Scott Martin Vouri

Scott Martin Vouri
University of Florida | UF · Department of Pharmaceutical Outcomes and Policy

PharmD, PhD

About

80
Publications
11,743
Reads
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572
Citations
Introduction
Scott Martin Vouri currently works at the Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida and University of Florida Health Physicians.
Additional affiliations
June 2018 - present
University of Florida
Position
  • Professor (Assistant)
June 2018 - present
University of Florida Health Physicians
Position
  • Managing Director
August 2011 - June 2018
St. Louis College of Pharmacy
Position
  • Professor (Assistant)
Education
June 2015 - June 2018
Saint Louis University
Field of study
  • Epidemiology
August 2013 - May 2015
August 2003 - May 2009
Butler University
Field of study
  • Pharmacy

Publications

Publications (80)
Article
Aims: To assess the gabapentinoid-oedema-loop diuretic prescribing cascade in adults using large administrative health care databases from the US and Denmark. Methods: This study used a sequence symmetry analysis to assess loop diuretic initiation before and after the initiation of gabapentinoids among patients aged 20 years or older without hea...
Article
Full-text available
Purpose Bariatric surgery has shown reductions in overactive bladder (OAB) symptoms; however, the impacts on OAB treatment is unknown. The goal of our study is to evaluate the impact of bariatric surgery on OAB medication utilization. Methods We used IBM® MarketScan® commercial databases from 2005 to 2018. We included patients aged ≥ 18 years with...
Article
Background: Florida House Bill 21 (HB21) was implemented in July 2018 to limit prescriptions of Schedule II opioids for acute pain patients, but it is unclear whether such restrictions have a collateral influence on the utilization of commonly prescribed adjuvant pain medications. Objective: The objective of this study was to assess whether this...
Article
Background: Drug-related adverse events associated with antihypertensive therapy may result in subsequent prescribing of other potentially harmful medications, known as prescribing cascades. The aim of this study was to assess the magnitude and characteristics of a beta-blocker - edema - loop diuretic prescribing cascade. Methods: A prescription...
Article
BACKGROUND: Patients with substance use disorders (SUD) and chronic hepatitis C virus infection (HCV) have limited access to direct-acting antivirals (DAAs) due to multilevel issues related to providers (eg, concern about reinfection); patients (eg, refusal); payers (eg, prior authorization); and health system structure, although clinical guideline...
Article
Background Clinical guidelines and black boxed warnings caution on the serious risks, including death, associated with concomitant use of prescription opioids and benzodiazepines. Objective This study aimed to characterize the co-utilization of a similar class of medications – non-benzodiazepine sedative ‘Z’-drugs – with opioids at ambulatory care...
Article
Purpose To identify the incidence of continuation of newly initiated loop diuretics upon intensive care unit (ICU) and hospital discharge and identify factors associated with continuation. Methods This was a single-center retrospective study using electronic health records in the setting of adult ICUs at a quaternary care academic medical center....
Article
Objectives To evaluate the prescription sequence symmetry analysis assumption regarding balance between marker drug (i.e., medication used to treat a drug-induced adverse event) initiation rates before and after initiation of an index drug (i.e., medication that is potentially associated with the drug-induced adverse event) in the absence of prescr...
Article
Full-text available
Background: Florida House Bill 21 (HB21) was implemented in July 2018 to limit Schedule II opioids prescriptions for patients with acute pain to a 3-day supply. Little is known about the potential unintended effects that such opioid restriction policies may have on chronic pain patients, who are exempt from the law. Objective: We aimed to evalua...
Article
Background The difference between the costs of the newer and older glucose-lowering drugs (GLMs) has been steadily increasing since 2010. In 2018, newer drugs cost 8-12 times more than older drugs (except for insulin). This study aimed to understand how the cost change influenced the cost-effectiveness of the newer GLMs. Methods Based on our previ...
