Saud Alarifi

Verified

Saud verified their affiliation via an institutional email.

Learn more

Verified

Saud verified their affiliation via an institutional email.

Learn more

• PhD
• Professor (Full) at King Saud University

Lycopene is known for protecting the skin from harmful UV rays, which is why it is widely used in cosmetics. In the present investigation, fruits and vegetables like Capsicum annuum (C.a.), Capsicum frutescens (C.f.), Carica papaya (C. p.), Citrullus lanatus (C. l.), and Solanum lycopersicum (S. l.) were used for the extraction and isolation of lyc...

The study presents a novel nanocarrier technology that integrates mesoporous silica nanoparticles (MSNs) with the bacterial effector protein SlrP for targeted cancer treatment. It is proposed that the conjugation of SlrP to carboxyl‐functionalized, fluorescein‐labeled mesoporous silica nanoparticles (MSNFITC/MPA) will facilitate regulated intracell...

Asthma is a prevalent airway inflammatory condition caused by exposure to various allergens. It is defined by the presence of airway inflammation, airway hyperresponsiveness, and excessive production of mucus. This work was undertaken to study the curative potentials of eupatorin against ovalbumin (OVA)‐exposed asthma in mice. The influence of eupa...

Nicotine, the most toxic factor in tobacco, can damage a wide range of biological molecules by inducing oxidative stress. This study aimed to investigate the protective effects of Teucrium polium Leaves extract (TPLE) against the toxic properties of nicotine in the spleen of mice. Twenty-four mice were equally divided into four groups (n = 6): norm...

Endometriosis is a gynecological condition characterized by the growth of uterine tissue outside the uterus, primarily affecting the peritoneal cavity and disrupting the female reproductive system due to estrogen. This study investigates the potential of phytochemicals from Caralluma stalagmifera L. to inhibit Vascular Endothelial Growth Factor Rec...

Global cancer mortality is rising yearly due to various factors. Silver nanoparticles (AgNPs) are widely utilized for their low cost and antibacterial properties compared to other noble metals. Here, AgNPs were synthesized using Cucurbita maxima leaf extract, which was analyzed by various analytical instruments. UV-visible spectra showed an absorba...

Glycine-modified chitosan anchored silver nanoparticles (SCG) were synthesized using a green method without a cross-linking agent. UV–Vis, FTIR, XRD, TEM and SEM techniques confirmed the formation of the SCG nanocomposite and silver nanoparticles. The SCG nanoparticles, estimated at 20 nm, are smaller than the chitosan stabilized Ag (SC) nanopartic...

Background and Objectives Brown seaweed, Sargassum muticum, can grow up to a maximum length of 10 m. This study aimed to create novel bimetallic nanoparticles (NPs) by utilizing the entire plant extract. The bimetallic green-Ag-CuNPs was synthesized by using these substances extract of Sargassum muticum algae, copper oxide (CuO), silver (AgCl) by a...

The present study focused on investigating the population structure and breeding biology of a species of Porcellanid crab, Petrolisthes boscii (Audouin, 1826). Evaluating the population ecology of the species is essential considering its crucial role in ecological functions including the nutrition cycle and its potential vulnerability to environmen...

Objective To evaluate the anticancer potential of Cymbopogon citratus extract. Methods GC-MS analysis was used to identify phytocomponents in the methanolic extract of Cymbopogon citratus . A fractionation method was employed to isolate and assess the bioactivity of different fractions and their cytotoxic activities against cancer cell lines HCT11...

The study was carried out in five regions of Bangladesh—Gazipur, Bogura, Jamalpur, Jashore, and Chattogram—utilizing a randomized complete block design and involving 17 genotypes of sweet potatoes. The objective was to evaluate their performance, environmental adaptability, and stability in terms of root yield. The analysis was carried out using fi...

The characteristics and biological qualities of the nanomaterial rely heavily on how it was made. Green nanoparticle production has been developed to minimize pollution, cut expenses, and enhance safety for both human health and the environment by reducing metal ions using plant extracts as opposed to industrial chemical agents. The goal of the cur...

Introduction Tobacco use is a major global health issue linked to psychiatric illnesses and high mortality rates. Nicotine, the primary compound absorbed during smoking, causes harm to various organs, particularly the brain. The current study examined the modulatory effect of Teucrium polium extract (TPE) on nicotine-induced biochemical and histolo...

