Sasidhar Rlc

Sasidhar Rlc
Chebrolu Hanumaiah Institute of Pharmaceutical Sciences | CHIPS · Department of Pharmaceutics

M.Pharm, Ph.D

About

64
Publications
21,365
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299
Citations
Citations since 2016
24 Research Items
255 Citations
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
Introduction
Development of Controlled release Dosage Forms, Solubility Enhancement of Certain Poorly Soluble Drugs
Education
October 2004 - July 2006

Publications

Publications (64)
Article
The objective of the present study was to develop floating microballoons of captopril in order to achieve an extended gastric retention in the upper GIT which may enhance the absorption and improve bioavailability. The floating microballoons were formulated with calcium silicate as porous carrier, Eudragit L100 and ethyl cellulose 7 cps as coating...
Article
A series of 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazole-2(3H)-one derivatives have been synthesized and characterized by various spectroscopic techniques including FTIR, mass and 1H NMR. In current study, we have followed standard methods for the synthesis of novel molecules, docking and screening against mycobacterium species. The compounds w...
Article
Full-text available
Objective: In the present investigation, an attempt was made to improve the surface characters and solubility of the drug by solid dispersion and coating it on the nonpareil sugar beads as pellets. Methods: Ezetimibe solid dispersions were prepared by kneading method using soluplus. Crospovidone was added as a disintegrant in pellets. Ezetimibe pel...
Article
Full-text available
Objective: The present study deals with the formulation and evaluation of fast dissolving buccal films for effective treatment option in the gastroesophageal reflux disease.Methods: Esomeprazole fast dissolving buccal films are a convenient formulation of which can be taken with or without water. In the present investigation, polyvinyl alcohol and...
Article
Full-text available
Objective: The objective and purpose of the analysis have sensibly assessed by selecting of a rapid and sensitive RP-HPLC method for Entecavir in bulk and pharmaceutical dosage form by using the most commonly employed C-18column with UV detection.Methods: In estimation by RP-HPLC method Agilent 1120 compact LC system with variable programmable UV d...
Article
A simple, precise, reliable, rapid and reproducible reversed-phase high performance liquid chromatography method was developed and validated for the simultaneous estimation of Tetracaine HCl and Oxymetazoline HCl chromatography is carried out isocratically on Xbridge C18 (250 × 4.6 mm, 5µm) with a mobile phase composed of 0.1% OrthoPhosphoric Acid...
Article
The present paper illustrates about development and validation of a new, simple, precise and accurate RP-HPLC method with enhanced sensitivity for the simultaneous determination of Doxylamine Succinate (DAS) and Pyridoxine Hydrochloride (PDH) in bulk and its dosage forms. The drug showed good absorbance in mobile phase at 263 nm. Under the optimize...
Article
Full-text available
Background: In the present investigation, an attempt was made to isolate starch from jackfruit seed powder and utilize it as a superdisintegrant to design fast dissolving tablets of irbesartan. Methods: Starch was isolated from jackfruit seeds via aqueous and alkali extraction processes and evaluated for its physicochemical properties, for phytoche...
Article
A novel stability indicating reverse phase liquid chromatographic method has been developed for the simultaneous estimation of Losartan Potassium, Ramipril and Hydrochlorothiazide in bulk and Pharmaceutical formulations by using reverse phase Kromasil 100-5 C18 column [250mm x 4.6mm].The mobile phase (Methanol: phosphate buffer-pH 4.0) in the ratio...
Article
Full-text available
A new reverse phase-high performance liquid chromatography (RP-HPLC) have been developed and validated for the determination of Erlotinib in bulk drug and pharmaceutical dosage form. The developed method is rapid, accurate, precise, simple and economical. The separation was carried out using column Hypersil ODS C-18 (150 mm x 4.6 mm 5 μm particle s...
Article
Full-text available
A stability indicating RP-HPLC method was developed for the simultaneous estimation of the anti hypertensive drugs Hydrochlorothiazide, Amlodipine Besylate and Telemisartan. These drugs were subjected to stress studies under different conditions as per ICH guidelines. The separations were carried out using C18 reverse phase column (Agilent ODS UG 5...
Article
Full-text available
The present study describes the development and validation of stability indicating RP - HPLC method for the estimation of nelarabine, a chemotherapy drug. Nelarabine was subjected to stress studies under different conditions as per ICH guidelines. The separations were carried out using C18 Reverse Phase Column (Cosmicsil Adge 150 × 4.6 mm, 5μm) emp...
Article
Full-text available
The objective of present study was to improve solubility and dissolution rate of rosuvastatin by formulating it as a self micro emulsifying drug delivery system (SMEDDS). The SMEDDS were prepared by using capmul McM and capryol 90 as oils Polaxomer 407 as surfactant and Transcutol hP and Soluphor P as co-surfactants. The liquid SMEDDS were then con...
Article
Full-text available
