Satyajit Sarker

Satyajit Sarker
Liverpool John Moores University | LJMU · School of Pharmacy and Biomolecular Sciences

BPharm (Hons), MPharm, PhD, FHEA

About

773
Publications
164,739
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Introduction
Professor of Pharmacy Director of School of Pharmacy and Biomolecular Sciences Liverpool John Moores University Editor-in-Chief, Phytochemical Analysis
Additional affiliations
October 2013 - present
Liverpool John Moores University
Position
  • Professor of Pharmacy, Director of School of Pharmacy & Biomolecular Sciences
November 2008 - September 2013
University of Wolverhampton
Position
  • Professor of Pharmacy, Deputy Head and Research Leader of Pharmacy
November 2004 - October 2008
Ulster University
Position
  • Reader in Pharmacy
Education
September 1991 - February 1995
University of Strathclyde
Field of study
  • Pharmaceutical Sciences (Phytochemistry)

Publications

Publications (773)
Chapter
The manipulation of matter on an atomic, molecular and supramolecular scale is known as nanotechnology; simply, it is the direct manipulation of materials at the nanoscale. It incorporates particles with dimensions and tolerances of 1-100 nanometres (nm). While the concept of nanotechnology was first introduced by Richard Feynman in 1959, the term...
Chapter
Nanoparticles or ultrafine particles are the particles with the diameter ranging from 1 to 100 nanometres (nm), and possess distinctly different physicochemical properties, for example, colloidal properties, compared to that of microparticles or coarse particles. In recent years, nanoparticles have found their applications in medicine, particularly...
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Arbutus pavarii Pamp. (Fam. Ericaceae), an endemic Libyan medicinal plant, is commonly known as "Shmeri", "Shmar" or "Libyan Strawberry", and almost exclusively found in the Al-Jabel Al-Akhdar mountainous region in Libya. This plant is a forage species for honeybees and thus, is important for honey production. A. pavarii has long been used in Libya...
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Angelica archangelica (Fam. Apiaceae) roots were extracted sequentially with n-hexane, dichloromethane (DCM) and methanol (MeOH) using a Soxhlet apparatus. The n-hexane and DCM extracts were fractionated by Vacuum Liquid Chromatography (VLC) over silica gel followed by Preparative Thin Layer Chromatography (PTLC) to yield two coumarins, osthol (1)...
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Objectives The recent emergence of the COVID-19 pandemic (caused by SARS-CoV-2) and the experience of its unprecedented alarming toll on humanity have shone a fresh spotlight on the weakness of global preparedness for pandemics, significant health inequalities, and the fragility of healthcare systems in certain regions of the world. It is imperativ...
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The Sundarbans, a UNESCO world heritage site, is one of the largest mangrove forests in one stretch. Mangrove plants from this forest are little studied for their endophytic fungi. In this study, we isolated fourteen endophytic fungi from the plants Ceriops decandra and Avicennia o cinalis collected from the Sundarbans. Five of them were identi ed...
Book
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In Biomolecules from Natural Sources: Advances and Applications, a team of accomplished researchers delivers up-to-date information on various bioresources, bioprocessing, production, mechanisms of action for selective bioactivity, biochemistry, targeted therapeutic roles and the advancements made on their bioactive potentials of new and novel biom...
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Alternanthera philoxeroides (Mart.) Griseb., commonly known as “Alligator weed” in English, and “Malancha” in Bengali, is a leafy vegetable from the family Amaranthaceae A. L. de Jussieu. This species is native to China, particularly to the provinces around the Yangtze River, other Far East and South-East Asian countries, and countries from other c...
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Nitric oxide (NO), an endogenous important signaling molecule, is being placed inside the cell and also between cells of the plants, animals, and bacteria cells. It participates in almost all cellular and bodily functions; it has a significant role in homeostasis in the regulation of the central nervous system, gastrointestinal, respiratory, genita...
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The current global antimicrobial resistance (AMR) crisis is a serious hazard to public health, food security, and development. Drug-resistant pathogens diminish the effectiveness of conventional antibiotics, thereby leading to frequent therapeutic failures and reducing the available antibiotic armory. There is an increasing risk of therapeutic impa...
