Sarah Bushra

Biopharma Services Inc., Canada

Conjugation combines protein domains to achieve new functionalities in therapeutic drugs by utilizing their functional and structural versatility creating highly diverse macromolecules. Several human recombinant protein drugs are being used for the treatment of different diseases. However to improve these recombinant protein drugs’ bioavailability...

Drosophila has been a powerful model organism that has played a vital role in discovering essential conserved neurological and developmental pathways. About 75 percent genes of the human genetic diseases have homologues in the fruit fly. The conserved nature of most of the signaling pathways among human and Drosophila makes it easy to genetically m...

New antimicrobials agents are needed to combat drugs resistance in microorganisms. The aqueous and methanolic extracts of Nigella sativa and Ficus carica seeds were used against bacteria (Staphylococcus aureus and Escherichia coli) and Fungi (Candida albicans, Fusarium oxysporium and Microsporum canis) to check their antimicrobial activities. For a...

The pncA gene encodes Pyrazinamidase enzyme which converts drug pyrazinamide to active form Pyrazinoic acid but mutations in this gene can prevent enzyme activity which leads to pyrazinamide resistance. The cross‐sectional study was carried out during 2016–2017 for twelve months. The purpose of the study was to detect mutation at codon 12 and codon...

This study analyzed the effects of the plant extracts (Citrus limon, Solanum lycopersicum, Zingiber officinale, Vitis vinifera and Allium sativum) on the growth of mammalian cells (Vero and MDA-MB-231) and evaluated the most effective plant extract for the expression of specific genes of the JAK/STAT pathway in human breast cancer cells. An antipro...

The coronavirus SARS-CoV-2 has turned our own health and the world economy upside down. While several vaccine candidates are currently under development, antivirals with the potential to limit virus transmission or block infection are also being explored. Plant production platforms are being used to generate vaccines and antiviral proteins inexpens...

Human height is a quantitative trait with high heritability, controlled by many gene pairs. It is influenced by environmental factors such as nutrition, disease and lifestyle. A study was carried out to compare the height trends of the local population of Rabwah with WHO standards. A total of 4293 accurate observations (male=2084 female =2209) were...