Saqib J Bashir

• Consultant at King's College Hospital NHS Foundation Trust

Irritant Dermatitis Skin irritation is a localized nonimmunologically mediated inflammatory process. It may manifest objectively with skin changes such as erythema, edema, and vesiculation or subjectively with the complaints of burning, stinging, or itching, with no detectable, visible, or microscopic changes. Several forms of objective irritation...

Introduction and Objectives: Data suggest 5% of lentigo maligna (LM) cases progress to lentigo maligna melanoma (LMM). Surgery, which may be extensive, is often performed although we have no means to predict which cases will remain indolent and which will progress. The molecular pathogenesis of cutaneous malignant melanoma has been extensively stud...

Aim: To investigate the effectiveness of ablative and non-ablative Fractional Photothermolysis (FP) lasers for treating facial acne scars. Method: A systematic literature search was performed using Boolean search method. This yielded 629 papers (PubMed= 250; Scopus= 370). 201 duplicates were removed. Of remaining 428 papers, 26 studies (13=ablative...

This review investigates the effectiveness of ablative and nonablative fractional photothermolysis (FP) lasers for treating facial acne scars. Twenty-six studies (13 ablative FP, 13 nonablative FP) published between 2003 and January 2011 were reviewed. Quantitative and qualitative data from each article were examined and analysed. Four studies were...

Ciclosporin (CsA) is an effective treatment for several inflammatory dermatoses, including psoriasis and eczema. In contrast to transplantation medicine, dermatologists do not routinely use CsA blood concentrations to guide therapy. To determine the range of CsA levels at 2 hours after dosing (C2 levels) and whether these C2 levels had any relation...

In frontal fibrosing alopecia (FFA), scalp alopecia dominates the clinical picture. However, eyebrow loss and hair loss in other body sites may also occur; this has been documented clinically, but rarely histopathologically. We describe the clinicopathological findings of 13 cases of FFA, with histopathologic data from the scalp, eyebrow, and body...

Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is a rare form of balanitis, with only a handful of cases reported since the disease was first described. Although the condition has been described as benign, there is increasing evidence of its premalignant potential, with several of the reported cases progressing to verrucous or squam...

Patients with chronic actinic dermatitis (CAD) frequently have positive patch or photopatch tests. In our previous study (period 1987-1992), the most prominent contact allergen was the sesquiterpene lactone mix (36% of patients with CAD). To assess whether contact allergy profiles in CAD patients between 2000 and 2005 have changed in respect to our...

We describe the challenging case of a patient presenting with extensive, eruptive mid-facial squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) consequent to radiotherapy. Our patient had a personal and family history of multiple KAs and SCCs. Multiple self-healing squamous epithelioma, otherwise known as Ferguson-Smith disease, was diagnos...

Bexarotene (Targretin) is a synthetic retinoid which is licensed for the treatment of advanced refractory cutaneous T-cell lymphoma (CTCL). To summarize our experience with bexarotene for patients with CTCL with the aim of assessing efficacy and safety. A retrospective study of 66 patients (44 male, 22 female) with mycosis fungoides (40 patients) o...

Infliximab, a mouse-human chimeric monoclonal antibody directed against tumour necrosis factor-alpha, has been shown to be effective for moderate to severe psoriasis, but there are few data published on its use in recalcitrant, treatment-resistant disease or in combination with other antipsoriatic therapies. To report our experience with infliximab...

In conclusion, nonimmunologic contact urticaria can be considered a form of skin irritation. As the clinical appearance can mimic irritant dermatitis, a thorough medical history is important in the assessment of these patients. Standard skin irritation tests may miss the diagnosis because of the immediate nature of the reaction so the methods descr...

Contact with external irritating agents such as dishwashing liquid, formaldehyde, or raw meat may result in irritant contact dermatitis (ICD), a localized nonimmunologic condition. ICD ensues when irritant stimuli overpower the defense and repair capacities of the skin [34, 86]. Exposure to highly potent irritants or exposure to mild irritants for...

Keratolytic efficacy of topical preparations containing salicylic acid was studied in humans utilizing adhesive tape stripping and quantifying SC removal by protein analysis. In combination with tape stripping, squamometry was used to evaluate the influence of salicylic acid on skin surface scaliness and desquamation. Furthermore, skin barrier pert...

Consensus exists on levels of nickel release that are well tolerated in exposure to nickel-containing items in direct and continuous contact with skin (e.g. watches). The clinical relevance of nickel-containing coins eliciting nickel dermatitis associated with extensive occupational exposure (e.g. coins handled by cashiers) has not been determined....

Topical corticoids are used to treat irritant contact dermatitis (ICD) in humans. However, their clinical efficacy remains sub judice. This study was designed to assess the efficacy of low- and medium-potency corticosteroids on irritant dermatitis. We induced an acute ICD via open application of sodium lauryl sulphate (SLS) on the hands of subjects...

Alefacept (B-9273) is an LFA-3-Ig fusion protein CD2 antagonist under development by Biogen for the potential treatment of autoimmune diseases, including psoriasis and transplant rejection [270267]. It is in phase III trials for psoriasis [349467]. In October 2000, the company reported that Amevive was on track for regulatory filing in the second h...

Background/aims: Tape stripping of human stratum corneum has been performed to measure stratum corneum mass, barrier function, drug reservoir and percutaneous penetration. However, the technique itself requires further development to facilitate interpretation. Methods: In this study we quantified stratum corneum (SC) tape stripping and water kineti...

At this seminar, several encouraging developments were demonstrated in various areas of dermatology practice. Much attention was focused on topical tacrolimus, the US approval of which, for the treatment of atopic dermatitis is much anticipated. The general consensus from trials was that the drug is safe and effective, and it is hoped that it will...

The present article is based on a recent review by Bashir and Maibach (1997). They defined compound allergy as an allergic contact dermatitis in which a preparation is believed to be allergenic on patch testing, whilst its individual ingredients show a negative patch-test result. Some or all of those ingredients must have interacted to form a new a...

Contact urticaria syndrome (CUS) was first defined by Maibach and Johnson [28], and since then numerous reports of contact urticaria to a variety of compounds such as foods, preservatives, fragrances, plant and animal products, metals and others, continue to be reported. Therefore, it is important to determine, in a scientific manner, whether or no...

This review defines the term "compound allergy" in the context of new findings, and discusses evidence that allergenic reaction products have been identified. Material was gathered by searching Index Medicus and the Science Citation Index, and reviewing several standard texts. Issues regarding the validity of patch test results are addressed and we...

This review defines the term “compound allergy” in the context of new findings, and discusses evidence that allergenic reaction products have been identified. Material was gathered by searching Index Medicus and the Science Citation Index, and reviewing several standard texts. Issues regarding the validity of patch lest results are addressed and we...

Not available for consultation without the author's permission until 1st August 2008. Thesis (M.D.) - University of Glasgow, 2006. Includes bibliographical references.