Sarah Tebeka

• Hôpital Louis-Mourier – Hôpitaux Universitaires Paris Nord Val de Seine

Background Various factors associated with long COVID have been evidenced, but the heterogeneity of definitions and epidemiological investigations has often hidden risk pathways relevant for understanding and preventing this condition. Methods This nationwide random sampling survey conducted in France after the Omicron waves in autumn 2022 assesse...

Introduction During the perinatal period, women have an increased risk for psychiatric disorders, which are highly prevalent in this context. In addition, there are significant delays in diagnosing these conditions, worsening their prognosis and increasing their societal burden. Studies describing psychiatric disorders in the perinatal period often...

Background Postpartum anxiety (PPA) symptoms have harmful effects on child development and mother–infant interactions. Accordingly, in-depth knowledge of associated risk factors is crucial for prevention policies. This study aimed to estimate PPA symptom prevalence at 2 months and to identify associated risk factors in a representative sample of al...

Background Assessing the risk of subsequent self-harm after hospitalisation for COVID-19 is critical for mental health care planning during and after the pandemic. Aims This study aims to compare the risk of admission to hospital for self-harm within 12 months following a COVID-19 hospitalisation during the first half of 2020, with the risk follow...

Several definitions of long COVID are used in research and practice what challenges epidemiological investigations. Here we present differences in long COVID prevalence accounting for several definitions and concordance between the definitions, as well as the risk factors associated with long COVID. Definitions considered were WHO post-COVID19 cond...

Objectives . To estimate postpartum depression at two months (PPD) prevalence and its related risk factors. Design . Multicentre prospective cohort study. Setting. France. Population or sample . Representative sample of 7,133 women participating to the French National Perinatal Survey (ENP) over one week in March 2021. Methods . Data on maternal ch...

Background To identify the different factors associated with postpartum blues and its association with postpartum depression, from a large French cohort. Methods We conducted an analysis of the Interaction Gene Environment in Postpartum Depression cohort, which is a prospective, multicenter cohort including 3310 women. Their personal (according to...

Postpartum depression (PPD) appears at two peak periods: early-onset prior to 2 months after delivery and late-onset (2 months after delivery and beyond). The aim of our study is to evaluate the different genetic factors associated with early- and late-onset PPD. With the French multicenter interaction of gene and environment of depression during p...

Introduction – Alerted by the scientific community to the possible impact of the COVID-19 epidemic on people’s mental health, Santé publique France set up a surveillance system in March 2020. With a focus on crisis management, the objective was to gather the information needed to establish preventive and protective measures for the population. Met...

Background To assess the associations between anxiety and depressive symptoms and post-COVID-19 condition (PCC) by exploring the direction of these associations and their relevance in the definition of PCC. Methods Nationwide survey among French adults, recruited between March and April, 2022, using a quota method to capture a representative sampl...

Women are unexplainedly more affected than men by post-COVID-19 persistent symptoms. Depressive symptoms may partially explain these gender differences. In the French population-based CONSTANCES cohort, depressive symptoms were measured with the 9-item Patient Health Questionnaire (PHQ-9) between April 6 and May 4, 2020. Between December 2020 and J...

Background Perinatal mental health disorders (PMHD) remain often undetected, undiagnosed, and untreated with variable access to perinatal mental health care (PMHC). To guide the design of optimal PMHC (i.e., coproduced with persons with lived experience [PLEs]), this qualitative participatory study explored the experiences, views, and expectations...

Objective: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD. Method: Meta-analyses were conducted on 18 cohorts of Eur...

COVID-19, like other infectious diseases, may be a risk factor for psychotic disorders. We aimed to compare the proportions of hospitalizations for psychotic disorders in the 12 months following discharge from hospital for either COVID-19 or for another reason in the adult general population in France during the first wave of the pandemic. We condu...

Background: Among antidepressants, serotonin-norepinephrine reuptake inhibitors (SNRIs) are particularly expected to increase the risk of hypertensive disorders of pregnancy (HDP) with regard to their biological mechanism. We aimed to evaluate the association between prenatal exposure to SNRI and HDP. Methods: In EFEMERIS, a French database includi...

