Sarad Pawar Naik Bukke

• Doctor of Philosophy
• Associate Professor and Research Coordinator at Kampala International University, Uganda

Background HIV/AIDS remains a global health challenge, with significant prevalence in sub-Saharan Africa. Highly active antiretroviral therapy (HAART) is the mainstay treatment for HIV, and the number of people living with HIV (PLWHIV) on HAART has considerably increased worldwide. The use of HAART has led to improved patient outcomes; however, it...

Background Medication use (MU) during pregnancy can increase the risk of maternal and fetal health consequences. Women's knowledge, attitude, and practice (KAP) regarding safe MU can influence pregnancy outcomes. The study aimed to assess and explore women's KAP regarding safe MU during pregnancy and identify possible determinants. Methods A cross...

Background and objective Despite its critical role in individual and societal health, food hygiene remains underexplored. Antibiotic-resistant pathogenic bacteria in ready-to-eat (RTE) food threaten public health. This scoping review collected data on the epidemiological prevalence of RTE food-contaminated pathogens resistant to antimicrobial drugs...

Non-thermal plasma (NTP) catalysis has emerged as a transformative technology for achieving sustainable chemical production, particularly within energy-intensive industries. With advantages like rapid response times, low thermal input, and the ability to operate at atmospheric pressures, NTP systems are well-suited for integration with renewable en...

The development of 3D-printed microneedle (MN) technology is a significant step in vaccine delivery, providing a painless, effective, and adaptable substitute for conventional injection-based techniques. Direct transdermal vaccination distribution without the need for needles is made possible by microneedle patches, which employ a variety of tiny n...

Background Chronic obstructive pulmonary disease (COPD) is a significant global health issue, worsened by pollution and modernisation. Ensifentrine (EFT), a new dual inhibitor of phosphodiesterase PDE3 and PDE4, is being developed for inhalation to target airway inflammation, bronchodilation, and ciliary function in COPD treatment. Objective This...

Biomaterials are essential in modern medicine, driving advancements in tissue engineering (TE), drug delivery, and medical devices. This review explores the intersection of biomaterials and sustainability, highlighting efforts to develop environmentally friendly materials through advanced technology. It examines key biomaterial characteristics for...

Background Osteoarthritis is characterised by degenerative changes, while rheumatoid arthritis is an inflammatory disorder characterised by swelling and inflammation in the synovial membranes of the joints, which leads to bone erosion and joint deformity. Although new drugs have expanded treatment options, severe rheumatoid arthritis can significan...

This systematic review delves into the potential of herbal remedies as anti-urticaria agents, examining recent advancements, current clinical status, and prospects. Despite advancements in conventional treatments, managing urticaria remains challenging. There is a growing interest in herbal remedies as potential anti-urticaria drugs. A comprehensiv...

Background and objective: Food hygiene has received little attention despite being crucial for individual and societal productivity and health. Ready-to-eat (RTE) food tainted with antibioticresistant pathogenic bacteria poses a serious risk to public health. This scoping review aims to create a database for epidemiological prevalence of RTE food-c...

Background Piperine, a secondary metabolite, affects the antihyperlipidemic effect of Ezetimibe (EZ). Hyperlipidemia is one of the independent risk factors for cardiovascular disorders such as atherosclerosis. Antihyperlipidemic drugs are essential for reducing cardiovascular events and patient mortality. Our study aimed to improve the solubility o...

As Ugandans grapple with an increase in metabolic diseases, researchers are turning to their rich tradition of natural remedies. This review explores promising plants, such as Moringa oleifera, bridging the gap between the wisdom of Ugandan healers and modern science. Although these plants show potential, challenges remain. Many lack rigorous testi...

Purpose Rational self-medication (SM) practice among healthcare students is essential to promote the safe, effective, and economical use of medicines for self-diagnosed conditions. The study aimed to assess pharmacy students’ knowledge, attitude, and practice about responsible self-medication. Methodology A cross-sectional online survey was conduc...

Background Ritonavir is an anti-retroviral protease inhibitor to treat HIV, AIDS infections. Methods The RN-SLNs were prepared by using hot homogenization followed ultrasonication method and optimized by using a two-factor, three-level central composte design (CCD). The independent variables were selected as phospholipids (X1) and type of surfacta...

