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Scott Jay Hunter

Scott Jay Hunter
WCG · Clinical Research Solutions

Ph.D., Clinical and Developmental Psychology
Research endpoints and measurement of cognitive and behavioral change in neurodevelopmental/rare disease clinical trials

About

140
Publications
29,575
Reads
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2,369
Citations
Introduction
Current: Senior Scientific Expert, Neurodevelopmental and Rare Pediatric Diseases, WCG Clinical Research Solutions, Princeton NJ USA; Previously (until 11-2021): Professor of Psychiatry, Behavioral Neuroscience, and Pediatrics, Pritzker School of Medicine, University of Chicago; Director of Neuropsychology, University of Chicago Medicine and Biological Sciences; Vice-Chair, UCM & Biological Sciences IRB, University of Chicago
Additional affiliations
October 2011 - October 2021
The University of Chicago Medical Center
Position
  • Director of Neuropsychology
January 2016 - October 2021
University of Chicago
Position
  • Professor (Full), Psychiatry & Behavioral Neuroscience, and Pediatrics
October 1999 - December 2015
University of Chicago
Position
  • Associate Professor of Psychiatry, Behavioral Neuroscience, & Pediatrics
Education
September 1988 - October 1996
University of Illinois Chicago
Field of study
  • Clinical & Developmental Psychology; Behavioral Neuroscience

Publications

Publications (140)
Article
Full-text available
Electronic patient portals represent a promising means of integrating mental health assessments into HIV care where anxiety and depression are highly prevalent. Patient attitudes toward portal-based mental health screening within HIV clinics have not been well described. The aim of this formative qualitative study is to characterize the patient-per...
Preprint
BACKGROUND Depression and anxiety are common among people living with HIV (PLWH) and contribute to adverse health outcomes. Conducting population-level depression and anxiety screening via the patient portal is a promising intervention and has not been studied in HIV care settings. OBJECTIVE To explore facilitators and barriers to implementing pop...
Article
Full-text available
Background Depression and anxiety are common among people with HIV and are associated with inadequate viral suppression, disease progression, and increased mortality. However, depression and anxiety are underdiagnosed and undertreated in people with HIV owing to inadequate visit time and personnel availability. Conducting population-level depressio...
Article
Background: Children born extremely preterm (EP) are at increased risk of cognitive deficits that persist into adulthood. Few large cohort studies have examined differential impairment of cognitive function in EP-born adolescents in relation to early life risk factors, including maternal social disadvantage, gestational age at delivery, and neonat...
Article
Background Extremely preterm (EP) birth is associated with higher risks of perinatal white matter (WM) injury, potentially causing abnormal neurologic and neurocognitive outcomes. MRI biomarkers distinguishing individuals with and without neurologic disorder guide research on EP birth antecedents, clinical correlates, and prognoses. Purpose To comp...
Preprint
Autism spectrum disorder (ASD) is a polygenic neurodevelopmental disorder; yet, there is significant disparity in ASD prevalence among males versus females. Research aims to disentangle the phenotypic/genotypic differences between males and females with ASD. This article provides a comprehensive review of the literature exploring sex differences in...
Article
Full-text available
This commentary is on the original article by Morris et al. on pages 954–962 of this issue.
Article
Numerous studies in the past 10 years have reported on the neurocognitive sequalae of pediatric Sleep Disordered Breathing (SDB). Variations in criteria used to define SDB in conjunction with the wide variety of neuropsychological measures selected to evaluate cognitive consequences of SDB have resulted in discrepancies within the literature. This...
Preprint
Full-text available
Numerous studies in the past 10 years have reported on the neurocognitive sequalae of pediatric Sleep Disordered Breathing (SDB). Variations in criteria used to define SDB in conjunction with the wide variety of neuropsychological measures selected to evaluate cognitive consequences of SDB have resulted in discrepancies within the literature. This...
