Santosh Ghule

Samart College of Pharmacy · Pharmacy

Gastroretentive clarithromycin floating tablets for the eradication of Helicobacter pylori were prepared using the matrix forming polymer hydroxypropyl methylcellulose (HPMC K15M), in different ratios by wet granulation method. Buoyancy of formulated tablets was achieved by an addition of an effervescent mixture consisting of sodium bicarbonate to...

Objective: To study central nervous system activity of ethanolic extract of leaves of Calotropis gigantea (C. gigantea) (Asclepiadaceae), such as anticonvulsant, sedative and muscle relaxation activity. Methods: The ethanolic extract of C. gigantea administered orally in experimental animals at different doses 100, 200 and 500 mg/kg body weight. Th...

To study the in vivo anti-inflammatory activity of Tabernaemontana divaricata leaf extract on male albino mice. Aqueous decoction and methanol leaf extracts were tested for their ability to reduce croton oil-induced edema in the mouse ear after topical application. The methanol leaf extract dose-dependently inhibited the croton oil-induced ear edem...

The aim of the present study was to investigate the immunomodulatory activity of ethanolic extract of Malvastrum tricuspidatum A. Gray (MTEE) whole plant in experimental models of immunity. Preliminary immunomodulatory activity was evaluated by studying the effect of MTEE (200, 500, and 1000 mg/kg, p.o.) on immunological organs weight and haematolo...

Godanti bhasma is an ayurvedic herbal mineral formulation used as antiulcer and antipyretic drug in Indian traditional systems of medicine. Godanti bhasma was evaluated for its toxicity, antiulcer and antipyretic activity in experimental animals. The experimental paradigms used for antiulcer activity were cold restraint stress induce ulcer model an...

Objective To evaluate anti-diarrhoeal activity of aqueous and alcoholic extract of the leaves of Murraya koenigii (M. koenigii)by using models of castor oil induced diarrhoea, charcoal meal test and PGE2 induced diarrhoea.Methods Alcoholic extract (400 mg/kg) and aqueous extract (200 mg/kg) of leaves of Murraya koenigii were used with loperamide as...

The anti-ulcer activity of Aqueous extract of the leaves of Murraya koenigii was evaluated by using models of acute gastric lesions induced by ethanol induced, asprin induced, cold restrain stress and pylorus ligation in rats. Animals pretreated with doses of 200 mg/kg and 400 mg/kg of Aqueous extract showed significant reduction in lesion index, t...

This study was designed to investigate the anti-diabetic hypoglycaemic properties of an ethanolic extract of the root of Celosia argentea which is widely used in India as a traditional treatment for diabetes mellitus. An ethanolic extract of C. argentea root was found to lower blood glucose in basal conditions and after a heavy glucose load in norm...

In order to scientifically apprise some of the anecdotal, folkloric, ethno medical uses of celosia argentea, the present study was undertaken to examine the antidiarrhoeal properties of alcoholic extract of leaves of Celosia argentea on diarrhoea by using different experimental models. Anti-diarrhoeal effect was evaluated by castor oil induced diar...

Microwave-assisted extraction (MAE) technique was developed & optimized for the extraction of different phytoconstituents i.e; flavonoids from Zanthoxylum budrunga W. (ZBW). Several influential parameters of the MAE procedure (solvent concentration, solvent volume, microwave power and extraction time) were studied through single factor experiments...