Saurabh Mandal

Henry Ford Health · Pancreatic Cancer Center

Pancreatic cancer is the third leading cause of cancer-related death in the US. Black or African American patients have a higher incidence of pancreatic cancer compared to other racial groups. It is unclear whether distinct molecular mechanisms are involved in the development of pancreatic cancer in different racial groups. To identify tumor molecu...

Oncotherapeutics research is progressing at a rapid pace, however, not many drugs complete the successful clinical trial because of severe off-target toxicity to cardiomyocytes which ultimately leads to cardiac dysfunction. It is thus important to emphasize the need for early testing for possible cardiotoxicity of emerging oncotherapeutics. In this...

Breast cancer, one of the leading causes of death in the world, has been largely considered to be drug resistant because of a small population of drug refractory cells, the cancer stem cells (CSCs). The CSCs are tightly regulated by self-renewal pathways such as the Wnt pathway, which is further regulated by a gamut of microRNAs. In this study, we...

Breast cancer is a leading cause of mortality in women across the globe. The major reason for its recurrence and high mortality is due to the presence of a drug refractory and self-renewing population of cells, the cancer stem cells (CSCs). Mesenchymal stem cells (MSCs) have recently emerged as a promising cell-based therapeutic agent for the treat...

Physical properties of a tissue engineering scaffold play a crucial role in maneuvering the cellular fate. Scaffold properties have been shown to significantly influence cellular growth kinetics as well as overall cell behavior. The purpose of the present investigation was to investigate the effect of varying physical properties of a dipeptide-hydr...

Background: Pancreatic cancer (PC) is among the leading causes of cancer-related deaths in the United States, with a 5-year survival rate of approximately 13%. Previous studies reported higher PC incidence and mortality rates among Black or African American (BAA) patients in comparison to White patients. Disadvantaged socioeconomic status (SES) and...

Methylmercury (MeHg), an organometallic contaminant is a well spotted cause for a series of disorders, especially in the central nervous system. As there is no proper treatment, Selinum vaginatum (Edgew) C. B. Clarke, a traditional medicinal plant, is taken in the present study for assessing its neuroprotective effect against MeHg induced toxicity...

Surging reports of peptide-based nanosystems and their growing potency in terms of biological utility demand for the search of newer and simpler peptide-based systems that could serve as smart templates for the development of self-assembled nanostructures. Use of simple amino acids as monomeric building blocks for synthesizing ensembles of nanostru...

The objective of the present study was to evaluate in vitro anti-inflammatory, antioxidant and anti-carcinogenic activity of novel synthesized phenanthridine derivatives (PHE 4i and PHE 4j), a polycyclic nitrogenous heterocyclic compound having planar structure. The in vitro anti-inflammatory activity was examined by erythrocyte membrane stabilizat...

Extensive amounts of research over the past two decades have shown the modulation of endogenous hydrogen sulfide (H2S) levels affected health and disease. Recent studies have reported that H2S acts as a mediator in various physiological and pathological processes of cancerous cells. Noni (Morinda citrifolia) is a medicinal plant which possesses var...

Cancer is a highly devastating disease killing millions of people each year. Cancer represents an enormous biomedical challenge for drug delivery and its treatment is very much dependent on the method of delivery. Drug resistance, altered bio-distribution, biotransformation, and fast drug clearance and multidrug resistance are some major issues. Th...

Currently, therapies to treat traumatic brain injury are based on modifying disease symptoms pharmacologically but do not promote neural tissue repair. The goal of our present study was to investigate the therapeutic potential of small self-assembling peptide nanofiber scaffolds for neural tissue engineering. As scaffold properties to a great deal...