Santhosh Chidangil

Santhosh Chidangil
Manipal Academy of Higher Education | MAHE · Centre for Atomic and Molecular Pysics

M.Sc. Physics and Ph.D. Physics

About

234
Publications
44,094
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,896
Citations
Citations since 2016
147 Research Items
2141 Citations
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500

Publications

Publications (234)
Article
Full-text available
Malaria, dengue and leptospirosis are three tropical infectious diseases that present with severe hematological derangement causing significant morbidity and mortality, especially during the seasonal monsoons. During the course of these infectious diseases, circulating red blood cells are imperiled to the direct ill-effects of the infectious pathog...
Article
Full-text available
Introduction Fiber optic probe based in-vivo spectroscopy techniques are fast and highly objective methods for intraoperative diagnoses and minimally invasive surgical interventions for all procedures where endoscopic observations are carried out for cancers of different types. The Raman spectral features provide molecular fingerprint-type informat...
Article
Droplet splitting by exploiting tailored surface wettability is emerging as an important pathway to creating ultralow volumes of samples that can have applications in bioassays, tissue engineering, protein chips, and material synthesis. Reduction of droplet volumes enables the encapsulation of single biological cells which allows high throughput sc...
Article
We have developed a potentially portable tabletop combined remote LIBS-Raman spectroscopy system using a high-resolution gated echelle spectrograph for measuring both atomic and molecular emission spectra at a standoff distance of 6.5 m. The system consists of a frequency-doubled Nd: YAG laser, a 4X beam expander, a Cassegrain telescope, and a gate...
Article
Ever-accumulating amounts of plastic waste raises alarming concern over environmental and public health. A practical solution for addressing this threat is recycling, and the success of an industry-oriented plastic recycling system relies greatly on the accuracy of the waste sorting technique adapted. We propose a multi-modal spectroscopic sensor w...
Article
Photoacoustic spectroscopy (PAS) can detect volatile organic compounds (VOCs) present in exhaled breath with very high sensitivity. A PAS setup using laser excitation at 266 nm and calibrated with Acetone, was used to record photoacoustic signals from a cohort of 20 normal healthy volunteers and 15 Asthma patients. The photoacoustic wave-form signa...
Article
Full-text available
Acute myocardial infarction (MI) is found to be a major causative factor for global mortality and morbidity. This situation demands necessity of developing efficient and rapid diagnostic tools to detect acute MI. Raman spectroscopy is a non-destructive optical diagnostic technique, which has high potential in probing biochemical changes in clinical...
Article
The present study explores the application of the micro-Raman spectroscopy technique to discriminate normal and cervicitis condition from cervical malignancy by analyzing the Raman signatures of tissues and plasma samples of the same subjects. The Raman peaks from tissue samples at 1026 cm⁻¹,1298 cm⁻¹ and 1243 cm⁻¹ are attributed to glycogen, fatty...
Article
This work demonstrates the significance of the synthesis routes, namely microwave and hydrothermal methods, of green-emitting carbon dots prepared from the same precursors in the selective detection of Hg2+ ions. Aside from providing the advantage of a shorter time scale for the synthesis of C-dots (5 min) compared to the hydrothermal route (8 h) a...
Article
A facile method of creating a sensitive and inexpensive superhydrophobic nanoporous anodic alumina (NAA) based surface-enhanced Raman spectroscopy (SERS) substrate is reported. A superhydrophobic NAA was created by coating polydimethylsiloxane on NAA via polymer evaporation technique which further coated with gold to fabricate NAA-based superhydrop...
Article
In spite of the great promise that contact lenses offer from vision correction to wearable sensing technologies, wearing contact lens often reported to result in dry eye problems and associated inflammation or corneal wound. To mitigate these health concerns, strategies to keep the lens moisturized by maintaining a tear film have currently been exp...
Article
The transformation of normal cervix to cervicitis as well as to cervical cancer is accompanied with biochemical alterations at cellular level. Laser induced fluorescence (LIF) can reflect those changes either as variations in the fluorescence intensity or as shift in the fluorescence maxima of bio fluorophores present in tissues. The curve resolved...
Article
Full-text available
There is an urgent need to have reliable technologies to diagnose post-coronavirus disease syndrome (PCS), as the number of people affected by COVID-19 and related complications is increasing worldwide. Considering the amount of risks associated with the two chronic lung diseases, asthma and chronic obstructive pulmonary disease (COPD), there is an...
