Scott H. Harrison

Scott H. Harrison
North Carolina Agricultural and Technical State University | NC A&T · Department of Biology

PhD

About

58
Publications
6,046
Reads
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1,044
Citations
Citations since 2017
25 Research Items
555 Citations
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2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
Introduction
There is a need to integrate targeted model-based studies of organisms and pathways with more comprehensive treatments of life's diversity. I have conducted analyses on a diverse variety of organisms. My laboratory team aspires to develop and implement biotechnological and bioinformatics workflows to allow for integrative modeling approaches that draw from multiple lines of evidence.
Additional affiliations
July 2018 - present
North Carolina Agricultural and Technical State University
Position
  • Professor (Associate)
January 2012 - June 2018
North Carolina Agricultural and Technical State University
Position
  • Professor (Assistant)

Publications

Publications (58)
Article
Full-text available
The chicken gastrointestinal tract has a diverse microbial community. There is increasing evidence for how this gut microbiome affects specific molecular pathways and the overall physiology, nervous system and behavior of the chicken host organism due to a growing number of studies investigating conditions such as host diet, antibiotics, probiotics...
Article
Full-text available
Background: Toxoplasma gondii (T. gondii) is a ubiquitous obligatory intracellular parasite which infects over 40 million Americans and causes toxoplasmosis. Inside the human body, T. gondii can damage tissues and invade vital organs. Methods: This study evaluated the association of T. gondii infection and liver disease using data from the Natio...
Article
Full-text available
The rise in antimicrobial resistant bacteria have prompted the need for antibiotic alternatives. To address this problem, significant attention has been given to the antimicrobial use and novel applications of copper. As novel applications of antimicrobial copper increase, it is important to investigate how bacteria may adapt to copper over time. H...
Article
Full-text available
This multi-institutional collaborative study of neoplasia in snakes reviewed medical records of snakes at each facility to determine species prevalence, survival, and methods of treatment. Complete species numbers of snakes were also collected at each facility. In total, 65 species, 133 snakes, and 149 unique neoplasias were included in this study....
Article
Full-text available
Background: There has been an increased usage of metallic antimicrobial materials to control pathogenic and multidrug resistant bacteria. Yet, there is a corresponding need to know if this usage leads to genetic adaptations that could produce more harmful strains. Methodology: Experimental evolution was used to adapt Escherichia coli K-12 MG1655 t...
Poster
LC-MS/MS-based proteomics analysis reveals correlations between kidney injury and mediators �of vascular pathology, inflammation, and oxidative stress in diabetic African American men
Chapter
There has been an increased usage of metallic antimicrobial materials to control pathogenic and multi-drug resistant bacteria, yet there is a corresponding need to know if this usage may lead to genetic adaptations that produce even more dangerous bacterial strains. In this paper we examine important recent results from the literature as well as re...
Article
The methane production and the microbial community dynamics of thermophilic anaerobic co-digestion (AD) of corn stover, swine manure and effluent were conducted at total solid (TS) content of 5%, 10% and 15%, the carbon to nitrogen ratio (C/N) of 20, 30 and 40 and the effluent volumetric percentage (EVP) of 20%, 40% and 60%. For batches with 5% TS,...
Article
Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3‐butadiene (BD). BD is a human carcinogen that exhibits multiorgan systems toxicity. Our previous studies demonstrated that the X‐C motif chemokine ligand 1 (XCL1) gene expression was upregulated 3.3‐fold in a p53‐dependent manner in TK6 lymphoblasts undergoin...
Poster
Neutrophils are cells of the innate immune system that have the ability to respond to stimuli. Galectin-8, a part of the family of galectins, has been shown to modulate the innate and adaptive immune system. The objective of this study was to analyze the effect of exogenous galectin-8 on global transcription in bovine neutrophils. Whole blood was c...
Article
Full-text available
As CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 technology becomes more mainstream in life science research, it becomes critical for undergraduate instructors to devise engaging ways to bring the technology into their classrooms. To help meet this challenge, the National Science Foundation sponsored a workshop for undergr...
