Santosh Kumar Verma

• Doctor of Philosophy
• Professor (Assistant) at ITM University

An analysis of the quantity and origins of bioactive agents can show the character of that natural products play in the finding of new therapeutic agents. At least 200,000 naturally occurring metabolites have different bioactive characteristics. Natural product discovery includes isolating, structurally elucidating, and establishing the bio-synthet...

Human epidermal growth factor receptor-2 (HER2)-positive breast cancer metastasis remains the primary cause of mortality among women globally. Targeted therapies have revolutionized treatment efficacy, with Trastuzumab (Trast), a monoclonal antibody, targeting HER2-positive advanced breast cancer. The tumor-homing peptide iRGD enhances the intratum...

For centuries, humans have harnessed the healing properties of plants to address diverse health conditions. Ancient systems like Ayurveda and Unani medicine hold a rich repository of knowledge extolling the virtues of herbal remedies. Achyranthes aspera, one prolific native herbaceous plant in the South America, Asia and Africa often prospers as on...

In these studies, endophyte bacteria were isolated from a medicinal plant root of Adhathoda beddomei (adosa). The antimicrobial activity was demonstrated against different pathogenic and nonpathogenic bacteria. Identification of endophytes was done based on external morphological characteristics with the help of a Scanning Electron Microscope (SEM)...

The roundworms that make up the Strongylidae family of parasitic nematodes are members of the genus Oesophagostomum. These worms can be found in Indonesia, the Philippines, Brazil, Africa, and China. Human infections caused by Oesophagostomum are most common in Ghana and northern Togo. Because the eggs of the species that cause human helminthomas m...

Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been implicated in immunopathogenesis of COVID-19 infection under different stages such as viral entry, escaping innate immunity, replication, and subsequent inflammatory processes. Prompted...

Ethnopharmacological relevance: Alchornea laxiflora (Benth.) Pax & K. Hoffm. (Euphorbiaceae) is an important traditional medicinal plant grown in tropical Africa. The stem, leaves, and root have been widely used in the folk medicine systems in Nigeria, Cameroon, South Africa, and Ghana to treat various ailments, including inflammatory, infectious,...

Nipah virus (NiV) is a highly pathogenic member of the family paramyxoviridae that encodes the surface glycoprotein F and G. Nipah virus; a member of the genus Henipavirus also belong to family paramyxoviridae is highly pathogenic to many species which emerged in 1998 from pteropod fruit bats (flying foxes) and microbats of several species. Nipah v...

Mouth ulcers often cause pain and irritation of the sores by salty, spicy and sour food items and may cause discomfort while healing occurs due to the use of chemical formulations. This project focuses on the preparation of a herbal mouth ulcer healing gel because of better cultural acceptability, better compatibility with human body and lesser sid...

Nucleophosmin-Anaplastic Lymphoma kinase fusion protein (NPM-ALK) is a chimeric protein. NPM-ALK originates from the fusion of the nucleophosmin (NPM) and the membrane receptor anaplastic lymphoma kinase (ALK) gene. The expression of NPM-ALK oncogene from a chromosomal translocation leads to the fusion of the ALK gene on 2p23 and the NPM gene on 5q...

Glucosidase (β-D-glucoside glucohydrolases; EC 3.2.1.21) occur ubiquitously in plants, fungi, mammals and microorganisms. It constitutes a major group in glucoside hydrolase families and catalyses the hydrolysis of aryl and alkyl -D-glucosides such as cyanogenic glucosides, thioglucosides, glucose dissacharides or phenolic glycosides. In plants -...

Bloom syndrome is a rare human disorder which is an autosomal recessive disease which belongs to the group of chromosomal breakage syndrome. Firstly, Dr. David Bloom, a New York dermatologist described this disease in 1954 in three children as congenital telangiectatic erythema resembling lupus erythematous in dwarfs. This can be examined by geneti...

β-Glucosidase (β-D-glucoside glucohydrolases; EC 3.2.1.21) occur ubiquitously in plant, fungi, mammals and microorganisms. It constitutes a major group in glucoside hydrolase families and catalyses the hydrolysis of aryl and alkyl -D-glucosides such as cyanogenic glucosides, thioglucosides, glucose dissacharides or phenolic glycosides. In plants ...

Abstract β-glucosidase is a remarkable enzyme in the field of enzyme technology.Firstly, it helps in producing ethanol from the plant waste and subsequently helps to cope up the oil crisis as well as in alcohol based industries. Secondly, it improves the taste and aroma of wine, tea and fruits. In the present study β-glucosidase was isolated from d...

In the present study the enzyme was isolated from different parts of maize and specific activity was measured. The maximum crude enzyme was found in coleoptile (2.86 ml) and maximum specific activity was measured in thumb/lower most leaf as 43.443 ml whereas maximum protein was found in second leaf blade (9.241 mg/ml)

ABSTRACT Resistance and tolerance are arbitrarily defined terms frequently interchangeable and after based on weather a given isolate can grow in the presence of selected heavy metal concentration in laboratory media. Total bacterial strains were isolated and screened on the basis of their heavy metal tolerance ability for cadmium and their PGPR ac...

Plants are the major source of herbal medicines and the presence of secondary metabolites with many therapeutic activities. A major part of the total population in developing countries still uses traditional folk medicine since Vedic period. The herbal drugs popularity increased and used widespread. The research is still lagging behind to get the e...