The perinatal period (in the broadest sense of the term, i.e. pregnancy, birth, and the first year postpartum) is a time of profound changes that can make women more vulnerable to the onset or worsening of psychiatric symptoms and disorders. As observed for previous pandemics, the SARS-CoV-2 pandemic and associated lockdowns may have exacerbated th...

Introduction Major depression episode (MDE) and postpartum depression (PPD) have the same diagnosis criteria, but dissimilarities may be present regarding the frequency and structure of depressive symptoms. Methods We used data from the IGEDEPP Cohort (France) to examine DSM-5 depressive symptoms in two groups of women: 486 with PPD and 871 with a...

Background and hypothesis: In this study, we aimed to determine the prevalence of Psychotics-Like Experiences according to age group and their association with psychiatric disorders through these different age-group, as well as their impact on quality of life. Study design: Using data from the second wave of the NESARC, a large general populatio...

Previous pandemics and related lockdowns have had a deleterious impact on pregnant women’s mental health. We studied the impact of the SARS-CoV-2/Covid-19 pandemic and France’s first lockdown on pregnant women’s mental health. A cross-sectional study was conducted in July 2020 using a web-questionnaire completed by 500 adult women who were pregnant...

COVID-19, like other infectious diseases, may be a risk factor for a first episode of psychosis or psychotic relapse. We aimed to compare the proportions of hospitalizations for psychotic disorders in the 12 months following discharge from hospital for either COVID-19 or for another reason in the adult general population in France during the first...

Background: Psychotic-like experiences (PLEs) constitute subthreshold symptoms of psychotic disorders, and belong to five distinct dimensions: Positive, Negative, Depressive, Mania and Disorganization. PLEs are associated with various psychiatric disorders. However, few studies examined their association with physical disorders. Objective: Our a...

Certain percentage of population experiences persistent symptoms months after an acute Covid-19 episode (Long-COVID), with a significant impact on daily-life. Few studies exist on its prevalence and its impact among the general population. The main objective of this survey was to estimate the prevalence of Long COVID among the general adult populat...

Introduction Although COVID-19 has been associated with psychiatric symptoms in patients, no study to date has examined the risk of hospitalization for psychiatric disorders after hospitalization for this disease. Objective We aimed to compare the proportions of hospitalizations for psychiatric disorders in the 12 months following either hospitali...

Introduction Postpartum depression (PPD) is defined as a major depressive disorder (MDD) beginning after childbirth. Wide debates aim to better understand PPD's specificities compared with MDD. One of the keys in differentiating PPD from MDD is to systematically study scientific “Areas Of Interest” (AOIs) of these disorders. Methods In November 20...

Previous pandemics and related lockdowns have had a deleterious impact on pregnant women’s mental health. We studied the impact of the SARS-CoV-2/Covid-19 pandemic and France’s first lockdown on pregnant women’s mental health. A cross-sectional study was conducted in July 2020 using a web-questionnaire completed by 500 adult women who were pregnant...

Objectives: The COVID-19 pandemic has challenged without precedent both healthcare and educational systems worldwide. How medical students could and should be engaged in the response remains unclear. Medical students were asked to help with communicating with patients’ relatives in our institution. Authors aimed: to (i) present the rapid implementa...

Background: Childhood trauma (CT) is associated with an increased risk of major depressive disorder, but little is known about the impact of CT on depression during pregnancy and the early and late postpartum period. The present study assesses whether CT is associated with perinatal depression, considering different types of CT. Methods: This stud...

Introduction The moving rubber hand illusion allows the evaluation both the sense of body ownership and agency using visuo-motor stimulations. Methods We used the moving rubber hand illusion in anatomic congruence with explicit measures to compare active asynchronous and passive synchronous movements in patients diagnosed with schizophrenia with f...

• Les troubles psychiatriques sont associés à un risque augmenté d’infection au COVID-19. • Les troubles psychiatriques sont associés à un risque augmenté de formes graves de COVID-19. • De manière indépendante du risque accru d’infection, les sujets souffrant de troubles psychiatriques présentent des taux de mortalité au COVID-19 plus importants q...

