Sara Bastida

Sara Bastida
Complutense University of Madrid | UCM · Departamento de Nutrición y Ciencia de los Alimentos. Nutrition & Food Science Department.

PhD

About

172
Publications
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Introduction
Sara Bastida currently works in Pediatrics, Nutritional Biochemistry & Nutrition and Dietetics. Their most recent publication Carob fruit extract-enriched meat, as preventive and curative treatments, improves gut microbiota and colonic barrier integrity in a late-stage T2DM model

Publications

Publications (172)
Article
High meat consumption has been associated with increased oxidative stress mainly due to the generation of oxidized compounds in the body, such as malondialdehyde, 4-hydroxy-nonenal, oxysterols, or protein carbonyls, which can induce oxidative damage. Meat products are excellent matrices for introducing different bioactive compounds, to obtain funct...
Article
Epidemiological and experimental studies have suggested that dietary fiber and proanthocyanidins play an important role on gut microbiota (GM), colonic integrity and body health. Type 2 Diabetes Mellitus (T2DM) is a prevalent disease in which the modifications in the GM and colonic markers stand out. This manuscript hypothesizes the consumption of...
Article
Full-text available
The repeated frying of food in sunflower oil produces thermo-oxidation and polymerization, potentially negative for health. The reaction of the gastrointestinal system to these compounds is unknown. Proanthocyanidins have antioxidant and lipid-lowering properties. We hypothesize that a carob-fruit extract rich in proanthocyanidins (CFE) improves th...
Article
Full-text available
High meat and meat-products consumption has been related to degenerative diseases. In addition to their saturated fatty acids and cholesterol contents, oxidation products generated during their production, storage, digestion, and metabolization have been largely implicated. This review begins by summarizing the concept of meat and meat-products by...
Article
The inclusion of functional bioactive compounds of dietary fiber in meat products has demonstrated to exert a significant impact on human health. Carob Fruit Extract (CFE) is a dietary fiber rich in proanthocyanidins with known antioxidant, hypolipidemic, and hypoglycemic effects. Consumption of CFE-enriched meat (CFE-RM) may provide interesting be...
Chapter
Las proantocianidinas (PA), también denominadas taninos condensados, son compuestos polifenólicos vegetales que pertenecen a la subcategoría de flavanoles. Constituyen el grupo más abundante de fenoles naturales de la dieta occidental. Las PA difieren en el grado de polimerización y estructura, lo que a su vez condiciona su metabolización y sus efe...
Chapter
Pregnancy is a crucial period where growth, development, maturation, and metabolic adaptations take place. This chapter deals with central aspects of nutrition throughout gestation on the embryonic and fetal periods. Details of the thrifty phenotype hypothesis are given, indicating that hypo-/subnutrition causes metabolic adaptations that permit th...
Chapter
Frying is a very common cooking method in the Mediterranean cuisine with fried-food consumption largely contributing to Mediterranean diet composition. New habits, kitchen facilities, and potential health hazard have modified old culinary practices, inducing reduction in fried-food consumption in Mediterranean countries. This review provides severa...
Article
This article describes the virtues of a research focused on silicon, one of the most important but least known ingredients in beer, and its protective action at the neurodegenerative level. Among the various factors contributing to the Alzheimer's disease induction and development, aluminum, by concentrating in brain induces, among other mechanisms...
Article
Insulin resistance (IR) produces qualitative, quantitative and kinetic changes of lipoproteins in Type 2 Diabetes Mellitus (T2DM). Carob-fruit-extract (CFE) has demonstrated antidiabetic properties but barely studies have evaluated the effect of CFE functional-meat consumption on early stages of T2DM. The current study was designed to analyze the e...
Article
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The prevalence of degenerative diseases has risen in western countries. Growing evidence suggests that demenia and other cognition affectations are associated with ambient factors including specific nutrients, food ingredients or specific dietary patterns. Mediterranean diet adherence has been associated with various health benefits and decreased r...
