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Saravanan Muthupandian

Saravanan Muthupandian
Saveetha Institute of Medical and Technical Sciences (SIMATS) · Saveetha Dental College - School of Basic Medical Science -Department of Pharmacology

Professor
Antimicrobial Resistance (AMR); Nano-Theragnostic materials for AMR and Cancer; Nano-Biosensor Based POCT and One Health

About

276
Publications
160,824
Reads
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17,583
Citations
Introduction
Antimicrobial Resistance (AMR) and Cancer have a significant role in public health by destroying the potency of the existing antibiotics and anticancer drugs.Our research team mainly focused on Biocompatible Nano-biomaterials and its controlled nano-drug delivery approaches to combat emerging and re-emerging infectious diseases and Cancer. Thrust Areas: Antimicrobial Resistance (AMR); Nano-Theragnostic materials for AMR and Cancer; Nano-Biosensor Based POCT and One Health approach to Combat AMR
Additional affiliations
October 2012 - present
Mekelle University
Position
  • Professor (Assistant)
January 2011 - September 2011
HUJI
Position
  • Nano-biotechnology and Controlled Drug Delivery
October 2005 - January 2011
SRM Institute of Science and Technology
Position
  • Research Assistant
Education
January 2006 - December 2010
Sathyabama Institute of Science and Technology
Field of study
  • Medical Microbiology, Nanobiotechnology and Nanomedicine
June 2003 - July 2004
Bharathidasan University
Field of study
  • Biotechnology
June 1998 - May 2000
Madurai Kamaraj University
Field of study
  • Microbiology Specilization Medical Microbiology

Publications

Publications (276)
Article
Full-text available
Antimicrobial resistance issues have risen dramatically in recent years, posing a severe concern to humans worldwide. The urgent need to find novel compounds for pharmaceutical applications prompts the research of under-explored environments such as marine ecosystems. The present study was designed to discover novel secondary metabolites, and we ha...
Article
Full-text available
Cancer cells use nutrients like D-glucose (Glc) and L-glutamine (Q) more efficiently for their development. This increased nutritional dependency of malignant cells has been commonly employed in various in vitro and in vivo models of anticancer therapies. This study utilized a combination of a low dose (25 μg mL −1) of S2, a phytosynthesized gold n...
Article
Full-text available
Background Experimental and epidemiological studies indicate an association between exposure to particulate matter (PM) air pollution and increased risk of type 2 diabetes. In view of the high and increasing prevalence of diabetes, we aimed to quantify the burden of type 2 diabetes attributable to PM2·5 originating from ambient and household air p...
Article
Introduction: There is a constant drive to improve disease treatments. Much effort has been directed at identifying less immunogenic anti-cancer agents that produce fewer and less severe side effects. For more than a decade, bacteriophages have been discussed as an effective treatment for cancer with an exact mode of delivery. Areas covered: We...
Article
Mucormycosis has become increasingly associated with COVID-19, leading to the use of the term "COVID-19 associated mucormycosis (CAM)". Treatment of CAM is challenging due to factors such as resistance to many antifungals and underlying co-morbidities. India is particularly at risk for this disease due to the large number of patients with COVID-19...
Chapter
Viral infections continue as the most public health challenges globally representing a significant mortality and mortality rates with an unfavourable socioeconomic impact. The increased and emerging of drug resistant viral strains and their adverse side effects associated with the prolonged use of antiviral drugs have limited the wide use of effect...
Chapter
Antimicrobial resistance is one of the biggest problems that the healthcare system faces nowadays, with an increasing burden due to the COVID-19 pandemic. Different alternatives to the current treatments of bacterial infections have been studied far away from the use of traditional antibiotics. One of them is nanotechnology, which proposes a suitab...
Book
Full-text available
Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance focuses on recent and emerging trends surrounding nanomaterials and nano-drug delivery approaches to combat antimicrobial resistance. The relationship between nanomaterials and antimicrobial activity needs to be deeply explored to meet the challenges o...
Article
Full-text available
In the current scenario, cardiovascular disease (CVD) is one of the most life-threatening diseases that has caused high mortality worldwide. Several scientists, researchers, and doctors are now resorting to medicinal plants and their metabolites for the treatment of different diseases, including CVD. The present review focuses on one such family of...
