
Sarvananda LetchumanAlagappa University · Department of Biotechnology
Sarvananda Letchuman
BSc BIOTECHNOLOGY BIOCHEMISTRY GENETICS
Biotechnology, Biochemistry, Natural products, Molecular biology, Drug discovery & Development and Genetic engineering
About
45
Publications
50,801
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104
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Introduction
🔬 Biotech|Biochem|Genetics Research spans Natural Products, Genetics, Virology, and mRNA Expression Studies. Experienced in drug manufacturing especially tablets and capsules, COVID-19 diagnostics,
Let's collaborate! 🌐👩
Connect via insights.ls.research@gmail.com.
Additional affiliations
June 2015 - December 2015
Biozone Research Technologies
Position
- Research intern
Description
- I was conducted research on MOLECULAR IDENTIFICATION OF THE MEDICINAL PLANT JUSTICIA GENDARUSSA USING MATK GENE.
February 2018 - May 2018
Celogen lanka pvt ltd
Position
- Production Chemist/Officer
Description
- Involved as an officer for Manufacturing of Drugs in the formed tablet, and process such as Compression, Coating, Inspection etc.
Education
May 2011 - November 2015
Bangalore University
Field of study
- Biotechnology, Genetics and Biochemistry
Publications
Publications (45)
Monoclonal antibodies (mAbs) have revolutionized therapeutic strategies across a broad spectrum of diseases, yet their efficacy remains constrained by challenges such as suboptimal tumor penetration and insufficient cytotoxicity. This study pioneers an integrative approach, harnessing the untapped potential of plant-derived glycosides and innovativ...
Edible chitosan coatings enhance food quality and health outcomes by providing significant nutritional and nutraceutical benefits. These coatings, which are made from chitin, offer a natural barrier that decreases microbial contamination and deterioration, prolonging the shelf life and preserving the freshness of food. Its bioactive qualities, whic...
Microbial cellulose (MC) is a versatile biomaterial synthesized by various microorganisms, possessing unique properties such as high tensile strength, biocompatibility, and biodegradability. These characteristics make MC suitable for applications in biomedical, food, and packaging industries. Traditionally, Acetobacter aceti has been the primary so...
The lack of fresh water is wreaking havoc on the population of the world's least developed countries. Water-borne illnesses account for 4.1 ` of total disability-adjusted life years (DALYs), with a death rate of 1.8 million people per year, according to the WHO. Many microorganisms and chemicals have the potential to cause waterborne illnesses in p...
Aquaporins are small membrane proteins belonging to the group of Major Intrinsic proteins (MIPs) that facilitate the transport of water and small molecules across biological membranes. They were initially identified as water channels and later it has become clear that they also play important roles in several other physiological processes in plants...
Munronia pinnata (Bin kohomba) and Andrographis paniculata (Heen Binkohomba) are two medicinal plants naturally distributed in a wide variety of habitats in Sri Lanka. They have been widely used in traditional medicine. Both plant species are known to have anti-inflammatory properties. However, drug-target interaction patterns of chemical constitue...
Gene discovery and gene mapping have been key areas of research in genetics and molecular biology for several decades. These processes are fundamental to understanding the genetic basis of numerous diseases and conditions, including cancer, diabetes, and heart disease. Gene discovery involves identifying new genes, while gene mapping involves deter...
Polyamines (PAs) are low molecular weight aliphatic nitrogenous base-containing molecules, are considered an organic compounds having more than two amino groups, and have potent biological activities. They play an important role in both eukaryotic and prokaryotic cells. In living organisms, PAs are mainly available as free PAs, covalently conjugate...
Genetic engineering is an integral approach to the development of new diagnostic techniques, drugs for human and animal diseases, foods for human health, development of tissues, and cells for xenotransplantation. The components of vaccine for disease control and nutraceuticals for human health provide proteins; peptides and other components may be...
Mitochondria are intracellular organelles located in the cytoplasm, that are essential for life and health. It is also known as the powerhouse of the cells and uses a process called oxidative phosphorylation to generate energy. In side mitochondria, the lipid monomer fatty acids act as energy sources, membrane constituents, and molecules for post-t...
Pluripotent stem cells (PSCs) are cells that can differentiate
into any cell type in the body, and they have the potential to
revolutionize genetic analysis and disease modeling. In this
essay, I will discuss how PSCs can be used to model diseases and
study their genetic basis. I will also examine the advantages and
limitations of this approac...