Ocular nanoparticles are tiny particles designed to deliver drugs to the eye and have increased drug stability, prolonged drug release, and thereby enhanced bioavailability. Nanoparticles utilized in ocular drug delivery include liposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, dendrimers, and niosomes. N...

Background The increase in bacterial infection, combined with antibacterial resistance, remains a global threat, fueling the popularity of medicinal herbs as people seek alternatives to synthetic medicine. This review synthesizes scientific evidence regarding the medicinal uses of lemon bottle-brush (Callistemon citrinus (Curtis) (C. citrinus) to i...

This narrative review explores the intersection of computational intelligence (CI) techniques and the Sustainable Development Goals (SDGs) in the context of female cancer patients. With the increasing prevalence of cancer among women worldwide, there is a pressing need to integrate advanced computational methods to enhance diagnosis, treatment, and...

Background Stroke is a major cause of illness, death, and long-term disability and a major health concern worldwide. Experts consider insulin resistance (IR), a defining feature of the metabolic syndrome and a significant risk factor for stroke. Insulin resistance, or IR, is common among stroke patients. The triglyceride-glucose (TYG) index's relev...

Pneumococcus, also known as Streptococcus pneumoniae, is the cause of several serious humanillnesses, including pneumonia, bronchitis, bacterial meningitis, sepsis, otitis media, and corneal ulcers.Some of these illnesses cause morbidity and mortality globally. Streptococcus pneumoniae is currentlyresponsible for most of pneumonia infections global...

Background The antihyperlipidemic action of Ezetimibe (EZ) is influenced by its secondary metabolite, piperine. Independent risk factors for cardiovascular illnesses, including atherosclerosis, include hyperlipidaemia. Preventing cardiovascular events and death in patients requires the use of antihyperlipidemic medications. We set out to find a way...

In this investigation, we synthesized five novel pyrimidine-benzofuran hybrids by seamlessly merging the pyrimidine and benzofuran motifs, resulting in unique heterocyclic structures. These compounds were meticulously crafted through a well-defined multistep synthesis process, commencing with 5-chlorosalicylaldehyde as the starting material. Rigoro...

Researchers and healthcare professionals are eager to understand how nutrition affects autoimmune diseases due to their rise. This chapter explores how diet affects autoimmune diseases, aiming to explain how nutrition can aid or hinder their development. Nutrition affects brain activity, muscle health, bone strength, nerve function, skin integrity,...

Background Physalis alkekengi is a medicinal plant rich in vitamins, flavonoids, and various bioactive substances. Its productivity is compromised by natural infection with the tobacco mosaic virus (TMV), which disrupts physiological processes. This study aimed to establish virus-free plantations of Physalis alkekengi using microcloning techniques....

Acute renal injury (ARI) post cardiac surgery leads to substantial difficulty in going about the treatment, that often results in aggravated morbidity and mortality rates. Through this manuscript, we have the opportunity to cover a basic assessment of ARI complexity, including comorbidities which have been categorized as preoperative, intraoperativ...

One of the most historical and devastating phenomena in the current century was Covid 19 pandemic. A major part of the world population was infected due to the sudden outbreak and claimed many lives. The pandemic impacts almost every aspects of the world infrastructure. The major hit back is observed in the healthcare sector. To combat the virus ou...

Ethnopharmacological relevance Gemlina arborea Roxb. ex. 's entire plant is utilized in medicine to treat several diseases. Objective and design Cerebral infarction occurs through multiple mechanisms, and herbs are natural multi-component with numerous protective mechanisms. This research investigates the neuroprotective effect of Gemlina arborea s...

Lipid-based colloidal carriers, particularly Solid Lipid Nanoparticles (SLNs), offer a versatile platform for formulating hydrophobic drugs, presenting significant pharmaceutical implications across diverse fields. This paper explores methodologies utilized in SLN production, ranging from high-pressure homogenization to microemulsion techniques, wi...

Medication (prescription or nonprescription) use during pregnancy is associated with a risk of harm to maternal and fetal health. Pregnant women’s knowledge, attitude, and practice (KAP) toward safe medication use can influence positive outcomes. The study aims to assess and explore the risk factors associated with KAP toward medication use during...

