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Sayed Abdelwahab

Sayed Abdelwahab
Minia University Faculty of Medicine · Microbiology and Immunology

PhD
My research interests include cellular immunity to viruses including HCV, HIV and HEV and published 95 papers

About

106
Publications
13,533
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Introduction
Dr Abdelwahab is currently a professor at Minia Faculty of Medicine, Minia University (Egypt). He obtained a Pharmacy degree from Assiut University in 1989 and completed his PhD in Immunology at the University of Maryland School of Medicine in 2002. Dr Abdelwahab research interests include cellular immunity to viruses including HCV, HIV and HEV and he has published 56 papers in international journals and 13 papers in local Egyptian journals. He supervised 26 Master's and PhD Students and refereed 13 different theses and dissertations. Dr Abdelwahab received 19 different awards including the State Incentive Award in Medical Sciences for 2007. He is a member in several professional organizations.
Additional affiliations
September 2014 - present
Taif University
Position
  • Professor
October 2002 - January 2004
University of Maryland, Baltimore
Position
  • Research Associate
August 2002 - January 2004
Institute of Human Virology
Institute of Human Virology
Position
  • Research Associate

Publications

Publications (106)
Article
Full-text available
The gold-standard approach for diagnosing and confirming Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) infection is reverse transcription-polymerase chain reaction (RT-PCR). This method, however, is inefficient in detecting previous or dormant viral infections. The presence of antigen-specific antibodies is the fingerprint and cardi...
Article
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Background and aims: Reports examine quinolone resistance mechanisms among Pseudomonas spp. are sporadic in the Kingdom of Saudi Arabia (KSA). We previously examined the genetic bases of plasmid-mediated quinolone resistance among Pseudomonas spp. clinical isolates. This study investigated chromosomally mediated quinolone resistance mechanisms via...
Article
Abstract Acute myeloid leukemia (AML) is a malignancy of the bone marrow characterized by hematopoietic insufficiency. Natural plant traditional medicines are one of the imperative sources to spot novel agents to cope with such a disease. Phytochemical investigation of Ficus benghalensis L. leaves revealed three known compounds, carpachromene (1),...
Article
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The aim of this study was to assess the efficiency of Spirulina platensis for removing Zn2+ ions from the aqueous solutions. The optimized conditions of 4.48 g/L algal dose, pH of 6.62 and initial zinc concentration of 29.72 mg/L obtained by response surface methodology were employed for Zn2+ biosorption by S. platensis and up to 97.90% Zn2+ was re...
Article
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Cancer is a very challenging issue in terms of people’s health and lives around the world. Cancer refers to a collection of illnesses distinguished by the formation of tumour cells, malignant cells, or cancer cells that have the potential to become cancerous. Millions of people across the globe are suffering from this illness. Several studies on ca...
Article
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Background The latest novel corona virus disease (COVID-19) pandemic shows a significant health concern. We aimed to study the prevalence of gastrointestinal symptoms among COVID-19 Egyptian patients. Methods A cross-sectional study was carried out on 860 patients with COVID-19 infection classified according to Ministry of Health Program (MOHP) in...
Article
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Cardiovascular disease is difficult to detect due to several risk factors, including high blood pressure, cholesterol, and an abnormal pulse rate. Accurate decision-making and optimal treatment are required to address cardiac risk. As machine learning technology advances, the healthcare industry’s clinical practice is likely to change. As a result,...
Article
Background Autoimmune hepatitis (AIH) is an inflammatory liver disease which is characterized histologically by interface hepatitis, biochemically by elevated transaminase levels, and serologically by the presence of autoantibodies. Toll-like receptor (TLR)-4 is a TLR family member that, upon activation in hepatocytes, initiates a cascade of events...
Article
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In this paper, a thorough radio- and chem-ecological evaluation of ElSibai-Abu ElTiyur granites located within Egypt’s crystalline basement rocks was conducted for risk and dose assessments. Twenty granitic samples from the study area’s various lithological units were analyzed using high-resolution γ-ray spectrometry to determine the natural radioi...
Article
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Insulin resistance contributes to several disorders including type 2 diabetes and cardiovascular diseases. Carpachromene is a natural active compound that inhibits α-glucosidase enzyme. The aim of the present study is to investigate the potential activity of carpachromene on glucose consumption, metabolism and insulin signalling in a HepG2 cells in...
Article
In this paper, the dynamics of cholera disease, using a mathematical model, have been investigated. The basic reproduction number, using the next generation matrix method, has been computed which informs us about disease spread or control among people. There are two types of equilibria: disease absent and disease present. Stabilities of both equili...
