Santosh Fattepur

Management and Science University | msu · School of Pharmacy

2023) A spotlight on application of microwave-assisted modifications of plant derived polymers in designing novel drug delivery systems, Designed Monomers and Polymers, 26:1, 106-116, ABSTRACT Polymers are a fundamental part of numerous industries and can be conjugated with many other materials and components to have a vast array of products. Bioma...

Skin wound healing, especially for chronic sores like diabetic foot ulcers, is still a medical emergency. Despite the abundance of treatment techniques that are currently accessible, none appear to be both effective and secure. In this context, we have emphasized the benefits of using clay and biopolymers to create nano-drug delivery systems. Pecti...

Diabetes mellitus is one of the most concerning conditions, and its chronic consequences are almost always accompanied by infection, oxidative stress, and inflammation. Reducing excessive reactive oxygen species and the wound’s inflammatory response is a necessary treatment during the acute inflammatory phase of diabetic wound healing. Malva sylves...

A brand-new nano-crystal (NC) version of the hydrophobic drug Paclitaxel (PT) were formulated for cancer treatment. A stable NC formulation for the administration of PT was created using the triblock co-polymer Pluronic F127. To achieve maximum entrapment effectiveness and minimal particle size, the formulation was improved using the central compos...

Currently, gastro-retentive dosage forms achieved a remarkable position among the oral drug delivery systems. This is a broadly used technique to hold the drug delivery systems for a long duration in the gastro intestine (GI) region, slow drug delivery, and overcome other challenges related to typical oral delivery such as low bioavailability. The...

Diabetes mellitus (DM) and its complications are a severe public health concern due to the high incidence, morbidity, and mortality rates. The present study aims to synthesize and characterize silver nanoparticles (AgNPs) using the aqueous leaf extract of Psidium guajava (PGE) for investigating its antidiabetic activity. Psidium guajava silver nano...

Alangium salvifolium is considered a medicinal plant in India and is used to heal various diseases. The traditional healers documented that roots, leaves, flowers, fruits, stems, and bark of Alangium salvifolium have potent medicinal properties. The researchers reported the nature of the phytoconstituents responsible for imparting therapeutic prope...

For a few decades, globally, erectile dysfunction (ED) has become more prominent even in young adults and represents a mounting health concern causing a significant effect on men’s quality of life. There is an expectation that by the end of 2025, the number of ED cases can rise to 322 million. We aimed to comprehensively analyze the scientific outp...

Citation: Sreeharsha, N.; Philip, M.; Krishna, S.S.; Viswanad, V.; Sahu, R.K.; Shiroorkar, P.N.; Aasif, A.H.; Fattepur, S.; Asdaq, S.M.B.; Nair, A.B.; et al. Multifunctional Mesoporous Silica Nanoparticles for Oral Drug Delivery. Coatings 2022, 12, 358.

Background: Tragacanth, a natural gum, is frequently used as stabilizerfor colloidal systems and as a binder in tablets. Materials from naturalsources are in increasing demand to solve the current global environmentalproblems arising from synthesis involving petroleum‑based substances.Objectives: In this context, we improved functionality of tragac...

The present work aimed to develop a chronotherapeutic system of valsartan (VS) using nanocrystal formulation to improve dissolution. VS nanocrystals (VS-NC) were fabricated using modified anti-solvent precipitation by employing a Box–Behnken design to optimize various process variables. Based on the desirability approach, a formulation containing 2...

Skin, an exterior interface of the human body is home to commensal microbiota and also acts a physical barrier that protects from invasion of foreign pathogenic microorganisms. In recent years, interest has significantly expanded beyond the gut microbiome to include the skin microbiome and its influence in managing several skin disorders. Probiotic...

Background Allergen immunotherapy (AIT) involves the regimen of gradually incrementing doses of the allergen, thereby inducing desensitization and tolerance. Sublingual Immunotherapy tablets (SLIT-tablets) have been formulated for several allergies and had manifested efficacy for allergic rhinitis and allergic asthma. SLIT promises an alternative m...

The COVID-19 infection caused by the new SARS-CoV-2 virus has been linked to a broad spectrum of symptoms, from a mild cough to life-threatening pneumonia. As we learn more about this unusual COVID-19 epidemic, new issues are emerging and being reported daily. Mucormycosis, also known as zygomycosis or phycomycosis, causes severe fungal illness to...

Rivastigmine, a reversible cholinesterase inhibitor, is frequently indicated in the management of demented conditions associated with Alzheimer disease. The major hurdle of delivering this drug through the oral route is its poor bioavailability, which prompted the development of novel delivery approaches for improved efficacy. Due to numerous benef...

Objective: The focus of this research has been to improve efficacy, decrease tolerance and increase the irinotecan pharmacokinetic profile. Methods: Proniosomesformulated with various surfactants, cholesterol and dicetyl phosphate using the slurry method. A slurry process was used to prepare proniosomes with maltodextrin as the carrier by using sur...

MiR-26 is a miRNA tumour suppressor that is frequently dysregulated in many tumour tissues and lines of tumour cells. Androgen and Estrogen receptor (AR & ER) were evolving as a target to examine among hormone proteins since it appears to show a part at numerous phases of growth of breast and prostate cancers. For that kind of reason, AR and ER are...

The SARS-CoV-2 outbreak is the COVID-19 disease, which has caused massive health devastation, prompting the World Health Organization to declare a worldwide health emergency. The corona virus infected millions of people worldwide, and many died as a result of a lack of particular medications. The current emergency necessitates extensive therapy in...