People are at risk of being infected with the SARS-CoV-2 virus, which causes COVID-19 disease. Once they develop the disease , it could be deadlier. To deal with COVID-19, any antiviral remedy is not a gift. For the invention of the latest drugs, herbal commodities with recognized safety profiles are a hopeful source. We conducted a comprehensive l...
In the contemporary generation, rapid urbanization, industrialization, and declining woodland lead to global weather modifications. The massive scale of deforestation for firewood, constructions, paper products, textile, and plenty of different packages are steadily enforcing a critical poor impact on the surroundings. Inherently, plant cellulose h...
In the contemporary generation, rapid urbanization, industrialization, and declining woodland lead to global weather modifications. The massive scale of deforestation for firewood, constructions, paper products, textile, and plenty of different packages are steadily enforcing a critical poor impact on the surroundings. Inherently, plant cellulose h...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disease in which mutations in a gene related to the G6PD enzyme lead to incomplete expression, reduction, or absence of the enzyme. Henna is a widely used product in some countries for cosmetic and therapeutic purposes. This natural hair dye doesn’t cause significant adverse effects on the bo...
Organic agriculture has become arising topic nowadays forcontrol of soil pollution, degradationand to ensure food security. Organic manures and bio fertilizers play a vital role in that process. Vermicomposting tea is a liquid organic bio fertilizerand itis composed of plant nutrient, plant hormone and microorganism(aerobic microorganisms) such as...
The discovery of antibiotics becomes one of the maximum groundbreaking improvements of drugs. This healthcare staple, liable for treating illnesses that when had been incurable, is now turning into much less and much less powerful due to antibiotic resistance. The microorganism accountable can emerge as immune to this medicinal drug through genetic...
Nyctaginaceae, the Four O'Clock Family, consists of around 33 genera and 290 species and it is well recognized for its ornamental and medicinal values. Pisonia alba span is one such medicinal plant of the Nyctaginaceae family with excessive medicinal practicable and is freely reachable in India. This study was intended to determine the major class...
Cholesterol is one of the vital compounds required maintain principal metabolic pathways and structural material in the human and animal body. Insects are lack of the essential enzymes required for the biosynthesis of cholesterol from precursor molecules in nature and which makes them depend on dietary cholesterol. Thus the blocking of cholesterol...
A momentous evolution has been made in describing cellular hierarchy and the stem cell (SC) niche in the human mammary gland. Mammary stem and progenitor cells exist in two different states: Epithelial and mesenchymal. Several features of the mammary SCs predispose them to play a critical role in breast cancer (BC) initiation, progression, and meta...
Neurodegenerative movement disorder of the central nervous system (CNS) (Parkinson’s disease [PD]) is characterized by necrosis of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. The etiology of PD is still unknown and is believed to be multifactorial, oxidative stress and mitochondrial dysfunction are widely cons...
The average human body consists of trillions of small building blocks called cells. Within each of these cells, there are numerous genes. Genes contain the necessary genetic information to govern our bodily
functions; as an example particular gene carries this unique “code” that is needed for the synthesis of this specific protein, which, in turn,...
Algae are a great source of mineral salts, vitamins, proteins and trace metals necessary for human metabolism. Interest of introducing algae into human nutrition in western countries has increased in recent years. Humans can also consume algae indirectly because they are a source of different compounds used in the food industry such as agar, algina...
Globally, approximately 70% of deaths from cancer occur in low- and middle-income countries due to the five leading behavioral and dietary risks such are high body mass index, intakes of low fruit and vegetable lack of physical activities, tobacco, and alcoholism. In low and middle-income countries, about 25% of infectious diseases are hepatitis an...
Worldwide statistics show8-12% of married couples have infertility problems. Between 80-90% of these were reported due to the male, and 10% due to the female. Orthodox western treatments are expensive and have side effects, so we tried an Ayurvedic regime, with its lower costs and fewer side effects. Fifteen infertile couples were selected for the...
Gram-negative bacteria such as E. coli plays a significant role in nosocomial infections and community-acquired infections particularly urinary tract infections. Though, still, there is no curable treatment for gram-negative bacterial infections. The tea samples were collected from different locations such as Haputhale, Ingiriya, and Galle, and Alo...
Plant breeding has been of immense importance to human beings throughout history. The present human population could not have been fed without the many-fold increases in crop yields that plant breeding has provided. Over the last decade, genetically modified crops have become accepted by many countries, provided that they are subjected to thorough...
