Saurav GhimireUniversity of Bordeaux · Institute of Neurodegenerative Diseases
Saurav Ghimire
PhD Molecular genetics
Identification of the central role of the Gut in causing Parkinsons Disease
About
13
Publications
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Introduction
Saurav is a diligent and result-oriented research scientist with experience and expertise in Molecular Genetics, Neuroscience, and Physiological and Behavioural experiments. Demonstrated track record of a successful meeting of scientific challenges and execution of the projects both individually and in the team. He is currently involved in understanding the key players that play vital role in neurodegeneration in earliest steps and by extension, the onset of neurodegenerative diseases like PD.
Additional affiliations
November 2019 - present
November 2015 - December 2019
September 2013 - August 2015
Publications
Publications (13)
Nephrolithiasis is one of the most common kidney diseases with poorly understood pathophysiology, but experimental study has been hindered by lack of experimentally tractable models. Drosophila melanogaster is a useful model organism for renal diseases because of genetic and functional similarities of Malpighian (renal) tubules with the human kidne...
Insects are highly successful, in part through an excellent ability to osmoregulate. The renal (Malpighian) tubules can secrete fluid faster on a per-cell basis than any other epithelium, but the route for these remarkable water fluxes has not been established. In Drosophila melanogaster , we show that 4 genes of the major intrinsic protein family...
Insects are highly successful, in part through an excellent ability to osmoregulate. The renal (Malpighian) tubules can secrete fluid faster on a per-cell basis than any other epithelium, but the route for these remarkable water fluxes has not been established. In Drosophila melanogaster , we show that 4 members of the Major Intrinsic Protein famil...
Dietary restriction (DR) is known to be one of the most effective interventions to increase stress resistance, yet the mechanisms remain elusive. One of the most obvious DR-induced changes in phenotype is an increase in locomotor activity. Although it is conceptually perceivable that nutritional scarcity should prompt enhanced foraging behavior to...
Parkinson's disease (PD) is the second-most common neurodegenerative disorder after Alzheimer's disease. The discovery of gene mutations associated with the onset of PD has allowed the creation of multiple animal models of PD to better understand the molecular mechanisms and pathophysiology of this disorder. Autophagy is an essential catabolic proc...
Synapses are critical for neuronal communication and brain function. To maintain neuronal homeostasis, synapses rely on autophagy. Autophagic alterations cause neurodegeneration and synaptic dysfunction is a feature in neurodegenerative diseases. In Parkinson's disease (PD), where the loss of synapses precedes dopaminergic neuron loss, various PD-c...
Automatic quantification of image parameters is a powerful and necessary tool to explore and analyze crucial cell biological processes. This article describes two ImageJ/Fiji automated macros to approach the analysis of synaptic autophagy and exosome release from 2D confocal images. Emerging studies point out that exosome biogenesis and autophagy s...
The insect renal (Malpighian) tubule has long been a model system for the study of fluid secretion and its neurohormonal control, as well as studies on ion transport mechanisms. To extend these studies beyond the boundaries of classical physiology, a molecular genetic approach together with the ‘omics technologies is required. To achieve this in an...
Aging is a complex process resulting in: i) a decline in body functions and capacity to withstand environmental stress and ii) an increased susceptibility to diseases including, but not limited to, cardiovascular disorders, diabetes, cancer and dementia. Among a number of herbal products used to alleviate symptoms associated with aging is Ilex para...
Jujube (Ziziphus Jujuba Mill.) fruit has been utilized as an adjunct to alleviate medical symptoms including, but not limited to, anorexia, fatigue, anxiety and mild diarrhea for centuries. Despite a growing body of literature revealing jujube fruit’s health promoting properties such as anti-cancer, anti-inflammation and anti-oxidant effects (shown...
Aging is defined as a collective process that alters organism's functional capacity and appearance over the course of life. Apart from an increase in susceptibility to many diseases, aging affects the cellular system that is responsible for decoding painful stimuli. Yet, aging-associated molecular mechanisms of pain perception remains elusive. Usin...
Background: Avipattikar churna, a poly-herbal formulation, is
one of the popular ayurvedic formulations which is used for
peptic ulcer diseases but the scientific documentation with regards to its effect for the indication is lacking.
Aims: This study was carried out to evaluate the anti-secretory
and the anti-ulcerogenic activities of the churna a...
Projects
Project (1)
The RENALTRACT training network aims to address these deficits and
provide a better understanding of the molecular and cellular pathways
that underlie renal tract defects and provide solutions to clinical
problems. This shall be achieved by using a multidisciplinary team
approach with laboratories working in disciplines as diverse as
developmental biology, renal physiology, proteomics and clinical
medicine.
