Satyajit Sarker

Liverpool John Moores University | LJMU · School of Pharmacy and Biomolecular Sciences

Plant triterpenoids represent a diverse group of secondary metabolites and are thought to be valuable for therapeutic applications. For drug development, lead optimization, better knowledge of biological pathways, and high-throughput detection of secondary metabolites in plant extracts are crucial. This paper describes a qualitative method for the...

Galangal (Alpinia galanga (L.) Willd) and bitter ginger (Zingiber zerumbet (L.) Roscoe) are aromatic rhizomatous plants that are typically used for culinary purposes. These rhizomatous plants have many biological properties and the potential to be beneficial for pharmaceutics. In this study, we evaluated the antioxidant and antimicrobial activities...

Background: The research is aimed at exploring the potential of marigold petal tea (MPT), rich in polyphenol contents, against oxidative stress and obesity in a rat model following a high-fat-sugar diet (HFSD). Methods: The MPT was prepared through the customary method of decoction and was subjected to analysis for its polyphenol composition using...

The genus Asphodelus L. (family: Asphodelaceae) comprises ca. 20 hardy herbaceous, perennial flowering plant species, and is native to Africa, the Indian subcontinent, the Mediterranean region, and temperate Europe, and naturalized in Australia, Mexico, New Zealand, and some parts of the USA. The Asphodelus species have long been used as traditiona...

Background: Lannea egregia Engl. & K. Krause (family: Anacardiaceae) is a well-known medicinal plant in Nigeria whose various parts have been shown to elicit several biological activities. This study specifically explored the leaf of L. egregia for potential cytotoxic compounds. Methods: n-Hexane, dichloromethane and methanolic extracts of the leaf...

Diabetic nephropathy, characterized by inflammation and oxidative stress, poses a management challenge. This study investigates the effect of Polygonum hyrcanicum extract on diabetic nephropathy in alloxan-induced diabetic mice. In this experimental animal study, the P. hyrcanicum extract was prepared using continuous macerations. Thirty male Albin...

Introduction: The Brassicaceae vegetables are a rich source of secondary metabolites that exhibit several health benefits and protection against numerous degenerative diseases.

Cancer, particularly lung cancer, remains a leading cause of mortality worldwide, highlighting the need for new remedies. The brown algae species, C. indica , has gained attention for its rich phytochemical composition and pharmacological potential. This study evaluated the genotoxic and cytotoxic effects of C. indica extract on human gingival fibr...

Introduction Organic molecules that bind to cannabinoid receptors are known as cannabinoids. These molecules possess pharmacological properties similar to those produced by Cannabis sativa L. High‐performance liquid chromatography (HPLC) and ultra‐performance liquid chromatography (UPLC, also known as ultra‐high‐performance liquid chromatography, U...

Background: Amesiodendron chinense (Merr.) Hu (family: Sapindaceae) is a Thai medicinal plant. The seed oil of this species has been used by folk healers and local people in southern Thailand for the treatment of wounds, skin disorders and common hair problems. This study aimed at the GC-MS-based determination of the chemical composition of the see...

Nature possesses an inexhaustible reservoir of agents that could serve as alternatives to combat the growing threat of antimicrobial resistance (AMR). While some of the most effective drugs for treating bacterial infections originate from natural sources, they have predominantly been derived from fungal and bacterial species. However, a substantial...

Background The global spice industry, recognized for its aromatic profiles and culinary significance, is susceptible to issues of adulteration, mislabeling, and contamination. These practices compromise the integrity of spice products, undermining consumer trust and jeopardizing the economic interests of legitimate stakeholders. Scope and Approach...

Background This review highlights the critical need for innovative biomarkers in authenticating milk and its derivatives to ensure quality, authenticity and safety in the food industry. The limitations of traditional methods in detecting sophisticated adulteration techniques underscore the urgency for advanced solutions. Scope and approach The rev...

Piceatannol is a stilbenoid, which has shown bioactivities in various cell culture models. However, its stability in cell culture medium is not clear. Here, UPLC-MS/MS was applied in situ to analyze the degradation products of piceatannol in Dulbecco's Modified Eagle's Medium (DMEM) and cell culture to investigate the compound's stability in DMEM....

Arsenic toxicity is a major problem across the world due to geogenic activity and has been supposed to generate free radicals and genotoxicity among the arsenic-poisoned population. There is a need to find suitable free radical quenching compounds for the arsenic-induced free radical-affected population. In the present study, Na3AsO3- induced ox...

In recent years, the incidence of cancers, inflammatory diseases, Alzheimer's disease, glucose metabolism disorder and diabetes has increased alarmingly which demands more research into the discovery of new drug candidates to treat these human diseases. Main phytochemicals from Humulus lupulus L. (hops) have been demonstrated to have positive impac...

