Santiago Herrera-Alvarez

Santiago Herrera-Alvarez
University of Chicago | UC · Department of Ecology & Evolution

PhD student at The University of Chicago

About

8
Publications
2,618
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
82
Citations
Introduction
Molecular evolution, population genetics, evodevo

Publications

Publications (8)
Preprint
Biological systems may be biased in the phenotypes they can access by mutation, but the extent of these biases and their causal role in the evolution of extant phenotypic diversity remains unclear. There are three major challenges: it is difficult to isolate the effect of bias in the genotype-phenotype (GP) map from that of natural selection in pro...
Article
Full-text available
A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions. Here, we examine the role of intramolecular epistasis in the recurrent evolution of resistance to cardioton...
Preprint
Full-text available
A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions. Here, we examine the role of intramolecular epistasis in the case of the recurrent evolution of resistance...
Article
Although gene duplication is an important source of evolutionary innovation, the functional divergence of duplicates can be opposed by ongoing gene conversion between them. Here, we report on the evolution of a tandem duplication of Na+,K+-ATPase subunit α1 (ATP1A1) shared by frogs in the genus Leptodactylus, a group of species that feeds on toxic...
Article
Full-text available
Gigantism results when one lineage within a clade evolves extremely large body size relative to its small-bodied ancestors, a common phenomenon in animals. Theory predicts that the evolution of giants should be constrained by two tradeoffs. First, because body size is negatively correlated with population size, purifying selection is expected to be...
Preprint
Full-text available
Gene duplication is an important source of evolutionary innovation, but the adaptive division-of-labor between duplicates can be opposed by ongoing gene conversion between them. Here we document a tandem duplication of Na ⁺ ,K ⁺ -ATPase subunit α1 (ATP1A1) shared by frogs in the genus Leptodactylus , a group of species that feeds on toxic toads. On...
Article
Full-text available
To what extent has body size driven body shape disparity across fish species? Friedman et al. (2019) found that, for Indo‐Pacific shore fishes, body size accounts for a low fraction of variation, suggesting that there is a very weak relationship between body size and shape in this group. This article is protected by copyright. All rights reserved
Preprint
Full-text available
Gigantism is the result of one lineage within a clade evolving extremely large body size relative to its small-bodied ancestors, a phenomenon observed numerous times in animals. Theory predicts that the evolution of giants should be constrained by two tradeoffs. First, because body size is negatively correlated with population size, purifying selec...

Questions

Question (1)
Question
I have generated a .gff file with some gene predictions (with Augustus) from a set of genomic DNA sequences. How can I extract the cds from these sequences? I've been using the getAnnoFasta.pl script from Augustus, but I think it is not working well.. Is there any other way to do this? Thanks!

Network

Cited By