Article
Background The (prescription) sequence symmetry analysis (PSSA) design has been used to identify potential prescribing cascade signals by assessing the prescribing sequence of an index drug relative to a marker drug presumed to treat an adverse drug event provoked by the index drug. Objectives This review aimed to explore the use of the PSSA desig...
Article
Background: Many states have implemented opioid days' supply restriction policies, leading to reductions in opioid prescribing. Although research within certain provider types exist, no study has evaluated a restriction policy by various provider types. Objective: To evaluate changes in opioid utilization following a days' supply restriction pol...
Article
Full-text available
Importance Previous research has shown an immediate reduction in new opioid users and use after implementation of the opioid supply restriction laws. Assessment of the association between opioid restrictions and alternative treatment options, such as nonsteroidal anti-inflammatory drugs (NSAIDs), is needed to evaluate potential unintended consequen...
Article
BACKGROUND: Florida's House Bill 21 (HB21), implemented into law on July 1, 2018, limited opioid prescriptions for acute pain to a 3-day supply. While the law has been associated with a decrease in opioid prescribing for acute pain, its effect on opioid volume dispensed at the plan level remains unknown. OBJECTIVES: To assess the impact of HB21 on...
Article
Background Dihydropyridine calcium channel blockers (DH CCBs) are commonly used for hypertension in older adults. However, loop diuretics can be inappropriately added to treat DH CCB-induced edema, putting individuals at increased risk for adverse events and potential decreases in quality of life.Methods We conducted a cross-sectional analysis usin...
Article
Aims This study aimed to compare cardiovascular benefits associated with the use of GLP-1RA versus SGLT2i as add-on therapies to metformin among adults with type 2 diabetes (T2D) with and without a history of cardiovascular complications, using real-world data. Methods Using data from the IBM® MarketScan® Commercial Claims Databases, metformin use...
Article
Introduction: Hepatitis C virus testing is recommended for people at high risk for infection, including those with substance use disorders. Little is known about the cascade of hepatitis C virus care (including testing, diagnosis, and treatments) among patients with substance use disorders in real-world clinical practice. This study aims to charac...
Article
Purpose There is an increased use in the (prescription) sequence symmetry analysis (PSSA); however, limited studies have incorporated a negative control, and no study has formally quantified and controlled for within‐patient time‐varying bias using a negative control. Our aim was to develop a process to incorporate the effect of negative controls i...
Article
Background Changes in gut anatomy following bariatric surgery impacts medication absorption, often requiring changes in medication formulations. Objective To assess changes in utilization of extended-release (ER), immediate-release (IR), and liquid formulations 360 days before and after bariatric surgery. Setting Large US administrative claims da...
Article
Background Bariatric surgery leads to an improvement in hyperlipidemia and subsequent decline in the use of hyperlipidemia-related medications, including statins. In patients with a history of atherosclerotic cardiovascular disease (ASCVD), it is recommended to continue statins; however, it is unknown if there is a differential risk for statin disc...
Article
Full-text available
Objective To assess the impact of Florida’s 3-day opioid prescription supply law, effective July 2018, on opioids dispensed for acute pain patients. Methods Pharmacy claims from a health plan serving a large Florida employer from January 2015 through March 2019 were analyzed. We used an interrupted time series study design accounting for autocorre...
Article
Aims To assess the order of glucose-lowering medication (GLM) discontinuation following bariatric surgery among patients taking ≥2 GLMs. Methods Patients with diabetes mellitus taking ≥2 GLM classes who underwent bariatric surgery were identified using health claims data from the United States. The order of discontinuation was assessed in patients...
Article
Full-text available
Background: Speculation on benefits and harms of prescription, over-the-counter and complementary medications has been widespread during the SARS-CoV-2 (or COVID-19) pandemic. This community-based survey assessed self-reported changes in medications including those stopped, started, or if access had been impacted. Methods: A survey was collected vi...
Article
Background: Gabapentinoids (e.g., gabapentin, pregabalin) are frequently used off-label for pain and psychiatric conditions. Gabapentin alone rose from the seventh most prescribed medication in 2017 to the fourth most prescribed medication in the United States by January 2019. Gabapentinoid-associated somnolence (i.e. drowsiness and fatigue) has an...
