Sean L. Wu

Sean L. Wu
University of California, Berkeley | UCB · Divisions of Epidemiology & Biostatistics

Doctor of Philosophy

About

70
Publications
6,564
Reads
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634
Citations
Additional affiliations
June 2020 - present
Microsoft
Position
  • Intern
Education
August 2014 - May 2016
University of California, Berkeley
Field of study
  • Epidemiology & Biostatistics
September 2008 - June 2013
University of California, Irvine
Field of study
  • International Studies & Statistics

Publications

Publications (70)
Article
Full-text available
Comprehensive data on transmission mitigation behaviors and both SARS-CoV-2 infection and serostatus are needed from large, community-based cohorts to identify COVID-19 risk factors and the impact of public health measures. We conducted a longitudinal, population-based study in the East Bay Area of Northern California. From July 2020-March 2021, ap...
Article
Background: Malaria is a risk factor for adverse pregnancy outcomes. Indoor residual spraying with insecticide (IRS) reduces malaria infections, yet the effects of IRS on pregnancy outcomes are not well established. We evaluated the impact of a large-scale IRS campaign on pregnancy outcomes in Eastern Uganda. Methods: Birth records (n = 59 992)...
Preprint
Vaccines have played a central role in mitigating severe disease and death from COVID-19 in the past 12 months. However, efficacy wanes over time and this loss of protection is being compounded by the emergence of the Omicron variant. By fitting an immunological model to population-level vaccine effectiveness data, we estimate that neutralizing ant...
Preprint
Full-text available
Comprehensive data on transmission mitigation behaviors and SARS-CoV-2 infection and serostatus are needed from large, community-based cohorts to identify SARS-CoV-2 risk factors and impact of public health measures. From July 2020 to March 2021, ≈5,500 adults from the East Bay Area, California were followed over three data collection rounds. We es...
Poster
Full-text available
MGDrivE (Mosquito Gene Drive Explorer) is an open-source modeling framework to simulate and evaluate novel genetic control tools in spatial mosquito populations. The software has four modules: A) a genetic inheritance module accommodates the dynamics of gene drive systems, B) a population dynamic module accounts for mosquito life history, D) a land...
Article
Full-text available
Background: Geospatial datasets of population are becoming more common in models used for health policy. Publicly-available maps of human population make a consistent picture from inconsistent census data, and the techniques they use to impute data makes each population map unique. Each mapping model explains its methods, but it can be difficult t...
Article
Full-text available
Background Malaria elimination is the goal for Bioko Island, Equatorial Guinea. Intensive interventions implemented since 2004 have reduced prevalence, but progress has stalled in recent years. A challenge for elimination has been malaria infections in residents acquired during travel to mainland Equatorial Guinea. The present article quantifies ho...
Preprint
Full-text available
A rare example of a successful long-term elimination of the mosquito Aedes aegypti is in Brisbane, Queensland, where the legislatively-enforced removal of rainwater tanks drove its disappearance by the mid-1950s. However, a decade-long drought led to the mass installation of rainwater tanks throughout the region, re-introducing critical breeding si...
Poster
Full-text available
MGDrivE (Mosquito Gene Drive Explorer) is an open-source modeling framework to simulate and evaluate novel genetic control tools in spatial mosquito populations. The software has four modules (right): i) a genetic inheritance module accommodates the dynamics of gene drive systems, ii) a population dynamic module accounts for mosquito life history,...
Article
Full-text available
Interest in gene drive technology has continued to grow as promising new drive systems have been developed in the lab and discussions are moving towards implementing field trials. The prospect of field trials requires models that incorporate a significant degree of ecological detail, including parameters that change over time in response to environ...
Preprint
Full-text available
Background Malaria elimination is the goal for Bioko Island, Equatorial Guinea. Intensive interventions implemented since 2004 have reduced prevalence, but progress has stalled in recent years. A challenge for elimination has been malaria infections in residents acquired during travel to mainland Equatorial Guinea. We quantify how off-island contri...
Article
Full-text available
Significance Newly available large-scale datasets of human population movement represent an opportunity to model how diseases spread between different locations. Combining infectious disease models with mechanistic models of host movement enables studies of how movement drives disease transmission and importation. Here we explore how modeled epidem...
Preprint
Full-text available
Background Malaria elimination is the goal for Bioko Island, Equatorial Guinea. Intensive interventions implemented since 2004 have reduced prevalence, but progress has stalled in recent years. A challenge for elimination has been malaria infections in residents acquired during travel to mainland Equatorial Guinea. We quantify how off-island contri...
Article
Full-text available
