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Introduction
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Publications
Publications (5)
High levels of circulating Lipoprotein (a) [Lp(a)] are an independent risk factor for CVD. One of the major limitations to investigating Lp(a) biology is the need for large volumes of plasma (4–10 mL) for its isolation. We developed an isolation technique requiring only 0.4 mL of plasma yielding an enriched Lp(a) fraction suitable for compositional...
Rationale: Prospective cohort studies question the value of HDL-C for stroke risk prediction.
Objective: Investigate the relationship between long-term functional recovery and HDL proteome and function.
Methods and Results: Changes in HDL protein composition and function (cholesterol efflux capacity, or CEC) in patients after acute ischemic stroke...
Recent developments in in situ microscopy have enabled unparalleled resolution of the architecture of the bone marrow (BM) niche for murine hematopoietic stem and progenitor cells (HSPCs). However, the extent to which these observations can be extrapolated to human BM remains unknown. In humans, adipose tissue occupies a significant portion of the...
Rationale
Elevated serum lipoprotein(a) [Lp(a)] levels are associated with increased cardiovascular disease risk. ABCA1-mediated cholesterol efflux from macrophages is believed to be an anti-atherogenic process. We recently identified plasminogen as a driver of ABCA1-mediated cholesterol efflux and showed that its action is inhibited by purified hu...
Since the discovery of Buckminster Fullerenes (C60), countless hours have been devoted to the study of this carbon nanoparticle. C60 has been investigated in context of photodynamic therapy of cancer, photovoltaic cells, semiconductors, and enzyme inhibition. However, the biological effects of C60 remain a mystery. The intention of this study was t...