Article
Full-text available
Candida albicans is the most prevalent fungus in humans, producing infections ranging from mucosal to systemic. C. albicans colonizes mucosal surfaces asymptomatically as commensal, but, if the host environment is disrupted, or if the host immune system is compromised, C. albicans can multiply and infect almost all places in the host. The present s...
Article
Full-text available
The alarming effect of antibiotic resistance prompted the search for alternative medicine to resolve the microbial resistance conflict. Over the last two decades, scientists have become increasingly interested in metallic nanoparticles to discover their new dimensions. Green nano synthesis is a rapidly expanding field of interest in nanotechnology...
Article
Full-text available
The use of chemically synthesized nanoparticles and crude plant extracts as antimicrobial -anticancer agents have many limitations. In this study, we have used Centella asiatica extract (CaE) having relatively less explored but tremendous medicinal properties, as reducing and stabilizing agents to green synthesize magnesium oxide nanoparticles (MgO...
Article
The increasing trend of industrialization leads to tremendous release of industrial effluents. Waste water treatment is one of the important sectors to focus in order to overcome the most threatening issue of waste disposal and to ensure sustainability. Sustainable and energy efficient treatment methods are the attractive technologies for their cur...
Article
Full-text available
Nowadays, nanotechnology is gaining interest on diagnostics for several chronic diseases. In the present study, the chemical oxidative method of aniline in acid medium with ammonium peroxydisulfate (APS) as an oxidant was employed to develop polyaniline (PANI)-based nanocomposite overflowing/doping on ZnO. The chemical properties, morphology, and s...
Article
Full-text available
Purpose: The emergence of antimicrobial resistance is a major global health challenge and becoming an urgent priority for policymakers. There is a paucity of scientific studies presenting the multidrug resistance pattern from one health perspective in Ethiopia. Therefore, a systematic review and meta-analysis aimed to determine the pooled prevalen...
Preprint
Neurotrophins play a crucial role in the development and regulation of neurons. Alterations in the functioning of these Neurotrophins leads to several Neurodegenerative Disorders. Albeit engineered medications which are accessible for the treatment of Neurodegenerative Disorders, due to their numerous side-effects, it becomes imperative to formulat...
Chapter
Microbial nanotechnology is a current booming field for the bio-based synthesis of metal nanomaterials with a green and sustainable approach that can overcome the drawbacks of traditional chemical and physical techniques for the preparation of these anomaterials. Microbial-mediated synthesis of metallic nanoparticles (MNPs) is a nontoxic, eco-frien...
Article
Full-text available
Purpose: This study aimed to evaluate the presence of CRISPR-Cas system genes and their possible association with antibiotic resistance patterns of Enterococcus faecalis and Enterococcus faecium species isolated from hospital wastewater (HWW) samples of several hospitals. Methods: HWW samples (200 mL) were collected from wastewater discharged fr...
Article
Full-text available
Organometallic nanoconjugates have raised great interest due to their bimodal properties and high stability. In the present study, we analyzed the cytotoxicity property of carbon dots (CDs) and a series of organometallic nanoconjugates including gold@carbon dots (Au@CDs) and silver@carbon dots (Ag@CDs) synthesized via an aqueous mode. We aimed to d...
Article
In the present study, we optimized the extraction of water-soluble crude sulfated polysaccharide (WSCSP) from Sargassum polycystum and its biological activity was investigated. The WSCSP was extracted from S. polycystum by the acidic water extraction method. The Box-Behnken experimental design was used as a tool for the extraction and evaluated in...
Article
Full-text available
This study aimed to determine the prevalence of bacterial vaginosis (BV) and aerobic vagini-tis (AV) and their associated risk factors among pregnant women from Ethiopia. Also, this study investigated the bacterial pathogens and their antibiotic resistance in AV cases. A total of 422 pregnant women from northern Ethiopia were participated in this s...
Article
Full-text available
Green-based synthesis of metal nanoparticles using marine seaweeds is a rapidly growing technology that is finding a variety of new applications. In the present study, the aqueous extract of a marine seaweed, Gracilaria edulis, was employed for the synthesis of metallic nanoparticles without using any reducing and stabilizing chemical agents. The v...
Article
Full-text available
Obesity, usually indicated by a body mass index of more than 30 kg/m2, is a worsening global health issue. It leads to chronic diseases, including type II diabetes, hypertension, and cardiovascular diseases. Conventional treatments for obesity include physical activity and maintaining a negative energy balance. However, physical activity alone cann...