Aim While the traditional use of Cola rostrata in treating illnesses and diseases has not been reported, the presence of cytotoxic principles has been reported in phylogenetically and biogeographically related species within the Cola genus. This study, therefore, evaluated the cytotoxic potential of extracts of the plant, and the associated cellula...

Ceiba pentandra (L.) Gaertn. (Bombacaceae) is popular for the quality of its wood. However, its leaf, stem bark and root bark have been popular in ethnomedicine and, apart from the inflorescence, have been subject of extensive phytochemical investigations. In this study, two compounds were isolated from the crude methanol extract of the inflorescen...

Introduction Cannabinoids are a group of compounds that bind to cannabinoid receptors. They possess pharmacological properties like that of the plant Cannabis sativa . Gas chromatography (GC) is one of the popular chromatographic techniques that has been routinely used in the analysis of cannabinoids in different matrices. Objective The article ai...

Olax subscorpioidea Oliv. is an important medicinal plant included in African traditional anticancer medicines. Little information about its safety and toxicity appears in the literature. This study thus aimed at evaluating the safety of its methanol root extract orally administered in laboratory animals. Fourier Transform Infrared (FTIR) spectroph...

Bioactivity-guided phytochemical fractionation of the methanol extract of Olax subscorpioidea root has led to the isolation of six triterpenes. Three of these compounds are previously undescribed triterpenoid saponins: oleanolic acid 3-O-[α-L-rhamnopyranosyl-(1→3)-β-D-glucopyranosyl-(1 → 2)-6-O-methyl-β-D-glucuronopyranoside]-28-O-β-D-glucopyranosy...

Oliveria decumbens Vent., an annual herb resistant to harsh environmental conditions, is an aromatic medicinal plant of the Apiaceae family. O. decumbens has numerous pharmacological, food and feed, and cosmetic applications. This species is endemic to Iran, Iraq, and Turkey. Published literature, available until 30 November 2022 on the morphology,...

Introduction: In recent decades, quantitative structure-activity relationship (QSAR) analysis has become an important method for drug design and natural product research. With the availability of bioinformatic and cheminformatic tools, a vast number of descriptors have been generated, making it challenging to select potential independent variables...

Introduction: Azadirachta indica A. Juss. is a well-known medicinal plant that has been used traditionally to cure various ailments in every corner of the globe. There are many in vitro and in vivo experimental evidences in connection with the bioactivity of the extracts of this plant. Lung cancer is the deadliest form of cancer and contributes to...

Background: Arjunolic acid (AA) is a potent phytochemical with multiple therapeutics effects. In this study, AA is evaluated on type 2 diabetic (T2DM) rats to understand the mechanism of β-cell linkage with Toll-like receptor 4 (TLR-4) and canonical Wnt signaling. However, its role in modulating TLR-4 and canonical Wnt/β-catenin crosstalk on insul...

Skimmianine is a furoquinoline alkaloid which is found in the Zanthoxylum genus and also in other plants of the Rutaceae family. This study evaluated the effects of skimmianine on the production of pro-inflammatory mediators in LPS-activated BV-2 microglia. Cultured BV-2 cells were treated with skimmianine (10, 20 and 30 μM), followed by stimulatio...

Three-dimensional printing (3DP) allows production of novel fast dissolving oral films (FDFs). However, mechanical properties of the films may not be desirable when certain excipients are used. This work investigated whether adding chitosan micro-ribbons or cellulose microfibres will achieve desired FDFs by fused deposition modelling 3DP. Filaments...

Phoenix sylvestris Roxb. (Arecaceae) seeds are used in the treatment of diabetes in the traditional system of medicine. The present study evaluated antihyperglyce-mic and antioxidant activities as well as the total phenolic and flavonoid content of the methanol extract of P. sylvestris seeds (MEPS). The constituents of the extract were identified b...

Background: Olax subscorpioidea Oliv. (Olacaceae) is a woody shrub that is widely distributed in Africa. It has trado-medicinal importance and is used in the treatment of asthma, cancer, convulsion, diabetes, intestinal worm infections, jaundice, mental illnesses, neurodegenerative disorders, sexually transmitted infections, swellings and rheumatis...

Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other therapeutically relevant biological properties, e...

Abstract Objectives Lung cancer is the commonest cause of cancer-related deaths, and current treatment involves the use of cytotoxic drugs which have many unwanted side-effects. Resveratrol, a natural polyphenol, has promising anticancer efficacy, but its therapeutic application is hindered by low bioavailability, which this study sought to improve...

