S.E. Atawodi

Verified

S.E. verified their affiliation via an institutional email.

Learn more

Verified

S.E. verified their affiliation via an institutional email.

Learn more

• PhD, FAAS., FAS., FAMedS., FNSBMB
• Head of Department & Director, Advancement and Linkages at Federal University Lokoja

Background: Fungal fermentation could provide a key opportunity for achieving great benefits of biomass utilization through bioconversion into the simple digestible nutrients and greatly improve nutritive value.Objective: Mixed fungal fermentation of maize cobs was carried out to determine the effects on nutrients and antinutrients compositions.Met...

Mixed fungal fermentation was carried out to upgrade the nutritive value of the maize cobs for use as inclusion in developing a balanced feed for animal production. Grounded maize cobs were alkaline pretreated, and fermented with mixed and single lignocellulolytic fungi of Lachnocladium flavidum and Aspergillus niger. A feeding experiment assessed...

Cancer remains a global health challenge, necessitating continuous advancements in diagnostic and treatment strategies. This review focuses on the utility of non-invasive biomarkers in cancer diagnosis and treatment, their role in early detection, disease monitoring, and personalized therapeutic interventions. Through a systematic review of the lit...

COVID-19, the global pandemic caused by SARS-Corona virus 2 (SARS-CoV-2), recently ravaged the World with various efforts charged towards finding therapeutic drug targets for this novel virus. The identification of COVID-19 main protease (Mpro) opened the possibility of testing new families of inhibitors as potential anti-coronaviral drugs. Protein...

The use of microorganisms for xylanase production plays important role in the bioconversion of lignocelluloses and also required in huge amount for industrial level application. This necessitates the need to select potent microorganisms for xylanase production, followed by optimization of media components for enhanced production. The effects of alt...

Rats exposed to 72-hour intrarectal instillations of N-methyl-N-nitrosourea (MNU) were fed with Dioclea reflexa seed-included diets (0, 2.5, 5.0, and 10%). Following sacrifice, organs and blood were collected and analyzed for indices of oxidative stress and carcinogenesis using spectrophotometric, ELISA, histological, and immunohistochemical techni...

Assessment of micronutrient contents of standardized commonly consumed native soups among Nupe people of Niger state was carried. The ingredients for the recipes of six (6) commonly consumed soups were standardized, prepared and evaluated for some mineral and vitamin contents using standard procedures. The results obtained showed that "eni kuka", "...

The capacity of Crassocephalum rubens (Juss Ex Jacq) leaf to protect against systemic oxidative stress was evaluated in N‐methyl‐N‐nitrosourea (MNU) – intoxicated rats fed at various inclusion rates for a period of twelve (12) weeks. Major organs and tissues were then assessed for indices of lipid peroxidation and oxidative stress. Crassocephalum r...

The preventive effect of Hyphaene thebaica fruit in colon carcinogenesis was evaluated in Wistar rats at 0, 2.5, 5 and 10% inclusion rates for twelve weeks with concomitant 72‐h intra‐rectal N‐methyl‐N‐nitrosourea (MNU) instillations. Indices of antioxidant status and carcinogenesis were analyzed using spectrophotometric, ELISA, histological and im...

Cellulases are considered the most prominent of enzymes involved in the microbial breakdown of lignocellulosic waste. This study was designed to investigate the effect of various fermentation conditions on cellulase enzyme production in maize cobs from single and mixed fungal cultures as an index of good degradation and digestibility. Maize cobs we...

Quasi-general models of membrane computing have been designed by means of rules which represent the processes taking place in a biological cell without explicitly specifying the specialties of the rules, viz: their mixture, chemical or physical characteristics as is obtainable in a biological cell. In this paper, an attempt to model a variant of me...

Chemoprevention leverages the ability of natural products to interfere with disease onset and progression. In this study, the preventive effect of dietary inclusion with Crassocephalum rubens at 0, 2.5, 5 and 10% levels on colorectal carcinogenesis initiated by N-methyl-N-nitrosourea (MNU) instillations in male Wistar rats was explored following 12...

Objective: The present study was aimed to investigate the possible mechanism of action of the active sub fraction of C. rutidosperma. This was done by in vivo and in vitro methods. Methods: Aqueous extract of C. rutidosperma was sequentially fractionated and re-fractionated to yield the active sub fraction (based on in vivo evaluation). In the in v...

Objective: An earlier anti-hyperglycemic study with crude extracts of Cleome rutidosperma indicated aqueous extract as the most effective. The present study was undertaken to in part identify the potent antihyperglycemic fraction from the aqueous extract of the plant, using bioassay guided fractionation. Methods: Aqueous extract of C. rutidosperma...