Peptic ulcer (gastric ulcer and duodenal ulcer) is very common chronic disorder of stomach which is mainly caused by the damage or impairment of stomach lining. Various factors such as pepsin, gastric acid, H. pylori, NSAIDs, prostaglandins, mucous, bicarbonate and blood flow to mucosa play an important role in causing peptic ulcer. In this review...

In Present time Novel coronavirus (SAR-CoV-2) was the biggest outbreak on human kind. SARS recognized febrile respiratory illness. It was first discovered in southern China in November 2002, and spread all other countries.Now SARS-CoV-2 was also originated from Wuhan, china. It was transmitted from human to human. For developing a molecular diagnos...

Chrono therapeutic drug delivery systems stay attaining prominence in the area of pharmaceuticals. It decreases dosing incidence, toxicity, and distributes a drug that matches the circadian rhythm of that definite disease when the signs are exciting to sorrier.ChrDDS is the essentially time-controlled drug delivery system. It offers a patient with...

The use bee products is know from thousands of years and its usage in treating various pathological condition has been well documented in various religious texts. Apis Mellifera Bee Venom (BV) have 18 pharmacological active compound and is known to treat many diseases such as arthritis and pain. No proven studies of Apis Mellifera Bee Venom on toxi...

Purpose Olanzapine is widely prescribed in the treatment of schizophrenia and various psychiatric illnesses. Schizophrenia patients have been reported to eat a diet that contain higher in fat and lower in fiber. High dietary fat intake can predispose to the development of metabolic abnormalities and exacerbate hepatic changes. The aim of the paper...

Background: Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. The use Morinda citrifolis L. extracts have been reported to exhibit a broad range of therapeutic effects, including antibacterial and antitumor. Objective: This study aims to investigate the anti-angiogenic properti...

Skin whitening body lotions are the cosmetics products which work on human skin by reducing a pigment called melanin in the skin. It also lightens naturally dark skin and dark spots. It is giving a moisturizing effect to the skin as a natural cosmetics body lotion. This study was aimed on a reduction of skin melanin by tyrosine inhibitory with plan...

A highly sensitive electrochemical sensor for Indigotine (IG) detection was fabricated at a carbon paste electrode (CPE) modified with TX-100 surfactant. The electrochemical behavior of IG was studied at TX-100 modified carbon paste electrode (TX-100MCPE). The effect of different pH values, scan rate and effect of concentration was also studied usi...

Objective: Hyperlipidemia is one of the risk factors that contribute to the prevalence of coronary heart diseases and antihyperlipidemic agents, such as statin, was used to treat hyperlipidemia as a current therapy. Boesenbergia pandurata has not been exploited for antihyperlipidemic effect. Hence, this study aims to screen for the antihyperlipidem...

Objective: The present study was designed to determine the neuroprotective effect of Abelmoschus esculentus L. on alloxan-induced diabetic neuropathy in rats.Methods: Diabetes was induced in rats with a single intraperitoneal injection of alloxan monohydrate (130 mg/kg b.w). The ethanol extract of A. esculentus L. at a dose of 100 and 200 mg/kg of...

Scholars Research Library Der Pharmacia Lettre, 2017, 9[12]: 1-15 [http://scholarsresearchlibrary.com/archive.html] ABSTRACT Objective: To evaluate the wound healing effect of ethanolic extract of Scutellaria barbata D(Lamiaceae) in rats. Methods: Male Sprague Dawley rats weighing 250-300 g were randomly divided into incision and burn wound groups....

Combination therapies for the treatment of bacterial infections can slow down the development of resistance. This study was carried out to study the synergistic effect of ethanolic extract of Melastoma malabathricum (MM) leaves and antibiotics on growth of pathogenic bacteria: Salmonella, E. coli, S. aureus & S. pyogenes. Kirby-Bauer disk diffusion...

Catharanthus roseus is a perennial plant commonly seen in tropical countries. Catharanthus roseus has been not been exploited for toxicological and pharmacological activities other than anticancer effect. Hence this study aim’s to screen ethanolic extract of Catharanthus roseus (CR extract) for toxicological and pharmacological (pain and inflammati...

The present study was aimed to evaluate the wound healing activity of extract of seeds of Swietenia macrophylla. It is well-known plant in Asian traditional medicines. On the basis of traditional use and literature references, this plant was selected for wound healing potential. The ethanolic extract of seeds of Swietenia macrophylla was examined f...

Diabetes mellitus is a heterogeneous metabolic disorder of carbohydrate, fat and protein characterized by chronic hyperglycaemia which resulted from loss of glucose homeostasis due to either insulin insufficiency, insulin dysfunction or both. Though different types of oral hypoglycemic agents are available for the management of diabetes mellitus, t...

Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complications including retinopathy, angiopathy, nephropathy and causing neurological disorders due to the involvement of free radicals. Due to the adverse effects of hypoglycemic agents, there has been an increased demand for the u...

To study the effect of saturated fatty acid (SFA)-rich dietary vegetable oils on the lipid profile, endogenous antioxidant enzymes and glucose tolerance in type 2 diabetic rats. Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rats. Twenty-eight-day-old normal (N) and diabetic (D) male Wistar rats were fed fo...

Effective antiretroviral therapy is required on a long-term basis to maintain viral suppression and reduce disease progression in HIV infections. An attempt has been made to implement the principles of novel drug delivery to antiretrovirals in order to overcome the drawbacks of existing therapy. Liposomal gels of lamivudine and stavudine respective...

In many of the preparations instead of saturated fatty acids (SFA), trans fatty acid (TFA) produced by partial hydrogenation of unsaturated oils were advocated as the preferred fatty acid base for soLid fats. The present study was designed to investigate the effects of dietary fats rich in SFA and TFA on lipid profile and endogenous antioxidant enz...