About
15
Publications
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114
Citations
Introduction
Current institution
Additional affiliations
November 2016 - present
IRAB
Position
- Head of PET radiopharmaceuticals production and cyclotron manager
January 2015 - October 2016
October 2013 - December 2013
MGH/HST Athinoula A. Martinos Center for Biomedical Imaging
Position
- Research stay
Education
September 2012 - June 2014
Universidad Complutense de Madrid
Field of study
- Biomedical Sciences Research
September 2006 - June 2007
September 2000 - June 2006
Publications
Publications (15)
Trehalose analogues bearing fluorescent and click chemistry tags have been developed as probes of bacterial trehalose metabolism, but these tools have limitations with respect to in vivo imaging applications. Here, we report the radiosynthesis of the ¹⁸F-modified trehalose analogue 2-deoxy-2-[¹⁸F]fluoro-D-trehalose ([¹⁸F]-2-FDTre), which in princip...
Purpose:
Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resolution and quantitative accuracy of the images. Since gene...
Methods:
Sixteen mice bearing a human tumor cell line xenograft (CH-157MN) were imaged with three different (68)Ga-DOTA-peptides (DOTANOC, DOTATATE, DOTATOC) using a small animal PET-CT scanner. Regional activities (input function and tumor) were obtained after manual delineation of regions of interest over the image. The algorithm was implemented...
Purpose
The goal of this study was to compare the tumor uptake kinetics and diagnostic value of three 68Ga-DOTA-labeled somatostatin analogues (68Ga-DOTATOC, 68Ga-DOTANOC, and 68Ga-DOTATATE) using PET/CT in a murine model with subcutaneous meningioma xenografts.
Methods
The experiment was performed with 16 male NUDE NU/NU mice bearing xenografts o...
Homing is an inherent, complex, multistep process performed by cells such as human bone marrow mesenchymal stem cells (hMSCs) to travel from a distant location to inflamed or damaged tissue and tumors. This ability of hMSCs has been exploited as a tumor-targeting strategy in cell-based cancer therapy. The purpose of this study was to investigate th...
Single-photon emission computed tomography (SPECT) offers the possibility to study the biodistribution of 111In-labeled human mesenchymal stem cells (hMSCs). This functional information can be complemented by magnetic resonance imaging (MRI) that provides the anatomical context to the SPECT image. However, acquiring such studies with separate SPECT...
Single-photon emission computed tomography (SPECT) offers the possibility to study the biodistribution of 111In-labeled human mesenchymal stem cells (hMSCs). This functional information can be complemented by magnetic resonance imaging (MRI) that provides the anatomical context to the SPECT image. However, acquiring such studies with separate SPECT...
Tumor-homing is a complex, multistep process used by many cells, like mesenchymal stem cells (MSCs), to travel from a distant location to a tumor. The purpose of this study is to investigate the applicability of 111In-oxine for tracking human MSCs in vivo with single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI)....
