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Publications
Publications (15)
Cardiofaciocutaneous (CFC) syndrome is a RASopathy characterized by intellectual disability, congenital heart defects, a characteristic facial appearance, gastro‐intestinal complications, ectodermal abnormalities and growth failure. The RASopathies result from germline mutations in the Ras/Mitogen‐activated‐protein‐kinase (MAPK) pathway. CFC is ass...
We analyzed data from 524 Argentinean infants hospitalized with lower respiratory tract illness (LRTI) due to respiratory syncytial virus (RSV) to inform selection of clinical end points for RSV vaccine efficacy trials. Cases of LRTI due to RSV that required a mask, continuous or bilevel positive airway pressure, or mechanical ventilation were clas...
Background:
Very low birth weight (VLBW) preterm infants have an increased risk of hemorrhage-related morbidity and mortality compared to their full-term counterparts. It's unclear if platelet function differs between preterm and full-term neonates. This is partly due to the large volumes of blood required to perform standard platelet function tes...
Rationale:
Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important cause of death in infants in the developing world. The relative contribution of social, biological, and clinical risk factors to RSV mortality in low-income regions is unclear.
Objectives:
To determine the burden and risk factors for morta...
Despite the advent of antiviral therapy, herpes simplex encephalitis (HSE) remains a devastating condition with significant morbidity and mortality. Neurologic relapse after initial improvement is generally attributed to herpes simplex virus reactivation. In 2013, inflammation caused by anti-N-methyl-d-aspartate receptor antibodies was reported in...
Sir, The medical profession is confronted by inequality in access to health care worldwide. There is an ethical responsibility that this be addressed during the training of new doctors. We examined the baseline interest in international child health among medical students in an Irish University and we looked at the impact of a clinical approach to...
Abstract
Background/aims Preterm infants have higher rates of haemorrhagic diathesis and respiratory complications than terms and adults. Platelets play a key role in haemostasis but detailed platelet function testing in neonate populations are lacking mainly due to the large blood volume requirements. To address this we developed a physiologically...
Arch Dis Child 2014;99:Suppl 2 A211-
Background/aims Preterm infants have higher rates of haemorrhagic diathesis and respiratory complications than terms and adults. Platelets play a key role in haemostasis but detailed platelet function testing in neonate populations are lacking mainly due to the large blood volume requirements. To address this we developed a physiologically relevant...
A baby girl was delivered by emergency caesarean section at 23+6 weeks gestation weighing 440 g. Apgar scores were 1, 3 and 4 at 1, 5 and 10 min, respectively. She was intubated and transferred to the neonatal intensive care unit. Umbilical arterial and venous lines and an orogastric tube (OGT) were inserted. On day 4 of life the OGT appeared to be...
We present the case of a 15-year-old girl who presented with polycythemia. CT abdomen revealed an enhancing mass in the upper pole of her left kidney with features suggestive of renal cell carcinoma. She underwent a laparoscopic radical nephrectomy. Histology demonstrated a well circumscribed, focally encapsulated, round blue cell tumour showing ar...
