Sar Fatou Bintou

• Professor
• Principal Investigator at Université Iba Der THIAM de Thiès

Physiology education in Africa faces challenges due to gaps in curricula across many of its universities, such as divergent content, a lack of standardized competencies, and suitable benchmarking. Here, we describe the development of Physiology Curriculum for African Universities (PhysioCAFUN), a competency-based curriculum development guideline, a...

We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing researc...

Mitracarpus hirtus, grass of the Rubiaceae family, is a seasonal species. Among other things, it is traditionally used to treat skin diseases and diabetes, and as an antibiotic and antidote to insect bites and stings. In order to establish the safety of these treatments, the aim of this study was to assess the effects of the acute and sub-acute tox...

Introduction: Although there are several previous publications related to risk factors of COVID-19 infection, in Benin there are very few data to explain the outbreak risk factors. Material and methods: This case-control study, conducted from 14 September to 20 October 2020, aimed to identify the risk factors associated with COVID-19 infection in...

Background Voacanga africana (VOC) has been widely used for many years in the African traditional medicine system for the treatment of a wide range of diseases, including mental disorders but VOC has never been tested in vivo in the context of neurodegenerative diseases for its potential symptomatic and/or disease-modifying action. Purpose We aim...

Background Apolipoprotein E is a multifunctional protein that plays an important role in lipid metabolism. It is encoded by the APOE gene. However, APOE gene polymorphism has not been very well studied in the Senegalese population. Therefore, we studied allele frequencies, genotype distributions, and the relationship between APOE gene polymorphisms...

Introduction Le SAHOS est fréquent, méconnu et sous-diagnostiqué. La qualité de vie des sujets atteints est altérée, du fait du retentissement du SAHOS sur la vie professionnelle et sociale. Les symptômes ne sont pas toujours connus de la population et des professionnels de santé. Les patients atteints peuvent être traités pendant longtemps pour fa...

Background: The mastery and supervision of traditional medicine in our country, particularly Senegal, would be of capital importance for the population. We were interested in the physiological effects of Voacanga africana (VOC) extracts in wound healing and topical inflammation. Aims and Objectives: This work was to evaluate the effects on inflamma...

Diabetes mellitus is a major public health disease, and it affects all segments of the population around the world. The progression of this disease is worrying, 460 million in 2019, the number of diabetics is estimated in 2045 at 700 million worldwide. The antioxidant and antidiabetic activities of the ethyl acetate (EA) and Butan-1-ol (But-ol) fra...

Objectif Le SAOS est caractérisé par des épisodes récurrents d’interruption de la ventilation avec hypoxémie, hypercapnie et hyper activation du système nerveux autonome. L’hypoxémie suivie de ré-oxygénation, entraîne une dysfonction endothéliale (DE) par formation de radicaux libres, stress oxydatif et inflammation vasculaire. L’objectif était d’é...

Introduction Le syndrome d’apnées obstructives du sommeil (SAOS) est fréquent, méconnu et sous-diagnostiqué. Différents questionnaires sont utilisés pour évaluer le risque de survenue, la confirmation diagnostique repose sur la polygraphie et/ou polysomnographie. L’objectif de cette étude transversale descriptive et analytique était d’identifier de...

The world is experiencing an outbreak due to the new and mysterious SARS-CoV-2. Information regarding its source and transmission dynamics in different environments as well as medications for its prevention and cure is weak. This review seeks to document on the epidemiology, clinical signs, control, prevention, and present some perspectives for SAR...

Résumé Introduction Le syndrome d’apnées hypopnées obstructives du sommeil (SAHOS) est une pathologie relativement fréquente, sous-diagnostiquée, potentiellement grave, de par les comorbidités cardiovasculaires et métaboliques, et les répercussions socioprofessionnelles. Jusqu’à l’heure actuelle, aucune donnée n’a été obtenue sur la prévalence de...

Résumé Le syndrome d’apnée-hypopnée obstructif du sommeil (SAHOS) est fréquent, sous diagnostiqué et grave. Il augmente la morbidité et la mortalité cardiovasculaires, réduit l’espérance de vie et altère la qualité de vie. L’objectif de ce travail était de faire une revue de la littérature scientifique sur le SAHOS, en Afrique Sub-Saharienne, de 20...

Background: Body composition plays a fundamental role in the occurrence of complications in rheumatoid arthritis. Authors conducted this study, which aimed to determine body composition and its effects on physiological status in African sub-Saharan polyarthritis women.Methods: The anthropometric parameters were measured after an interview and a com...

Impact of the prescription and delivery of benzodiazepines in the occurrence of addictions in the district of Mbour. Introduction: Benzodiazepines (BZD) are widely used nowadays and are at the origin of an addiction. Objectives: The objective was to evaluate the quality of benzodiazepine prescribing and delivery in the Mbour department of Seneg...

Background: Gestational diabetes is an intolerance of glucose with the first appearance during the pregnancy. This hyperglycaemia status, because of the pre-existing insulin-resistance, constitute a favourable land of arterial stiffness. The aim of this study is to determine the impact of non obese gestational diabetes on arterial stiffness by meas...