Human Papilloma Virus affects human skin and the moist membranes that line the body, such as the throat, mouth, feet, fingers, nails, anus and cervix from the papillomavirus family. There are over 100 types of which 40 can affect the genital area they may eventually develop into Cervical intraepithelial neoplasia (CIN) - cervical cancer, Penile int...

Nipah virus (NiV) is a newly emerging paramyxovirus that causes lethal infections in various species including humans. The case fatality rate of Nipah virus encephalitis was found to be 70% in India and Bangladesh. NiV have single-stranded negative-sense RNA that encodes six viral proteins out of which Matrix protein of Nipah virus plays a vital ro...

Nipah virus (NiV) is a newly emerging paramyxovirus that causes lethal infections in various species including humans. The case fatality rate of Nipah virus encephalitis was found to be 70% in India and Bangladesh. NiV have single-stranded negative-sense RNA that encodes six viral proteins out of which Matrix protein of Nipah virus plays a vital ro...

Blue Baby Syndrome or Methemoglobinemia is caused by de-creased ability of blood to carry oxygen, resulting in oxygen de-ficiency in different body parts.Due to a deficiency of the enzyme diaphorase-1(NADH methemoglobin reductase), So the NADH Cyt.b5 reductase was chosen for the present study. The wide variety of Computational tools available enabl...

Blue Baby Syndrome or Methemoglobinemia is caused by de-creased ability of blood to carry oxygen, resulting in oxygen de-ficiency in different body parts.Due to a deficiency of the enzyme diaphorase-1(NADH methemoglobin reductase), So the NADH Cyt.b5 reductase was chosen for the present study. The wide variety of Computational tools available enabl...

In this study the effect of metal stress and antibiotics was evaluated on pathogenic strains of bacteria and fungi, due to an alarming rate of diseases caused by emergence of multi drug resistant pathogenic microorganisms and patients, untreated due to lack of appropriate drugs. The study was performed by standard Kirby Bauer Disk diffusion method...

Citrobacter freundii, is aerobic gram-negative bacilli. In the Biotech industry, C. freundii produces many important enzymes including phosphatase, α-galactosidase and selenocysteine beta-lyase. While Klebsiella pneumoniae is a nosocomial pathogen. In spite of its potential pathogenicity, it has several metabolic potentials, such as able to produce...

The leaves extract of Calotropis gigantea were screened for its antibacterial and phytochemical activities. The solvents used for the leaves extraction were n-Hexane, Ethanol, Methanol, Chloroform, Water and Ethyl acetate. The extract was tested against Bacillus cereus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aure...

In the present study Murraya koenigii commonly called “curry leaf” leaves extracts subjected to a screening study to detect potential antimicrobial activity against Strains of Escherichia coli, Bacillus cereus, Staphylococcus aureus, Bacillus subtilis Klebsiella pneumonia, Staphylococcus epidermidis, Pseudomonas aeruginosa, Staphylococcus faecalis,...

In the present study Murraya koenigii commonly called “curry leaf” leaves extracts subjected to a screening study to detect potential antimicrobial activity against Strains of Escherichia coli, Bacillus cereus, Staphylococcus aureus, Bacillus subtilis Klebsiella pneumonia, Staphylococcus epidermidis, Pseudomonas aeruginosa, Staphylococcus faecalis,...

The physicochemical and interfacial properties of the monomeric surfactants cetyltrimethyl ammonium bromide (CTAB), cetyltriphenyl phosphonium bromide (CTPB), tetradecyl triphenyl phosphonium bromide (TTPB), cetyldiethylethanol ammonium bromide (CDEEAB), cetyltrimethyl ammonium chloride (CTACl), tetradecyltrimethyl ammonium bromide (TTAB), and a ge...

Many improved recovery processes involve injection of a fluid whose properties are different than water. The fluidhydrocarbon- rock interactions lead to improved recovery. An example of an improved recovery process is polymer flooding. In this method, polymer, a water-soluble chemical, is added to improve the phase mobility ratio, which leads to im...

The kinetics of hydrolysis of p-nitrophenyl acetate catalyzed by α-chymotrypsin (α-CT) has been studied in the presence of several cationic surfactants having different head groups maintaining the dodecyl hydrophobic residue and bromide counterion. The enzyme activity was tested in the presence of dodecyl trimethylammonium bromide (DTAB), dodecylpy...

This paper describes the development of a comprehensive polymer flood modeling capability within a reservoir simulator that uses an unstructured grid framework. The polymer modeling capability includes a number of specialized capabilities. Polymer solution viscosity is modeled as a function of polymer concentration, shear rate, multiple salt compon...

Many improved recovery processes involve injection of a fluid whose properties are different than water. The fluid-hydrocarbon-rock interactions lead to improved recovery. An example of an improved recovery process is polymer flooding. In this method, polymer, a water-soluble chemical, is added to improve the phase mobility ratio, which leads to im...

This paper presents the development of a simple and precise analytical method for the determination of nitrogen dioxide in ambient air. In this method nitrogen dioxide is determined in the form of nitrite. The determination of nitrogen dioxide needs no reagents except for a solution of sodium hydroxide mixed with sodium arsenite (NaOH–Na2As2O3) whi...