Saroj Jayasinghe

Saroj Jayasinghe
University of Colombo · Department of Clinical Medicine

MBBS (Colombo), MD (Colombo), FRCP (Lond), FCCP, MD (Bristol), PhD (Colombo)

About

254
Publications
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Publications

Publications (254)
Preprint
Background: Buddhist-derived meditation is a well-known phenomenological practice that enhances overall well-being of individuals. However, broad and less-rigorous criteria in recruiting suitable meditation practitioners affect the reliability of results obtained through meditation research. Therefore, we aimed at developing an instrument to identi...
Article
Background: Infrastructure, equipment and staff constraints are often cited as barriers to the recognition and rescue of deteriorating patients in resource-limited settings. The impact of health-system organisation, decision-making and organisational culture on recognition of deterioration is however poorly understood. This study explores how healt...
Article
Full-text available
Background: The critical phase of dengue carries a high risk of bleeding. Associations of coagulation test parameters and the risk of bleeding in the critical phase is unclear. This study examines the association of rotational thromboelastometry (ROTEM delta and ROTEM platelet) with bleeding risk of patients with dengue in the critical phase. Met...
Poster
Full-text available
Abstract Background Dengue and diabetes are major health concerns in many low and middle income counties in the tropics and subtropics. Identifying the risk of diabetes on the clinical presentations and outcomes of dengue infection is of high relevance. However the current epidemiological evidence is very limited. Therefore we explored the morbidit...
Preprint
Full-text available
Background Osteoarthritis (OA) has become a burden globally for the healthcare sector due to its high prevalence and incidence. Among that Knee Osteoarthritis (KOA) is the most common form of arthritis causing disability and impaired quality of life especially in elderly. Currently pharmacological, non-pharmacological and surgical measures are cons...
Article
Full-text available
Increasing prevalence of endemic chronic kidney disease of unknown etiology (CKDu) in Sri Lanka is a major health problem since the 1990s. Despite numerous studies on CKDu, research groups have been unable to develop a comprehensive approach to mitigate the disorder, and thereby to identify research gaps. We conducted a systematic literature review...
Article
Racial bias and language discrimination are recognized in the health sector in countries such as Sri Lanka. This may extend to images used in health communication and educational literature. We analyzed the racial and ethnic representation in a sample of newspapers and websites related to health obtained over a period. Most of the human figures in...
Article
Full-text available
Background: COVID-19 pandemic has resulted in varying clinical manifestations and mortality rates. There is no consensus on the symptomatology that would guide researchers and clinicians. Aims and Objectives: The objective was to identify symptoms and their frequencies of COVID-19 with a meta-analysis of studies from several countries. Materials...
Conference Paper
Cardiovascular diseases(CVDs) are the world's leading cause of death. Endothelial Dysfunction is an early stage of cardiovascular diseases and can effectively be used to detect the presence of the CVDs, monitor its progress and investigate the effectiveness of the treatment given. This study proposes a reliable approach for the screening of endothe...
Conference Paper
Introduction and Objectives: Early identification of cardiovascular disease risks has been a promising solution to take preventive precautions. Vasodilatory endothelial dysfunction has been recognized as a potential precursor for early detection of CVD risks using non-invasive physiological parameters with artificially induced reactive hyperemia. T...
Article
The current rapid, often unplanned urbanisation across Asia has wide-ranging economic, environmental, health, and social impacts. In an attempt to document the implications of this demographic transition, the Journal of Cities & Health in collaboration with the International Society for Urban Health (ISUH) launched a special issue. This special iss...
Book
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This workbook in Palliative Medicine is compiled to help students achieve essential knowledge and skills in the subject, identification of physical, social, psychological and spiritual suffering of patients due to illnesses and caregivers. It also helps to achieve knowledge and skills, on assessment of these patients in order to relieve / minimize...
Method
Background and study aims: Osteoarthritis (OA) has become a burden globally for the healthcare sector due to the number of people developing or living with the condition. Knee osteoarthritis (KOA) is the most common form of arthritis causing disability and impaired quality of life especially in the elderly. The WHO report on priority diseases and...
Article
Full-text available
Background Erythrocyte pyruvate kinase is expressed under the control of the PKLR gene located on chromosome 1q21. Pyruvate kinase catalyzes the final steps of the glycolytic pathway and creates 50% of the red cell total adenosine triphosphate. Pyruvate kinase deficiency is the commonest glycolytic defect causing congenital non-spherocytic hemolyti...
