Saweta Garg

Saweta Garg
Newcastle University | NCL · School of Chemical Engineering and Advanced Materials

Master of Pharmacy
Research Assistant

About

10
Publications
843
Reads
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90
Citations
Citations since 2017
10 Research Items
90 Citations
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201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050

Publications

Publications (10)
Article
Full-text available
In the presented work, pure pluronic and mixed micelles of normal pluronics (F108, F127, P85 and P84) with reverse pluronic (10R5) have been studied to enhance the solubilization of the hydrophobic drug silymarin (SLY) at different % w/v proportions (4:1, 2.5, 1:4 and 5). Solubilization capacity of SLY in the mixed micelles was found to be higher t...
Article
Polysorbates and Pluronic polymers are straightforward to use to improve the performance of hydrophobic molecules, however, colloidal systems of these polymers are not fully understood and loading of drug molecules in these Polysorbate micelles rely on a plethora of factors. Thus, it is a laborious task to select the optimal Polysorbate as a drug d...
Article
Pluronic (PEO-PPO-PEO) block copolymers can form nano-sized micelles with a structure composed of a hydrophobic PPO core and hydrophilic PEO shell layer. Pluronics are U.S. Food and Drug Administration approved polymers, which are widely used for solubilization of drugs and their delivery, gene/therapeutic delivery, diagnostics, and tissue engineer...
Article
Full-text available
The present study aimed at isolation of endophytic basidiomycetous fungi and evaluation of their in-vitro and in-vivo antidiabetic potential. Preliminary screening for in-vitro activity was carried out using α-glucosidase inhibition assay. An endophytic isolate Sch1 (isolated from Aloe vera) , identified to be Schizophyllum commune Fr. on molecular...
Article
Full-text available
Musculoskeletal pain is a widespread complex regional pain syndrome associated with altered emotional and cognitive functioning along with heightened physical disability that has become a global health concern. Effective management of this disorder and associated disabilities includes accurate diagnosis of its biomarkers and instituting mechanism–b...
Article
Full-text available
Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies. Thus, there is a need to develop an efficacious alternate treatment regimen for pain-depression dyad. Skimmetin and osthole are molecules of natural origin that have been explored for an anti-hype...
Article
Full-text available
Fibromyalgia is a refractory syndrome characterized by chronic wayward pain and complex co-morbid psychological trepidation. The current treatments have a limited role and proper clinical benefits are far from satisfactory. Naturally occurring coumarins such as osthole are known to have analgesic and anti-inflammatory activities. Therefore, the cur...
Article
In this work, we studied the solubilization capacityof the hydrophobic drugs Clozapine (CLZ) and Oxcarbazepine (OXC) in mixed micelles of low molecular weight pluronics (L64 and L35) and high molecular weight pluronics (P84, F127, F68 and P123) using UV–visible spectroscopy. The drug solubility, drug loading efficiency, the micelle–water partition...
Article
The current investigation was aimed at in vivo MAOA inhibitory activity of coumarins angelicin, bergapten, and scopoletin isolated from the roots of Angelica archangelica. The isolated compounds were screened for MAOA (pdb ID 2Z5y) binding through molecular docking studies. The molecular docking results displayed that bergapten has a maximum affini...

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