Saurav Ghimire

Saurav Ghimire
University of Bordeaux · Institute of Neurodegenerative Diseases

PhD Molecular genetics
Identification of the central role of the Gut in causing Parkinsons Disease

About

13
Publications
1,374
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75
Citations
Introduction
Saurav is a diligent and result-oriented research scientist with experience and expertise in Molecular Genetics, Neuroscience, and Physiological and Behavioural experiments. Demonstrated track record of a successful meeting of scientific challenges and execution of the projects both individually and in the team. He is currently involved in understanding the key players that play vital role in neurodegeneration in earliest steps and by extension, the onset of neurodegenerative diseases like PD.
Additional affiliations
November 2019 - present
University of Bordeaux
Position
  • PostDoc Position
November 2015 - December 2019
University of Glasgow
Position
  • PhD Student
September 2013 - August 2015
Inje University
Position
  • Master's Student

Publications

Publications (13)
Article
Nephrolithiasis is one of the most common kidney diseases with poorly understood pathophysiology, but experimental study has been hindered by lack of experimentally tractable models. Drosophila melanogaster is a useful model organism for renal diseases because of genetic and functional similarities of Malpighian (renal) tubules with the human kidne...
Article
Full-text available
Insects are highly successful, in part through an excellent ability to osmoregulate. The renal (Malpighian) tubules can secrete fluid faster on a per-cell basis than any other epithelium, but the route for these remarkable water fluxes has not been established. In Drosophila melanogaster , we show that 4 genes of the major intrinsic protein family...
Preprint
Full-text available
Insects are highly successful, in part through an excellent ability to osmoregulate. The renal (Malpighian) tubules can secrete fluid faster on a per-cell basis than any other epithelium, but the route for these remarkable water fluxes has not been established. In Drosophila melanogaster , we show that 4 members of the Major Intrinsic Protein famil...
Article
Full-text available
Dietary restriction (DR) is known to be one of the most effective interventions to increase stress resistance, yet the mechanisms remain elusive. One of the most obvious DR-induced changes in phenotype is an increase in locomotor activity. Although it is conceptually perceivable that nutritional scarcity should prompt enhanced foraging behavior to...
Chapter
Parkinson's disease (PD) is the second-most common neurodegenerative disorder after Alzheimer's disease. The discovery of gene mutations associated with the onset of PD has allowed the creation of multiple animal models of PD to better understand the molecular mechanisms and pathophysiology of this disorder. Autophagy is an essential catabolic proc...
Article
Synapses are critical for neuronal communication and brain function. To maintain neuronal homeostasis, synapses rely on autophagy. Autophagic alterations cause neurodegeneration and synaptic dysfunction is a feature in neurodegenerative diseases. In Parkinson's disease (PD), where the loss of synapses precedes dopaminergic neuron loss, various PD-c...
Article
Full-text available
Automatic quantification of image parameters is a powerful and necessary tool to explore and analyze crucial cell biological processes. This article describes two ImageJ/Fiji automated macros to approach the analysis of synaptic autophagy and exosome release from 2D confocal images. Emerging studies point out that exosome biogenesis and autophagy s...
Chapter
The insect renal (Malpighian) tubule has long been a model system for the study of fluid secretion and its neurohormonal control, as well as studies on ion transport mechanisms. To extend these studies beyond the boundaries of classical physiology, a molecular genetic approach together with the ‘omics technologies is required. To achieve this in an...
Article
Full-text available
Aging is a complex process resulting in: i) a decline in body functions and capacity to withstand environmental stress and ii) an increased susceptibility to diseases including, but not limited to, cardiovascular disorders, diabetes, cancer and dementia. Among a number of herbal products used to alleviate symptoms associated with aging is Ilex para...
Article
Full-text available
Jujube (Ziziphus Jujuba Mill.) fruit has been utilized as an adjunct to alleviate medical symptoms including, but not limited to, anorexia, fatigue, anxiety and mild diarrhea for centuries. Despite a growing body of literature revealing jujube fruit’s health promoting properties such as anti-cancer, anti-inflammation and anti-oxidant effects (shown...
Article
Full-text available
Aging is defined as a collective process that alters organism's functional capacity and appearance over the course of life. Apart from an increase in susceptibility to many diseases, aging affects the cellular system that is responsible for decoding painful stimuli. Yet, aging-associated molecular mechanisms of pain perception remains elusive. Usin...
Article
Full-text available
Background: Avipattikar churna, a poly-herbal formulation, is one of the popular ayurvedic formulations which is used for peptic ulcer diseases but the scientific documentation with regards to its effect for the indication is lacking. Aims: This study was carried out to evaluate the anti-secretory and the anti-ulcerogenic activities of the churna a...

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Projects

Project (1)
Project
The RENALTRACT training network aims to address these deficits and provide a better understanding of the molecular and cellular pathways that underlie renal tract defects and provide solutions to clinical problems. This shall be achieved by using a multidisciplinary team approach with laboratories working in disciplines as diverse as developmental biology, renal physiology, proteomics and clinical medicine.