Book
Students of the Faculty of Medicine, Sabaragamuwa University of Sri Lanka, study cardiology as a separate cardiology appointment of 2 weeks at the Teaching Hospital Ratnapura. During this period, they will be attached to the cardiology unit under the consultant cardiologist(s) appointed by the Ministry of Health. This workbook in cardiology is comp...
Book
Students of the Faculty of Medicine, Sabaragamuwa University of Sri Lanka, study Pulmonology as a separate appointment of 2 weeks, at the Respiratory Unit, Teaching Hospital, Rathnapura and District Chest Clinic, Rathnapura During this period, they will be supervised by the Consultant Pulmonologist appointed to Teaching Hospital, Rathnapura by the...
Book
Students of the Faculty of Medicine, Sabaragamuwa University of Sri Lanka, study nephrology as a separate appointment of one week at Teaching Hospital Ratnapura. During this period, they will be attached to the nephrology unit under the consultant Nephrologist appointed by the Ministry of Health. This workbook in nephrology is compiled to help stud...
Conference Paper
Full-text available
In Sri Lanka there are specific families: “Weda Parampara '', who practice their own treatment methods with the use of specific remedies. They have a long history of use in disease prevention and treatment, particularly for chronic diseases like Joint disorders, Sandiroga. The aim of this study was to find out current practices and knowledge on San...
Article
Full-text available
Background The COVID-19 pandemic is adversely impacting modern human civilization. A global view using a systems science approach is necessary to recognize the close interactions between health of animals, humans and the environment. Discussion A model is developed initially by describing five sequential or parallel steps on how a RNA virus emerge...
Article
Although large piezoresistive sensor arrays are vital in obtaining 2D pressure distributions in many applications, they suffer from crosstalk forming parasitic parallel paths as a result of their generic shared row-column architecture. Existing software based algorithms and post processing is the industrially utilized crosstalk suppression mechanis...
Article
COVID-19 has stressed healthcare systems across the globe. We present the experience of an intern medical officer working in a tertiary care hospital during the first wave of the pandemic in Sri Lanka. Her narrative describes how the stress of the pandemic brought into sharp focus the strengths and weaknesses in the health system. We suggest some s...
Article
Sri Lanka, once a colony of Britain, gained independence in 1948. However, especially the health sector continues to use English as its main medium of communication. Such language bias leads to marginalization of those less fluent in English, and hinders achieving a higher level of health literacy. Discrimination of people or social groups based on...
Article
Full-text available
A significant decrease in dengue fever cases and a contrasting increase in leptospirosis cases were reported for the second quarter of 2020 compared with 2019 in Sri Lanka. In the absence of significant environmental and weather-related differences to account for these changes in incidence, we investigated the possibility that the effects of the CO...
Article
Full-text available
The article “Slum Health: Arrresting COVID-19 and Improving Well-Being in Urban Informal Settlements”, written by Jason Corburn et al.
Preprint
Full-text available
Systemic diseases such as diabetes, hypertension, atherosclerosis are among the leading causes of annual human mortality rate. It is suggested that retinal and conjunctival vascular tortuosity is a potential biomarker for such systemic diseases. Most importantly, it is observed that the tortuosity depends on the thickness of these vessels. Therefor...
Article
Full-text available
Dengue fever has a wide range of clinical manifestations from asymptomatic disease to complicated dengue haemorrhagic fever and dengue shock syndrome. Bleeding manifestations in dengue is well known but thrombotic events complicating dengue is uncommon. ST elevation myocardial infarction during dengue is rare and poses important management dilemma....
Article
Full-text available
Dengue fever has a wide range of clinical manifestations from asymptomatic disease to complicated dengue haemorrhagic fever and dengue shock syndrome. Bleeding manifestations in dengue is well known but thrombotic events complicating dengue is uncommon. ST elevation myocardial infarction during dengue is rare and poses important management dilemma....
Article
Full-text available
Mind wandering (MW) is a very common cognitive activity of the human mind. In recent times studying its functional correlates have gained the attention of cognitive scientists and psychologists. Most studies have focussed on neurophysiological studies to model and explain it. The current article explores the phenomenological dimensions of MW and at...
Article
Full-text available
We studied the clinical course and virus shedding of all patients referred to Welikanda Hospital, in one month. There were 53 positives for COVID-19 by PCR. 24 (45%) were male, with an age range of 11-94 years. Of these, 41 (77%) were asymptomatic, 9 had cough, 4 had sore throat and six had fever. Pulse, blood pressure, respiratory rate and capilla...