Introduction: Systemic scleroderma is a chronic inflammatory disease with cardiovascular complications that make it is a serious condition. There would be a body modification during autoimmune, systemic and chronic inflammatory states. These changes would be responsible for one part of the cardiovascular morbidity and mortality of the disease. It i...

Background: Long regarded as Western diseases, diabetes and hypertension are becoming a serious threat to public health in developing countries and particularly in Sub-Saharan Africa [SSA]. However, there is few or no door-to-door study of cardiovascular disease [CVD] in SSA rural areas and particularly in Senegalese areas. Our aim was to determine...

Introduction Le coût de la prise en charge de l’asthme peut être un facteur de mauvais contrôle de la maladie. Cette étude a été menée dans le but d’évaluer le coût direct de la prise en charge des patients asthmatiques. Méthodes Il s’agit d’une étude transversale menée du 7 janvier au 13 avril 2016 auprès de 66 patients suivis en ambulatoire à la...

Background: The catholic lenten fasting is the period of 40 days of fasting that precedes Easter. It is one of religious fasting less documented in the scientific literature. Thus the aim of our study was to evaluate the evolution of anthropometric and body composition and biochemical profile during Catholic lenten fasting. Methods: We conducted a...

Regular and intensive physical activity induces the "athlete's heart". So we compared the heart function of football players and wrestlers. We conducted a cross-sectional study from 01 April to 31 August 2014, involving young players and high-level wrestlers. A resting electrocardiogram was performed for each subject. The QRS duration was more prol...

Systemic sclerosis (SSc) is a connective desease affecting connective tissue and vessels of any caliber. The affect of large arteries appears by a stiffness that can be an element of disease monitoring. The aim of this study was to evaluate the contribution of pOpmètre in the arterial stiffness measurement in patients with SSc. It was a descriptive...

The goal of the present study was to test whether fasting during the holy period of Ramadan may disturb blood rheology in sickle cell trait (SCT) carriers more than in a group of subjects with normal hemoglobin. Twenty African male students participated in the study: 10 SCT carriers and 10 subjects with normal hemoglobin (CONT). Biochemical paramet...

Treatment failure or tolerance, which rapidly leads to a reduced hemodynamic effects and therapeutic efficacy is the major limitation of long-term use of nitrates, including nitroglycerin (NTG) in the treatment of coronary artery disease. These effects are most often associated with oxidative stress. Thus, in this work, we were interested in the pr...

In our previous studies, pharmacological actions of Senegalese plants on the modulation of tracheal contractile responses induced by acetylcholine were demonstrated. Here, we aim to demonstrate whether the pharmacological effects previously observed, could be obtained with other contractile agonists, such as histamine and potassium chloride (KCI),...

Cette étude compare les modifications érythrocytaires entre un groupe de sujets porteurs de trait drépanocytaire (PTD) et un groupe témoin (sujets avec hémoglobine normale) au cours d’un match de football avec ou sans hydratation. La déformabilité érythrocytaire des sujets a été évaluée par le coefficient de la rigidité érythrocytaire (Tk) qui a ét...

This study compared erythrocyte changes between a group of subjects with sickle cell trait (SCT) and controls (subjects without hemoglobinopathy) during a soccer game in two conditions: with and without hydration. Erythrocyte deformability of subjects was assessed by the coefficient of erythrocyte rigidity (Tk) which was calculated before and after...

Objective To establish determinants of lactatemia after race on 200 m and 400 m in African athletes specialized in these distances. Methods Seven male athletes participated in the study. Their mean age was 24.57 ± 3.41 years. Measured anthropometric parameters were weight, height, body mass index (BMI), fatty mass by the cutaneous folds’ method an...

Avicins are complex electrophile triterpene glycosides with high anticancer potential, and until now only isolated from an Australian desert tree, Acacia victoriae. In order to discover new avicins analogues, nine Mimosaceae (Leguminosea) from three different genera (Albizia, Acacia and Dischrostachys) collected in Senegal were screened for their s...

This paper evaluates lung functions in subjects with sickle cell trait (SCT) at rest, comparing them to those of subjects with normal hemoglobin (control group). 29 students from Dakar INSEPS (National Institute for Popular Training and Sports) were selected to carry out the survey, 14 of them being sickle cell trait patients (SCT) with their ages...

In endothelium-denuded arteries, the nitric oxide (NO) donor S-nitrosoglutathione (GSNO) induced a persistent hypo-reactivity to vasoconstrictors, and low-molecular weight thiols such as N-acetyl cysteine (NAC) produced a relaxant effect. These effects were attributed to the formation of vascular NO stores. In arteries with a functional endothelium...

Physical activity is gaining more and more importance in the everyday lives of many Senegalese people living in urban areas and who are conscious of the negative effects stemming from its absence on their wellbeing. The objective of our study is to look at some of the aspects of health in light of the practice of physical activities on physiologica...

Background/Aim: Previous studies reported that important body fluid losses impaired significantly performance. The aim of this investigation was to assess body fluid and fat losses under heat conditions on soccer players; and subsequent influence on their performance. Materiel and methods: Thirteen Senegalese professional soccer players of 20 ± 3 y...