Poor understanding of the clinicopathological features of prostate cancer (CaP) in Black men (BM) is one of the major challenges implicated in the management and prevention of the disease. The development of CaP involves an accumulation of multiple oncogenic events with associated increase in prostate specific antigen (PSA) and stress related hormo...

Background: Reports have shown that consumption of acha (Digitaria exilis) is beneficial to both diabetic and hypertensive patients considering its low glycaemic index, if fortified could assist to improve health and in combating hidden hunger. Aims: This work was aimed at establishing the technology of fortifying acha (Digitaria exilis) grains wit...

Ethnopharmacological relevance: Brachystegia eurycoma seed is used as dietary condiment and as part of recipes for treating colorectal disorders, while laboratory studies have established that it contains crude fiber and polyphenols which are important in cancer prevention. Aim of the study: To establish the efficacy of a Nigerian diet in colon...

Background: Prostate cancer is a significant public health problem affecting men globally. In 2012, it was the second most commonly diagnosed cancer among men worldwide and disproportionately impact men of African ancestry. Established risk factors for this disease include older age; family history; and African ancestry. While these factors are non...

The various ecologies and weather conditions, together with the agricultural and cultural practices, in addition to the poor postharvest technologies and storage systems employed by the operators in the entire pepper value-chain often predispose the peppers to fungal infection, growth and colonization and consequent mycotoxin contamination. Red pep...

Prostate cancer (CaP) is the most common male gender cancer and present with a 5-year prevalence, incidence and mortality rate in Nigerian Black men. There is disproportionate prevalence and poor understanding of CaP in Black men globally. The Prostate Cancer Transatlantic Consortium (CaPTC) has documented significant CaP burden among Nigerian blac...

Traditional alternative medicine providers are widely patronized in many parts of Africa. Inflammatory bowel diseases (IBD), anorectal and gastrointestinal disorders (AGD) usually designated as piles could be signs of early stage polyposis and are significant risk factors in colorectal cancers. A survey report reveals that over 20% of adults in Nor...

p>The research was aimed at understanding the perception and raising awareness on colorectal cancer among the public and in particular among individuals with anorectal and gastrointestinal disorders, usually traditionally designated as “pile” in northern Nigeria. The fact that some gastrointestinal abnormalities with symptoms of inflammation and he...

In the twentieth century, science makes substantial breakthrough in management and cure of diseases by chemotherapy due to discovery of antibiotics and other chemotherapeutic agents. In the twenty first century, man and other animals are still, however being challenged by emergence of new infectious and non-infectious diseases that have proven to b...

Medicinal plant cultivation is more of a rarity than common in Nigeria, similar to other areas in Africa, where these unquantifiable resources are rather shoddily harvested from the wild. This review identifies five cultivated medicinal plants species of Nigeria, i.e.: Vernonia amygdalina Del, Cyperus esculentus, Cymbopogon citratus Stapf, Khaya se...

With its location in an extensive geographical area that spread from the Mangrove forest in the south to the Sahel savannah in the north, Nigeria has diverse tropical vegetation with varying economic and medicinal significance. The vegetation, among other uses is a source of herbal medicine on which a large proportion of its populace relies for pri...

Detaruim microcarpum Guill. & Perr is a leguminous African plant with significant nutritional and medicinal uses. In an experimental -methyl nitroso urea (MU) induced colon carcinogenesis in rats, various concentrations of pulverized D. microcarpum fruits were included in diets of rats and the chemopreventive effects of these supplemented diets wer...

Purpose: To investigate the antihyperglycaemic and hypolipidemic potential of the methanol extracts of leaf, stem and root of Ageratum conyzoides in streptozotocin (STZ)-induced diabetic rats. Methods: The extract of each of the plant part was obtained by extraction in methanol. A total of 60 male Wistar albino rats (30 induced with diabetes and 30...

Evaluation of Brachystegia eurycoma (harms) seed dietary inclusion in the prevention of colon carcinogenesis Atawodi Sunday, Iliemene Uju Ahmadu Bello University, Dept. of Biochemistry, Zaria, Nigeria, Introduction: Considering cancer as an end stage of a chronic disease process which can be prevented by a positive lifestyle and natural medicin...

p class="abstract"> Background: This study was carried out to determine the growth performance of rats fed graded levels of Corchorus olitorius supplemented diet. Methods: Twenty male wistar rats weighing between 70g and 90g were purchased and randomly allocated into four treatment groups with graded levels of Corchorus olitorius ( 2.5%, 5% and 10%...

