...
Article
Introduction Assessing objective measures of sleep fragmentation could yield important features reflecting impaired sleep quality in people with insomnia. Survival analysis allows the specific examination of the stability of NREM sleep, REM sleep and wake. The objective of this study was to assess the differences between survival dynamics of NREM s...
Article
Full-text available
Objective Measurement of respiratory rate and effort is useful in various applications, such as the diagnosis of sleep apnea and early detection of patient deterioration in medical conditions, such as infections. A chest-worn accelerometer may be an easy and non-intrusive method, provided it is accurate and robust. We investigate the use of a novel...
Article
Full-text available
Background and Objective: Snoring is a prevalent phenomenon. It may be benign, but can also be a symptom of obstructive sleep apnea (OSA) a prevalent sleep disorder. Accurate detection of snoring may help with screening and diagnosis of OSA. Methods: We introduce a snore detection algorithm based on the combination of a convolutional neural networ...
Article
Full-text available
Introduction: Assessing objective measures of sleep fragmentation could yield important features reflecting impaired sleep quality in people with insomnia. Survival analysis allows the specific examination of the stability of NREM sleep, REM sleep and wake. The objective of this study was to assess the differences between survival dynamics of NREM...
Article
Full-text available
Introduction: The core symptoms of narcolepsy such as excessive daytime sleepiness and cataplexy are well known. However, there is mounting evidence for a much broader symptom spectrum, including psychiatric symptoms. Disordered sleep has previously been linked with dissociative symptoms, which may imply that patients with narcolepsy are more prone...
Article
Full-text available
Introduction Excessive Daytime Sleepiness is a core symptom of narcolepsy and idiopathic hypersomnia, which impairs driving performance. Adequate treatment improves daytime alertness, but it is unclear whether driving performance completely normalizes. This study compares driving performance of patients with narcolepsy and idiopathic hypersomnia re...
Article
Full-text available
A new algorithm based on singular value decomposition (SVD) to remove cardiac contamination from trunk electromyography (EMG) is proposed. Its performance is compared to currently available algorithms at different signal-to-noise ratios (SNRs). The algorithm is applied on individual channels. An experimental calibration curve to adjust the number o...
Article
Full-text available
Rationale: The mechanisms underlying impaired sleep quality in insomnia are not fully known, but an important role for sleep fragmentation has been proposed. Objectives: The aim of this study is to explore potential mechanisms of sleep fragmentation influencing alterations of perceived sleep quality. Methods: We analyzed polysomnography (PSG)...
Chapter
As early as the 1920s, pathological studies of encephalitis lethargica allowed Von Economo to correctly identify hypothalamic damage as crucial for the profound associated sleep-related symptoms that helped define the condition. Only over the last 3 decades, however, has the key role of the hypothalamus in sleep–wake regulation become increasingly...
Article
Full-text available
Study objectives While poor sleep quality has been related to increased risk of Alzheimer’s disease, long-time shift workers (maritime pilots) did not manifest evidence of early Alzheimer’s disease in a recent study. We explored two hypotheses of possible compensatory mechanisms for sleep disruption: Increased efficiency in generating deep sleep du...
Article
Polysomnography (PSG) is the current gold standard for the diagnosis of sleep disorders. However, this multiparametric sleep monitoring tool also has some drawbacks, e.g. it limits the patient's mobility during the night and it requires the patient to come to a specialized sleep clinic or hospital to attach the sensors. Unobtrusive techniques for t...
Article
None: Narcolepsy is a chronic neurological sleep disorder, debuting before the age of fifteen in one-third of the cases. Narcolepsy has a negative influence on quality of life, with daily functioning being affected by concomitant cognitive, behavioral and social problems. In December 2019, a new coronavirus emerged world-wide, causing a severe a r...
Article
Recent evidence indicates that disrupted sleep could contribute to the development of Alzheimer’s disease (AD) by influencing the production and/or clearance of the amyloid‐β protein. Studies however are limited to acute, short‐term effects. Therefore, we investigated the association between long‐term work‐induced sleep disruption, cognition, and b...
Article
Full-text available
Objective The maturation of neural network-based techniques in combination with the availability of large sleep datasets has increased the interest in alternative methods of sleep monitoring. For unobtrusive sleep staging, the most promising algorithms are based on heart rate variability computed from inter-beat intervals (IBIs) derived from ECG-da...
Article
Full-text available
Objective: Respiratory sinus arrhythmia (RSA) refers to heart rate oscillations synchronous with respiration, and it is one of the major representations of cardiorespiratory coupling. Its strength has been suggested as a biomarker to monitor different conditions and diseases. Some approaches have been proposed to quantify the RSA, but it is unclea...
Article
The 25th Congress of the European Sleep Research Society, 22‐24 September 2020, Virtual Congress https://doi.org/10.1111/jsr.13181
Article
Increased incidence rates of narcolepsy type-1 (NT1) have been reported world-wide after the 2009-2010 H1N1 influenza pandemic (pH1N1). While some European countries found an association between the NT1 incidence increase and the H1N1 vaccination Pandemrix, reports from Asian countries suggested the H1N1 virus itself to be linked to the increased N...
