Sarah Elheis

Sarah Elheis
University of Southampton · Academic Unit of Human Development and Health

About

23
Publications
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131
Citations

Publications

Publications (23)
Article
Full-text available
Background: Evidence linking prenatal maternal vitamin D supplementation with the offspring's risk of atopic eczema is inconsistent, with most data coming from observational studies. Objective: To examine the influence of maternal cholecalciferol supplementation during pregnancy on risk of atopic eczema in the offspring at ages 12, 24 and 48 mon...
Article
Full-text available
The infant gut microbiome contains a portion of bacteria that originate from the maternal gut. In the infant gut these bacteria encounter a new metabolic environment that differs from the adult gut, consequently requiring adjustments in their activities. We used pilot community RNA sequencing data (metatranscriptomes) from ten mother-infant dyads p...
Article
Objective: Better preconception metabolic and nutritional health are hypothesized to promote gestational normoglycemia and reduce preterm birth, but evidence supporting improved outcomes with nutritional supplementation starting preconception is limited. Research design and methods: This double-blind randomized controlled trial recruited from th...
Data
Selection of study group sample from the Southampton Women’s Survey (SWS) cohort. Note: *Non assisted conception, regular cycle, sure/certain of last menstrual period (LMP), not on oral contraceptive pill prior to LMP, dating range scan data available, LMP consistent with date of conception, first positive pregnancy test, scan data, and gestation a...
Data
Fetal and infant growth and atopic eczema DAG. Notes: Confounding variables: maternal BMI, maternal education, gestational age, and breastfeeding duration. Competing exposures (variables adjusted for to improve precision of model): maternal eczema, smoking during pregnancy, and infant sex. Abbreviations: BMI, body mass index; DAG, directed acyclic...
Article
Full-text available
Background Infants with atopic eczema have an increased risk of impaired growth, but the origin of this impairment is unclear. The aim of this study was to examine fetal and infant growth in relation to infantile atopic eczema. Methods Within the UK Southampton Women’s Survey, 1,759 infants with known maternal menstrual data had anthropometric mea...
Chapter
Rates of childhood obesity and associated noncommunicable diseases (NCDs) are increasing at alarming rates. Such NCDs now account for 60% of deaths globally. There is an urgent need to identify the risk factors for obesity and the underlying mechanisms, with a view to preventing obesity. There is now substantial observational and experimental data...
Article
Background: There is now increasing evidence that asthma and atopy originate in part in utero, with disease risk being associated with the altered epigenetic regulation of genes. Objective and methods: To determine the relationship between variations in DNA methylation at birth and the development of allergic disease, we examined the methylation...
Article
The cover image, by S. El-Heis et al., is based on the Original Article Maternal stress and psychological distress preconception: association with offspring atopic eczema at age 12 months, DOI 10.1111/cea.12910
Article
Full-text available
Background: Improved maternal nutrition and glycaemic control before and during pregnancy are thought to benefit the health of the mother, with consequent benefits for infant body composition and later obesity risk. Maternal insulin resistance and glycaemia around conception and in early pregnancy may be key determinants of maternal physiology and...
Article
Background: Perinatal maternal stress and low mood have been linked to offspring atopic eczema. Objectives: To examine the relation of maternal stress/mood with atopic eczema in the offspring, focusing particularly on stress/psychological distress preconception. Methods: At recruitment in the UK Southampton Women's Survey, preconception matern...
Article
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Click for the corresponding questions to this CME article.
Article
Background: Evidence that atopic eczema partly originates in utero is increasing, with some studies linking the risk of developing the condition with aspects of maternal diet during pregnancy. Nicotinamide, a naturally occurring nutrient that is maintained through the dietary intakes of vitamin B3 and tryptophan, has been used in the treatment of...
Article
Topical calcineurin inhibitors have been used outside their approved indications for a number of conditions, including topical steroid-induced rosacea. However, tacrolimus ointment itself has been reported to trigger rosacea in a small number of cases. We report a case of a rosacea-like eruption in a 39-year-old woman occurring after the use of pim...
Article
Patterns of health, illness and disease are influenced at different stages of the lifecourse by a combination of genetic, epigenetic and environmental factors. Substantial research has demonstrated that during early development, responses to a range of stimuli are likely to ‘programme’ the risk of metabolic and other non-communicable disorders, as...
Article
Full-text available
Sixteen years after a long admission for a serious occupational accident, a 38-year-old man presented with intermittent atypical chest pain. Upon investigations a retained fragment of a pulmonary artery catheter was found in the right ventricle. Throughout the years between his accident and the current presentation he did not have any symptoms or s...

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