Background The incidence of neurodegenerative diseases has skyrocketed alongside the extension of the average human lifespan. Oxidative stress is a hallmark of this group of diseases, its involvement in disease onset and/or progression is incompletely understood. Polyphenols are among the most promising natural compounds for their neuroprotective c...

Background:This study developed and evaluated bilosomes containing Nimodipine (NDP) to create an appropriate formulation for a sustained-release transdermal gel.The generated bilosomal gel formulation was tested for its potential to increase...

Background Women living with HIV are at increased risk of developing cervical cancer (CC). Screening for cancer is an important preventive strategy for the early detection of precancerous lesions and its management. There has been inadequate evidence on cervical cancer screening (CCS) practices among HIV-positive women in rural western Uganda. This...

Objective The objective of this study is to investigate the effects of an ethanolic extract derived from Agaricus subrufescens on rat models exhibiting Polycystic Ovarian Syndrome (PCOS) induced by Letrozole. Methods A total of thirty female Wistar rats were divided into five groups, each consisting of six rats. The negative control group was admi...

In many newborn infants, neutropaenia is a self-resolving condition. Nevertheless, it is thought that in premature infants, neutrophil formation and function are a little different. Since neutrophils play a crucial role in innate immunity, neonatal neutropenia in premature infants needs to be quickly identified and treated according to the risk fac...

Objective To examine the impact of an ethonolic extract of Agaricus subrufescens on rat models of Polycystic Ovarian Syndrome (PCOS) produced by letrozole. Methods Thirty female Wistar rats were split into five six-rat groups. Negative controls received 1 mL of 0.5% carboxy methylcellulose (CMC). Other groups received letrozole (1 mg/kg) for 21 day...

The floating drug delivery system (FDDS) is also called a hydrodynamically balanced system (HBS). In FDDS, the drugs carriers float in gastric juice to ensure that drugs do not leave stomach shortly. It efficiently increases drug bioavailability by prolonging the release period.

Noro virus also called as winter vomiting bug. This is a positive single stranded RNA virus belongs to family of calciviridae. It is the main causative agent for gastroenteritis. This virus can cause sudden onset of diarrhoea and vomiting. It spreads through contaminated water and food. Infection begins in 12-48 hrs after exposure. Symptoms lost wi...

The objective of the study is to formulate and evaluate the sustained release matrix tablets of glimipride using natural polymers tamarind seed mucilage and guar gum. Glimepiride is a first third generation sulphonyl urea agent for the treatment type II diabetes mellitus. The drug excipient mixtures were subjected to pre-formulation studies. The ta...

Many elderly persons face difficulties in administering conventional oral dosage forms because of hand tremors and dysphasia. The aim of this work is to prepare and evaluate fast dissolving tablets of Naproxen sodium using super disintegrates like croscarmellose sodium, crospovidone, sodium starch glycolate to improve patient compliance. Naproxen i...

Corona virus belongs to wide class of virus that causes respiratory illness. A novel corona virus known as 2019-nCoV or Covid-19 emerged in Wuhan, located in china, at the end of 2019.In humans there are seven forms of corona virus. The mode of transmission is contagious like through coughing, sneezing etc., Symptoms like cough fever and shortness...

The concept of targeted drug delivery is designed for attempting toconcentrate the drug inthe target tissues of interest while reducing the relativeconcentration of the medication in the remaining tissues i.e., other than target tissues, so that the drugis localized on the targeted site. Hence, other/surrounding tissues are notaffected by the drug....

Diacerein (DCN) is a new anti-inflammatory analgesic and antipyretic drug developed specially for the treatment of osteoarthritis. The main objective of the study was to formulate and evaluate bioadhesive buccal tablets to avoid the first pass metabolism in liver. Bioadhesive buccal tablets were prepared by direct compression method using bioadhesi...

Antibiotics are the powerful medicines that fight with bacterial infections but the inappropriate use of these can cause bacterial resistance. Misuse of antibiotics due to lack of knowledge on it becoming a public health problem world widely. Consequently, auditing antibiotic prescription patterns can improve efficacy and safety.

Adults aged ≥ 50 years are fastest segment of the population in many countries and often have multiple medical conditions like hypertension (HTN), diabetes and arthritis etc. Increasing the medications leads to increase complexity and poor compliance. There are many interrelated factors like psychological, behavioral and treatment leading to cause...