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Background: Leea indica (Burm. f.) Merr. (fam. Vitaceae), commonly known as 'bandicoot berry', is a Thai medicinal plant, and distributed widely in the far-east and southeast Asian countries, and in some parts of northern Australia. In Thailand, this plant has traditionally been used for the treatment of diarrhoea, pain, gastric ulcer, viral infect...
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Received: 03/02/2022 Background Three-dimensional printing (3DP) has been investigated widely for applications in pharmaceutical sciences. Different 3DP techniques have been employed such as fused deposition modelling (FDM 3DP), powder bed 3DP, stereolithography 3DP (SLA 3DP), selective laser sintering (SLS 3DP), pates-extrusion 3DP and inkjet 3DP....
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High-performance liquid chromatography (HPLC), is considered as the most powerful and versatile chromatographic separation techniques for chemical profiling or fingerprinting the components in a herbal mixture and also to identify and quantify the phyto-components. This chapter focuses on the applications of HPLC techniques, including UPLC (ultra-p...
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Malaria was successfully treated with both natural and synthetic products. However , recent progress in battling malaria has stalled due to drug resistance. Therefore , the search of novel antimalarials capable of reversing or evading resistance is much needed and this could be achieved through ethnomedicinal approaches. Six medicinal plants were s...
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Purpurogallin (PPG), an orange-red crystalline compound from nutgalls and oak bark, is an exemplar of numerous, ubiquitous natural colorants, biosynthesized through oxidative dimerization-decarboxylation of phenolic compounds. It possesses antioxidant, anticancer, and anti-inflammatory effects. Herein, a robust method is presented to allow students...
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Plants act as a rich source of novel natural pesticides. In the backdrop of the recent revival of interest in developing plant-based insecticides, this study was carried out to investigate the pesticidal activity of Sundarban mangrove plants. A total of nine different plant parts from five plants, namely, Aegiceras corniculatum, Excoecaria agalloch...
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The aim of the study was to compare the physicochemical parameters, sugar, vitamin C, and phenolic profiles in five genotypes of local indeterminate tunnel tomato hybrid (LITTH) (LITTH-778, LITTH-784, LITTH-786, LITTH-788, and LITTH-790) of natural parthenocarpic tomato (NPT) and normal seeded tomato (NST). Samples were collected from the experimen...
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Xylaria species associated with termite nests or soil have been considered rare species in nature and the few which have been reported upon have been found to act as a rich source of bio-active metabolites. This study evaluated 10 ethyl acetate extracts of five new Xylaria species associated with termite nests or soil for their antioxidant activity...
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Background Uvaria chamae (UC) and Olax subscorpioidea (OS) roots are included in traditional anti-cancer remedies and some studies have identified their chemopreventive/chemotherapeutic potential. This study aimed to identify some cellular/molecular mechanisms underlying such potential and the associated chemical constituents. Methods Effect on th...
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Background: Erythrina fusca Lour. (fam. Fabaceae) is a flowering tree, found extensively in tropical and subtropical Asian countries, and is known for its use in traditional medicine for the treatment of various human ailments, for example, fever, liver complications, infections, and headaches. Objective: To carry out phytochemical study, and antim...
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The aim of this review article is to present, for the first time, an appraisal of the phytochemical, ethnobotanical and pharmacological data on Bunium species. The literature search was conducted using the Scopus, Google Scholar and PubMed databases. The genus Bunium has been found to produce both essential oil (EO) , mainly comprising monoterpenes...
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Chalcones belong to the flavonoid class of phenolic compounds. They form one of the largest groups of bioactive natural products. The potential anticancer, anti-inflammatory, antimi-crobial, antioxidant, and antiparasitic properties of naturally occurring chalcones, and their unique chemical structural features inspired the synthesis of numerous ch...
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The Natural Resources for Human Health (NRFHH): An interdisciplinary new journal dedicated to natural sciences is published by Visagaa Publishing House. The editorial board is leaded by Highly Cited Researcher Prof. Jesus Simal-Gandara, together with many other internationally recognised researchers. The editorial board comprises of 38 editors from...
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Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different species, mainly distributed in the Mediterranean region. Ruta species have long been used in traditional medicines as an abortifacient and emmenagogue and for the treatment of lung diseases and microbial infections. The genus Ruta is rich in essential oil...