The present research work was focussed on the preparation as well as the evaluation of Aceclofenac solid dispersions for analgesic, anti-inflammatory and immunosuppressant activities. Solid dispersions were formulated using cros-carmellose sodium as polymer in different ratios. The solid dispersions were prepared using physical mixture, solvent eva...
Article
Full-text available
Aim: The present work was aimed to formulate Verapamil hydrochloride (HCl) an antihypertensive agent as controlled release (CR) matrix tablets using naturally occurring hydrophobic gum such as dammar gum as a polymer. Methods: In the present investigation, an attempt was made to induce hydrogel formation using polyelectrolytes such as calcium hydro...
Article
Full-text available
The objective of the present investigation is to prepare and evaluate the sustained release matrix tablets of Diltiazem hydrochloride. In this investigation, sustained release matrix tablets of Diltiazem hydrochloride were prepared using a natural polymer, is Gum karaya. Total twelve formulations (DK1-DK12) were prepared by using different proporti...
Article
The present paper illustrates about development and validation of a new, simple, precise and accurate Spectrophotometric and RP-HPLC method with enhanced sensitivity for the determination of the antidepressant paroxetine (PXT) in bulk and its dosage forms. The drug showed good absorbance in water at 294 nm, hence water is selected as a solvent and...
Article
Osmotically controlled oral drug delivery systems utilize osmotic pressure as energy source for the controlled delivery of drugs, independent of pH and hydrodynamic conditions of gastro intestinal tract (GIT). The present study was aimed to develop osmotic controlled extended release formulations of Verapamil Hydrochloride an angiotensin II recepto...
Article
In the present work an attempt has been made to increase the solubility and dissolution rate of lansprozole by formulating it as solid dispersions by lipid carriers such as compritol 888 ATO Phospholipon 90 H and Lipoid S100 by using Fusion method, Kneading method and solvent evaporation method. Further the solid dispersions were compressed as orod...
Article
Aim: The present investigation highlights the formulation and evaluation of matrix tablets of propranolol hydrochloride (HCl) using a natural polymer, is gum kondagogu. Materials and Methods: Wet granulation method was used for the preparation of matrix tablets of propranolol HCl using varying proportions of natural polymer as a release retardant,...
Article
Aim: This study deals with the formulation of fast dissolving buccal films of doxylamine succinate is an antihistaminic commonly used for the prevention and treatment of nausea and vomiting in pregnancy. Doxylamine is a histamine H1 antagonist with pronounced sedative properties. It is used in allergies, antiemetic, and hypnotic. Doxylamine has als...
Article
A simple, rapid, specific and precise liquid chromatography–tandem mass spectrophotometric (LC-MS/MS) method was developed and validated for quantification of Erlotinib, in human plasma. Erlotinib d6 was used as internal standard, added to plasma sample prior to extraction using acetonitrile as a precipitating agent. Chromatographic separation was...
Article
A simple, rapid, specific and precise liquid chromatography-tandem mass spectrophotometric (LC-MS/MS) method was developed and validated for quantification of busulfan, in human plasma. busulfan d8 was used as internal standard, added to plasma sample prior to extraction using acetonitrile as a precipitating agent. Chromatographic separation was ac...
Article
Full-text available
The objective of present study was to improve solubility and dissolution rate of rosuvastatin by formulating it as a self micro emulsifying drug delivery system (SMEDDS). The SMEDDS were prepared by using capmul McM and capryol 90 as oils Polaxomer 407 as surfactant and Transcutol hP and Soluphor P as co-surfactants. The liquid SMEDDS were then con...
Article
Full-text available
In the present investigation an attempt has been made to formulate medicated lozenges containing amoxicillin trihydrate. There are several amoxicillin trihydrate dosage forms in the market such as tablet, capsule, suspension and syrup. Still there is a need for more variant dosage forms which acts effectively and locally. The benefits of the presen...
Article
Full-text available
Purpose: To prepare and characterize tablets loaded with self-nanoemulsifying drug delivery system (SNEDDS) containing docetaxel (DTL). Method: SNEDDS of docetaxel were prepared using various oils, surfactants, co-surfactant and solvents to improve the dissolution rate and bioavailability of the poorly water-soluble chemotherapeutic agent. The SNED...
Article
Full-text available
The present study deals with the formulation of fast dissolving films of Rizatriptan benzoate that is used for the treatment of Migraine. The concept of fast-dissolving drug delivery emerged from the desire to provide patient with more conventional means of taking their medication. In the present research work, various trials were carried out using...
Article
The purpose of the present study was to formulate valsartan nanosuspension to increase the aqueous solubility and to improve its oral bioavailability. Valsartan is a poorly water-soluble drug which results in its insufficient bioavailability. Low oral bioavailability of poorly water-soluble drugs poses a great challenge during drug development. Poo...