Objective: To identify risk factors for early and late-onset postpartum depression (PPD) among a wide range of variables including sociodemographic characteristics, childhood trauma, stressful life events during pregnancy and history of personal and family psychiatric disorders; and to assess the contribution of each risk factor. Design: Nested...

Background IGEDEPP (Interaction of Gene and Environment of Depression during PostPartum) is a prospective multicenter cohort study of 3,310 Caucasian women who gave birth between 2011 and 2016, with follow-up until one year postpartum. The aim of the current study is to describe the cohort and estimate the prevalence and cumulative incidence of ear...

Objective Sadness is a common symptom in the general population. We tested the hypothesis that sadness is an intermediate state on a continuum from well-being to major depressive disorder (MDD). Methods Using data from The National Epidemiologic Study of Alcohol and Related Conditions III (NESARC-III), a large and representative US population samp...

Background Postpartum period is associated with an increased risk of bipolar disorder diagnosis and relapse, mainly major depressive episode. Onset during this period might be associated with specific characteristics. Aim To compare the socio-demographic and clinical characteristics of parous women presenting with bipolar disorder and an index dep...

Introduction: In 1959, Kurt Schneider [1] has identified a set of symptoms very specific in schizophrenia named first-rank symptoms (FRS), in which patients do not interpret their thoughts or action as their own. Schneiderian symptoms seem to be the result of self-recognition impairments, including sense of agency and body ownership disturbances. A...

Background: IGEDEPP (Interaction of Gene and Environment of Depression during PostPartum) is a prospective multicenter cohort study of 3,310 Caucasian women who gave birth between 2011 and 2016, with follow-up until one year postpartum. The aim of the current study is to describe the cohort and estimate the prevalence and cumulative incidence of ea...

Background The COVID-19 pandemic and associated lockdown may have psychiatric consequences and increase the number of psychiatric emergency consultations. Methods Three psychiatric centers in Paris and its suburbs took part in the study. We compared the number of total psychiatric emergency consultations during the 4 first weeks of the lockdown in...

Background Fibromyalgia has been associated with various physical and mental disorders. However, these comorbidities need to be quantified in a population‐based study. Method We compared participants with and without self‐reported fibromyalgia to assess (1) The prevalence of self‐reported fibromyalgia and its sociodemographic characteristics in a...

Background Negative Symptoms (blunted affect, alogia, anhedonia, avolition, and asociality) are usually described in schizophrenia but they are also present in other psychiatric disorders. The diagnosis and prognosis relevance of negative symptoms (NS) self-assessment during a first psychiatric episode is still unknown. Aims To determine (i) the r...

Objective The association of obesity with a large range of physical conditions and numerous psychiatric disorders has been extensively studied. Our study sought the extent to which physical conditions or psychiatric disorders associated with obesity mediate the association of obesity with unemployment or disability. Method Using data from the Nati...

Résumé Objectifs L’évaluation du risque suicidaire est une étape essentielle de l’entretien psychiatrique. Cependant, de nombreux médecins sont en difficultés ou redoutent d’interroger les patients sur leurs idées suicidaires. L’objectif de cette étude est d’évaluer l’intérêt d’un atelier de simulation avec des patients standardisés pour améliorer...

Background Heavy episodic drinking (HED) is a frequent pattern of alcohol use in women of childbearing age with severe consequences for both women and child, making it a major public health issue. Some states in the US have reported laws that target the use of alcohol during pregnancy. Our aim was to examine the evolution of 12-month alcohol use an...

The lack of comprehensive data on the association between psychiatric and substance use disorders and habitual sleep duration represents a major health information gap. This study examines the 12-month prevalence of mental disorders stratified by duration of sleep. Data were drawn from face-to-face interviews conducted in the National Epidemiologic...

Background: To what extent Psychotic Like Experiences (PLEs) are associated with nonpsychotic psychiatric disorders and whether the number of PLEs is associated with higher rates of psychiatric disorders remains unclear. Methods: The sample was composed of 34,653 civilian participants, aged 18 years and older from wave 2 National Epidemiologic S...