Article
Despite the growing interest of research in the trace element detection in liquids via laser-induced breakdown spectroscopy (LIBS), the measurement of the ultra-low concentration of trace elements remains a challenge due to splashing, plasma cooling which in turn leads to shorter plasma lifetime. However, due to the promising emerging applications...
Article
Full-text available
In this work, we present the synthesis and surface immobilization of Au nanostars, Au nanocubes and Au nanorods for localized surface plasmon resonance (LSPR)-based refractometric sensing applications. Au nanostructures exhibiting LSPR peak positions in 500–900 nm spectral range were prepared by seed-mediated synthesis method. The refractive index...
Article
Anisotropic rare-earth ion (RE3+) doped fluoride upconversion particles are emerging as a potential candidate in diverse areas, ranging from biomedical imaging to photonics. Here, we develop a facile strategy to synthesize NaYF4:Yb, Er, Gd and NaYF4:Yb, Tm, Gd upconversion nanorods via microwave synthesis route by controlling the synthesis time and...
Article
Full-text available
The fabrication of a thick oxide layer onto an aluminum surface via anodization has been a subject of intense research activity for more than a century, largely due to protective and decorative applications. The capability to create well-defined pores via a cost-effective electrochemical oxidation technique onto the surface has made a major renaiss...
Article
1. The properties of plastics make them highly useful for various purposes in modern life. But the impact of waste produced from the same is raising serious environmental concerns because most of the plastic in use are non-biodegradable. Though there are attempts to develop plastics that are eco-friendly, the production of the same is in the initia...
Chapter
Optical techniques are becoming increasingly popular for the analysis of body fluids, particularly so after the onset of the COVID-19 pandemic. Raman spectroscopy has found special significance among them due to its ability to perform label-free investigations of biological solutions with high sensitivity and specificity. The integration of Raman s...
Preprint
Full-text available
Laser induced breakdown spectroscopy (LIBS) has become a proven contemporary workhorse for qualitative and quantitative analysis of materials. Recent developments in LIBS have been limited either to signal enhancement strategies or to advances in data analysis techniques that yield better interpretation of LIBS data. Explorations of the initial las...
Article
The quest for improving the limits of trace elemental detection and reproducibility in Laser-Induced Breakdown Spectroscopy (LIBS) resulted in the development of novel methodologies for sample excitation and plasma collection. Efficient plasma collection and coupling to the detector is of utmost importance in LIBS studies for meaningful and logical...
Article
Full-text available
Research activities are in full swing globally to translate the use of saliva as a non-invasive and highly potential specimen for clinical diagnostics, particularly for COVID-19 detection. Being comprised of a pool of biomarkers also enriched with ACE-2 receptors, saliva can provide vital information regarding the state of the human body. Advanceme...
Article
Due to their unique optical properties, anisotropic silver and gold nanostructures are widely studied for applications ranging from catalysis to sensing and imaging. The wet chemical synthesis method provides a convenient route to produce desired nanostructures with good control over the morphology of nanoparticles. Nanostructures prepared in the s...
Article
A facile and cost-effective method was developed to create superhydrophobic surfaces onto a superhydrophilic commercial paper for the application of droplet splitting of microliter droplets into nano and sub-nano-liter droplets. The high wettability contrast of nearly 180° between the superhydrophobic region created via candle soot coated onto the...
Article
Full-text available
Different types of Glutaredoxins (GRXs) that play a major role in cellular anti-oxidative reactions have been studied for their structure and function from various organisms. Glutathione (GSH), an anti-oxidant with several medical benefits, binds to GRXs. This work has structurally characterized GRX2 from C. reinhardtii (CrGRX2) using biophysical,...
Article
Introduction: Human blood and saliva are increasingly under investigation for the detection of biomarkers for early diagnosis of non-communicable (e.g.cancers) and communicable diseases like COVID-19. Exploring the potential application of human tears, an easily accessible body fluid, for the diagnosis of various diseases is the need of the hour.Ar...
Article
Full-text available
3-Benzylchroman-4-ones (homoisoflavanones) are oxygen-containing heterocycles with a sixteen-carbon skeleton. They belong to the class of naturally occurring polyphenolic flavonoids with limited occurrence in nature and possess anti-inflammatory, antibacterial, antihistaminic, antimutagenic, antiviral, and angioprotective properties. Recently, we r...