Article
Global data, including those from Saudi Arabia, that examined public knowledge, attitudes, and practices (KAP) toward hepatitis E virus (HEV) are limited. This study examined KAP levels of the general population in Saudi Arabia toward HEV. A cross-sectional study was conducted among 768 participants. An Arabic electronic questionnaire that containe...
Article
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With the effect of discrete time delay in deliberation, we propose and analyze a conceptual mathematical model for the tumor-immune interaction. The proposed model is delineated by a system of three coupled non-linear ordinary differential equations (ODEs), namely tumor cells, effector cells and cytokine Interleukin-2 (IL-2). Though simple, the mod...
Article
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SARS-CoV-2 virus mutations might increase its virulence, and thus the severity and duration of the ongoing pandemic. Global drug discovery campaigns have successfully developed several vaccines to reduce the number of infections by the virus. However, finding a small molecule pharmaceutical that is effective in inhibiting SARS-CoV-2 remains a chall...
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The safety of personal protective equipment (PPE) is very important, and so is the choice of materials used. The ability of electrostatic charges (ESCs) generated from the friction of engineered materials to attract or repel viruses has a significant impact on their applications. This study examined the ESCs generated on the surface of PPE used by...
Article
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Bronchial asthma is one of the most chronic pulmonary diseases and major public health problems. In general, asthma prevails in developed countries than developing countries, and its prevalence is increasing in the latter. For instance, the hygiene hypothesis demonstrated that this phenomenon resulted from higher household hygienic standards that d...
Article
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SARS-CoV-2 (COVID-19), a novel coronavirus causing life-threatening pneumonia, caused a pandemic starting in 2019 and caused unprecedented economic and health crises all over the globe. This requires the rapid discovery of anti-SARS-CoV-2 drug candidates to overcome this life-threatening pandemic. Strawberry (Fragaria ananassa Duch.) and ginger (Zi...
Article
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Selecting a vaccine for fighting a pandemic is one of the serious issues in healthcare. Novel decision models for vaccine selection need to be developed. In this study, a novel vaccine selection decision-making model (VSDMM) was proposed and developed, based on the analytic hierarchy process (AHP) technique, which assesses many alternatives (vaccin...
Article
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In this paper, a stochastic HIV/AIDS epidemic model has been studied numerically. A discussion among the solutions related to deterministic HIV/AIDS model and stochastic HIV/ AIDS epidemic model has shown that the stochastic solution is more realistic than the deterministic solution. To control the diseases, the threshold parameter R 0 plays a key...
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The present study is conducted to analyse the computational dynamical analysis of the stochastic susceptible-infected-recovered pandemic model of the novel coronavirus. We adopted two ways for stochastic modelling like as transition probabilities and parametric perturbation techniques. We applied different and well-known computational methods like...
Article
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At the end of December 2019, the Wuhan Municipal Health Commission, revealed several cases of pneumonia of unknown etiology. Later, this etiology was called the coronavirus disease 2019 (COVID-19). COVID-19 disease is rapidly spreading around the globe, affected millions of people, compelling governments to take serious actions. Due to this deadly...
Article
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Several deadly epidemics that have recognized as serious problems all over the world in the last few decades. Lassa hemorrhagic fever, coronavirus, dengue fever, malaria, and HIV are well-known deadly diseases in humans. In this research, we analysed the dynamics of the canine distemper virus (CDV) and rabies epidemics in the red fox population of...
Article
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Mathematical modeling plays an important role to better understand the disease dynamics and designing strategies to manage quickly spreading infectious diseases in lack of an effective vaccine or specific antivirals. During this period, forecasting is of utmost priority for health care planning and to combat COVID-19 pandemic. In this study, we pro...
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In this paper, we will propose a novel system for remote detecting COVID-19 patients based on artificial intelligence technology and internet of things (IoT) in order to stop the virus spreading at an early stage. In this work, we will focus on connecting several sensors to work together as a system that can discover people infected with the Corona...
Article
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Background Interleukin-18 (IL-18) and interferon-γ (IFN-γ) are cytokines of crucial role in inflammation and immune reactions. There is a growing evidence supporting important roles for IL-18 and IFN γ in tuberculosis (TB) infection and anti-tuberculosis immunity. Objective To evaluate the role of polymorphisms in IL-18-607 and -137 and INF-γ +874...
Article
Full-text available
Background and aim: Data available in the Kingdom of Saudi Arabia (KSA) about public knowledge, attitude, and practice (KAP) toward viral hepatitis infection are scarce. Such information is essential for designing effective intervention strategies for the prevention and control of viral hepatitis. This study aimed to assess the knowledge, attitude,...