Article
A new class of picolinohydrazide analogs (5-7) was synthesized via the one-pot reaction between fusaric acid (1) and aryl hydrazines (2-4) using amide coupling reagents. The synthesized compounds (5-7) were characterized using density-functional theory (DFT) computational spectroscopy, and instrumental methods. Global and local reactivity descripto...
Article
Full-text available
At present, the potential role of the AgNPs/endo-fullerene molecule metal nano-composite has been evaluated over the biosystems in-vitro. The intra-atomic configuration of the fullerene molecule (C60) has been studied in-vitro for the anti-proliferative activity of human breast adenocarcinoma (MDA-MB-231) cell lines and antimicrobial activity again...
Article
Full-text available
Cervical cancer, a malignant neoplasm arising from cervix cells, remains one of the leading global cause of women cancer-related deaths. The present study was aimed to conduct a comprehensive systematic review to show the anticancer activity of biological mediated gold nanoparticles (AuNPs) against cervical cancer cells. To identify the articles, a...
Article
Full-text available
Regenerative medicine, a therapeutic approach using stem cells, aims to rejuvenate and restore the normalized function of the cells, tissues, and organs that are injured, malfunctioning, and afflicted. This influential technology reaches its zenith when it is integrated with the CRISPR-Cas (clustered regularly interspaced short palindromic repeats—...
Article
One of the modern challenges is to provide clean and affordable drinking water. Water scarcity is caused by the growing population in the world and pollutants contaminate all remaining water sources. Innovative water treatment solutions have been provided by nanotechnology. Microorganisms, organic suspensions, and inorganic heavy metal ions, among...
Article
Indoor walls are constantly exposed to fungal aerosols, resulting in the highest indoor fungal pollutant. The antifungal activity of silver nanoparticles (AgNPs) synthesized using Passiflora foetida fruit extract and coated with liner wallpaper was investigated against indoor fungus, Fusarium sp. Successful biosynthesis of AgNPs was observed by ult...
Chapter
Biohybrid microswimmers consist of biological switch and artificial delivery carriers and have been exposed to protruding theranostic applications. Microalgae create distinct microswimmers for targeting necrotic regions of tumor surroundings. Biocompatibility, penetrating ability through extracellular matrices, biodegradability, and load efficiency...
Book
Full-text available
Nanotechnology is an interdisciplinary research field that integrates chemistry, engineering, biology, and medicine. Nanomaterials offer tremendous opportunity as well as challenges for researchers. Of course, cancer is one of the world's most common health problems, responsible for many deaths. Exploring efficient anticancer drugs could revolution...
Chapter
In defiance of substantial progress in the production of a broad range of cancer delivery systems based on nanocarriers remain unattached to many prevailing problems, such as the aggressive battle against cancer multidrug resistance (MDR) and the low penetration efficiency of the supply systems. In recent years, the production of new metal-based na...
Article
Full-text available
Being considered minor vexations, fungal infections hinder the life of about 15% of the world population superficially, with rare threats to life in case of invasive sepsis. A significant rise in the intrusive mycoses due to machiavellian fungal species is observed over the years due to increased pathology and fatality in people battling life-threa...
Article
The present study was aimed to carry out a novel, non-toxic, cost-effective, and green way to prepare Zinc oxide nanoparticles (ZnONPs) using Bergenia ciliate extract as both reducing and capping agents without any harmful material. The bioreduced ZnONPs were characterized using powder X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV–V...
Article
Full-text available
Background Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex an...
Article
Full-text available
Rising incidents of urinary tract infections (UTIs) among catheterized patients is a noteworthy problem in clinic due to their colonization of uropathogens on abiotic surfaces. Herein, we have examined the surface modification of urinary catheter by embedding with eco-friendly synthesized phytomolecules-capped silver nanoparticles (AgNPs) to preven...
Article
Full-text available
This study aimed to investigate the antioxidant, anti-inflammatory and biosorption properties of starch nanocrystals (SNC). The characterization of synthesized SNC was done using various analytical techniques like microscopic and spectroscopic analysis. The antioxidant property was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and met...
Chapter
The homology modeling is the computational method, and it is one of the essential steps to construct the 3D protein structure using the query sequences of amino acid and template protein. If the query sequence has similar with template structure, then the model structure can be easily predicted with high resolution. The homology modeling for struct...
Chapter
The computational methods are extensively used in the drug discovery research. The molecular modeling approach is widely employed to understand the mechanism of protein‐inhibitor complex to provide more insights in the drug discovery process. The covalent inhibitor provides the plausible mechanism with the protein target which leads to identify pro...
