Satyan S Kalkunte

Brown University

Preeclampsia is a major pregnancy complication with potential short- and long-term consequences for both mother and fetus. Understanding its pathogenesis and causative biomarkers is likely to yield insights for prediction and treatment. Herein, we provide evidence that transthyretin, a transporter of thyroxine and retinol, is aggregated in preeclam...

Although replete with cytotoxic machinery, uterine NK (uNK) cells remain tolerant at the maternal-fetal interface. The mechanisms that facilitate the uNK cell tolerance are largely unknown. In this study, we demonstrate that vascular endothelial growth factor (VEGF) C, a proangiogenic factor produced by uNK cells, is responsible for their noncytoto...

The cytotoxic, anti-proliferative and apoptotic effects of 3-Bromoacetoxy Calcidiol (B3CD), a derivative of vitamin D3 precursor calcidiol, on human neuroblastoma (NB) cells were examined. NB, predominantly a tumor of early childhood, is the most common extracranial solid tumor. Despite aggressive treatments, survival for advanced stages remains lo...

Lipophilic extracts of Ginkgo biloba L. leaves were tested for their possible role on rodent models of depression and stress. Lipophilic extracts of Ginkgo leaves (LEG) at (50 and 100 mg/kg, p.o.) exhibited dose dependent, significant antidepressant activity in the behavioral despair test and learned helplessness rodent model of depression. The act...

Bioactivity guided isolation of American cranberry yielded fractions having cytotoxicity towards platinum- resistant human ovarian cancer cell lines, neuroblastoma and prostate cancer cell lines. MALDI- TOF characterization of the most active fractions indicated the presence of proanthocyanidins (PACs) of M.W. (M+Na) between DP- 2 to DP- 12 with 1-...

Lipophillic exts. of Ginkgo biloba L. leaves (LEG) were evaluated on rodent models of depression and stress. LEG (50 or 100 mg /kg, p.o) exhibit dose dependent, significant anti- depressant activity in behavioral despair and learned helplessness model. The activities were comparable to imipramine (15 mg /kg) and EGb 761 (50 mg /kg) . In cold immobi...