In this research, two primary bioactive components were isolated from Cynodon dactylon (L) Pers, commonly known as Durva grass. A gradient reverse phase High performance liquid chromatography coupled to Photodiode array detector (RP-HPLC-PDA) technique was established to identify and quantify these major bioactive constituents in 70% hydroalcoholic...

In the present research work, Fe-doped bismuth oxychloride (Fe doped BiOCl) photocatalyst is synthesised through the precipitation technique, and the mineralisation of textile dye is investigated in the presence of light-emitting diode (LEDs) irradiation (400–700 nm). The prepared photocatalysts were characterised through various spectroscopic tech...

Lead is one of the major environmental pollutants which is highly toxic to plants and living beings. The current investigation thoroughly evaluated the synergistic effects of oxalic acid (OA) and salicylic acid (SA) on Zea mays L. plants subjected to varying durations (15, 30, 30, and 45 days) of lead (Pb) stress. Besides, the effects of oxalic aci...

The advent of pH-sensitive liposomes (pHLips) has opened new opportunities for the improved and targeted delivery of antitumor drugs as well as gene therapeutics. Comprising fusogenic dioleylphosphatidylethanolamine (DOPE) and cholesteryl hemisuccinate (CHEMS), these nanosystems harness the acidification in the tumor microenvironment and endosomes...

Chili pepper cultivation in the Indian subcontinent is severely affected by viral diseases, prompting the need for environmentally friendly disease control methods. To achieve this, it is essential to understand the molecular mechanisms of viral resistance in chili pepper. The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) genes are known to p...

In recent decades, there has been a dramatic increase in fundamental microbial disease pervasiveness. The evolution of multi-drug resistant organisms (MDROs) is attributed to the broad usage of commercial antibiotics, which indicates that the previously active antibiotics are now limited in their efficacy. Therefore, this work was designed to exami...

Heavy metal pollution is a significant environmental concern with detrimental effects on ecosystems and human health, and traditional remediation methods may be costly, energy-intensive, or have limited effectiveness. The current study aims were to investigate the impact of heavy metal toxicity in Eisenia fetida, the growth, reproductive outcomes,...

Bio-inspired zinc oxide nanoparticles are gaining immense interest due to their safety, low cost, biocompatibility, and broad biological properties. In recent years, much research has been focused on plant-based nanoparticles, mainly for their eco-friendly, facile, and non-toxic character. Hence, the current study emphasized a bottom-up synthesis o...

Propranolol (PRO) is a beta-blocker drug used for the treatment of anxiety, chest pain, migraine and tremors. The present study investigated whether sublethal concentrations of PRO have effects on the body condition, biochemistry, and hematology of Clarias gariepinus juveniles. The 96-h median lethal concentration (LC50) of the drug, which was esta...

The efficient use of lignocellulosic biomass for the production of new value compounds reduces our overdependence on fossil fuels. The use of fossil fuels emits a greater quantity of greenhouse gases, contributing to climate change, health risks and global warming. Pyrolysis is the most efficient method to convert lignocellulosic material into soli...

Background The healing of burn wounds is a complicated physiological process that involves several stages, including haemostasis, inflammation, proliferation, and remodelling to rebuild the skin and subcutaneous tissue integrity. Recent advancements in nanomaterials, especially nanofibers, have opened a new way for efficient healing of wounds due t...

A tremendous increase in the green synthesis of metallic nanoparticles has been noticed in the last decades, which is due to their unique properties at the nano dimension. The present research work deals with synthesis mediated by the actinomycete Streptomyces tendae of silver nanoparticles (AgNPs), isolated from Little and Greater Rann of Kutch, I...

The increase in rice straw production and their non-utilization is a major global challenge. Even though it is an eco-friendly feedstock for the bioconversion of energy production separation of cellulose from the rice straw fiber is one of the main limitations that obstruct the application of such lignocellulosic feedstock. In the present research...

Introduction: Previous publications have shown that STIM1, ORAI1, and KDM2B, are implicated in Ca²⁺ signaling and are highly expressed in various cancer subtypes including prostate cancer. They play multiple roles in cancer cell migration, invasion, and metastasis. In the current study we investigated the expression of the above biomarkers in circu...

Nanotechnological applications involving the fabrication of potential nanomaterials and novel strategies for mitigation of contaminants have helped a lot in environmental cleanup. The chemical route for silica nanoparticle (NPs) synthesis using tetra ethyl oxy silicone and tetramethyl oxy silicone is expensive and energy intensive. Silica NPs synth...