School closures may reduce the size of social networks among children, potentially limiting infectious disease transmission. To estimate the impact of K–12 closures and reopening policies on children's social interactions and COVID-19 incidence in California's Bay Area, we collected data on children's social contacts and assessed implications for t...
Article
Full-text available
Background Dengue fever is a mosquito-borne infectious disease that has caused major health problems. Variations in dengue virus (DENV) genes are important features of epidemic outbreaks. However, the associations of DENV genes with epidemic potential have not been extensively examined. Here, we assessed new genotype invasion of DENV-1 isolated fro...
Preprint
Full-text available
After more than a century of sustained work by mathematicians, biologists, epidemiologists, probabilists, and other experts, dynamic models have become a vital tool for understanding and describing epidemics and disease transmission systems. Such models fulfill a variety of crucial roles including data integration, estimation of disease burden, for...
Poster
Full-text available
CRISPR/Cas9-based technologies have revitalized interest in gene-editing technologies as means to control mosquito-borne diseases. Amongst candidate disease-control mechanisms, gene- replacement strategies are considered some of the most promising due to their resilience to generation of resistant alleles (caused by errors in homology-directed repa...
Article
Full-text available
Objective To use the case-only gene-environment (G E) interaction study design to estimate interaction between pregnancy before onset of MS symptoms and established genetic risk factors for MS among White adult females. Methods We studied 2,497 female MS cases from 4 cohorts in the United States, Sweden, and Norway with clinical, reproductive, and...
Preprint
Full-text available
Interest in gene drive technology has continued to grow as promising new drive systems have been developed in the lab and discussions are moving towards implementing field trials. The prospect of field trials requires models that incorporate a significant degree of ecological detail, including parameters that change over time in response to environ...
Article
Full-text available
Accurate estimates of the burden of SARS-CoV-2 infection are critical to informing pandemic response. Confirmed COVID-19 case counts in the U.S. do not capture the total burden of the pandemic because testing has been primarily restricted to individuals with moderate to severe symptoms due to limited test availability. Here, we use a semi-Bayesian...
Preprint
Full-text available
Background Large-scale school closures have been implemented worldwide to curb the spread of COVID-19. However, the impact of school closures and re-opening on epidemic dynamics remains unclear. Methods We simulated COVID-19 transmission dynamics using an individual-based stochastic model, incorporating social-contact data of school-aged children d...
Preprint
Full-text available
Geospatial datasets of population are becoming more common in models used for health policy. Publicly-available maps of human population in sub-Saharan Africa make a consistent picture from inconsistent census data, and the techniques they use to impute data makes each population map unique. Each mapping model explains its methods, but it can be di...
Preprint
Full-text available
Accurate estimates of the burden of SARS-CoV-2 infection are critical to informing pandemic response. Current confirmed COVID-19 case counts in the U.S. do not capture the total burden of the pandemic because testing has been primarily restricted to individuals with moderate to severe symptoms due to limited test availability. Using a semi-Bayesian...
Article
Full-text available
The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, and concern, for the invasiveness and potential irreversibility of a release. Gene drive systems that display threshold-dependent behavior could pot...
Article
Full-text available
Mosquitoes are important vectors for pathogens that infect humans and other vertebrate animals. Some aspects of adult mosquito behavior and mosquito ecology play an important role in determining the capacity of vector populations to transmit pathogens. Here, we re-examine factors affecting the transmission of pathogens by mosquitoes using a new app...
Preprint
Full-text available
Newly available data sets present exciting opportunities to investigate how human population movement contributes to the spread of infectious diseases across large geographical distances. It is now possible to construct realistic models of infectious disease dynamics for the purposes of understanding global-scale epidemics. Nevertheless, a remainin...
Article
Full-text available
Regional sensitivity analysis, RSA, has been widely applied in assessing the parametric sensitivity of environmental and hydrological models, in part because of its inherent simplicity. In that spirit, this paper reports an example of an augmented approach to improve its utility in ranking parameter importance, beyond reliance solely on the univari...
Article
Full-text available
1.Malaria, dengue, Zika, and other mosquito‐borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide‐based tools and antimalarial drugs. The advent of CRISPR/Cas9‐based gene editing and its demonstrated ability to streamline the development of gene drive systems has r...
Preprint
Full-text available