Article
Full-text available
Objective To describe the spatio-temporal dynamics and interactions during linguistic and memory tasks. Methods Event-related electrocorticographic (ECoG) spectral patterns obtained during cognitive tasks from 26 epilepsy patients (aged: 9-60 y) were analyzed in order to examine the spatio-temporal patterns of activation of cortical language areas...
Article
Objectives: To estimate birth prevalence of congenital cytomegalovirus (cCMV) in HIV-exposed uninfected children born in the current era of combination antiretroviral therapy and describe cCMV-related neurodevelopmental and hearing outcomes. Study design: The Surveillance Monitoring for ART Toxicities cohort study follows HIV-exposed uninfected...
Article
Objectives: To examine elevated neonatal inflammatory and neurotrophic proteins from children born extremely preterm in relation to later childhood brain Magnetic Resonance Imaging volumes and cognition. Study design: We measured circulating inflammation-related proteins and neurotrophic proteins on postnatal days 1, 7, and 14 in 166 children at...
Article
Full-text available
The initial version of the Multicultural Guidelines, titled Guidelines on Multicultural Education, Training, Research, Practice, and Organizational Change for Psychologists, was published in 2002. Since then, there has been significant growth in research and theory regarding multicultural contexts. The revised Multicultural Guidelines are conceptua...
Article
Youth perinatally HIV infected (PHIV) or HIV exposed, but uninfected (PHEU), are aging into adolescence and adulthood with multiple complex risk factors for mental health (MH) problems and poor MH treatment utilization. Our aims were to estimate prevalence of MH diagnoses, clinically significant symptoms, and MH treatment utilization among youth wi...
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Article
Full-text available
Objectives: To test the hypothesis that higher blood levels of neurotrophic proteins (proteins that support neuronal survival and function) in the first 2 weeks of life are associated with a lower risk of cognitive impairment at 10 years. Study design: We evaluated 812 10-year-old children with neonatal blood specimens enrolled in the multicente...
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Article
Cambridge Core - Neuropsychology - Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Article
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Article
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Chapter
Neuropsychological Conditions Across the Lifespan - edited by Jacobus Donders August 2018
Article
The association of hand preference (left, mixed, and right) with cognitive, academic, motor, and behavioral function was evaluated in 864 extremely preterm children at 10 years of age. Left-handed and right-handed children performed similarly but mixed-handed children had greater odds of functional deficits across domains than right-handed children...
Article
Full-text available
Introduction: Almost 2 million U.S. youth are estimated to live on the streets, in shelters, or in other types of temporary housing at some point each year. Both their age and living situations make them more likely to engage in high-risk behaviors, particularly during adolescence, a time of increased risk taking. Much of self-control appears relat...
Article
Background Attention deficit hyperactivity disorder (ADHD) incidence is higher among children born very preterm than among children who are mature at birth. Methods We studied 583 ten-year old children born before 28 weeks of gestation whose IQ was above 84 and had a parent-completed Child Symptom Inventory-4 (CSI-4), which allowed classifying the...
Article
Full-text available
Although multiple sources link inflammation with attention difficulties, the only human study that evaluated the relationship between systemic inflammation and attention problems assessed attention at age 2 years. Parent and/or teacher completion of the Childhood Symptom Inventory-4 (CSI-4) provided information about characteristics that screen for...
Article
Full-text available
It has been almost one year now since I agreed to become the Editor-in-Chief for this important open access journal, for which I have served as a member of the editorial board since its early inception.[...].
Article
Background: Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm. Aim: To estimate the risk of attention problems at age 10years in children born very preterm to overweight (i.e., body mass index (BM...
Article
Full-text available
Background Numerous studies over the past several decades have illustrated that children who suffer from sleep-disordered breathing (SDB) are at greater risk for cognitive, behavioral, and psychiatric problems. Although behavioral problems have been proposed as a potential mediator between SDB and cognitive functioning, these relationships have not...