Article
Full-text available
Human saliva can be treated as a pool of biological markers able to reflect on the state of personal health. Recent years have witnessed an increase in the use of optical devices for the analysis of body fluids. Several groups have carried out studies investigating the potential of saliva as a non-invasive and reliable clinical specimen for use in...
Article
There has been a long-standing interest in Raman spectroscopic investigation of optically trapped single functional cells. Optical trapping using a Gaussian beam has helped researchers for decades to investigate single cells suspended in a physiological medium. However, complete and sensitive probing of single cells demands further advancements in...
Article
There has been a long-standing interest in Raman spectroscopic investigation of optically trapped single functional cells. Optical trapping using a Gaussian beam has helped researchers for decades to investigate single cells suspended in a physiological medium. However, complete and sensitive probing of single cells demands further advancements in...
Article
Crystalloid fluids, a subset of intravenous (IV) fluid solutions are commonly used in clinical settings. The influence of these fluids on the functions of blood components are least explored. Raman spectroscopy combined with optical trapping has been widely used to evaluate the impact of external stress agents on red blood cells. The present study...
Article
We report the synthesis of Ag nanocubes by using a sodium sulfide assisted solvothermal method. Small edge-length nanocubes (32 and 44 nm) were obtained at 145 and 155 °C reaction temperature in the synthesis process. The refractive index sensitivity of synthesized nanocubes was investigated with an aqueous solution of glucose. The refractive index...
Article
Introduction: The unprecedented outbreaks of corona virus disease of 2019 (COVID-19) have highlighted the necessity of readily available, reliable, precise, and faster techniques for its detection. Nasopharyngeal swab has been the gold standard for the diagnosis of COVID-19. However, it is not an ideal screening procedure for massive screening as i...
Article
Recently, laser-induced heating assisted assembly of colloidal particles is emerging as a popular technique against direct light-assisted particle assembling methods. Herein, we demonstrate the trapping and assembly of yeast cells and upconversion particles at laser excitation intensities as low as 11 μW/μm² via localized heating of non-plasmonic c...
Article
The outbreak of life-threatening pandemic like COVID necessitated the development of novel, rapid and cost-effective techniques that facilitate detection of viruses like SARS-CoV-2. The presently popular approach of a collection of samples using the nasopharyngeal swab method and subsequent detection of RNA using the real-time polymerase chain reac...
Article
Full-text available
Determination of the pH value of a medium without the usage of less photostable and toxic dye molecules or the dye incorporated particles still remains a challenging task. Here, we...
Article
Development of multi-modal optical spectroscopic sensors for sample analysis is often challenged by the requirement of signal collection and measurement devices utilized for specific techniques. In the present study, the...
Conference Paper
Investigation of body fluids is of paramount importance since it carries a pool of biological markers, which can reflect the health status of humans. Technological advancements in the field of biophotonics offer highly sensitive, objective and rapid detection of abnormal health conditions from body fluid analysis. Raman spectroscopy has been widely...
Conference Paper
Photoacoustic spectroscopy is a well-known spectroscopic method for gas detection. Exhaled breath contains volatile organic compounds (VOCs) as bio-markers of specific health condition. Detection and quantification of VOC bio-markers from exhaled breath can provide valuable information about the health status. We report the design and development o...
Article
Exhaled breath contains small molecules and complex volatile organic compounds (VOCs) such as H 2 O, CO 2 , NO, NH 3 , ketones, aldehydes, alcohols, and hydrocarbons. Analysis of VOCs can provide valuable information about health status, especially in several disorders and disease conditions. In view of pandemics like the recent COVID-19 incidences...
Article
Inspired by lotus-effect, superhydrophobicity has attracted considerable interest in various areas such as self-cleaning, antifouling and liquid transportation, and so on. Superhydrophobic surfaces can be prepared mostly by altering the surface with creating micro/nanoscale structures or with chemically modifying by materials of low surface energy....
Article
The penultimate aim of all analytical techniques is to provide best quantitative information with high sensitivity and accuracy. Such techniques then can be ideal to estimate the concentration of different species in a sample or to measure the surface concentration and so on. The preliminary step involved in quantitative analysis is evaluation of t...
Article
Full-text available
Hydroxyethyl starch (HES) is a commonly used intravenous fluid in hospital settings. The merits and demerits of its application is still a debatable topic. Investigating the interaction of external agents like intravenous fluids with blood cells is of great significance in clinical environments. Micro-Raman spectroscopy combined with an optical twe...