Article
Full-text available
The COVID-19 pandemic has undoubtedly become an era-defining challenge for the entire world. It has implications not only in the public health sector but also in the global economy and political landscape. The prevention strategy that has been followed in Sri Lanka is unique. Early action taken by the government and the ministry of health, being on...
Book
Full-text available
In this little book we explain in which health condition cities and people living in cities are in today, why health is a systemic concept and what we can gain from applying systems thinking to cities, what a systems approach to urban health means in general and specifically applied to urban health equity and we provide some examples of initiatives...
Article
Chronic Interstitial Nephritis in Agricultural Communities (CINAC) continues to attract controversy in the scientific community. It was previously known as Chronic Kidney Disease of Unknown Etiology (CKDu) and is not associated with the common aetiological factors such as diabetes. There is general acceptance that it is an environmentally induced d...
Article
Full-text available
The ongoing COVID-19 outbreak that originated in the city of Wuhan, China, has caused a significant damage to the world population and the global economy. It has claimed more than 0.8 million lives worldwide, and more than 27 million people have been infected as of 07th September 2020. In Sri Lanka, the first case of COVID-19 was reported late Janu...
Article
Full-text available
The COVID-19 pandemic has resulted in increasing number of infections and deaths every day. Lack of specialized treatments for the disease demands preventive measures based on statistical/mathematical models. The analysis of epidemiological curve fitting, on number of daily infections across affected countries, provides useful insights on the chara...
Article
Full-text available
In order to bring the new coronavirus pandemic in the country under control, the government of Sri Lanka implemented a set of control strategies including social distancing, quarantine, lockdowns, travel restrictions, and isolation of villages. The aim of this study is to investigate the effectiveness of the overall control process with the aid of...
Article
The COVID-19 pandemic caused by the SARS-CoV-2 virus has infected millions and overburdened the healthcare infrastructure globally. Recent studies show that the endothelial dysfunction caused by the virus contributes to its high morbidity and mortality. A parameter that can identify patients who will develop complications early will be valuable in...
Article
Full-text available
Background: The first case of a coronavirus 2019 (COVID-19) infection in a Sri Lankan was reported on March 11, 2020. The situation in Sri Lanka changed with the rapid increase of personnel contracting COVID-19 in a naval base camp that housed more than 4000 people. This provided a unique opportunity to study the effectiveness of hydroxychloroquin...
Article
Sponsorship of medical conferences by the pharmaceutical industry has led to many ethical issues, especially in resource-poor developing countries. The core issue in these instances is to reduce or avoid conflicts of interests (COIs). COI is a set of circumstances that creates a risk that professional judgment or actions regarding a primary interes...
Article
Full-text available
Background: Burden of stroke is rising due to the demographic and epidemiological transitions in Sri Lanka. Assessment of success of stroke-management requires tools to assess the quality of life (QOL) of stroke survivors. Most of currently used QOL tools are developed in high-income countries and may not reflect characteristics relevant to resour...
Research
Full-text available
effect of COVID-19 on routine healthcare: An experience of a tertiary care unit.
Article
Full-text available
Introduction: Hereditary hemochromatosis is an inherited disorder of iron metabolism, characterized by excessive iron deposition in major organs of the body, leading to multi-organ dysfunction. It is a genetically heterogeneous disease caused by mutations in one or more different genes, the most common being mutations in the HFE gene. HFE heredita...
Research
Full-text available
Background: COVID-19 pandemic has resulted in varying clinical manifestations and mortality rates. There is no consensus on the symptomatology that would guide researchers and clinicians. Objective: The objective of the study was to identify symptoms and their frequencies of coronavirus disease 2019 with a meta-analysis of studies from several coun...
Conference Paper
Full-text available
Peripheral vascular flow in response to induced reactive hyperemia of the radial artery is used as a benchmark for non-invasive assessment of the endothelial function. As an alternative to standard modalities, this study investigates the suitability of impedance plethysmography to estimate peripheral vascular flow variations associated with the rea...
Preprint
Full-text available
Background: COVID-19 pandemic has resulted in varying clinical manifestations and mortality rates. There is no consensus on the symptomatology that would guide researchers and clinicians. Objective: The objective was to identify symptoms and their frequencies of COVID-19 with a meta-analysis of studies from several countries. Data sources: A syst...
Preprint
Full-text available
Objectives To compare carriage rates of Staphylococcus aureus in patients with and without chronic kidney disease (CKD) and identify associated factors. Results We enrolled 64 CKD (A-1 = 13, A-2 = 17, A-3 = 34) and 56 non-CKD controls (B). Patients were categorized as: stage 5 CKD on haemodialysis (A-1), stage 5 CKD not on haemodialysis (A-2), ren...