Article
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Carob fruit extract (CFE) has shown remarkable in vitro antioxidant properties and reduces postprandial hyperglycemia and hyperlipidemia in healthy animals. Development of functional meat products that contain bioactive components are presented as a great nutritional strategy. Until now, the effect of the consumption of restructured meat enriched w...
Article
Full-text available
Restructuring pork (RP) by adding new functional ingredients, like Chia oil (one of the richest natural source of α-linolenic acid) or hydroxytyrosol (HxT) (potent antioxidant), both with hypolipidemic activities, is one of the strategies that may help to reduce the potential negative effects of high meat products consumption. The aim of this study...
Article
Full-text available
In this work on celiac disease, the authors focus mainly on the most relevant historical aspects that have been patterning knowledge on celiac disease. Once more details of the disease through their symptoms have been known, a more rigorous profile of this pathology was made. Thus, the Celiac Diseases first was considered a chronic indigestion with...
Article
Increased postprandial lipemia is a cardiovascular disease (CVD) risk factor. Carob fruit extract (CFE) contains condensed tannins whose intake has been inversely related to CVD. The objective was to evaluate the in vitro pancreatic lipase activity in presence of CFE and the in vivo effect of CFE on postprandial lipemia of healthy Wistar rats in ac...
Article
Full-text available
Aluminum consumption has been associated with various neurodegenerative diseases. Previous studies suggest that regular beer intake reverses the pro-oxidant and inflammatory statuses induced by aluminum nitrate intoxication. This paper aims to evaluate the in vitro antioxidant capacity and acetylcholinesterase inhibitory activity of non-alcoholic b...
Article
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Conclusion: In conclusion, TyG appears to be a suitable tool for identifying IR at birth, justifying the further insulin determination in those neonates. TyG ≥ 7.8 is recommended as cut-off point in neonates. The need for a follow-up study to confirm the TyG as early IR marker is desirable. What is known: • HOMA-IR and the triglyceride-glucose i...
Article
Full-text available
The frying performance of two virgin olive oils (VOO) from Cornicabra olives of different ripeness indices, 2.08 for VOO1 and 4.13 for VOO2, was evaluated. Thermal, oxidative and hydrolytic alterations were determined throughout 40 frying operations with potatoes. The initial oils showed similar fatty acid compositions and oxidative stability indic...
Article
Metabolic syndrome (MS) has a multifactorial and not yet fully clarified origin. Insulin resistance is a key element that connects all the accepted components of MS (obesity, dyslipemia, high blood pressure, and hyperglycemia). There is strong evidence that epigenetic changes during fetal development are key factors in the development of MS. These...
Conference Paper
Full-text available
High meat-product consumption has been related to cardiovascular disease (CVD). However, previous results suggest the benefits of consuming reduce fat meat products on lipoproteins. Present study aims to assess the effect of consuming reduced fat-Pâté and Frankfurter on some anthropometric and inflammatory markers (e.g. body fat and tumor necrotic...
Article
The postprandial state plays a central role in the development and setting of chronic diseases. Condensed tannins (CT) are polyphenols with a known ability to modify carbohydrate digestion and absorption. The high concentration of CT in the pulp of carob fruit suggests a potential antidiabetic effect. The aim of this work was to analyze the in vitr...
Article
Glucomannan-enriched squid surimi improves cholesterolemia and liver antioxidant status. The effect of squid surimi enriched with glucomannan or glucomannan plus spirulina on liver and heart structures and cell damage markers was tested in fa/fa rats fed highly saturated-hyper-energetic diets. Animals were fed 70% AIN-93M rodent diet plus six versi...
Article
Full-text available
Background: Lipoapoptosis has been identified as a key event in the progression of nonalcoholic fatty liver disease (NAFLD), and hence, antiapoptotic agents have been recommended as a possible effective treatment for nonalcoholic steatohepatitis (NASH). Silicon, included in meat as a functional ingredient, improves lipoprotein profiles and liver an...