Article
Coagulase-negative staphylococci (CoNS) are frequently isolated from wound infections. There are limited data examining the prevalence of methicillin-resistant CoNS (MRCoNS) among Egyptian patients after surgery. Thus, we studied 208 hospitalised patients, who had skin and soft tissue infections (SSTIs) due to various causes. Samples were cultured...
Article
Variations in the immune response could explain resistance to hepatitis C virus (HCV) infection. Toll-like receptor gene (TLR)-3 is an innate detector of dsRNA viruses, and the TLR9 gene recognizes bacterial and viral unmethylated CpG motifs. We previously reported that TLR3.rs3775290 CC genotype was associated with HCV chronicity and that the TLR9...
Article
Increasing resistance of microbes to available antifungals has necessitated a search for alternative natural products with antifungal properties. Combinations of essential oils (EOs) with known antifungal activities may increase antimicrobial activity, reduce side effects, and overcome resistance. This study determined the antifungal activity of ba...
Article
Increasing resistance of microbes to available antifungals has necessitated a search for alternative natural products with antifungal properties. Combinations of essential oils (EOs) with known antifungal activities may increase antimicrobial activity, reduce side effects, and overcome resistance. This study determined the antifungal activity of ba...
Article
Full-text available
Background: Macrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cells in the lung during allergic asthma, which is the most common chronic respiratory disease of both adults and children. Macropha...
Article
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Background: Macrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cells in the lung during allergic asthma, which is the most common chronic respiratory disease of both adults and children. Macroph...
Article
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Background and objective: Acinetobacter baumannii (A. baumannii) is a common nosocomial pathogen, which developed multi-drug-resistance to different classes of antibiotics including carbapenems. This study examined ten common carbapenemase genes among 32 carbapenem-resistant A. baumannii clinical isolates recovered from Taif, Saudi Arabia. Method...
Article
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Background: Quinolones are among the most effective antibiotics against Pseudomonas spp. Several chromosomal and/or plasmid-mediated quinolone-resistance mechanisms have been found in Pseudomonas. Plasmid-mediated quinolone-resistance (PMQR) is mediated by quinolone-resistance (QNR) proteins, modifying enzymes or efflux pumps. Only a few previous s...
Article
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Previous studies showed that interleukin (IL)-28B gene polymorphisms were associated with hepatitis C Virus (HCV) infection and treatment outcomes. We tested whether single-nucleotide polymorphisms (SNPs) in IL-28A and IL-28B are associated with HCV infection among Egyptians with HCV genotype 4 infections. We enrolled 144 chronic HCV patients, 72 s...
Article
A general strategy towards total synthesis of (-)-codonopsinine, (-)-codonopsine and codonopsinine analogues has been developed from (D)-tartaric acid via the intermediate (3S,4R)-1-methyl-2-oxo-5-(2,2,2-trichloroacetamido)pyrrolidinediacetate (7). α-amidoalkylation studies of 7 with electron rich benzene derivative 8a-g as C-nucleophiles afforded...
Article
Full-text available
Toll-like receptors (TLRs) give the innate immune system a considerable specificity for a large range of pathogens. TLR3 detects dsRNA of viruses while TLR9 recognizes bacterial and viral unmethylated CpG motifs. This study examined whether there is a potential association between single-nucleotide polymorphisms (SNPs) in the TLR3.rs3775290 (c.1377...
Article
Full-text available
Background: RNA-dependant protein kinase R (PKR) is a primary mediator in the defence mechanism of interferon against viral replication and pathogenesis during Hepatitis C virus (HCV) infection. In the present study, we have examined the role of Single Nucleotide Polymorphisms (SNPs) in the promoter region of PKR and the serum level of the same pro...
Article
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Acute Hepatitis C (AHC) infections, resolves spontaneously in 15‐40% of patients. Factors favoring spontaneous viral clearance remain undefined. In this study, predictors of spontaneous viral clearance in symptomatic AHC patients were investigated. Epidemiological, clinical and virologic parameters were also examined. Symptomatic AHC patients were...
Article
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Purpose: To determine the efficacy of eugenol for the treatment of Candida keratitis in an experimental model. Methods: The in vitro antifungal activity of eugenol and fluconazole was tested against C. albicans strains via the microbroth dilution method. An experimental model of Candida albicans keratitis was used. Rabbits were classified into t...