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Anthocyanins are naturally occurring water-soluble plant pigments belonging to the flavonoids chemical class. The red, blue and purple colours of leaves, flowers and fruits of plants confirm that they are rich sources of anthocyanins. Many in vivo and in vitro studies reveal that anthocyanins have different health beneficial effects such as antioxi...
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The plant-derived bioflavonoid amentoflavone has many important biological activities, among them remarkable antiviral effects, even against severe acute respiratory syndrome coronavirus (SARS-CoV). It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) with an IC50value of 8.3 µM. TMPRSS-2 activity is now thought to be the only facto...
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Oxyresveratrol (OXY) is a small molecule of phytochemical known as hydroxystilbenoids, which have been reported significantly important biological activities. The aim of this study was to elucidate the gene expression and biological pathways altered in MCF7, breast cancer cells. The cytotoxicity to different cancer cell lines was screened using MTT...
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Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Bee pollen contains bioactive compounds including protein...
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Abstract: Antifungal activity of Monotheca buxifolia methanolic extract and its various fractions were assessed against Macrophomina phaseolina, a soil-borne fungal pathogen of more than 500 vegetal species. Different concentrations of methanolic extract (3.125 to 200 mg mL-1) inhibited fungal biomass by 39-45%. Isolated n-hexane, chloroform, and e...
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Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted t...
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Ruta chalepensis L. (Rutaceae), a perennial herb with wild and cultivated habitats, is well known for its traditional uses as an anti-inflammatory, analgesic, antipyretic agent, and in the treatment of rheumatism, nerve diseases, neuralgia, dropsy, convulsions and mental disorders. The an-timicrobial activities of the crude extracts from the fruits...
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The cancer chemopreventive potential of various solvent extracts from six medicinal plants was evaluated by their ability to activate the transcription factor Nrf2 using AREc32 cells, which contain a luciferase gene under the control of antioxidant responsive element promoters. Nrf2 regulates the expression of many detoxification enzymes, making it...
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Objectives The effects of a root extract of Zanthoxylum zanthoxyloides on neuroinflammation in BV-2 microglia stimulated with LPS and hemozoin were investigated. Methods ELISA, enzyme immunoassay and Griess assay were used to evaluate levels of cytokines, PGE2 and NO in culture supernatants, respectively. Microglia-mediated neurotoxicity was evalu...
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Background Endophytic fungi play a vital role in plant defense system by secreting various antimicrobial agents. To evaluate the antimicrobial activity of the endophytic fungi of the mangrove plant Heritiera fomes (Buch. -Ham), plants were collected from the Sundarbans, Bangladesh. The endophytic fungi were subsequently isolated and identified. Re...
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Professor Bidyut Kanti Datta, a renowned professor of the Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, died at the age of 73 on Friday 11 September 2020 in Canada (Canadian time 7.10 am and BD time 5.10 pm), as a consequence of COVID-19 infection followed by pneumonia. This article is a brief review of his research work where t...
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Alzheimer's disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of...
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Cassia singueana L. is widely used in traditional medicine for the treatment of various ailments. The present work was set to investigate the antioxidant and antimicrobial activity of this plant and its secondary metabolites. Three bioactive compounds, lupeol, eugenol and octadecadienoic acid methyl ester, were isolated from the root extract of the...
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Calanolides are tetracyclic 4-substituted dipyranocoumarins. Calanolide A, isolated from the leaves and twigs of Calophyllum lanigerum var. austrocoriaceum (Whitmore) P. F. Stevens, is the first member of this group of compounds with anti-HIV-1 activity mediated by reverse transcriptase inhibition. Calanolides are classified pharmacologically as no...
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The influence of commercial prebiotics (fructo-oligosaccharides and inulin) and sugars (glucose and sucrose) on enhancing equol production from soymilk isoflavones by Bifidobacterium longum BB536 and Bifidobacterium breve ATCC 15700 was evaluated in vitro. Sterilized soymilk was inoculated with each bacterial species at 37 °C for 48 h. The growth a...
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Nature has provided prodigious reservoirs of pharmacologically active compounds for drug development since times. Physcion and physcion 8-O-β-D-glucopyranoside (PG) are bioactive natural anthraquinones which exert anti-inflammatory and anti-cancer properties with minimum or no adverse effects. Moreover, physcion also exhibits anti-microbial and hep...