Mosquitoes are important vectors for pathogens of humans and other vertebrate animals. Some aspects of adult mosquito behavior and mosquito ecology play an important role in determining the capacity of vector populations to transmit pathogens. Here, we re-examine factors affecting the transmission of pathogens by mosquitoes using a new approach. Un...
Preprint
Full-text available
Background: Dengue fever is a mosquito-borne infectious disease that has caused major health problems. Variations in dengue virus (DENV) genes are important features of epidemic outbreaks. However, the associations of DENV genes with epidemic scale have not been extensively examined. Here, we assessed new genotype invasion of DENV-1 isolated from G...
Thesis
Full-text available
The recent discovery of CRISPR-Cas9 and its use in gene drive systems has sparked global interest in their use to control the spread of mosquito-borne pathogens. In particular, the discovery of the Mutagenic Chain Reaction (MCR), which ensures homozygous inheritance of a desired homing allele, has rendered gene drive as a viable technology. However...
Preprint
Full-text available
The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, and concern, for the invasiveness and potential irreversibility of a release. Gene drive systems that display threshold-dependent behavior could pot...
Article
Full-text available
The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilita...
Presentation
Full-text available
In this work, we present our framework with applications to various novel gene-drive systems such as: reciprocal chromosomal translocations, toxin-antidote-based underdominant systems. In doing so, we show how our model can be used to answer relevant questions in the field of mosquito-borne diseases elimination, such as: how to make fair comparison...
Poster
Full-text available
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world. The advent of CRISPR/Cas9-based gene editing and its demonstrated ability to streamline the development of gene drive systems has reignited interest in the application of this technology to the control of mosquitoes and...
Presentation
Full-text available
In this work, we present MGDrivE with example applications to threshold-dependent drives (reciprocal chromosomal translocations and toxin-antidote-based underdominant systems). We show how the timing of the releases can be optimized for the drives to fixate in the population with a minimum cost, and how this information can be applied to simulate r...
Preprint
Full-text available
The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed "precision guided SIT" (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facili...
Preprint
Full-text available
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. The advent of CRISPR/Cas9-based gene editing and its demonstrated ability to streamline the development of gene drive systems has rei...
Poster
Full-text available
The control of malaria and other vector-borne diseases represents a significant challenge to public health worldwide. Sustained transmission of malaria requires mosquitoes to carry parasites from one host to another. Here, we model the movement of mosquitoes, and by consequence the transmission of parasites, as an emergent property of the distribut...
Article
Full-text available
As Africa-wide malaria prevalence declines, an understanding of human movement patterns is essential to inform how best to target interventions. We fitted movement models to trip data from surveys conducted at 3–5 sites throughout each of Mali, Burkina Faso, Zambia and Tanzania. Two models were compared in terms of their ability to predict the obse...
Article
Full-text available
Background Despite great achievements by insecticide-treated nets (ITNs) and indoor residual spraying (IRS) in reducing malaria transmission, it is unlikely these tools will be sufficient to eliminate malaria transmission on their own in many settings today. Fortunately, field experiments indicate that there are many promising vector control interv...
Data
Model schematic diagram. Flow diagram for the mosquito ecological model, mosquito SEI model, and human SI model. (TIF)
Data
Illustrations of the impact of indoor interventions. The schematic illustrates the probability of mosquito being repelled or killed upon encountering indoor interventions. (TIF)
Data
Illustrations of VCOM’s simple graphic user interface. (TIF)
Data
Parameter values for the vector and human components of the model. (DOCX)
Data
Basic parameter estimates for the vector ecology and control model. (DOCX)
Data
Evaluating the impact of combining ITNs at 50% and 80% coverage with additional tools against An. funestus. (TIF)
Data
Parameter for the effectiveness of all interventions considered. (DOCX)
Data
Brief description of the model parameter values. (DOCX)
Data
VCOM software—User graphical interface. (DOCX)
Data
Targeting mosquito on multiple fronts. The schematic highlights opportunities for vector control to target biological and environmental mosquito resources. (TIF)
Data
Sensitivity analysis results for An. funestus. (TIF)
Data
Full details of the mathematical models. (DOCX)
Poster
Full-text available
Mosquito-borne diseases, such as dengue, Zika, chikungunya, and yellow fever, pose significant health problems in tropical regions of the world. Control of the main vector for these diseases, the Aedes aegypti mosquito, remains elusive despite extensive efforts using traditional vector control interventions. Recent development in gene-drive technol...