Article
Full-text available
African Americans are disproportionately burdened by diabetic kidney disease (DKD). However, little is known about the cellular and molecular mechanisms underlying the onset and progression of DKD in this population. The goal of the current study was to determine the association between specific inflammation markers and kidney injury in diabetic Af...
Article
Full-text available
Diabetes is the leading cause of chronic kidney disease. African Americans are disproportionately burdened by diabetic kidney disease (DKD) and end stage renal disease (ESRD). Disparities in DKD have genetic and socioeconomic components, yet its prevalence in African Americans is not adequately studied. The current study used multiple biomarkers of...
Article
Full-text available
Background: Tuberculosis (TB) is a serious health concern, particularly in developing countries. Various delays, such as patient delay (PD) and healthcare system delay (HSD) in the TB process, are exacerbating the disease burden and increasing the rates of transmission and mortality in various global communities. Therefore, the aim of this study i...
Article
Full-text available
Background The modeling of genetic interactions within a cell is crucial for a basic understanding of physiology and for applied areas such as drug design. Interactions in gene regulatory networks (GRNs) include effects of transcription factors, repressors, small metabolites, and microRNA species. In addition, the effects of regulatory interactions...
Article
Triple-negative breast cancers (TNBC) accounts for up to 20% of breast cancer cases. These tumors are negative for estrogen, progesterone, and HER2 receptors, which are markers used for diagnosis and treatment of other types of breast cancer. Clinically, TNBCs are notoriously aggressive, respond poorly to targeted therapies, have high rates of rela...
Article
Causes of morbidity and mortality for various species of tenrecs have not been widely published, aside from several reports of neoplasia, and these data are crucial for advancing objectives for preventive medicine, diagnosis, and treatment. A survey on husbandry, morbidity, and mortality of lesser hedgehog tenrecs (Echinops telfairi) in Association...
Conference Paper
Iron is an essential metabolic cofactor for various biological functions, including hemoglobin synthesis, oxygen delivery, and energy production. Imbalances and disruptions to the systemic availability of iron and its role in cellular metabolism have been reported in association with various diseases. Laboratory and clinical studies of diabetic hum...
Conference Paper
Tuberculosis (TB) is a global emergency that continues to be a serious health problem, particularly in developing countries. Various delays, such as patient delay (PD) and healthcare system delay (HSD) in the TB process, may exacerbate the disease, increase the transmission rate, and increase the mortality rate in the community. This study aims to...
Article
Full-text available
Escherichia coli can rapidly evolve resistance to silver nanoparticles (AgNP). Here we utilize experimental evolution to demonstrate that selection for Ag+ resistance confers resistance to AgNPs. By generation 200, the minimum inhibitory concentration of Ag-selected increased by ~9.5-fold compared to control replicates. Ag-selected replicates also...
Article
Full-text available
Adequate brain iron levels are essential for enzyme activities, myelination, and neurotransmitter synthesis in the brain. Although systemic iron deficiency has been found in genetically or dietary-induced obese subjects, the effects of obesity-associated iron dysregulation in brain regions have not been examined. The objective of this study was to...
Article
Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Triple-negative breast cancer (TNBC) accounts for 15-20% of the breast cancer cases. These tumors are heterogeneous and aggressive, fail to respond to targeted therapy, have poor prognosis, and a high risk of relapse. The molecular basis of this breast cancer subtype...
Article
Full-text available
Gene regulatory networks represent an abstract mapping of gene regulations in living cells. They aim to capture dependencies among molecular entities such as transcription factors, proteins and metabolites. In most applications, the regulatory network structure is unknown, and has to be reverse engineered from experimental data consisting of expres...
Article
Full-text available
A majority of antibiotic-resistant bacterial infections in the United States are associated with biofilms. Nanoscale biophysical measures are increasingly revealing that adhesive and viscoelastic properties of bacteria play essential roles across multiple stages of biofilm development. Atomic Force Microscopy (AFM) applied to strains with variation...
Research
Full-text available