Preprint
Full-text available
Background: The indigenous population in Sri Lanka called “Veddas” estimated to be around 0.05% of the total population in the island. This population is unique that they used to live mostly in jungles with primitive lifestyles. The objective was to study the cardiovascular risk factors in this indigenous (Vadda) community. Methods: A descriptive c...
Preprint
Full-text available
Background: The first case of a corona virus 2019 (COVID-19) infection among Sri Lankan was reported on 11th March, 2020. The situation in Sri Lanka changed with the rapid increase of personnel contracting COVID-19 in a Naval base camp that housed more than 4000 people. This provided a unique opportunity to study the effectiveness of hydroxychloroq...
Preprint
Full-text available
Background: The first case of a corona virus 2019 (COVID-19) infection in a Sri Lankan was reported on March 11, 2020. The situation in Sri Lanka changed with the rapid increase of personnel contracting COVID-19 in a Naval base camp that housed more than 4000 people. This provided a unique opportunity to study the effectiveness of hydroxychloroquin...
Preprint
Full-text available
The COVID-19 pandemic has resulted in increasing number of infections and deaths on a daily basis. There is no specific treatment or vaccine identified and the focus has been preventive measures based on statistical and mathematical models. These have relied on analyzing the behavior of populations and characteristics of the infection and applying...
Preprint
Full-text available
In order to bring the new coronavirus pandemic in the country under control, the government of Sri Lanka implemented a set of control strategies including social distancing, quarantine, lockdowns, travel restrictions and isolation of villages. The aim of this study is to investigate the effectiveness of the overall control process with the aid of c...
Article
SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibi...
Article
Introduction Environmental pollution, especially by toxic trace elements, is a global health concern. Heavy metals such as Cadmium (Cd), Arsenic (As) and Lead (Pb) are associated with numerous disorders and are considered by some as an aetiological factor for the Chronic Kidney Disease (CKDu¹) epidemic in Sri Lanka. This study explores patterns of...
Article
Full-text available
The informal settlements of the Global South are the least prepared for the pandemic of COVID-19 since basic needs such as water, toilets, sewers, drainage, waste collection, and secure and adequate housing are already in short supply or non-existent. Further, space constraints, violence, and overcrowding in slums make physical distancing and self-...
Preprint
The ongoing COVID19 outbreak originated in the city of Wuhan, China has caused a significant damage to the world population and the global economy. It has claimed more than 50,000 lives worldwide and more than one million of people have been infected as of 04th April 2020. In Sri Lanka, the first case of COVI19 was reported late January 2020 was a...
Preprint
The SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has in...
Conference Paper
Endothelial dysfunction has been recognized as a precursor of cardiovascular diseases, thus enable the possibility of early detection. However, non-invasive measurement of ED is only possible with peripheral vasodilatory regulation stimulated by artificially induced reactive hyperemia. These measurements include physiological parameters such as flo...
Article
Full-text available
Introduction: High anion gap metabolic acidosis can occur due to various medications. This case report presents a patient with high anion gap metabolic acidosis due to azithromycin and paracetamol combination presenting with shortness of breath. Case Presentation: A 19-year-old Sri Lankan girl who was being evaluated for nephrotic syndrome presente...
Article
A chronic kidney disease of unknown etiology is devastating agricultural communities of Sri Lanka, Central America, areas of India, and Egypt. Researchers are yet to agree on its etio-pathogenesis despite many cross-sectional, case-control and cohort studies done in these countries. These approaches are broadly based on a reductionist approach. We...
Article
Full-text available
Introduction: Sri Lanka has a predominantly rural population. However, there is a dearth of research on health and socioeconomic issues in this group. Objective: To describe basic socioeconomic characteristics and health profile in a rural population. Methods: A descriptive cross-sectional household survey was conducted in 1950 households in t...
Article
Full-text available
Background: A major challenge in dengue management in resource limited settings is the confirmation of diagnosis. Clinical features of dengue often overlap with other infections and molecular diagnostic tools are not readily accessible to clinicians at hospitals. In addition, the prediction of plasma leakage in dengue is also difficult. Hematocrit...
Article
Full-text available
Introduction : Stroke is a leading disease accounting for burden of chronic NCDs especially in lower and lowermiddle income (LMI) settings. Quality of Life (QOL) is considered as an important facet of determination of success of patient management. EQ-5D-3L is a generic QOL tool. It provides an index score amalgamating responses for five descriptiv...