The manipulation of matter on an atomic, molecular and supramolecular scale is known as nanotechnology; simply, it is the direct manipulation of materials at the nanoscale. It incorporates particles with dimensions and tolerances of 1-100 nanometres (nm). While the concept of nanotechnology was first introduced by Richard Feynman in 1959, the term...

Nanoparticles or ultrafine particles are the particles with the diameter ranging from 1 to 100 nanometres (nm), and possess distinctly different physicochemical properties, for example, colloidal properties, compared to that of microparticles or coarse particles. In recent years, nanoparticles have found their applications in medicine, particularly...

Arbutus pavarii Pamp. (Fam. Ericaceae), an endemic Libyan medicinal plant, is commonly known as "Shmeri", "Shmar" or "Libyan Strawberry", and almost exclusively found in the Al-Jabel Al-Akhdar mountainous region in Libya. This plant is a forage species for honeybees and thus, is important for honey production. A. pavarii has long been used in Libya...

Angelica archangelica (Fam. Apiaceae) roots were extracted sequentially with n-hexane, dichloromethane (DCM) and methanol (MeOH) using a Soxhlet apparatus. The n-hexane and DCM extracts were fractionated by Vacuum Liquid Chromatography (VLC) over silica gel followed by Preparative Thin Layer Chromatography (PTLC) to yield two coumarins, osthol (1)...

Objectives The recent emergence of the COVID-19 pandemic (caused by SARS-CoV-2) and the experience of its unprecedented alarming toll on humanity have shone a fresh spotlight on the weakness of global preparedness for pandemics, significant health inequalities, and the fragility of healthcare systems in certain regions of the world. It is imperativ...

The Sundarbans, a UNESCO world heritage site, is one of the largest mangrove forests in one stretch. Mangrove plants from this forest are little studied for their endophytic fungi. In this study, we isolated fourteen endophytic fungi from the plants Ceriops decandra and Avicennia o cinalis collected from the Sundarbans. Five of them were identi ed...

In Biomolecules from Natural Sources: Advances and Applications, a team of accomplished researchers delivers up-to-date information on various bioresources, bioprocessing, production, mechanisms of action for selective bioactivity, biochemistry, targeted therapeutic roles and the advancements made on their bioactive potentials of new and novel biom...

The genus Ficus is one of the largest genera of the mulberry family (Moraceae) consisting of about 800 species of woody trees, shrubs, vines and climbers collectively known as ‘figs’ occurring in most tropical and subtropical forests worldwide. Fig plants are known for their ethnopharmacological, therapeutic and commercial importance and have been...

Alternanthera philoxeroides (Mart.) Griseb., commonly known as “Alligator weed” in English, and “Malancha” in Bengali, is a leafy vegetable from the family Amaranthaceae A. L. de Jussieu. This species is native to China, particularly to the provinces around the Yangtze River, other Far East and South-East Asian countries, and countries from other c...

The current global antimicrobial resistance (AMR) crisis is a serious hazard to public health, food security, and development. Drug-resistant pathogens diminish the effectiveness of conventional antibiotics, thereby leading to frequent therapeutic failures and reducing the available antibiotic armory. There is an increasing risk of therapeutic impa...

Nitric oxide (NO), an endogenous important signaling molecule, is being placed inside the cell and also between cells of the plants, animals, and bacteria cells. It participates in almost all cellular and bodily functions; it has a significant role in homeostasis in the regulation of the central nervous system, gastrointestinal, respiratory, genita...

Background: Leea indica (Burm. f.) Merr. (fam. Vitaceae), commonly known as 'bandicoot berry', is a Thai medicinal plant, and distributed widely in the far-east and southeast Asian countries, and in some parts of northern Australia. In Thailand, this plant has traditionally been used for the treatment of diarrhoea, pain, gastric ulcer, viral infect...

Received: 03/02/2022 Background Three-dimensional printing (3DP) has been investigated widely for applications in pharmaceutical sciences. Different 3DP techniques have been employed such as fused deposition modelling (FDM 3DP), powder bed 3DP, stereolithography 3DP (SLA 3DP), selective laser sintering (SLS 3DP), pates-extrusion 3DP and inkjet 3DP....

High-performance liquid chromatography (HPLC), is considered as the most powerful and versatile chromatographic separation techniques for chemical profiling or fingerprinting the components in a herbal mixture and also to identify and quantify the phyto-components. This chapter focuses on the applications of HPLC techniques, including UPLC (ultra-p...

Malaria was successfully treated with both natural and synthetic products. However , recent progress in battling malaria has stalled due to drug resistance. Therefore , the search of novel antimalarials capable of reversing or evading resistance is much needed and this could be achieved through ethnomedicinal approaches. Six medicinal plants were s...