Article
The management of chronic noncancer pain (CNCP) with chronic opioid therapy (COT) is controversial. There is a lack of consensus on how COT is defined resulting in unclear clinical guidance. This scoping review identifies and evaluates evolving COT definitions throughout the published clinical and scientific literature. Databases searched included...
Article
Objective To evaluate opioid prescribing, dispensing, and use in relation to hydrocodone -containing product (HCP) rescheduling. Methods Seven biomedical databases and grey literature sources were searched with keywords and database-specific controlled vocabulary relevant to HCP rescheduling for items published between January 2014 and July 2019....
Article
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Anticholinergic cognitive burden (ACB) may be associated with detrimental effects on mobility and physical independence in older adults. We evaluated the incidence of major mobility disability (MMD), persistent major mobility disability (PMMD), and injurious falls among participants within the Lifestyle Interventions for Elders (LIFE) trial accordi...
Article
Objective. To assess student pharmacists' ability to impact the administration of complex prescription regimens using the universal medication schedule in a standardized laboratory exercise. Methods. First and third professional year (P1 and P3) student pharmacists at three colleges of pharmacy completed a required activity to simplify and organize...
Article
Full-text available
Objective Compare rates of lactic acidosis (LA) among metformin‐exposed and unexposed patients with type 2 diabetes mellitus and varying degrees of chronic kidney disease (CKD). Research Design and Methods Retrospective, nested case‐control study using data from national VA Corporate Data Warehouse. All adult patients with type 2 diabetes and CKD...
Article
Pharmacists serving older individuals should be encouraged to avoid prescribing cascades by recommending medication discontinuation or dose reduction, whenever possible.
Article
Background Chloroquine or hydroxychloroquine (chloroquine) plus azithromycin is considered as therapy for COVID19. With benefit evaluations underway, safety concerns due to potential additive effects on QTc prolongation should be addressed. Objective We compared risk of cardiac adverse events between combinations of chloroquine and azithromycin an...
Article
Evaluation of a ceiling effect on the association of new resistance development to antipseudomonal beta-lactam exposure in the critically ill - Besu F. Teshome, Scott Martin Vouri, Nicholas B. Hampton, Marin H. Kollef, Scott T. Micek
Article
We conducted a cross‐sectional analysis using a database from commercial health plans in the United States to describe trends in the use of antidiabetic medications among patients with type‐2 diabetes and heart failure (HF) from 2006 through 2017. We used loop diuretic dose as a surrogate for HF severity (mild‐HF 0‐40 mg/day, moderate‐severe HF >40...
Article
Full-text available
Importance Calcium channel blockers, specifically dihydropyridine calcium channel blockers (DH CCBs, eg, amlodipine), may cause lower-extremity edema. Anecdotal reports suggest this may result in a prescribing cascade, where DH CCB–induced edema is treated with loop diuretics. Objective To assess the magnitude and characteristics of the DH CCB pre...
Article
Introduction Overactive bladder (OAB) affects adults of all ages. The risk for medication-related adverse events (AEs) may differ between age groups, given age-related changes in pharmacokinetics and pharmacodynamics. No previous study has differentiated the risk of AEs between older and non-older adults with OAB. Objective Our objective was to as...
Article
Study objective: Minimizing the duration of broad-spectrum antimicrobial exposure in the critically ill is a commonly used strategy aimed at preventing resistance. Our objective was to correlate the duration of exposure to antipseudomonal β-lactam antibiotics with the development of new resistance in critically ill patients. Design: Single-cente...
Article
Importance: Forty percent to 75% of community-dwelling older adults are not able to adhere to their medication routine. A medication management assessment can correctly identify the reasons for nonadherence and the barriers contributing to it. Objective: To further develop the HOME-Rx, an in-home medication management assessment, by modifying sc...