Introduction Les expériences psychotiques font l’objet de plusieurs travaux récents en population générale. Leur évaluation en pratique clinique peut être complexe. Un outil simple et acceptable en population adolescente est l’auto-évaluation par le questionnaire Prodromal Questionnaire PQ16. Nos objectifs étaient d’évaluer la prévalence des différ...

Le suicide est un problème de santé publique mondiale avec 1 million de mort par an. L’Organisation Mondiale de la Santé (OMS) a ainsi lancé un plan d’action de santé mentale depuis 2013 qui comporte l’objectif de réduire le taux de suicide par pays de 10 % d’ici 2020. Une difficulté rencontrée dans la prévention et la réduction de ces conduites su...

L’adolescence est une période de vulnérabilité qui peut s’exprimer sous forme de Symptômes Psychotiques Atténués (SPA) et/ou de Comportements Suicidaires (CS). Les objectifs sont de déceler la nature, l’intensité et la fréquence des SPA dans une population d’adolescents reçus en urgence puis d’établir quels SPA sont subjectivement pourvoyeurs de CS...

Objective: Sadness is both a common experience in general population and one of the main criteria of major depressive disorder (MDD). We tested the hypothesis of a depressive continuum using sadness as an intermediate experience between well-being and disorder. Methods: A French cross-sectional Mental Health survey in General Population intervie...

Objective: To assess prospectively the association of the number of past pregnancies on the evolution of bipolar disorder (BD). Methods: Data were drawn from the 2 waves of the National Epidemiologic Study of Alcohol and Related Conditions (NESARC), a representative sample of the US population of 34,653 participants. All women diagnosed with BD...

Background: Recent research, especially from the USA, suggests that comorbid binge eating (BE) behaviour and BE disorder are frequent in individuals with Bipolar Disorder (BD). Although basic clinical associations between BD and BE have been investigated, less is known about psychological or temperamental dimensions and qualitative aspects of eati...

Introduction Stigma affects subjects with psychiatric disorders and has a significant impact on their disability, particularly because of a following lack of adherence in cares and medications. Bipolar disorders (BD) were named “manic-depressive psychosis” in France until the 1990s. Then, social representations and stigma of BD underwent major chan...

Antipsychotics are commonly prescribed in the general population since they have many indications. They can be used in acute care such as agitation or behavior disorders, or to treat more characterized psychiatric disorders like psychotic or mood disorders. Consequently, any practitioner will have to prescribe or renew a prescription of antipsychot...

Despite the severity of the loss of a parent and the frequency of parental divorce, few studies compared their impact on mental health in the general adult population. The aim of this study was to estimate the prevalence, sociodemographic correlates, and psychiatric comorbidity of parental loss and parental divorce during childhood and adolescence....

Objective: To estimate the prevalence and determinants for the peripartum depression. Methods: Data were extracted from the 2 waves of the National Epidemiologic Study of Alcohol and Related Conditions (NESARC), a representative sample of the US population corresponding to 34,653 participants. All women pregnant during the year before the second...

Postpartum depression. Postpartum depression affects over 10% of women in the year following childbirth; it has deleterious consequences for the mother - especially a significant risk of recurrence over the life - and the child development. Its detection is sometimes difficult because of polymorphic symptoms, whose severity is typically moderate bu...

INTRODUCTION Jusqu’à récemment, l’éthylphénidate (EPH) était connu comme le métabolite de la méthylphénidate (MPH) quand il est consommée avec de l’alcool. Cette substance peut aussi être produite à partir de la MPH, à l’aide d’acide chlorhydrique et d’éthanol. L’EPH est décrit pour avoir des propriétés psychostimulantes mais, à ce jour, il n’y a p...

Though the carrying out of involuntary psychiatric care (IPC) mainly follows from a subjective appraisal of the patient's state, some specific clinical criteria have been proposed on regards to the underlying disorder. French national recommendations are synthesized hereby, and completed by a literature review. In psychotic disorders, the level of...

- La dépression du post partum est une pathologie fréquente, invalidante pour la mère comme pour l’enfant. - Le dépistage est parfois difficile devant des tableaux trompeurs ou pauci symptomatiques. - La clinique est polymorphe, allant d’une dépression masquée par des plaintes somatiques, à des formes sévères de mélancolie. - Le baby blues, non pa...