Saranya Siva Shanmuga Vadivel

• Doctor of Philosophy
• Research Associate at Bharathidasan University

DNA replication origins play a crucial role in cellular division and are evolutionarily conserved across domains. This study investigated the evolutionary transitions of replication origins between archaea and bacteria by analyzing 2733 bacterial and 257 archaeal genomes. Our findings revealed that certain methanogens and bacteria share phylogeneti...

Space exploration and research are uncovering the potential for terrestrial life to survive in outer space, as well as the environmental factors that affect life during interplanetary transfer. The presence of methane in the Martian atmosphere suggests the possibility of methanogens, either extant or extinct, on Mars. Understanding how methanogens...

Cyclotides are small disulfide-rich peptides (28–37 amino acids) with a wide range of biological activities. The Rubiaceae family is a good source for cyclotide production, but the quantity produced is not sufficient. Therefore, we aimed to enhance cyclotide production in Oldenlandia umbellata (Rubiaceae family) cell cultures using a fungal elicita...

The oil and gas industry produces significant amounts of waste including petroleum wastewater, waste drilling fluid, and oil sludge. Bioremediation uses microorganisms and plants to degrade toxic substances. This offers a cost-effective and less labor-intensive solution for managing waste and recovering contaminated areas. Methanogens play a key ro...

Our study focused on enhancing the production of anthraquinone derivatives in Oldenlandia umbellata using fungal elicitors. Aspergillus niger, Mucor prayagensis, and Trichoderma viride were used to elicit the anthraquinone derivatives in root cultures. The elicitation process led to an increase in the production of phytochemicals and secondary meta...

“In silico organisms” are computational genome-scale metabolic models used in systems and synthetic biology developed by constraint-based metabolic simulations using multi-omics and phenotypic data. The quality of these models is hidden because of the limited availability of genomic information and genome-scale metabolic reconstruction methods. In...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease (COVID-19) pandemic and has infected more than 561M people worldwide. The World Health Organization (WHO) has declared it an international public health concern. Approximately 80% of subclinical COVID-19 cases continue to rapidly spread in...

Snake venom metalloproteinases (SVMPs) are enzymatic proteins found in snake venom and are known for their diverse biological activities, including induction of hemorrhage and degradation of fibrinogen. This study aimed to design and characterize anticancer peptides (ACPs) derived from an SVMP library based on their physicochemical properties. A co...

Traditional commercial media are costly and not ideal for large-scale probiotic production in aquaculture. Choosing the right carbon source for probiotic growth and understanding how biomass production works can offer valuable insights for potential use in aquaculture. In this study, we tested 12 starchy extracts as potential cost-effective alterna...

Ophiocordyceps sinensis is widely used in traditional Asian medicine and grows at high altitudes (3,000–4,000 meters) on the Qinghai-Tibet Plateau. This fungus is an expensive and rare species that is difficult to cultivate. Increasing global demand, limited commercial trade, and precious resources drive an urgent need for the development of artifi...

Marvels of Artificial and Computational Intelligence in Life Sciences is a primer for scholars and students who are interested in the applications of artificial intelligence (AI) and computational intelligence (CI) in life sciences and other industries. The book consists of 16 chapters (9 of which focus on AI and 7 of which showcase the benefits of...

Biogas reactors operating with protein-based biomass have a high methane potential and industrial value. Protein-rich materials, including gelatin processing and ossein factory waste, are suitable feedstocks for use in ammonia-tolerant biogas digesters. However, the anaerobic digestion of these materials is limited by the accumulation of ammonia, h...

Objective: Clostridium botulinum type A is a neurotoxin-producing, spore-forming anaerobic bacterium that causes botulism in humans. The evolutionary genomic context of this organism is not yet known to understand its molecular virulence mechanisms in the human intestinal tract. Hence, this study aimed to investigate the mechanisms underlying viru...

Coronavirus disease (COVID-19) has rapidly expanded into a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Genetic drift in global SARS-CoV-2 isolates and protein evolution have an impact on their ability to escape from current antiviral therapeutics. Hence, our study aimed to reveal how mutations in the...

Coronavirus disease (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new coronavirus isolated from Wuhan, China. It is a global health emergency, and there is no effective antiviral therapeutics available to date. Continuous structural genomic insights of SARS-CoV-2 proteins provide a warranty for the...

Coronavirus disease (COVID-19) rapidly expands to a global pandemic and its impact on public health varies from country to country. It is caused by a new virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is imperative for relapsing current antiviral therapeutics owing to randomized genetic drift in global SARS-CoV-2 isolates. A...

Coronavirus disease (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a global health emergency and no clinically approved vaccines or antiviral drugs available to date. Intensive research on SARS-CoV-2 is urgently warranted to understand its pathogenesis and virulence mechanisms and to disco...

Oldenlandia umbellata L. (Rubiaceae), commonly called as 'Indian Madder', is well known for its dyeing property in addition to medicinal values. This plant is used to extract red dye from its matured roots. Due to diversification and exploitation of this plant for medicinal and dyeing purposes, a simple and reproducible protocol has been establishe...