Background: Carbonic anhydrase is found in the blood of all vertebrate and thus playing a fundamental role in the maintenance of acid-base homeostasis. Erythrocytes are intrinsically prone to oxidative stress because of their exposure to high oxygen tension. Aim: The study aimed to investigate the changes of erythrocytes anti-oxidative enzymes in S...

Abstract Background: Carbonic anhydrase (CA) is a ubiquitous enzyme catalyzing the reversible hydration of CO2 to 3 HCO− and H+. CA plays a crucial role in CO2 transport, acid-base balance, and in linking local acidosis to O2 unloading from hemoglobin and also facilitates lactate shuttling across the monocarboxylate transporters (MCT). The study ai...

Aims: To investigate the hepatoprotective and nephroprotective potential of the methanolic extracts of the leaves, stem bark, seeds, fruit pulp, fruit bark and roots of Tamarindus indica Linn in acute and chronic rat model of organ injuries. Study Design: The acute-injury model involved intraperitoneal pre-treatment with 10 mg/kg body weight of the...

Occurring widely in Africa and beyond is Kigelia africana (Lam.) Benth, a medicinal plant with several attributes and considerable potentials. Various parts of the plant are used locally to treat cancer, ulcer, gynecological disorders, genital infections, skin diseases, diabetes, epilepsy, bacterial and fungal infections as well as being used as co...

Objective: The present study was aimed to investigate the possible mechanism of action of the active sub fraction of C. rutidosperma. This was done by in vivo and in vitro methods. Methods: Aqueous extract of C. rutidosperma was sequentially fractionated and re-fractionated to yield the active sub fraction (based on in vivo evaluation). In the in v...

Objective: An earlier anti-hyperglycemic study with crude extracts of Cleome rutidosperma indicated aqueous extract as the most effective. The present study was undertaken to in part identify the potent antihyperglycemic fraction from the aqueous extract of the plant, using bioassay guided fractionation. Methods: Aqueous extract of C. rutidosperma...

This book contains 14 chapters and provides up-to-date basic information on antioxidant plants from different sources and on the role of different abiotic and biotic stresses, endophytes and mycorrhizal fungi in the development of antioxidant compounds in plants. Some transgenic approaches to the scavenging of reactive oxygen species, and of the an...

The ethanol extracts of leaves, stem bark, and root bark of Vitex doniana were evaluated for antioxidant activity in poloxamer-407-induced hyperlipidemic rats. Fifty four (54) mixed sex Wistar rats weighing between 100 and 200 g were used. The animals were divided into nine different groups of six rats per group; normal control, hyperlipidemic cont...

Negedu A, Joseph Ab, Umoh VJ, Atawodi SE, Rai MK. 2014. Biodeterioration of stored castor (Ricinus communis) seeds by Aspergillus tamarii. Nusantara Bioscience 6: 126-131. Biodeteriorative changes induced by Aspergillus tamarii in seeds of castor stored for a period of 180 days were investigated. Using Sabouroud Dextrose Agar (SDA) and direct plati...

The present study aimed to investigate the acute antihyperglycemic effects of four different solvent extracts (Petroleum ether, acetone, absolute ethanol and water) of two plants: Cleome rutidosperma (leaves) and Senecio biafrae (root) in STZ-induced diabetic mice and their in vitro antioxidant activities as well as their phytoconstituents. A singl...

Objective: To investigate the ameliorative role of Tetrapleura tetraptera (Schum and Thonn) Taub (T. tetraptera) leaf in hyperglycemia with associated conditions like oxidative stress, kidney damage and disorders in lipid metabolism. Methods: Five groups of five rats each intraperitoneally received the following treatment schedules for 7 d: untr...

Aim: To evaluate the protective and ameliorative roles of methanolic extract of Byrsocarpus coccineus, Schum. & Thonn. leaf against acute and chronic carbon tetrachloride (CCl 4)-induced oxidative stress and Injuries to Liver, Kidney and Heart in Rats. Methods: To study the protective effects of the extract against oxidative stress, the rats were p...

Objective: To investigate the effect of methanolic extract of Dioclea reflexa Hook F seed on male rats following single (acute) or repeated (chronic) carbon tetrachloride intoxication. Methods: Male albino rats were divided into groups of six each consisting of plant extract only, plant extract + carbon tetrachloride, solvent only, solvent + carbon...

Aim: To establish the in vivo effects of the methanolic extract of Afzelia africana seed on CCl 4-induced organ damage on some biochemical parameters. Methods: The rats were divided into 7 groups of 5 rats each. In the single administration experiment, rats were intraperitoneally pre-treated with the extract (10mg/kg) for two days before CCl 4 into...