Article
Chia oil has the highest recognized α-linolenic acid (ALA) content. ALA is associated with beneficial changes in plasma lipids and the prevention of cardiovascular diseases. Present article aims to analyze the effect of Chia oil-enriched restructured pork (RP) on aged rats in a nonalcoholic steatohepatitis (NASH) model. Groups of six male Wistar ra...
Chapter
Full-text available
Information on insulin resistance/sensitivity in term-normoweight neonates is scarce. The hypothalamus-pituitary-adrenal cortex axis and pancreas are implicated in several aspects of foetal maturation and programming. This study aims to analyse the effects of a combination of hyperinsulinaemia plus hypercortisolaemia in such neonates together with...
Article
The positive effects of Si on cardiovascular disease (CVD) and diabetes mellitus (DM) have been mooted. However, the effect of Si on postprandial state has not been evaluated. Postprandial hypertriglyceridaemia and hyperglycaemia are considered risk factors for cardiovascular disease. The effects of Si supplementation on postprandial hypertriglycer...
Article
Full-text available
We evaluated the effects of glucomannan or glucomannan plus spirulina-restructured pork (RP) on liver fatty acid profile, desaturase/elongase enzyme activities and oxidative status of Zucker fa/fa rats for seven weeks. Control (C), glucomannan (G) and glucomannan/spirulina (GS)-RP; HC (cholesterol-enriched control), HG and HGS (cholesterol-enriched...
Article
Archeological evidence suggests that cultivation of sunflower (Helianthus annuus L.) began as early as 2600 BC in Northern American countries. Sunflower ranks among the most important annual field crops in the world. Most of its economic value derives from the sunflower oil production that has increased in the last few decades. In this article, sev...
Article
Full-text available
In this article, we have tried to analyse the core aspects that not only make it difficult to investigate but also transfer knowledge and technology in Spain and other countries, especially non-English speaking ones. Major factors affecting research expenses and the role of managers and mediators are analysed. The paper ends with a reflection on th...
Article
Objectives: Cardiovascular disease (CVD) is prevalent in people at high meat-product consumption. To study the effect of consuming different Pâté and Frankfurter formulations on clinical/emergent CVD biomarkers in male volunteers with different initial LDL-cholesterol levels (< and 􀁴 3.36 mmol/L). Method: Eighteen male volunteers with at least two...
Article
Full-text available
Abstract Background. An increase of cardiovascular disease (CVD) risk in the younger population has been reported in Spain. Adolescents have changed their dietary habits and increased the risk of metabolic syndrome (MS). The Longitudinal study in the area of Toledo aims to evaluate food intake and nutritional habits and their relationship with earl...
Article
High meat-product consumption has been related to cardiovascular disease (CVD). However, previous results suggest the benefits of consuming improved fat meat products on lipoprotein-cholesterol and anthropometric measurements. Present study aims to assess the effect of consuming different Pâté and Frankfurter formulations on emergent CVD biomarkers...
Article
Full-text available
Meat is a well accepted food with appreciable appealing. Due to its high nutritional value it plays a central role in human development. Meat/meat derivates are important sources of proteins, minerals and vitamins. Their nutritional importance is paralleled to their economic impact. Paying attention to the social alarm originated by a recent public...
Article
The influence of maternal fat mass and obesity (FTO) gene polymorphism on neonatal insulin sensitivity/resistance biomarkers and lipoprotein profile has not been tested. The study aimed to assess the association between the FTO rs9939609 polymorphism in mother-neonate couples and neonatal anthropometrical measurements, insulin sensitivity/resistanc...
Article
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Background: Pork is an essential component of the diet that has been linked with major degenerative diseases and development of non-alcoholic steatohepatitis (NASH). Previous studies have. Previous studies have demonstrated the in vitro antioxidant activity of silicon (Si). Furthermore, when Si is added to restructured pork (RP) strongly counterba...