Article
Objective: To assess changes over time in the use of antimuscarinics (AM) among visits in adult men treated with bladder outlet obstruction (BOO) medication therapy (ie, alpha blocker and 5-alpha reductase inhibitors). Methods: We used the National Ambulatory Medicare Care Survey database (2006-2014) to identify men aged 40 or older, who initiat...
Article
Introduction: Although antimuscarinics are typically the first-line pharmacological treatment option for overactive bladder, patients often discontinue therapy. The aim of this research project is to identify the rate of antimuscarinic discontinuation, switching, and continuation and differences in discontinuation among different antimuscarinics....
Article
Objectives: Dihydropyridine calcium channel blockers (DH-CCB) are associated with lower-extremity edema (LEE). Loop diuretics have been used inappropriately to treat DH-CCB-associated LEE, constituting a prescribing cascade (PC). The aim of this work was to identify the prevalence and factors associated with potential DH-CCB-LEE-loop diuretic PC....
Article
Full-text available
We performed a population‐based case–control study of United States Medicare beneficiaries age 60–90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use of immunosuppressants. Inosine monophosphate dehydrogenase inhibitors (relative risk = 0.64; 95%...
Article
Highlights en • There is a de‐escalation of antidiabetes medications prescribed following bariatric surgery. • Antidiabetes medication utilization following bariatric surgery does not appear to be consistent with clinical practice guidelines.
Article
Background: Oral oxybutynin has been associated with the development of cognitive impairment. Objective: The objective of this study was to describe the use of oral oxybutynin versus other antimuscarinics (e.g., tolterodine, darifenacin, solifenacin, trospium, fesoterodine, transdermal oxybutynin) in older adults with documented cognitive impair...
Article
Full-text available
OBJECTIVES/SPECIFIC AIMS: We evaluated the accuracy of diagnosis and procedure codes to identify acute urinary retention (AUR) due to lack of existing validation studies. METHODS/STUDY POPULATION: We performed a cross-sectional validation study at a single medical institution in the emergency department (ED) and outpatient Urology Clinic in men ≥45...
Article
Introduction Perspectives from faculty regarding team-based learning (TBL) are not well understood. Previous studies describe faculty preference for TBL due to increased student interaction despite requiring increased time for design. The perception of changes in faculty workload over multiple semesters has not been measured. This research evaluate...
Article
Full-text available
Objective To explore influences of co-investigators on the successful publication of a pharmacy residency project. Methods We analyzed published and non-published research presented at a regional pharmacy conference. Abstracts were matched 1:1 based on state and abstract year. We assessed university affiliation, number, degree, and H-Index of co-i...
Article
Objectives: The aim of this study was to assess pharmacists’ and student pharmacists’ understanding of drug-induced adverse events (DIAEs) and prescribing cascades (PC) and assess their willingness to use system-level approaches to identify DIAEs and PC for future patient interventions. Methods: Following a continuing education presentation on DIA...
Article
Background: The prevalence and difference in likely indications of urinary catheterization (UC) in treated-and-released emergency department (ED) visits between men and women are currently unknown. Methods: This was a cross-sectional analysis using the 2013 National Emergency Department Sample for all treated-and-released visits in persons aged...
Article
Full-text available
What is known and objective: A prescribing cascade if often treated by discontinuing both medications. We describe an intervention to mitigate a prescribing cascade while continuing a clinically necessary medication without negatively impacting the patient. Case summary: A 77-year-old women experienced probable acetylcholinesterase inhibitor-ind...
Article
Full-text available
Introduction: Antimuscarinics should be used with caution in older adults with overactive bladder (OAB) due to anticholinergic adverse events (AEs). Systematic reviews and meta-analyses (SRMAs) have analyzed safety-related outcomes but have not specified risk in the elderly, the population at highest risk for AEs. The aim of this review is to expl...
Article
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Purpose: The impact of resident research publication on early-career publication success is evaluated. Methods: This study included a retrospective cohort of pharmacy residents' abstracts presented at the Great Lakes Pharmacy Resident Conference (GLPRC). Published residency research projects at GLPRC (n = 76) were matched 1:1 to unpublished proj...