The latest Conference of the Parties (COP) demonstrated that development and 'Climate change’ are inextricably intertwined, making them the primary fields to be tackled in addressing rational global tendencies. Since the beginning of urbanization, asphalt, and concrete have supplanted natural vegetation, which has led to an increase in energy deman...

Background: Smoking tobacco is a serious global health problem that is associated with psychiatric disorders and increased mortality rates. Nicotine, the main compound consumed during smoking, causes damage to different organs, especially the brain. The current study assessed the modulatory impact of Teucrium polium extract (TPE) on nicotine-induce...

KDM2B, a histone lysine demethylase, is expressed in a plethora of cancers. Earlier studies from our group, have showcased that overexpression of KDM2B in the human prostate cancer cell line DU-145 is associated with cell adhesion, actin reorganization, and improved cancer cell migration. In addition, we have previously examined changes of cytosoli...

Background: Nicotine can be consumed in many forms, the most common of which is smoking tobacco. Tobacco smoking is a global problem that negatively affects human health. Natural plants are vital antioxidants that may antagonize the toxic effects of smoking. We designed the present study to assess the protective potential of Teucrium polium extract...

Water hyacinth (Eichhornia crassipes) as a aquatic weed has become a source of concern for value addition. This study aimed to determine the feasibility of the weedy biomass in sustainable bioethanol production using Phanerochaete chrysosporium and Saccharomyces cerevisiae. The results indicated that P. chrysosporium significantly utilized 70.9% of...

This comprehensive review explores the physiological and pathophysiological significance of VPS13A, a protein encoded by the VPS13A gene. The VPS13A gene is associated with Chorea-acanthocytosis (ChAc), a rare hereditary neurodegenerative disorder. The review covers essential aspects, beginning with the genetics of VPS13A, highlighting its role in...

The synthesis of the nanomaterial is crucial for its characteristics, as well as physiological features. Green nanoparticle production, which reduces metal ions using natural extracts rather than industrial chemical agents, has been created to lower costs, minimize pollution, and improve environmental and human health safety. An aqueous and methano...

Colorectal cancer is known for its substantial impact on global morbidity and mortality, with higher prevalence in developed regions. This study delves into the potential treatment advantages of resveratrol (RSV) in addressing colorectal cancer. Apoptosis and gene expression associated with apoptotic factors were explored using Caco-2 cells, a pert...

Herbs and herbal products were used as an integral part of traditional medicine for centuries. In India the traditional medicines have unavoidable uses in all aspect of healthcare system and has become a part of lifestyle. The use spreads from treating common cold to serious illnesses like organ failures. Traditional medicines and treatments during...

Nanosized lanthanum oxide particles (La2O3) are commonly utilized in various industries. The potential health risks associated with La2O3 nanoparticles, cytotoxic effects at varying doses and time intervals, and the mechanisms behind their induction of behavioral changes remain uncertain and necessitate further investigation. Therefore, this study...

A R T I C L E I N F O Keywords: Cytotoxicity Protein profiling array Oxidative stress HCT-116 cell Caspase-3, caspase-8, p21, and p53 gene expressions A B S T R A C T Background: In this experiment, we synthesized a new compound, 1-(4-chlorobenzoyl)-4-(dimethylamino) pyridin-1-ium chloride (SM-9), and examined its toxicity and anticancer activity i...

Objective Cardiovascular diseases (CVD) are the leading cause of death globally. Metabolic syndrome (MtS) is a risk factor that increases the likelihood of CVD. The atherogenic index (AIP), calculated as the logarithm of the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL) cholesterol in plasma, is a valuable marker for hig...

Background Antitumor research aims to efficiently target hepatocarcinoma cells (HCC) for drug delivery. Nanostructured lipid carriers (NLCs) are promising for active tumour targeting. Cell-penetrating peptides are feasible ligands for targeted cancer treatment. Methods In this study, we optimized gefitinib-loaded NLCs (GF-NLC) for HCC treatment. T...

Nanoparticles' size-dependent features make them exceptional and necessary in a wide range of human activities. We examined the toxicity and apoptotic activities of Cu/Fe nanocomposite (green Cu/Fe nanoparticles [g-Cu-FeNPs]) on human liver (HuH-7) and breast cancer (MCF-7) cells for 24 h. Prior to the treatment of g-Cu-FeNPs, the size of the nanop...