Article
Full-text available
The objective of the present study was to investigate the influence of polymer level and type of some hydrophobic polymers, Dammar gum and Copal gum with meltable carriers such as Poly ethylene glycol 6000 (PEG 6000) and carnauba wax, on the release rate and mechanism of lamivudine (LM) from matrix tablets prepared by hot- melt granulation techniqu...
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Full-text available
A cataract is a condition where clouding of the eye’s natural lens occurs. It acts a major complication in case of diabetes mellitus. The present study investigates the effect ofmethanolic extract ofZiziphusxylopyrus fruiton cataract induced by glucose. Ziziphusxylo pyrus, a traditional folklore plant has antioxidant, antiulcer properties. Goat eye...
Article
Full-text available
Rizatriptan Benzoate is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain. The aim of present work is to...
Article
Full-text available
A. Abstract: a formulation of Fast dissolving Tablets (FdTs) using solid dispersions (sds) and cyclo-dextrin (cd)-based complexes will improve the solubility, dissolution rate and, hence, bioavailability of certain poorly soluble drugs. In the present study, an attempt was made to improve the solubility and dissolution rate of Telmisartan by sd tec...
Article
Full-text available
A. Abstract: a formulation of Fast dissolving Tablets (FdTs) using solid dispersions (sds) and cyclo-dextrin (cd)-based complexes will improve the solubility, dissolution rate and, hence, bioavailability of certain poorly soluble drugs. In the present study, an attempt was made to improve the solubility and dissolution rate of Telmisartan by sd tec...
Article
Full-text available
A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Hydrochlorothiazide, Amlodipine Besylate and Telmisartan in pharmaceutical formulation using RP - C18 column. The mobile phase (acetonitrile: acetate buffer adjusted to pH 5 with orthophosphoric acid) was pumped at a flow rate of 1.0...
Article
Full-text available
Osmotically controlled oral drug delivery systems utilize osmotic pressure as energy source for the controlled delivery of drugs, independent of pH and hydrodynamic conditions of gastro intestinal tract (GIT). The present study was aimed to develop osmotic controlled extended release formulations of Losartan potassium an angiotensin II receptor ant...
Article
Full-text available
Solubility is an important physicochemical factor affecting absorption of drug and it's therapeutic effectiveness. The present research work is to improve the solubility and dissolution rate of olmesartan medoxomil by complexation with HP ß-Cyclodextrins. The inclusion complexes were prepared by lyophilization and solvent evaporation method. The pr...
Article
Full-text available
The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. Many different methods have been tried over a long period for enhancing the solubility of poorly soluble drugs. Preparing a solid dispersion is one among the methods. Solid dispersions in water-soluble carriers have shown promising results as a...
Article
Venlafaxine hydrochloride is used in the treatment of depression and anxiety disorders. The objective of the present study was to prepare the orodispersible tablets of venlafaxine hydrochloride by sublimation method. Camphor and menthol are used as subliming agents. Tablets are prepared by direct compression process with calcium silicate and sodium...
Article
Full-text available
A simple, fast, precise reverse phase isocratic high performance liquid chromatographic (HPLC) method has been developed for the simultaneous estimation of Olmesartan medoxomil (OM) and hydrochlorothiazide (HCTZ) in marketed formulations. Estimation of drugs in this combination was done with a C18 column [ODS UG 5 column, 250mm × 4.5mm] using mobil...
Article
Osmotically controlled oral drug delivery systems utilize osmotic pressure as energy source for the controlled delivery of drugs, independent of pH and hydrodynamic conditions of gastrointestinal tract (GIT). The present study was aimed to develop osmotic controlled extended release formulations of verapamil hydrochloride an angiotensin II receptor...
Article
Full-text available
A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous estimation of hydrochlorothiazide, amlodipine besylate and telmisartan in bulk and in combined tablet dosage form. The stock solutions were prepared in methanol followed by the further required dilutions with distilled water...
Article
The objective of this study was to develop a solid dispersion method for enhancing the aqueous solubility of aprepitant (BCS class II drug). In the present study a simplified definitive equivalent formulation is targeted by preparing a solid dispersion using hot melt extrusion. Model formulation isolated from a range of carrier-plastizer mixtures b...
Article
The present investigation was focused on the development and evaluation of controlled release pellets of losartan potassium with eudragit S 100 and hydroxypropyl methyl cellulose phthalate (HPMCP) by employing pan coating technique. eudragit S 100, a high viscosity grade controlled release polymer, was mainly used as coating agent for regulating th...
Article
Full-text available