Elimination of malaria has been successfully recorded, but still continues as a major health hazard in developing countries. As malaria control relies mainly on indoor residual spraying of insecticides, it has become a fear task due to widespread resistance in malaria vectors. However, any disease control studies taken can influence its success (ve...
Eating disorders are also symbolic of sociology food. It represents how control eating disorders do not limit to anorexia. These disorders include bulimia and binge eating as well. Some people often use food as a comfort, or negative thing to avoid, even though if necessary survival. The relationships between food and people are very large complex;...
Seaweeds are aquatic angiosperms, which are widespread in many coastal settings. Due to their various type of application, for instance, therapeutic agents, they are considered as one of the key environmental resources. In order to find out the diversity, abundance and pattern of species distribution of algae, a study was carried out in the three s...
Objective: Glutathione is an antioxidant, which presents in mammalian and known as the most powerful antioxidant. Glutathione is called as "Master Antioxidant" because of its intracellular and possesses the aptitude to exploit the performance of other antioxidants, these include vitamins C & E, CoQ10 (ubiquinone) and alpha-lipoic acid, and rich in...
Macroscopic and microscopic evaluation and chemical profiling techniques have their own limitations for authentication of plant species. DNA-based markers give the new directions to pharmacognosy. It is important to distinguish accurately the authentic plant sources for herbal drugs because adulteration and substitutions diminish their efficacy and...
Coral reefs being highly diverse to marine ecology, yet most of the mystery remain unsolved. Coral reefs are of ecological as well as economic importance. Corals support commercial and subsistence fisheries, tourism, and are of medicinal value. It also creates a barrier against storms, flooding, and erosion by reducing wave action. Further, Corals...
Hygrophila auriculata is belonging to family Acanthaceae, Usually called as "Neermulli in Tamil" is a grow in wet places. It is an important herbal plant, broadly spread in Sri Lanka India, and is used to treat various diseases. Hygrophila auriculata (L.) Nees, Acanthaceae, is a source of traditional medicine; the aerial parts of the plant are used...
Non-communicable diseases (NCDs) are highly challenges to this world due to several reasons such as emerging trendurbanization,
lifestyle transformations, and related factors. Individually and cumulatively, the epidemiological, demographic
and socioeconomic transitions are fueling a surge in NCDs, which now account for 65% of all deaths in the coun...
Herbal plants play a major role in the development of modern civilization. Justicia gendarussa is an interesting example for traditional plant with medicinal values and have been proved by many research works. The present study which is focused on the Molecular characterization for the plant Justicia Gendarussa using Matk gene shows that the DNA is...
The immune system is known to be involved in the etiology as well as pathophysiological mechanisms of many diseases Traditional medicine gives emphasis on promotion of health a concept of strengthening host defenses against different diseases. Rasayana plants are particularly recommended for the treatment of immune disorder, Ayurveda may play an im...
Seaweeds are aquatic angiosperms widespread in coastal environments and considered as a key environmental resource because of numerous importance of therapeutic agent. In this study extensive surveys carried out the algal diversity on their abundance and distribution were determined along transects down to the bottom sand plain on Ahagama, Thalpe a...
DNA Barcoding is most important techniques in biological sciences to identify new species or organism to understand taxonomy in biology and helps to identify organisms.
DNA barcoding is a system for fast and accurate species identification. It’s creates ecological system more accessible by using short DNA sequence instead of whole genome and is used for eukaryotes and prokaryotes. The short DNA sequence is generated from standard region of genome known as marker. This marker is different for various species like C...
The aim of this study is to find the action in reducing risk of non-communicable diseases using traditional medicinal plants. The burden of chronic non-communicable diseases (NCD) cannot be reduced without equitable access to essential medicines. NCD medicines are critical to the treatment of cardiovascular diseases, diabetes chronic respiratory di...
LOCUS KY069062 750 bp DNA linear PLN 08-APR-2017
DEFINITION Justicia gendarussa maturase K (matK) gene, partial cds; chloroplast.
ACCESSION KY069062
VERSION KY069062.1
Herbal plants play a major role in the development of modern civilization. Justicia gendarussa is an interesting example for traditional plant with medicinal values and have been proved by many research works. The present study which is focused on the Molecular characterization for the plant Justicia Gendarussa using Matk gene shows that the DNA is...