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The continuing rise in cancer morbidity and mortality all over the world makes cancer the No. 2 cause of death in humans, posing a major public health challenge. Currently, surgery, radiotherapy, and chemotherapy are the three major approaches to treat cancer. However, the disadvantages of serious side effects, and poor therapeutic effect of the af...
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The first review article on steroid dimers by Li and Dias in 1997, followed by the second review and a book on steroid dimers by Nahar and Sarker in 2007 and 2012, respectively, covered steroid dimers reported until the end of 2010. Since then, there have been considerable amounts of research carried out on steroid dimers, prompting the need for an...
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Introduction: Organic molecules that interact with the cannabinoid receptors are called cannabinoids, which can be endogenous, natural or synthetic compounds. They possess similar pharmacological properties as produced by the plant, Cannabis sativa L. Before cannabinoids can be analysed, they need to be extracted from the matrices. Objective: To...
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Plukenetia huayllabambana is an edible plant traditionally used to cure wounds and various infections. The present work assessed, for the first time, the antibacterial efficacy of solvent fractions from P. huayllabambana fruits. The crude methanol extract was obtained applying ultrasound-assisted extraction, followed by partitioning through success...
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Phenylethanoid glycosides (PhGs) are generally water‐soluble phenolic compounds that occur in many medicinal plants. Until June 2020, more than 572 PhGs have been isolated and identified. PhGs possess antibacterial, anticancer, antidiabetic, anti‐inflammatory, antiobesity, antioxidant, antiviral, and neuroprotective properties. Despite these promis...
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Phytochemical study of the leaves and the stem bark of Pseudospondias microcarpa (A. Rich.) Engl. afforded eight phenolic compounds: scopoletin (1), ferulic acid (2), isovitexin (3), rhoifolin (4), quercetin 3-O-α-L-rhamnopyranoside (5), justicialoside A (6), granduloside A (7) and pithecellobiumol B (8). The structures of the isolated compounds we...
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Nature as an infinite treasure of chemotypes and pharmacophores will continue to play an imperative role in the drug discovery. Natural products (NPs) such as plant and fungal metabolites have emerged as leads in drug discovery during recent years due to their efficacy, safety and selectivity. The current review summarizes natural sources as well a...
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Background Garlic (Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so fa...
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Plant-derived natural products have shown beneficial effects in many diseases associated with liver. The present study aimed to appraise the effects of Trichosanthes dioica (TD) peel extract on oxidative stress, inflammation as well as fibrosis exhibited by the ovariectomized rats in which hepatic damage had been induced by the administration of ca...
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Although the first antibiotic, penicillin, was discovered in 1928 from a microbial natural source (a mold, Penicillium notatum), there is earlier evidence of using natural materials including molds and herbs for the treatment of infections. Following the serendipitous discovery of penicillin by Alexander Fleming, there have been hundreds of antibio...
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The genus Opopanax W.D.J. Koch is a member of the Apiaceae family, distributed throughout the Mediterranean region and comprises only three recognized and well-defined species, O. chironium (L.) W.D.J. Koch, O. hispidus (Friv.) Griseb. and O. persicus Boiss. The species of this genus with yellow flowers are well-known in traditional medicine and co...
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The species of the genus Lagochilus (Lamiaceae) are widespread in Central, South-Central, and Eastern Asia. Some of these species are used for their medicinal and therapeutic effects, in particular as hemostatic, anti-inflammatory and anti-epileptic agents. A new iridoid, glucoside 7- cinnamoyllamalbide, along with known compounds lagochilin, 5-hyd...
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Artocarpus lakoocha Wall. ex Roxb. (family: Moraceae) has been used as a traditional Thai medicine for the treatment of various parasitic diseases. This species has been reported to be the source of phytochemicals, which show potent biological activities. The objective of this study was to investigate the phytochemical profile of the extracts of th...
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The Solanaceae is an important plant family that has been playing an essential role in traditional medicine and human nutrition. Members of the Solanaceae are rich in bioactive metabolites and have been used by different tribes around the world for ages. Antimicrobial peptides (AMPs) from plants have drawn great interest in recent years and raised...
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Cancer, one of the major causes of human morbidity and mortality, is a disease caused by uncontrolled division of abnormal cells. It is estimated that there will be approximately 20 million new cancer cases globally by the end of the year 2025, which clearly demonstrates the need for finding more effective and safer treatment options for cancers th...