Article
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Background: Orthodontic treatment with fixed appliances increases biofilm accumulation on the irregular surfaces of the brackets which may lead to enamel demineralization. Data examining the adhesion of different cariogenic bacteria to orthodontic brackets with different methods of ligation are limited. Objective: To quantitatively analyse the adhe...
Article
Full-text available
Background: Orthodontic treatment with fixed appliances increases biofilm accumulation on the irregular surfaces of the brackets which may lead to enamel demineralization. Data examining the adhesion of different cariogenic bacteria to orthodontic brackets with different methods of ligation are limited. Objective: To quantitatively analyse the adhe...
Article
Hepatitis C virus (HCV) infection is widespread in Egypt. This study compared HCV RNA with HCVcAg for the detection and quantification of viraemia among a sample of Egyptians. Sera from 80 suspected HCV-positive individuals were tested simultaneously for HCV-RNA load using real-time polymerase chain reaction (PCR) and HCVcAg level using ELISA. Of t...
Article
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The IL28B gene is associated with spontaneous or treatment-induced HCV viral clearance. However, the mechanism by which the IL28B single nucleotide polymorphism (SNP) affects the extra-hepatic HCV immune responses and its relationship to HCV pathogenesis have not been thoroughly investigated. To examine the mechanism by which IL28B affects HCV clea...
Article
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Objective: To describe the characteristics of hepatitis E virus (HEV) infection in a cohort of children from Upper Egypt using data from a large multicentre prospective study of acute viral hepatitis (AVH). Methods: Data from subjects aged 2-18 years with AVH or close contacts of those with AVH found to have asymptomatic AVH were included in the...
Article
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A single-nucleotide polymorphism (SNP) in the interleukin (IL)-28B gene was used as a major predictor of the response to treatment in patients with hepatitis C virus (HCV) infection. Data examining the role of IL-10 and IL-18 gene polymorphisms among HCV genotype 4 (G4)-infected Egyptians in response to pegylated interferon (PEG-IFN) plus ribavirin...
Article
Full-text available
The prevalence of Enterococcus faecalis (E. faecalis) infections among Egyptians with urinary tract infection (UTI), their antimicrobial susceptibility and mechanisms of resistance are under investigated. In this study, 300 urine samples were collected from UTI patients to identify E. faecalis. Antimicrobial susceptibility to 18 antimicrobial agent...
Article
Full-text available
Background: HCV is a major global health problem. IL-27 is a member of the IL-6/IL-12 cytokine family with a broad range of anti-inflammatory properties. Recent studies highlighted the effect of a SNP in the IL-27 promoter region on modulating the progression of infectious diseases and individual responses to therapy. Aim of the work: The presen...
Article
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Hepatitis C Virus (HCV) causes chronic infection and represents a global health burden. To date, there is no licensed vaccine for HCV. The high viral replication rate and the existence of several HCV genotypes and quasispecies hamper the development of an effective universal vaccine. In this regard, the current HCV vaccine candidates show genotype-...
Article
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Background: Occult Hepatitis C Virus (HCV) infection (OCI) was reported in an apparently disease-free state in the absence of liver disease, anti-HCV and HCV-RNA in the serum. The existing data examining the clinical significance of OCI and its potential as a source of HCV infection among hemodialysis patients are very limited. We examined the pre...
Article
Full-text available
To date, there is no licensed Hepatitis C Virus (HCV) vaccine and what constitutes a protective immune response or correlate of protection against HCV infection is still vague. The Egyptian case of HCV is unique with a prevalence of ~15% among the general population and ~90 of the isolates belonging to genotype 4. This constitutes a great risk for...
Article
Hepatitis E virus (HEV) is yearly responsible for approximately 20 million infections worldwide. Although most infections occur in developing countries, HEV appears to be an emerging problem in several industrialized countries, where it is mostly associated with either traveling to an HEV endemic area or contact with pigs, which represent a major r...
Article
A series of novel pyrrolo[2,1-b][1,3]oxazepine-8,9-diol derivatives 12–15 were synthesized starting from l-tartaric acid, which was transformed into anhydride which then reacted with allylamine in xylene to afford the imide 2. The target molecules 12–15 were achieved via ring-closing metathesis with the Grubbs catalyst, followed by reduction of the...
Article
Full-text available
Several host and viral factors affect the natural history of Hepatitis C Virus (HCV) infection. Interleukin 28B (IL28B).rs12979860 single nucleotide polymorphism (SNP) was found to predict viral clearance with and without therapy. Subjects with the CC (favorable) genotype of IL28B.rs12979860 were more likely to spontaneously clear the infection and...