Article
Objective: Compared with children born near term, those born extremely preterm (EP) are at much higher risk for attention-deficit hyperactivity disorder (ADHD). Little information is available about differences in neuropsychological outcomes among EP children with and without ADHD. Our analyses aimed to evaluate the neuropsychological correlates o...
Article
Aim: A DSM-5 diagnosis of Attention-Deficit/Hyperactive Disorder (ADHD) requires that symptoms be present in two settings. We wanted to see how teachers and parents compare on their assessments. Methods: We evaluated how well Child Symptom Inventory-4 (CSI-4) reports from 871 parents and 634 teachers of 10-year old children born before the 28(th...
Article
Difficulties with executive functioning may underlie both overweight and loss of control (LOC) eating behavior across the age spectrum, but there is a relative paucity of research in children with both conditions. This study aimed to characterize general executive functioning among children with overweight and LOC eating as compared to their overwe...
Article
Objective: To assess the association between maternal prepregnancy body mass index and adequacy of pregnancy weight gain in relation to neurocognitive function in school-aged children born extremely preterm. Study design: Study participants were 535 ten-year-old children enrolled previously in the prospective multicenter Extremely Low Gestationa...
Article
Objective Primary snoring (PS) and obstructive sleep apnea (OSA) not only affect the quality of sleep in a large number of young children, but have also been repeatedly associated with a variety of behavioral and cognitive problems. However, little is known about the potentially differing relationships of behavioral and cognitive pathology within t...
Article
Reviews the book, Development of Perception in Infancy: The Cradle of Knowledge Revisited by Martha E. Arterberry and Philip J. Kellman (see record 2016-21176-000 ). The book provides an updated examination of what is known presently about the perceptual capabilities during early life, coalescing findings from over fifty years of significant effort...
Article
Full-text available
Objective: To assess the efficacy of lovastatin on visuospatial learning and attention for treating cognitive and behavioral deficits in children with neurofibromatosis type 1 (NF1). Methods: A multicenter, international, randomized, double-blind, placebo-controlled trial was conducted between July 2009 and May 2014 as part of the NF Clinical Tr...
Article
Sleep disordered breathing (SDB) in children has been associated with inattention, impulsivity and hyperactivity, but the associations between SDB severity and the type and severity of behavioural disruption are unclear. 1022 children aged 5–7 years old prospectively underwent sleep studies and behavioural assessments through completion of standard...
Article
In the past three decades, several new antiepileptic drugs (AEDs) have been marketed across the world, although with a surprisingly modest improvement in overall seizure control. During the same period, the use of AEDs as mood stabilizing or impulse control agents has been trending upwards, due to a notable increase in comorbid mood and behavior di...
Article
Aims: KCNJ11-related diabetes is the most common form of permanent neonatal diabetes and has been associated with a spectrum of neurodevelopmental problems. We compared neurodevelopmental outcomes in patients with KCNJ11 mutations and their sibling controls. Methods: Through our Monogenic Diabetes Registry (http :// monogenicdiabetes.uchicago. e...
Article
Full-text available
Background and objectives: Sleep-disordered breathing (SDB) in children is associated with cognitive challenges. However, potential associations between SDB severity and neurocognitive functioning, and the presence of a SDB cut-off have not been fully explored. Methods: 1,010 5-to-7 year-old snoring and non-snoring children were prospectively re...
Article
Full-text available
Introduction: Adolescents are a unique and sometimes neglected group in the planning of healthcare services. This is the case in many parts of sub-Saharan Africa, where more than eight out of ten of the world's HIV-infected adolescents live. Although the last decade has seen a reduction in AIDS-related mortality worldwide, largely due to improved...
Article
Pediatric epilepsy is frequently associated with psychiatric comorbidities such as mood, anxiety, psychosis, attentiondeficit/ hyperactivity disorder and disruptive behavior disorder. The incidence of suicide is also higher in this population. Psychiatric conditions were traditionally considered to be a consequence of the seizure disorder; however,...