Nanoparticles are widely used in the pharmaceutical, agriculture, and food processing industries. In this study, we have synthesized green lead nanoparticles (gPbNPs) by using an extract of Ziziphus spina-christi leaves and determined their cytotoxic and apoptotic effect on the human breast cancer MDA-MB-231 cell line. gPbNPs were characterized by...

Electrospun composite nanofiber scaffolds are well known for their bone and tissue regeneration applications. This research is focused on the development of PVP and PVA nanofiber composite scaffolds enriched with hydroxyapatite (HA) nanoparticles and alendronate (ALN) using the electrospinning technique. The developed nanofiber scaffolds were inves...

Dyes are toxic organic compounds released as effluent from various industries that need proper treatment as they pose serious hazards to the environment and living beings, including humans. Nanocomposites can be employed as photocatalysts for the elimination of such organic compounds from wastewater. One such attempt is made in this present researc...

Electrospinning is a versatile method for fabrication of précised nanofibrous materials for various biomedical application including tissue engineering and drug delivery. This research is aimed to fabricate the PVP/PVA nanofiber scaffold by novel electrospinning technique and to investigate the impact of process parameters (flow rate, voltage and d...

Metal nanoparticle fabrication through plant-based green methods is considered the gold standard among the various synthesis techniques owing to its simplicity, eco-friendliness, ease of use, and the huge diversity of plant species. Copper nanoparticles (CuONPs) have proven their potential in the fields of medicine, agriculture, pharmaceutics, and...

Rice constitutes a foundational cereal and plays a vital role in the culinary sector. However, the detriments of abiotic stress on rice quality and productivity are noteworthy. Carotenoid cleavage oxygenases (CCO) hold vital importance as they enable the particular breakdown of carotenoids and significantly contribute towards the growth and respons...

Background The purpose of this study is to analyzed the involvement of chorein in microtubules organization of three types of malignant; rhabdomyosarcoma tumor cells (ZF), rhabdomyosarcoma cells (RH30), and rhabdomyosarcoma cells (RD). ZF are expressing high chorein levels. Previous studies revealed that chorein protein silencing in ZF tumor cells...

The anti-inflammatory effect of the ethyl acetate extract of F. microcarpa bark (EAFMB) was investigated in acute and chronic (21 days) inflammation induced in Wistar albino rats. EAFMB (200 mg/kg b.w.) exhibited comparable anti-inflammatory effects to the reference drug, with a reduction of 59.48% at 4 h in acute inflammation and 83.96% on day 21...

The dehydration of ethanol into diethyl ether over a SO4/SiO2 catalyst was investigated. The SO4/SiO2 catalysts were prepared by the sulfation method using 1, 2, and 3 M of sulfuric acid (SS1, SS2, and SS3) via hydrothermal treatment. This study is focused on the synthesis of a SO4/SiO2 catalyst with high total acidity that can be subsequently util...

Green synthesis of nanoparticles has drawn huge attention in the last decade due to their eco-friendly, biocompatible nature. Phyto-assisted synthesis of metallic nanoparticles is widespread in the field of nanomedicine, especially for antimicrobial and anticancer activity. Here in the present research work, investigators have used the stem extract...

Nanoparticles have shown promising potential for efficient drug delivery, circumventing biological interferences like immunological and renal clearance and mechanical and enzymatic destruction. However, a handful of research papers have questioned the biomedical use of metal-based nanoparticles like cadmium telluride quantum dots (CdTe-QDs) for the...

Abstract: Microplastic (MP) pollution is a prevalent and global threat to fish. MP contamination was investigated in Harpadon nehereus collected from the principal fishing harbors of India’s northwest coast. A total of 213 specimens were collected from the major fishing harbors of Gujarat state (Jakhau, Okha, and Jaffrabad) and Maharashtra state (M...

Chorein is variably expressed in different cancer cells. In various non-malignant cell types, this protein regulates cytoskeleton microstructure and signaling. However, the role of chorein in regulating the actin cytoskeleton in tumor cells remains elusive. Here, we investigated chorein expression in various breast tumor cells and the involvement o...

In recent times, the herbicide atrazine (ATZ) has been commonly used before and after the cultivation of crop plants to manage grassy weeds. Despite its effect, the toxic residues of ATZ affect soil fertility and crop yield. Hence, the current study is focused on providing insight into the degradation mechanism of the herbicide atrazine through bac...