A new rapid, precise and sensitive reverse phase high performance liquid chromatographic (RP-HPLC) method hss been developed snd validated for the estimstion of cinitspride snd pantoprazole simultaneously in combined dosage form. The two components cinitapride and pantoprazole were well resolved on an isocratic 018 column, utilizing a mobile phase...
Article
Physicochemical properties such as low solubility or high lipophilicity were the major unavoidable problems faced by the pharmaceutical industry in the development of a pharmacologically active substance with relevant activity and minimum toxicity. Hence, various techniques are used for the improvement of the solubility of poorly water soluble drug...
Article
Full-text available
The aim of the present study was to develop controlled-release pellets of diltiazem HCl with ethyl cellulose and hydroxylpropyl methylcellulose phthalate as the release rate retarding polymers by fluid bed coating technique. The prepared pellets were evaluated for drug content, particle size, subjected to Scanning Electron Microscopy (SEM) and Diff...
Article
Full-text available
In the present investigation an attempt has been made to increase therapeutic efficacy, reduced frequency of administration and improved patient compliance by developing controlled release matrix tablets of verapamil hydrochloride. Verapamil hydrochloride was formulated as oral controlled release matrix tablets by using the polyethylene oxides (Pol...
Article
The purpose of the present study was to prepare an acceptable nanosuspension of ritonavir by increasing the aqueous solubility, dissolution and hence oral bioavailability. Ritonavir is having low aqueous solubility and high permeability which can be considered as drug belonging to class-II according to BCS. In this study nanosuspension technology w...
Article
The present investigation was mainly focused on the development of controlled release pellets of verapamil HCl with ethyl cellulose and hydroxylpropyl methyl cellulose phthalate (HPMCP) by employing PAN coating technique. Ethyl cellulose 7cps a high viscosity grade controlled release polymer was mainly used as coating agent for regulating the drug...
Article
The present study deals with the formulation of fast dissolving buccal films of Zolmitriptan which is used for thetreatment of Migraine. The concept of fast dissolving drug delivery emerged from the desire to provide patient withmore conventional means of taking their medication. In the present research work polyvinyl alcohol and polyvinylpyrrolidi...
Article
Full-text available
A simple precise and economical reverse phase high performance liquid chromatographic method has been developed and validated for the estimation of atenolol and nifedipine simultaneously in combined dosage form. The method was developed using agilent ODS C18 column with a mobile phase constituting of methanol:acetonitrile:phosphate buffer(60:20:20)...
Article
Full-text available
A simple, accurate and precise reverse phase high performance liquid chromatography (RPHPLC) method has been developed and validated for the simultaneous determination of aspirin and simvastatin in combined dosage form. Separation was performed on a C18 column [ODS column, 250mm × 4.5mm with particle size 5μm. with a mobile phase consisting of acet...
Article
The present study deals with the formulation of fast dissolving films of nizatidine as a model drug which is used for the treatment of acid-reflux disorders, peptic ulcer disease, and active duodenal ulcer. Rapidly dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties. In the present re...
Article
Full-text available
Venlafaxine hydrochloride was formulated as oral controlled release matrix tablets using hydrophilic polymer such as hydroxypropyl methyl cellulose (HPMC K 15 M) along with electrolytes. In this work a new attempt was made for in situ interactions between drug and electrolytes were devised to control the release of highly water soluble drugs from o...
Article
Full-text available
Solid dispersions of lovastatin were formulated using pregelatinised starch (PGS) as super disintegrant and were further compressed into tablets by using various diluents such as lactose, dicalcium phosphate (DCP) and microcrystalline cellulose (MCC) to enhance the bioavailability. The solid dispersions were prepared by physical mixing, solvent eva...
Article
The current study is to validate spectrophotometric method with UV detection for identification and determination of losartan potassium in respect of analytical parameters accuracy, precision, linearity. This simple, sensitive, accurate, economical and reproducible UV Spectrophotometric method can be applied for the determination of Losartan Potass...
Article
In the present investigation controlled release formulations of losartan potassium were formulated using poly(ethylene oxides) as release rate controlling polymer. Different excipients like ethyl cellulose, di calcium phosphate and starch 1500 were used in the preparation of matrix tablets and evaluated for their influence on controlled drug releas...
Article
In the present investigation an attempt has been made to increase therapeutic efficacy, reduced frequency of administration and improved patient compliance by developing controlled release matrix tablets of Losartan Potassium. Losartan Potassium was formulated as oral controlled release matrix tablets by using poly(ethylene oxides) { Polyox WSR 303...

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