Article
Background: Perinatal HIV (PHIV) infection may place youth at risk for impairments in executive functioning (EF). We examined associations of EF with HIV infection, disease severity and other factors among youth with PHIV and perinatally HIV-exposed, uninfected youth (PHEU). Methods: Within the US-based Pediatric HIV/AIDS Cohort Study, 354 PHIV...
Article
Full-text available
The current study aimed to establish a fine-grained, efficient characterization of the concurrent neuropsychological contributions to social functioning in neuropsychologically-referred youth. A secondary aim was to demonstrate a useful statistic approach for such investigations (Partial Least Squares Regression; PLSR), which is underutilized in th...
Article
Reviews the book, Adolescents and Adults With Autism Spectrum Disorder edited by Fred R. Volkmar, Brian Reichow, and James C. McPartland (see record 2014-16349-000 ). The challenge to better provide a means for guidance and support for the community of older individuals with autism spectrum disorder (ASD) was first taken up in a significant manner...
Article
Background: Long-term effects of in utero and neonatal antiretroviral (ARV) exposure on cognitive and academic development in HIV-exposed, uninfected school-age children are unknown. Methods: HIV-exposed, uninfected children, ages 5-13 years, in Pediatric HIV/AIDS Cohort Study Surveillance Monitoring for Antiretroviral Treatment Toxicities, a US...
Article
Full-text available
Objective: This cross-sectional study investigated the relationships between psychiatric and substance-related disorders, high-risk behaviors, and the onset, duration, and frequency of homelessness among homeless youth in Chicago. Methods: Sixty-six homeless youth were recruited from two shelters in Chicago. Demographic characteristics, psycho-p...
Article
The aims of this study were to examine the prevalence and comorbidities of personality disorders among incarcerated juveniles and to investigate the validity of these results. A sample of 790 incarcerated youth (650 boys and 140 girls; mean age = 16.8 years) completed an assessment of Axis II diagnoses (Structured Interview for DSM-IV Personality)....
Article
Children with neurofibromatosis-1 (NF1), a neurodevelopmental disorder resulting from a mutation of the NF1 gene (17q11.2), often have difficulties with learning and attention, but there is little research in the early childhood years. In this study, the cognitive and psychosocial functioning of 40 young children with NF1 (ages 3 through 6) was exa...
Chapter
Executive dysfunction occurs in many clinical conditions and has significant impact on multiple facets of life. This book summarizes executive function and dysfunction for practitioners, researchers and educators, covering lifespan development, assessment, impact and interventions. Drawing together clinical, neurobiological and developmental viewpo...
Chapter
Executive dysfunction occurs in many clinical conditions and has significant impact on multiple facets of life. This book summarizes executive function and dysfunction for practitioners, researchers and educators, covering lifespan development, assessment, impact and interventions. Drawing together clinical, neurobiological and developmental viewpo...
Book
Executive dysfunction occurs in many clinical conditions and has significant impact on multiple facets of life. This book summarizes executive function and dysfunction for practitioners, researchers and educators, covering lifespan development, assessment, impact and interventions. Drawing together clinical, neurobiological and developmental viewpo...
Chapter
Executive dysfunction occurs in many clinical conditions and has significant impact on multiple facets of life. This book summarizes executive function and dysfunction for practitioners, researchers and educators, covering lifespan development, assessment, impact and interventions. Drawing together clinical, neurobiological and developmental viewpo...
Chapter
Executive dysfunction occurs in many clinical conditions and has significant impact on multiple facets of life. This book summarizes executive function and dysfunction for practitioners, researchers and educators, covering lifespan development, assessment, impact and interventions. Drawing together clinical, neurobiological and developmental viewpo...
Chapter
Executive dysfunction occurs in many clinical conditions and has significant impact on multiple facets of life. This book summarizes executive function and dysfunction for practitioners, researchers and educators, covering lifespan development, assessment, impact and interventions. Drawing together clinical, neurobiological and developmental viewpo...