It is well known that some plants have the capability of taking up sulfur as a nutrient from the atmosphere through foliar absorption and can survive well in polluted environments. In order to observe the effects of the relationship between atmospheric hydrogen sulfide (H2S) deposition and soil sulfur nutrition, the current study used Brassica peki...

It is well known that some plants have the capability of taking up sulfur as a nutrient from the atmosphere through foliar absorption and can survive well in polluted environments. In order to observe the effects of the relationship between atmospheric hydrogen sulfide (H2S) deposition and soil sulfur nutrition, the current study used Brassica peki...

It has become crucial to biosynthesize efficient, secure, and affordable nanoparticles thatwe use for the treatment of various infections, including surgical site infection and wound in-fection, due to the rapid development of microbial resistance to numerous antibiotic drugs.The objective of the present study is to biosynthesize cobalt nanoparticl...

BACKGROUND Owing to the significance of metal oxide nanomaterials for energy storage supercapacitors, sustainable, cost‐effective and scalable synthesis of facile nanomaterials is a great challenge in the current era. Here, we have hydrothermally synthesized and functionalized a facile ternary metal oxides (MoO3/NiO/PdO/Pd) nanomaterial using the g...

Drought has a deleterious impact on the growth, physiology, and yield of various plants, including soybean. Seaweed extracts are rich in various bioactive compounds, including antioxidants, and can be used as biostimulants for improving yield and alleviating the adverse effect of drought stress. The purpose of this study was to evaluate the effect...

The unwavering pursuit of natural sources for sustainable synthesis of gold nanoparticles (AuNPs) is essential in nanomedicine. The present work describes the use of Decalepis hamiltonii (Wight & Arn) methanol root extracts evaluating its in vitro antioxidant assay, anti-cancer, AuNPs characterization, and antioxidant and antibacterial studies ADME...

The unwavering pursuit of natural sources for sustainable synthesis of gold nanoparticles (AuNPs) is essential in nanomedicine. The present work describes the use of Decalepis hamiltonii (Wight & Arn) methanol root extracts evaluating its in vitro antioxidant assay, anti-cancer, AuNPs characterization, and antioxidant and antibacterial studies ADME...

Cellulitis is a skin disease which is caused by the pathogen Staphylococcus aureus. The protein Dihydrofolate reductase is an important drug based target for Trimethoprim. Dihydrofolate reductase is reversibly inhibited by the drug trimethoprim. One of the major enzymes responsible for converting dihydrofolic acid into tetrahydrofolic acid. The scr...

Background and Objectives: Colon cancer (CC) is the second most common cancer in Saudi Arabia, and the number of new cases is expected to increase by 40% by 2040. Sixty percent of patients with CC are diagnosed in the late stage, causing a reduced survival rate. Thus, identifying a new biomarker could contribute to diagnosing CC in the early stages...

Advancements in the metal oxides‐based electrode material for the fabrication of supercapacitors have been an important focus of research in recent times. The electrochemical properties of electrode materials play a vital role in the excellent performance of the supercapacitor. In this regard, the doping of Co 3 O 4 nanoparticles (NPs) with PdO/Pd...

The implementation of nanostructure designs that optimize the benefits of all constituent elements and facilitate interfacial interactions between them represents a promising approach for enhancing electrochemical efficiency. This study uses a simple single source precursor technique to produce distinctly shaped Nd2S3:Ni9S8:Co9S8. The material’s cr...

Pearl millet [Pennisetum glaucum (L.) R. Br.] is the essential food crop for over ninety million people living in drier parts of India and South Africa. Pearl millet crop production is harshly hindered by numerous biotic stresses. Sclerospora graminicola causes downy mildew disease in pearl millet. Effectors are the proteins secreted by several fun...

The distribution of heavy metals in the seafood intake by various age group representatives around the Kalpakkam coastal region was part of the baseline study. Totally 40 different types of fish species were estimated on heavy metals (Cu, Cr, Co, Cd, Pb, Ni, Zn, and Mn) in the coastal zone; the average concentration of heavy metals were 0.71, 0.06,...

We examined the photodynamic activation of Curcumin under blue light in glioblastoma T98G cells. The therapeutic effect of Curcumin, in both the absence and presence of blue light, was measured by the MTT assay and apoptosis progression using flow cytometry. Fluorescence imaging was carried out to evaluate Curcumin uptake. Photodynamic activation o...