Data
Composition of the Restructured Pork (RP) incorporated to the experimental diets fed 1-year old male Wistar rats. C, control RP diet; CHOL-C, cholesterol enriched high saturated/high cholesterol control RP diet; CHOL-HxT, hydroxytyrosol RP cholesterol enriched high saturated/high cholesterol diet; CHOL-Si, silicon RP cholesterol enriched high satur...
Chapter
Frying is a common and popular method of food preparation in the Mediterranean countries—one whose origins cannot be separated from those of olive tree cultivars and their exploitation. As a consequence, fried foods are considered to be an important part of the Mediterranean diet. Frying presents undoubted advantages: it decreases food preparation...
Article
Full-text available
Type 2 diabetes is a very prevalent chronic disease. Among dietary factors for its prevention and treatment, interest has grown in satiating fibre (konjac glucomannan) and spirulina. Our previous studies suggest that glucomannan itself and/or in conjunction to spirulina displayed hypolipemic and antioxidant effects when incorporated to squid surimi...
Article
Full-text available
Zucker fa/fa rats easily develop dyslipidemia and obesity. Restructured pork (RP) is a suitable matrix for including functional ingredients. The effects of glucomannan- RP or glucomannan plus spirulina-enriched RP on plasma lipid/lipoprotein levels, cytochrome P450 7A1 (CYP7A1) expression, and arylesterase activity in growing fa/fa rats fed high-en...
Article
Full-text available
Research has shown that silicon can play an important role in protecting against degenerative diseases. Restructuring pork by partially disassembling meat would permit the incorporation of active components with potential functional effects. However, there has been no research to date on the impact that silicon, as a functional ingredient in restru...
Article
Full-text available
Cholesterolemia is associated with pro-oxidative and proinflammatory effects. Glucomannan- or glucomannan plus spirulina-enriched surimis were included in cholesterol-enriched high-saturated diets to test the effects on lipemia; antioxidant status (glutathione status, and antioxidant enzymatic levels, expressions and activities); and inflammation b...
Article
The effect of high-fat squid-surimi diets enriched in glucomannan or glucomannan–spirulina on lipemia, liver glutathione status, antioxidant enzymes and inflammation biomarkers was determined in Zucker Fa/Fa rats. Groups of eight rats each received for 7 weeks the squid-surimi control (C), glucomannan-enriched squid-surimi (G) and glucomannan–spiru...
Article
Full-text available
Mediterranean diet consumption is associated to low prevalence of major degenerative diseases. Low Mediterranean-diet-adherence (MDA) score has been related to high insulin and homeostatic model assessment-insulin resistance levels at birth. The relationship between maternal MDA and offspring lipoprotein profile at birth has been scarcely reported....
Article
Ripening modifies oil attributes and composition. However, the influence of the olive ripening on the virgin olive oil (VOO) thermal oxidative stability on food-frying has not been studied yet. Oils from Picual olives of low (VOO1), medium (VOO2) and high (VOO3) ripeness were obtained and their thermal oxidative stability during 40 potato-fryings t...
Article
Full-text available
Background Hydrogen peroxide (H2O2) is a toxic agent that induces oxidative stress and cell death. Silicon (Si) is a biological element involved in limiting aluminium (Al) absorption with possible preventive effects in Alzheimer’s disease. However, Si has not yet been associated with other neuroprotective mechanisms. Methods The present experiment...
Article
The effect of high-fat squid-surimi diets enriched in glucomannan or glucomannan–spirulina on lipemia, liver glutathione status, antioxidant enzymes and inflammation biomarkers was determined in Zucker Fa/Fa rats. Groups of eight rats each received for 7 weeks the squid-surimi control (C), glucomannan-enriched squid-surimi (G) and glucomannan–spiru...