The ethno medicinal applications of plant species used primarily to manage hypertension among the Igala people of Kogi State, Nigeria were surveyed. A total of ten plant species belonging to nine families were found to have varying applications against the disease. The plants include Kigelia africana (Bignoniaceae), Ficus capensis (Moraceae), 4536...

ABSTRACT Aim: To evaluate the polyphenols, flavonoids and the in vitro antioxidant activity of different parts of Tamarindus indica Linn. Study Design: Methanolic extracts of the leaves, stem bark, root bark, fruit pulp, fruit bark and seeds of Tamarindus indica Linn were analyzed for their total polyphenol contents, flavonoid concentration and ant...

Methanolic extract of Dioclea reflexa seed was investigated following acute or chronic carbon tetrachloride intoxication in male albino rats. In the acute experiment, rats were pre-treated with extract at 5 mg/kg for three days before administration of carbon tetrachloride (0.6 mL/kg) while in the chronic model, rats received extract at 2.5 mg/kg f...

The in-vivo antioxidant effect of the methanol extract of Afzelia africana SM seed on carbon tetrachloride (CCl4)-induced oxidative stress in rats was investigated. In the acute liver injury experiment, rats were intraperitoneally pre-treated with the extract (5 mg/kg) for three days before CCl4 intoxication at 0.6 mL/kg, while in the chronic liver...

The present study was carried out to investigate the effects of oral administration of aqueous extracts of Cleome rutidosperma leaves and Senecio biafrae roots on blood glucose, biochemical parameters, lipid profile, antioxidant enzymes activity and hepatic glucose regulating enzyme activities in Streptozotocin (STZ)-induced diabetic rats. STZ was...

To evaluate in vivo antioxidant and hepatoprotective activities of the methanolic extract of the root of Cassia singueana in rats following acute and chronic carbon tetrachloride intoxication. Malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin as indices of liver damage and lipid peroxidation were...

The antioxidant and hepatoprotective effects of Parinari curatellifolia Planch. ex Benth root methanolic extract on rats administered single (0.6 mL/kg) and repeated doses of carbon tetrachloride (0.3 mL/kg) were investigated in male albino rats allotted into six groups of five animals each. Three days pre-treatment with extract (5 mg/kg), resulted...

This study aimed at evaluation of in vivo antioxidant effects of the methanolic extracts of different parts of Tamarindus indica Linn. in rats. To this end, rats were administered (pre-treatment) with plant extracts (5 mg/kg) for 3 days and intoxication with carbon tetrachloride (0.6 mL/kg) for acute liver injury experiment. The chronic liver injur...

The study investigated the anti-diabetic and haematological effects of n-butanol fraction of Alchornea cordifolia in streptozotocin-induced diabetic wistar rats. In this work, thirty six adult strain of albino wistar rats were used, which included six normal, diabetic untreated and twenty four diabetic treated rats. Diabetes mellitus was induced by...

The study investigated the hypolipidemic and hepato-protective effects of n-butanol fraction of Alchornea cordifolia leaf extract in streptozotocin-induced diabetic rats. To achieve this set objective, 16 hours fasted rats were made diabetic by single intraperitoneal injection of 60 mg/kg body weight dose of streptozotocin dissolved in 0.1 ml fresh...

Castor seed is important because of the castor oil content (40 – 57%). The oil enjoys tremendous world demand in the pharmaceutical, paint, cosmetics, textile, leather, lubricant, chemical, plastic, fibre, automobile and engineering industries. Castor oil, aside being a renewable resource, it is biodegradable and eco- friendly. Agricultural product...

Documentation and preservation of indigenous knowledge deserve high priority if future generations are to benefit from it, especially with the current surge of emerging problems in health, agriculture and pharmaceutical industry. To this end, a study was conducted to assess and document plant species used in ethnomedicine by the indigenous Kanuri t...

The present study is aimed at evaluating the toxicological and antioxidant activity of Parinari curatellifolia (P.C) methanolic root extract on oxidative stress induced by carbon tetrachloride (CCl 4) in rats. The degree of treatment in this activity has been measured by using biochemical parameters such as serum aspartate aminotransferase (AST), a...

Polyphenols are ubiquitous in plant foods, and many have been associated with a variety of biological activities, including antimutagenic and anticarcinogenic properties. Some African foodstuffs have been analyzed for antimutagenic polyphenols by High-Performance Liquid Chromatography–Electrospray Ionization–Mass Spectrometry (HPLC-ESI-MS). The res...