Acinetobacter baylyi ADP1 is an ideal bacterial strain for synthetic biology and metabolic engineering due to its high natural transformability and capability for processing diverse chemical compounds. For the production of compounds within industrial bioreactors, it is optimal to have a uniform dispersal of bacterial cells within solution, but mut...
Research
Full-text available
The emerging field of live cell nanoscopy and force spectroscopy could revolutionize the way biologists explore the living cell at a molecular resolution. Atomic Force Microscope (AFM) and force spectroscopy analysis have been used to directly measure reversible physiochemical and specific binding interactions between cells. Stickiness is important...
Research
Acinetobacter baylyi ADP1 is an ideal bacterial strain for synthetic biology and metabolic engineering due to its high natural transformability and capability for processing diverse chemical compounds. For the production of compounds within industrial bioreactors, it is optimal to have a uniform dispersal of bacterial cells within solution, but mut...
Article
Full-text available
The recent exponential increase in the use of engineered nanoparticles (eNPs) means both greater intentional and unintentional exposure of eNPs to microbes. Intentional use includes the use of eNPs as biocides. Unintentional exposure results from the fact that eNPs are included in a variety of commercial products (paints, sunscreens, cosmetics). Ma...
Article
Full-text available
Acinetobacter baylyi ADP1 is an ideal bacterial strain for synthetic biology and metabolic engineering due to its high natural transformability and capability for processing diverse chemical compounds. For the production of compounds within industrial bioreactors, it is optimal to have a uniform dispersal of bacterial cells within solution, but mut...
Article
Cancer health disparities exist among different ethnicities and races. Various factors such as lifestyle, environmental exposure, genetics, and epigenetics are thought to play a role in the existence of these disparities. Viruses, which outnumber cells in the human body by 100-fold, have a major impact on human health. Viruses have been estimated t...
Conference Paper
The rapid pace of data production in scientific research has required new methods for analytical processing and interpretation. In the area of biology, large volumes of data have been challenging to navigate as they are generated from rapidly developing technologies and systems-level investigations. The discipline of bioinformatics has arisen to ma...
Article
Full-text available
Although pooled-population sequencing has become a widely used approach for estimating allele frequencies, most work has proceeded in the absence of a proper statistical framework. We introduce a self-sufficient, closed-form, maximum-likelihood estimator for allele frequencies that accounts for errors associated with sequencing, and a likelihood-ra...
Article
The current feline vaccine with a single strain of calicivirus has been used for captive tigers, yet it may not protect against virulent systemic calicivirus infections. A cross-institutional study investigated the humoral response to a new dual-strain, killed-virus calicivirus vaccine for nine captive tigers. The subspecies of these tigers were Am...
Article
Full-text available
Circuit simulation is a powerful methodology to generate differential mathematical models. Due to its highly accurate modeling capability, circuit simulation can be used to investigate interactions between the parts and processes of a cellular system. Circuit simulation has become a core technology for the field of electrical engineering, but its a...
Article
Full-text available
Using visual models is common in science and should become more common in classrooms. Our research group has developed and completed studies on the use of a visual modeling tool, the Concept Connector. This modeling tool consists of an online concept mapping Java applet that has automatic scoring functions we refer to as Robograder. The Concept Con...
Article
Cells without intact mitochondrial DNA have been shown to lack the bystander effect, which is an energy-dependent process. We hypothesized that cells harboring mutations in mitochondrial genes responsible for ATP synthesis would show a decreased bystander effect compared to normal cells. Radiation-induced bystander effects were analyzed in two norm...
Article
Full-text available
For over a decade, genome 43 sequences have adhered to only two standards that are relied on for purposes of sequence analysis by interested third parties (1, 2). However, ongoing developments in revolutionary sequencing technologies have resulted in a redefinition of traditional whole genome sequencing that requires a careful reevaluation of such...
Article
Full-text available