Article
The effect of high-fat squid-surimi diets enriched in glucomannan or glucomannan–spirulina on lipemia, liver glutathione status, antioxidant enzymes and inflammation biomarkers was determined in Zucker Fa/Fa rats. Groups of eight rats each received for 7 weeks the squid-surimi control (C), glucomannan-enriched squid-surimi (G) and glucomannan–spiru...
Article
Full-text available
Background: Seaweeds are good sources of dietary fibre, which can influence glucose uptake and glycemic control. Objective: To investigate and compare the in vitro inhibitory activity of different extracts from Undaria pinnatifida (Wakame), Himanthalia elongata (Sea spaghetti) and Porphyra umbilicalis (Nori) on -glucosidase activity and glucose di...
Article
Full-text available
Abstract There is a general assumption that seaweeds are hypocholesterolemics and antioxidants. However, controversial results suggest specific properties for each individual alga. This study aims to assess the effect of including Sea Spaghetti alga (S) in a restructured-pork (RP) diet, both enriched and not enriched with dietary cholesterol, on ar...
Article
Full-text available
Background: The relationship between serum minerals and homocysteine, lipoprotein and glucose homeostasis markers at birth has been scarcely reported. This study aims to determine a) the relationship between calcium, magnesium, cardiovascular disease (CVD) markers (e.g. lipids, lipoproteins, homocysteine) and insulin sensitivity/ resistance markers...
Article
Pregnancy is a crucial period where growth, development, maturation, and metabolic adaptations take place. This chapter deals with central aspects of nutrition throughout gestation on the embryonic and fetal periods. Details of the thrifty phenotype hypothesis are given, indicating that hypo/subnutrition causes metabolic adaptations that permit the...
Chapter
The importance of algae as components of functional foods with special application to cardiovascular diseases, due to their high dietary fiber, mineral, vitamin and phytochemical contents, and their polyunsaturated fatty acid profile is discussed. The chapter reviews controlled studies and publications by the authors regarding the effect of consumi...
Article
Surimi is considered a healthy food. Hypocholesterolemic and antioxidant properties of soluble fiber and microalgae may reduce cardiovascular disease risk, making them potential functional ingredients. This study aims to determine whether glucomannan-enriched or glucomannan plus spirulina-enriched squid-surimi improve plasma lipid/lipoprotein level...
Article
Full-text available
Restructured pork (RP) enriched in Seaweeds are potential functional foods. The antiapoptotic and hypocholesterolemic effects of consuming cholesterol enriched diets containing Wakame-RP (CW), Nori-RP (CN) and Sea Spaghetti (CS) were tested in a 1-wk study. Groups of six rats per group were fed a mix of 85% AIN-93M rodent-diet containing cholestero...
Article
Full-text available
Pregnancy is a vital period where several hyperplasic, hypertrophic processes together with metabolic adaptation and preparation for extra-uterine life take place. Present review accounts for central aspects of nutrition throughout gestation on the embryonic and fetal periods. It is centered in the major changes occurring in fetal pancreas, with sp...
Article
Full-text available
Early alterations in glucose homeostasis increase the risk of developing insulin resistance and obesity later in life. The concurrence of altered lipids and insulin sensitivity/resistance markers at birth has been scarcely investigated. The study aimed to ascertain level ranges of homocysteine (tHcyt), arylesterase (AE), lipids/lipoproteins, and in...
Article
Background. There has been some indications that seaweeds could be used anti-diabetic foods/ingredients but the mechanisms of action remain unclear. Glucagon-like-peptide (GLP-1) is an incretin hormone secreted by the small intestine in response to nutrient ingestion, regulates the insulin secretion by pancreatic -cells. Long-term infusion of GLP-...
Article
Full-text available
Resumen El embarazo es una etapa de vital importancia, donde tienen lugar múltiples procesos hiperplásicos, hipertróficos, de adaptación metabólica y de preparación para la vida extrauterina. En esta revisión se analizan aspectos centrales de la nutrición durante el embarazo, tanto en la etapa embrionaria como fetal. Se exponen los cambios más impo...