Article
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Practice-related projects and pharmacy practice research are requirements to complete postgraduate pharmacy residency programs. Many residents will complete residencies without fully developing the skills needed to perform research required for new clinical and academic positions. Many studies have quantified successes and identified characteristic...
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To examine changes in mood after nine months of enrollment in a Program of All-Inclusive Care for the Elderly (PACE). Cohort study. Alexian Brothers PACE, St. Louis, Missouri. Newly enrolled patients 55 years of age and older, living in the PACE service area, eligible for nursing facility care and able to live safely in the community, with continuo...
Article
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To review the literature regarding the efficacy and safety of mirabegron for the treatment of overactive bladder (OAB). A literature search was performed using MEDLINE (PubMed) prior to December 31, 2013, using the terms "mirabegron" and "randomized-controlled trial." All published, double-blind, randomized-controlled trials assessing mirabegron we...
Article
Full-text available
The symptoms of overactive bladder (OAB) can be treated with oral medications using a variety of antimuscarinic medications and, more recently, mirabegron, a beta-3 agonist. However, the use of these medications may be limited for patients because of adverse drug reactions, contraindications, and those who are refractory to oral medications. Recent...
Conference Paper
Objective: To determine the publication rate among pharmacy resident research projects in a region of the United States and to compare characteristics of published and unpublished projects. Methods: Research project abstracts from the Great Lakes Pharmacy Residency Conference in 2003, 2005, and 2007 were reviewed. Two independent investigators c...
Article
Team-based learning (TBL) is increasingly used for presenting educational information to students in colleges of pharmacy. Several studies have shown a positive impact on students both in terms of academic performance and comprehension. Current literature does not provide the full perspective of faculty, who are incorporating this methodology into...
Article
Objective: To determine whether use of the Medication Reconciliation Review of Systems Subject (MR ROSS) tool is an effective method to identify errors of omission at an initial visit in an outpatient geriatric clinic. Design: Retrospective chart review. Setting: Alexian Brothers Community Services (ABCS) Program of All-inclusive Care for the...
Article
Full-text available
Bisphosphonates are efficacious for a variety of antiosteoporotic endpoints, most notably for vertebral, nonvertebral, and hip outcomes, including fractures. Currently the prevalence of osteoporosis in patients undergoing dialysis ranges from 13% to 80%. There are very limited data on the use of bisphosphonates within this population. This review d...
Article
Creating opportunities for students of multiple health professions to achieve the interprofessional competencies is critical to prepare them to enter the health care system and provide effective team-based care. Challenges can be experienced by any health profession school when establishing these opportunities; independent, private schools with lim...
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The prevalence of human immunodeficiency virus (HIV) infection in older and elderly adults is significant worldwide. This population poses new challenges and opportunities in the management of HIV. In addition to the risks affecting HIV patients of all ages, including risk of opportunistic infection and medication resistance, age-related changes in...
Article
Tadalafil is a phosphodisesterase (PDE)-5 inhibitor recently approved by the United States Food and Drug Administration for lower urinary tracts symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). The mechanism for improved LUTS is thought to be related to three principal theories: alterations in nitric oxide levels, Rho-associated...
Article
Full-text available
A program of all-inclusive care for the elderly (PACE) is a medical care model currently used in 75 clinical settings across the country. The goal of the model is to allow a participant to live independently in the community as an alternative to living in a long-term care facility. To be eligible for enrollment, participants must meet the following...
Article
Full-text available
HIV infections are a growing concern in the elderly as a result of improvements in therapeutics and monitoring, which have extended the life span for this HIV-infected population. Elderly patients potentially are more complicated to treat than younger HIV-infected individuals because of comorbidities and the physiological effects of aging on pharma...
Article
Limited data exist on the use of bisphosphonates in patients with poor kidney function due to a contraindication derived from inadequate experience among patients with kidney failure, accounting for as much as 25% of nonprescribing when otherwise appropriate. To determine whether bisphosphonate use in patients with decreased renal function, as outl...