Sarah Brown

Sarah Brown
Barts Health NHS Trust · Paediatric Respiratory Medicine

Doctor of Medicine
Royal London Children's Hospital Queen Mary University of London Clinical Lead for Paediatric Respiratory Medicine

About

44
Publications
1,630
Reads
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381
Citations
Additional affiliations
February 2020 - present
Queen Mary University of London
Position
  • Senior Lecturer
Education
August 2009 - August 2011
Independent Researcher
Independent Researcher
Field of study
  • MD (Res) - Department of Leukocyte Biology
January 2004 - January 2005
London School of Journalism
Field of study
  • Freelance and Feature Writing
August 1998 - August 1999
University College London
Field of study
  • Immunology and Cell Pathology

Publications

Publications (44)
Article
Full-text available
Cystic fibrosis (CF) is a multisystem, genetic disease with a significantly reduced life expectancy. Despite substantial progress in therapies in the last 10-15 years, there is still no cure. There are dozens of drugs in the development pipeline and multiple clinical trials are being conducted across the globe. The UK Cystic Fibrosis Trust's (CFT)...
Conference Paper
Introduction The number of children with neuro-disability surviving childhood and transitioning to adult services continues to grow. These children have complex needs, and many have respiratory issues including recurrent chest infections, aspiration, scoliosis and disordered breathing. Despite this healthcare provision for these children and young...
Article
Full-text available
Background: Proline-glycine-proline (PGP) is a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP-9) and prolylendopeptidase (PE), and capable of eliciting neutrophil chemotaxis and epithelial remodelling. PGP is normally then degraded by leukotriene A4 hydrolase (LTA4H) to limit inflammation and remodelling....
Conference Paper
Introduction Worldwide, non-cystic fibrosis bronchiectasis is a significant cause of morbidity and mortality, particularly in indigenous communities, and prevalence is higher than cystic fibrosis (CF). Despite this, research into non-CF bronchiectasis is limited. Often the aetiology is unknown and presumed to be secondary to a significant respirato...
Article
Full-text available
Introduction: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has been shown to improve the nutritional status and lung function of cystic fibrosis patients with the G551D mutation in clinical trials. The objective of this study was to describe the real-world progress of children receiving ivacaftor. Met...
Article
Full-text available
Introduction Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has been shown to improve the nutritional status and lung function of cystic fibrosis patients with the G551D mutation in clinical trials. The objective of this study was to describe the real-world progress of children receiving ivacaftor. Metho...
Conference Paper
Introduction and objectives Childhood obesity is an increasing problem leading to significant health concerns. Children are referred to our Tier 3 obesity service if they have BMI ≥3.5 standard deviations (SD) or BMI ≥3 SD with comorbidities. There are currently 120 children under the care of the service; 22 have severe sleep disordered breathing (...
Article
A number of risk factors have been identified for deterioration of lung disease in children with Cystic Fibrosis (CF), and current management strategies are based on the prevention and treatment of such elements. Further challenge ensues when a patient has co-morbid disease in addition to CF, particularly when faced with rapidly deteriorating pulmo...
Thesis
Many paediatric airway diseases are characterised by persistent neutrophilic inflammation, which can lead to damage to the airways and lung parenchyma. One possible mechanism for the persistence of neutrophilic inflammation is failure of the normal active resolution of the inflammatory process. There is limited published literature on the role of i...
Article
Full-text available
12/15-Lipoxygenases (LOX) in monocytes and macrophages generate novel phospholipid- esterified eicosanoids. Here, we report generation of two additional families of related lipids, comprising 15-ketoeicosatetraenoic acid (KETE) attached to four phosphatidylethanolamines (PE). The lipids are generated basally by 15-LOX in IL-4-stimulated monocytes,...
Conference Paper
Full-text available
Background A small proportion of patients with long standing severe asthma develop irreversible airway obstruction (persistent airflow limitation (PAL)). There is no agreed definition of PAL in children, but pragmatically, most would define it as post steroid, post-bronchodilator FEV1 percent predicted <80% or Z score less than −1.96, with normativ...
Article
Full-text available
Cystic fibrosis (CF) is characterized by bronchoalveolar neutrophilia and submucosal lymphocytosis. We hypothesized that Th17 lymphocytes are part of this submucosal infiltrate. Quantification and phenotyping of the lymphocytic infiltrate in the bronchial submucosa of patients with CF (n = 53, of which 20 were newly diagnosed), non-CF bronchiectasi...
Article
Vitamin D (vD) levels have been reported to correlate with (a) lung function in healthy populations and (b) disease severity in pulmonary TB, COPD and asthma. The proposed mechanism, supported by in vitro studies, relates to vD response elements in the promoter regions of genes encoding molecules involved in innate immunity such as defensins and ca...
Article
Over the past decades, the continued improvement in survival of patients with cystic fibrosis (CF) has partly been attributed to improved nutritional status and aggressive treatment of respiratory exacerbations.1 Standard intravenous antibiotic treatment for an exacerbation lasts 14 days, and most centres follow this guideline.2 Some patients recei...
Article
We report on a child with Mycoplasma pneumonia, who developed an unexplained new oxygen requirement. He was found to have an ileo-femoral thrombosis and an acute pulmonary embolus, with positive anti-phospholipid antibodies and acquired activated protein C resistance. These are both acquired risk factors for venous thrombosis. He was successfully a...
Article
Croup is the commonest cause of acute airway obstruction in young children. Here the author describes its diagnosis and management in primary care and advises on when to admit for emergency treatment. Copyright © 2006 Wiley Interface Ltd
Article
The current literature suggests that cord blood (CB) cells are functionally immature. We previously reported that CB sera inhibit T cell proliferation and suggested that the microenvironment in which CB T cells reside may be, in part, responsible for their reduced function. In this study we have tried to explain some of the actions of the CB sera o...

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