Saruban Pasu

East Sussex Healthcare NHS Trust · Department of Ophthalmology

AIMS: To report spectral-domain optical coherence tomography (OCT) findings in cases of impending or occult central retinal artery occlusion (CRAO) in which a diagnosis other than CRAO was made on initial presentation. METHODS: Retrospective, observational case series of patients diagnosed with CRAO for whom on initial presentation fundal examinati...

Aims: To report spectral domain optical coherence tomography (OCT) findings in cases of impending or occult central retinal artery occlusion (CRAO) in which a diagnosis other than CRAO was made on initial presentation. Methods: Retrospective, observational case series of patients diagnosed with CRAO for whom on initial presentation fundal examin...

Importance The value of facedown positioning following surgery for large full-thickness macular holes is unknown. Objective To determine whether advice to position facedown postoperatively improves the outcome for large macular holes. Design, Setting, and Participants This randomized, parallel group superiority trial with 1:1 randomization strati...

Since 1991 when Kelly and Wendel published the first case series of a surgical technique to repair macular holes, both the closure rates and functional outcomes have improved. The four novel studies presented in this thesis all have the subject of macular hole as a common theme running throughout. A comprehensive review of the pathophysiology, imag...

Background: The treatment of idiopathic full-thickness macular holes involves surgery to close the hole. Some surgeons advise patients to adopt a face-down position to increase the likelihood of successful macular hole closure. However, patients often find the face-down positioning arduous. There is a lack of conclusive evidence that face-down posi...

Purpose: Persistent hyperplastic primary vitreous (PHPV) is a developmental anomaly in which the normal regression of the primary vitreous and hyaloid vasculature does not occur. In the literature, there are a few cases of PHPV in adulthood. We report the novel presentation of phacoanaphylactic glaucoma secondary to posterior capsular rupture in a...

Background: Idiopathic macular holes are an important cause of blindness. They have an annual incidence of 8 per 100,000 individuals, and prevalence of 0.2 to 3.3 per 1000 individuals with visual impairment. The condition occurs more frequently in adults aged 75 years or older. Macular holes can be repaired by surgery in which the causative tracti...

This is a rare presentation of brain tumour in the region of the lateral geniculate nucleus (LGN) presenting as a homonymous horizontal sectoranopia (HHS). The case highlights that subtle field defects can be asymptomatic and only detected by formal perimetry. Although homonymous sectoranopia is a rare form of visual field defect, it should be reco...

Ocular angiogenesis and macular oedema are major causes of sight loss across the world. Aberrant neovascularisation, which may arise secondary to numerous disease processes, can result in reduced vision as a result of oedema, haemorrhage, and scarring. The development of antivascular endothelial growth factor (anti-VEGF) agents has revolutionised t...

Purpose To assess the efficacy of intravitreal aflibercept (2.0 mg) in patients with treatment-resistant neovascular age-related macular degeneration.Methods Retrospective analysis of eyes treated with aflibercept with persistent subretinal and/or intraretinal fluid despite a minimum of 14 previous treatments with intravitreal ranibizumab (0.5 mg)....

Eye is the official journal of the Royal College of Ophthalmologists. It aims to provide the practising ophthalmologist with information on the latest clinical and laboratory-based research.

Fraser syndrome is a rare autosomal recessive multisystem disorder with a reported incidence of 0.043 per 10,000 live born infants and 1.1 in 10,000 stillbirths[1]. The condition is characterised by cryptophthalmos, cutaneous syndactyly, laryngeal and genitourinary malformations, craniofacial dysmorphism, orofacial clefting, musculoskeletal anomali...

The principal aim of this study was to develop tests of source memory in both the verbal and visuo-spatial domains, which would be brief and easy to use in clinical and population settings. Source memory, that is, memory for context or attributes, is very vulnerable to the effects of ageing and to the early stages of dementia. Because longitudinal...