Article
The 25th Congress of the European Sleep Research Society, 22‐24 September 2020, Virtual Congress https://doi.org/10.1111/jsr.13181
Article
Full-text available
Background: Recent evidence indicates that disrupted sleep could contribute to the development of Alzheimer's disease by influencing the production and/or clearance of the amyloid-β protein. We set up a case-control study to investigate the association between long-term work-induced sleep disruption, cognitive function, and brain amyloid-β burden....
Article
Full-text available
A large part of the worldwide population suffers from obstructive sleep apnea (OSA), a disorder impairing the restorative function of sleep and constituting a risk factor for several cardiovascular pathologies. The standard diagnostic metric to define OSA is the apnea–hypopnea index (AHI), typically obtained by manually annotating polysomnographic...
Preprint
Full-text available
Study objectives: While poor sleep quality has been related to increased risk of Alzheimer’s disease, long-time shift workers (maritime pilots) did not manifest evidence of early Alzheimer’s disease in a recent study. We explored two hypotheses of possible compensatory mechanisms for sleep disruption: Increased efficiency in generating deep sleep d...
Chapter
Almost a century ago, Constantin von Economo observed that in patients with encephalitis lethargica lesions in the upper brain stem and posterior hypothalamus impaired consciousness. From lesion studies in cats and anatomical data, the idea arose that the brain stem reticular formation is the origin of the ascending reticular activating system (ARA...
Chapter
The autonomic nervous system innervates the visceral organs, the glands and the blood vessels. It regulates the internal environment, and it is largely responsible for maintaining normal bodily functions such as respiration, blood pressure and micturition. The peripheral autonomic nervous system consists of two parts, a thoracolumbar or sympathetic...
Article
Full-text available
Acute total sleep deprivation and partial sleep deprivation have negative impacts on cognitive performance. Studies in subjects who regularly experience sleep loss, however, are rare and often restricted to examination of internal sleeping disorders. To address this issue, we set up a pilot study to explore the effects of a week characterized by sl...
Article
Study objective To ascertain the presence of cognitive and attention problems in treatment naïve children with narcolepsy type 1 (NT1) and to explore whether children recently diagnosed with NT1 improve with respect to cognition and attention problems one year after regular treatment for NT1. Methods Fifteen treatment naïve children (7-15 years) w...
Article
Introduction Excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA) is associated with an increased risk of driving accidents. Solriamfetol, a dopamine/norepinephrine reuptake inhibitor, is approved in the US (Sunosi®) for EDS associated with OSA (37.5-150 mg/day). This study evaluated solriamfetol’s effects on on-road dr...
Article
Introduction Patients with narcolepsy have an increased risk of automobile accidents. Solriamfetol, a dopamine/norepinephrine reuptake inhibitor, is approved in the US (Sunosi®) for adults with excessive daytime sleepiness (EDS) associated with narcolepsy (75-150 mg/day). This study evaluated the effects of solriamfetol on on-road driving performan...
Article
Objective: Respiratory activity is an essential parameter to monitor healthy and disordered sleep, and unobtrusive measurement methods have important clinical applications in diagnostics of sleep-related breathing disorders. We propose a respiratory activity surrogate extracted from wrist-worn reflective photoplethysmography validated on a heterog...
Preprint
Full-text available
Background: Recent evidence indicates that disrupted sleep could contribute to the development of Alzheimer’s disease by influencing the production and/or clearance of the amyloid-β protein. We set up a case-control study to investigated the association between long-term work-induced sleep disruption, cognitive function, and brain amyloid-β accumul...
Preprint
Full-text available
Background: Recent evidence indicates that disrupted sleep could contribute to the development of Alzheimer’s disease by influencing the production and/or clearance of the amyloid-β protein. We set up a case-control study to investigate the association between long-term work-induced sleep disruption, cognitive function, and brain amyloid-β burden....
Article
Study Objectives To validate a previously developed sleep staging algorithm using heart rate variability (HRV) and body movements in an independent broad cohort of unselected sleep disordered patients. Methods We applied a previously designed algorithm for automatic sleep staging using long short-term memory recurrent neural networks to model slee...
Article
Full-text available
We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included, because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1. HLA-DQB1-associa...
Article
Full-text available
Study objective To elucidate the contribution of time estimation and pre sleep arousal to the component of sleep onset misperception not explained by sleep fragmentation. Methods At-home ambulatory polysomnograms (PSGs) of 31 people with insomnia were recorded. Participants performed a time estimation task and completed the Pre Sleep Arousal Scale...
Article
Objective: Studies have shown an increased cardiovascular risk in obstructive sleep apnea (OSA) patients. In order to prioritize treatment of high risk patients, there is a need for improved cardiovascular OSA phenotyping. This study investigates the use of oxygen saturation ( SpO2) parameters for cardiovascular risk assessment of OSA patients. To...
Article
Full-text available
Insomnia, i.e., difficulties initiating and/or maintaining sleep, is one of the most common sleep disorders. To study underlying mechanisms for insomnia, we studied autonomic activity changes around sleep onset in participants without clinical insomnia but with varying problems with initiating or maintaining sleep quantified as increased sleep onse...