Chapter
Full-text available
The control of ubiquitous wetting behavior that is determined by the surface free energy of the solid and the surface tension of the interacting liquid is an area of intense research, largely due to its applications in various sectors, ranging from healthcare to automotive industry. The failure and/or toxic nature of the conventionally employed che...
Article
This review discusses the importance of hyphenating different laser-based techniques such as Laser-Induced Breakdown Spectroscopy (LIBS), Raman spectroscopy and Laser-Induced Fluorescence spectroscopy (LIF) and the applications of the hybrid systems. These spectroscopic techniques, in single and multi-modes, are widely accepted as an efficient tool...
Article
Full-text available
Derangements in bilirubin metabolism and/or dysfunctions in the hepato-biliary system lead to the unhealthy buildup of bilirubin in blood, resulting in jaundice. During the course of this disorder, circulating red cells are invariably subjected to toxic effects of serum bilirubin and an array of inflammatory compounds. This study aimed to investiga...
Article
We report the synthesis of Ag triangular nanoplates and its application for the detection of bulk refractive index change resulting from low molecular weight analyte molecules. Triangular nanoplates of different edge lengths were synthesized using seed mediated approach with small modification in the earlier reported method [Adv. Funct. Mater. 18,...
Article
Electrons and .OH-radicals have been generated by using low-energy laser pulses of 6 ns duration (1064 nm wavelength) to create plasma in a suspension of plasmid DNA (pUC19) in water. Upon thermalization these particles induce single and double strand breakages in DNA along with possible base oxidation/base degradation. The time-evolution of the en...
Article
The secondary structure analyses of proteins hold immense importance in the field of protein science because it plays a vital role in its hierarchical classification. It is the most important transitional step in the prediction of the three‐dimensional structure of any protein. The aim of the current study is to quantitatively determine the seconda...
Article
Extracellular tonicity has a significant influence on human red blood cell deformation capability. Advancements in the area of laser physics and optical trapping have opened up a plethora of applications for understanding cell structure and dynamics. Here, Raman Tweezers technique was employed to investigate the impact of extracellular tonicity by...
Article
Full-text available
Advancements in the field of nanotechnology have resulted in the emergence of a large variety of engineered nanomaterials for innumerable applications. Despite the ubiquitous use of nanomaterials in daily life, concerns regarding the potential toxicity and safety of these materials have also been raised. There is a high demand for assessing the unw...
Article
The control of ubiquitous wetting behavior that is determined by the surface free energy of the solid and the surface tension of the interacting liquid is an area of intense research, largely due to its applications in various sectors, ranging from healthcare to automotive industry. The failure and/or toxic nature of the conventionally employed che...
Article
The influence of static electric field of about 4.9 kV/cm on optically trapped polystyrene bead has been studied using micro-Raman spectroscopy. This experimental method could explore the response of electronic polarizability of molecules to the static electric field by measuring the Raman intensity. It is observed that, the atomic electrons in pol...
Article
There are a number of analytical techniques used to study material related problems. Most of them imply experimental determination of parameters and functions by means of which elemental, optical and other properties of materials can be described. Laser Induced Breakdown Spectroscopy (LIBS) and Raman spectroscopy are highly complementary spectrosco...
Article
Full-text available
Aim To synthesize biocompatible nanoparticles of FAp co-doped with Yb/Er and Nd/Yb for bioimaging applications. Methods Yb/Er FAp and Nd/Yb FAp was synthesized using microwave assisted wet precipitation and hydrothermal method respectively. Trisodium citrate was used as an organic modifier for the synthesis and then subjected to heat treatment for...
Article
Highly-ordered nanoporous anodic alumina (NAA) with varying thicknesses were prepared by changing the anodization time from 10 min to 10 h, using a two-step electrochemical oxidation in oxalic acid. Three optical characterizations, namely, Ultraviolet–Visible–Near Infrared (UV–VIS–NIR), Photoluminescence (PL), and Reflective interference spectra we...
Article
Alcohol is commonly used as sterilizing agent in hospital settings. Alcohol abuse is also associated with numerous medical complications. It influences the coagulation mechanics and erythropoiesis. Optical tweezers are being extensively used in research labs for the trapping as well as manipulation of biological cells. The biochemical investigation...
Article
Full-text available
The dermal penetration of bisphenol-A (BPA) from thermal papers into the human skin is a matter of major health concern due to its extensive use in developing countries like India, one of its largest users in the world. Bisphenol A is widely used in the manufacture of many consumer goods like polycarbonate water bottles, baby bottles, food containe...