Stored castor (Ricinus communis L.) seeds collected from four different parts of Kogi State, Nigeria were screened for associated mycoflora. Using the direct plating method, samples were plated out on Sabouroud Dextrose Agar (SDA) as growth medium and incubated at room temperature (27±1°C) for 7-12 days. The resulting growth was visually and micros...

The aim of this study was to determine the possible underlying mechanism of the hypoglycaemic activity of the ethanolic extract of Nauclea latifolia leaves in rats. The extract, glibenclamide or water was administered orally in a glucose, sucrose and maltose tolerance tests. In addition, the effect of the extract on α-glucosidase enzymes was also s...

Anti-trypanosomal effects of the petroleum ether, chloroform, methanol and aqueous extracts from the dried powdered leaves, stem and root barks of Bombax costatum was evaluated using Trypanosoma brucei brucei. In vitro anti-trypanosomal effect was evaluated by monitoring the rate of motility for 60 minutes at extract concentration of 10mg/ml and 20...

Dietary polyphenols are antioxidants that can scavenge biological free radicals, and chemoprevent diseases with biological oxidation as their main etiological factor. In this paper, we review our laboratory data vis-ὰ-vis available literature on prostate cancer chemopreventive substances in Nigerian foodstuffs. Dacryodes edulis fruit, Moringa oleif...

The methanolic extract of Grewia mollis leaves was evaluated in vivo for its antioxidant and hepatoprotective properties. Oxidative stress was induced in rats by administering carbon tetrachloride (CCl(4)) intraperitoneally at a dose of 0.6 mL/kg, whereas the crude plant extract and standard antioxidant (vitamin E) were administered at a dose of 5...

In vitro and in vivo anti-trypanosomal effects as well as reagent-based chemical screening of the aqueous and methanolic extracts of the roots, leaves and stem bark of Terminalia avicennioides were undertaken. In vitro, cessation or drop in the parasite motility, compared to the control, was taken as a measure of the anti-trypanasomal efficacy of t...

Methanol and ethanol extracts of a new polyherbal formulation, "Ata-Ofa" polyherbal tea (A-Polyherbal) which is composed of Twenty one (21) plant products, including Tamarindus indica, Ginger officinalle, Khaya senegalensis, Nauclea latifolia, Moringa oleifera, Phyllantus amarus, Camellia sinensis, Anacardium occidentale, Mangifera indi-ca, Aframom...

Solvent extracts of the various parts of Boswellia dalzielii (leaves, stem bark and root bark) were screened in vitro and in vivo for antitrypanosomal activity against Trypanosoma brucei brucei. Methanolic extract of the leaves, stem bark and root bark of Boswellia dalzielii at 20 mg/ml caused motility to cease after 35, 20 and 20 minutes, respecti...

Polyphenols have been shown in both in vitro and in vivo experiments to induce responses that are consistent with the protective effects of diets rich in fruits and vegetables against degenerative conditions such as cardiovascular disorders and cancer. Red palm oil, extracted from the fruit mesocarp of Elaeis guineensis is very important in the die...

Polymerase Chain Reaction (PCR) is a rapid procedure for in vitro enzymatic amplification of specific DNA sequences using two oligonucleotide primers that hybridize to opposite strands and flank the region of interest in the target DNA. Repetitive cycles involving template denaturation, primer annealing and the extension of the annealed primers by...

Due to their potent toxicity, mycotoxins have attracted worldwide attention over the years and recently, there has been an increasing disquietness on the part of governments, producers, processors, marketers and consumers over the health and economic significance. The diversity in occurrence, structure and chemistry of mycotoxins make their impact...

Certain constituents of food, including polyphenols, could reduce the risk of diseases like cancer, diabetes, cardiovascular disorders, etc because of their antioxidant properties. This paper reports the polyphenol content and antioxidant potential of methanol extract of the seeds of Irvingia gabonensis Baill (Family: Irvingiaceae), a popular condi...

Syzygium aromaticum (L.) Merr.& Perry (syn. Eugenia caryophyllata, Caryophyllus aromaticus, L); Family: Myrtaceae, commonly called clove, and locally known as 'kenepeli' (Igala) and 'Kanumpari' (Hausa), was investigated for its polyphenol constituents and antioxidant/radical scavenging properties. Polyphenols detected by a combination of mass selec...

The possible hepatotoxic effects of chloroform extract of Artemisia maciverae was evaluated biochemically and histologically using male Swiss albino rats, randomly assigned into four groups of 24 animals each. The groups (control, 50, 100 and 200 mg/kg body weight) were treated for 60 days and then monitored for another 30 days before sacrifice. Al...