SIGS1 was convened on March 13-14, 2009 at Michigan State University, East Lansing, Michigan, USA to review progress toward publication of the first issue of the Standards in Genomic Sciences (SIGS) eJournal. In attendance were members of the advisory and founding editorial board members. SIGS was conceived to fill a growing need: to provide a geno...
Article
Full-text available
The interest in indentifying novel biomarkers for early stage breast cancer (BRCA) detection has become grown significantly in recent years. From a view of network biology, one of the emerging themes today is to re-characterize a protein's biological functions in its molecular network. Although many methods have been presented, including network-ba...
Poster
The Standards in Genomic Sciences eJournal (SIGS; http://standardsingenomics.org) is a newly established standards-supportive publication being developed to report on the exponentially increasing volume of genomic and metagenomic data.
Article
Full-text available
A central focus of clinical proteomics is to search for biomarkers in plasma for diagnostic and therapeutic use. We studied a set of plasma proteins accessed from the Healthy Human Individual's Integrated Plasma Proteome (HIP(2)) database, a larger set of curated human proteins, and a subset of inflammatory proteins, for overlap with sets of known...
Article
Full-text available
New systems biology studies require researchers to understand how interplay among myriads of biomolecular entities is orchestrated in order to achieve high-level cellular and physiological functions. Many software tools have been developed in the past decade to help researchers visually navigate large networks of biomolecular interactions with buil...
Article
Full-text available
With the introduction of increasingly powerful mass spectrometry (MS) techniques for clinical research, several recent large-scale MS proteomics studies have sought to characterize the entire human plasma proteome with a general objective for identifying thousands of proteins leaked from tissues in the circulating blood. Understanding the basic con...
Article
Full-text available
Wildlife Safari, a zoo located in Winston, Oregon, has fed donated carcass meat as a diet to carnivores for over 30 yr. Carcass meat is an alternative to commercially prepared meat. Donated meat arrives at Wildlife Safari as an entire animal. Cattle (Bos taurus), horse (Equus caballus), deer (Odocoileus hemionus), and elk (Cervus elaphus roosevelti...
Article
Full-text available
We review the resources available to systematic biologists who wish to use computers to build classifications. Algorithm development is in an early stage, and only a few examples of integrated applications for systematic biology are available. The availability of data is crucial if systematic biology is to enter the computer age.
Article
Criterion concept maps developed by instructors in the C-TOOLS project contain numerous expert-generated or "correct" propositions manually created by expert users connecting two object or subject phrases together with a linking phrase. WordNet, an electronic lexical database, was then used to construct additional proposition derivatives by supplyi...
Article
A mathematical model of cluster patterns for mapped genes with known phenotypes in Escherichia coli predicted thatfunctional genes may account for a maximum of two-thirds of the total chromosomal space. The corollary prediction was that one-third of the chromosome comprised noncoding space. Open reading frame (ORF) analyses for 15 phylogenetically...
Article
A Fourier Transform of Equal Symbols (FTES) was applied as a spectral density analysis method to identify DNA bases that repeat at any frequency in selected protein-coding genes. The analysis especially focused on identification of bases responsible for the dominant signal at frequency f=1/3 found in all protein-coding genes. The study included hom...
Article
Full-text available
The C-TOOLS research group has developed and released a new assessment tool, the Concept Connector, consisting of a web-based, concept mapping Java applet with automatic scoring. The Concept Connector was designed to enable students in large introductory science classes at the university level to visualize their thinking online and receive immediat...
Article
Full-text available
The C-TOOLS project is developing and validating a new assessment tool, the Concept Connector, consisting of a web-based, concept mapping Java applet with automatic scoring. The Concept Connector tool is being designed to enable students in large introductory science classes at the university level to visualize their thinking online and receive imm...

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Projects

Projects (2)
Project
There are strong correlation between bacterial cell adhesion and antimicrobial resistance. We are trying to address this important biofilm phenomenon using advanced Nanotechnology techniques
Project
Study impacts of evolution on antimicrobial resistace