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Reliable methods of imaging myelin are essential to investigate the causes of demyelination and to study drugs that promote remyelination. Myelin-specific compounds can be developed into imaging probes to detect myelin with various imaging techniques. The development of multimodal myelin-specific imaging probes enables the use of orthogonal imaging...
Luminescent Eu(III)- and Tb(III)-complexes based on functionalized tetraazamacrocycle (cyclen) or dipicolinic acid (dpa) metal binding sites, and carrying 2- or 5-linked uridine moieties were prepared. The light-harvesting antennae were either a coumarin (in the cyclen-based architectures) or the dpa-moiety itself. Antenna excitation resulted in me...
When Alzheimer's disease (AD) progresses, several pathological features arise including accumulation of misfolded protein aggregates [e.g., amyloid-β (Aβ) plaques], metal ion dyshomeostasis, and oxidative stress. These characteristics are recently suggested to be interconnected through a potential factor, metal-associated Aβ (metalAβ) species. The...
A multimodal, β-amyloid-targeted contrast agent was synthesized and studied in vitro. The agent has a higher relaxivity than a clinically approved contrast agent and interacts with β-amyloid aggregates producing changes in relaxation rate and fluorescence emission.
This review describes recent research efforts focused on increasing the specificity of contrast agents for proton magnetic resonance imaging (MRI). Contrast agents play an indispensable role in MRI by enhancing the inherent contrast of images; however, the non-specific nature of current clinical contrast agents limits their usefulness. This limitat...
Polyaminopolycarboxylate-based ligands are commonly used to chelate lanthanide ions, and the resulting complexes are useful as contrast agents for magnetic resonance imaging (MRI). Many commercially available ligands are especially useful because they contain functional groups that allow for fast, high-purity, and high-yielding conjugation to macro...
The investigations on a variety of proteins present in corn zein, wheat gluten, milk whey and soya have shown that these proteins possess the ability to form films which can be used in food packaging. We, therefore, selected cowpea (Vigna unguiculata), a cereal abundantly available in Sri Lanka, to investigate its polymer film forming ability. Our...