Article
The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread rapidly worldwide, freezes all sectors, and was declared a life-threatening disease by the World Health Organization on Jan 30, 2020. So far, no specific drugs are identified or approved for treating SARS-CoV-2. In the past few years, nanomaterials are in the limelight fo...
Article
Full-text available
This study was aimed to evaluate the antibacterial and biofilm inhibitory activity of Penicillium chrysogenum-derived silver nanoparticles (AgNPs) against the standard and pathogenic Acinetobacter baumannii using a 96-well microtiter plate-based method. The AgNPs were characterized by using UV–Vis, TEM, AFM, XRD, DLS, Zeta potential, and FT-IR. The...
Article
Full-text available
Cancer is one of the biggest healthcare concerns in our century, a disease whose treatment has become even more difficult following reports of drug-resistant tumors. When this happens, chemotherapy treatments fail or decrease in efficiency, leading to catastrophic consequences to the patient. This discovery, along with the fact that drug resistance...
Article
Full-text available
Background High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across...
Article
Nanoarchitectonics is the process of fabricating functional materialsby combining nanotechnology with other fields including supramolecular chemistry, self-organization, chemical synthesis and biotechnology. Nanoarchitectonics find applications in diversified areas such asmaterial fabrication, organization, energy, environment and biomedical techno...
Chapter
Green nanotechnology can be described as the use of biological techniques as a cost-effective, environmentally benign, and simple route for generation, manipulation, and use of materials at the scale of 1 to 100 nm. Green nanotechnology refers to the ability of nature to minimize the potential environmental and human health risks and costs for nano...
Article
This study was aimed to fabricate Zataria multiflora-derived silver nanoparticles (AgNPs) and evaluate the antibacterial activity and biofilm inhibitory activity of plant-mediated fabricated AgNPs (P-AgNPs) compared to commercial AgNPs (C-AgNPs) against Staphylococcus aureus ATCC 25923. The P-AgNPs were characterized by using UV-vis spectroscopy, T...
Article
Full-text available
In recent decades, the major concern of emerging and re-emerging viral diseases has become an increasingly important area of public health concern, and it is of significance to anticipate future pandemic that would inevitably threaten human lives. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged virus that c...
Chapter
The release of a division of extracellular entities with 40–100 nm dimension from both tumor and varied mesenchymal stem cells during pathologic conditions is termed as exosomes that are shown to actively participate in chemical signaling events occurring in multicellular organisms’ infection. Exosomes act as a vehicle for shifting amino acids, lip...
Chapter
Back in the mid-nineties, the discovery of antimicrobials denoted a profound and remarkable achievement in medicine which was capable of saving lives. However, recently, antimicrobial resistance became a major global issue facing modern medicine and significantly increased among bacteria, fungi, and viruses which results in reduced efficacy of many...
Chapter
The impact of nanotechnology has triggered significant advances in a wide variety of fields, especially medicine. Within the biomedical field, the identification of key compounds involved in different pathologies and the diagnoses of those has become a pivotal activity that has been tremendously benefited from the use of nanobiosensors. These nanos...
Chapter
In the United States, breast cancer is the second leading cause of cancer-related deaths in women, according to the reports of the American Cancer Society (ACS) in 2019. Nanotechnology provides innovative strategies to combat breast cancer. In addition to current nanoplatforms such as liposomes and dendrimers that are designed for cancer therapeuti...
Chapter
This study was aimed to discuss the recent advantages and future prospects of controlled and targeted drug delivery systems based on mesoporous silica nanoparticles. We provided valuable information including the laboratory studies that have been confirmed the benefits of these nanoparticles through delivery of antibiotics, antihypertensive, NSAIDs...
Chapter
Back in the mid-nineties, the discovery of antimicrobials denoted a profound and remarkable achievement in medicine which was capable of saving lives. However, recently, antimicrobial resistance became a major global issue facing modern medicine and significantly increased among bacteria, fungi, and viruses which results in reduced efficacy of many...
Article
Full-text available
Coronavirus disease (COVID-19) has emerged as a fast-paced epidemic in late 2019 which is disrupting life-saving immunization services. SARS-CoV-2 is a highly transmissible virus and an infectious disease that has caused fear among people across the world. The worldwide emergence and rapid expansion of SARS-CoV-2 emphasizes the need for exploring i...