Santa Mandal

• Doctor of Pharmacy
• Senior Assistant Professor at Assam Down Town University

This review article provides a comprehensive overview of the Musa genus, focusing on its significance, diversity, cultivation practices, commercial applications, and impact on health and well-being. The introduction highlights the economic importance of the Musa genus, particularly bananas, and plantains, as globally consumed fruit crops. It emphas...

The rising prevalence of neurodegenerative disorders (NDs) necessitates innovative therapeutic approaches, and ethnopharmacology provides a promising link between traditional medicine and modern drug discovery. This paper examines how ethnopharmacological wisdom can be integrated with contemporary scientific methods to treat NDs like Alzheimer's, P...

Drug resistance has become a challenge in the field of biomedical research, posing a threat to the effectiveness of many therapeutic interventions. This article aims to provide a comprehensive overview of the current state of the science regarding drug resistance, focusing on recent advancements in understanding of the underlying mechanisms and str...

Adaptogenic plants are increasingly being recognized as potential therapeutic agents in the treatment of mental health disorders. In this review, we summarized current evidence of their efficacy, safety, and mechanisms of action in the treatment of mental health disorders. The findings of the clinical studies showed that adaptogens, such as ashwaga...

The use of artificial intelligence (AI) into natural product research marks a paradigm breakthrough in the area of pharmaceutical sciences, providing new prospects for expediting medication discovery and development. Traditional techniques of natural product discovery have historically faced obstacles such as extensive screens, poor hit rates, and...

The study's objective is to provide a rapid, simple, accurate, and cost-effective RP-HPLC assay technique for the simultaneous quantification of domperidone and cinnarizine in pharmaceutical bulk. Domperidone and cinnarizine in bulk have been successfully separated using this approach. Separation was carried out at 226 nm on a C18 SunfireTM (5 m, 2...

The pharmacy field stands on the brink of a transformative era driven by technological innovations and futuristic paradigms. This chapter delves into the multifaceted dimensions of automation, technology integration, personalized medicine, pharmacogenomics, artificial intelligence (AI), machine learning, nanotechnology, and advanced drug deliver...

Background & objectives Vector control measures are important in lowering the spread of infections spread by mosquito. Synthetic pesticides used to suppress vector populations during the larval stage have had adverse impacts on people and the environment. The early III instar larvae of Aedes aegypti and Anopheles stephensi were the targets of the c...

Most pharmacological medications frequently exhibit poor dosage proportionality, significant intra-and inter-subject variability, and limited oral bioavailability when taken orally. It has been estimated that around 40% of innovative medication candidates don't dissolve very well in water. The development of a microemulsion drug delivery system may...

Most pharmacological medications frequently exhibit poor dosage proportionality, significant intra-and inter-subject variability, and limited oral bioavailability when taken orally. It has been estimated that around 40% of innovative medication candidates don't dissolve very well in water. The development of a microemulsion drug delivery system may...

Feeding the rapidly growing population of the world is a major challenge that human beings face today and ensuring food security of all individuals is a major goal. This is never truer than in the case of India with a population of 1.32 billion expected to touch 1.65 billion by 2050. The present rates of crop production while significantly increase...

Objectives: To explore the therapeutic role of a single dose combination of montelukast (MON) and dexamethasone (DXM) through intra-peritoneal route against paraquat (PQ)-intoxicated experimental Wistar rats. Methods: In vivo the survival rate was investigated following the administration of both MON and DXM in PQ exposed rats. Lungs parameters inc...

Background: Defense personnel utilize capsaicin based ocular sprays as non-lethal agents for law implementation during instances of mob violence. This study involves the capsaicin antagonist Capsazepine, and the investigation whether Capsazepine’s antagonistic approach can be favorably utilized for defense utilization to block capsaicin-initiated p...

Resealed erythrocytes (RSE) are potential, site-specific carrier system for drug delivery with prolonged drug release activity. In this study, erythrocytes obtained from Wistar albino rats were loaded with ambroxol hydrochloride (AH) with the focus to convenience the lung targeting possibility of the carrier erythrocytes. AH loading in erythrocytes...

Objective: Melatonin and pumpkin seed oil, along with US FDA approved UV filters were incorporated into a formulation for enhancement of UV protection by exerting an antioxidant effect. The objective of this study was to assess the protective effect of this formulation against ultraviolet (UV) radiation-induced photo dermatitis in rats, which is an...

The presence of 40–50% more UV radiation in high altitude areas renders the plethora of sunscreen products available in the market virtually ineffective. In this light of event, four US FDA approved UV filters were combined with melatonin and pumpkin seed oil to produce a broad spectrum sunscreen cream, which is envisaged to provide optimum sunprot...

Paraquat (PQ), a highly popular agricultural herbicide, is a serious occupational hazard with lethality reported at doses as low as 35 mg/kg body weight with intoxication occurring via inhalation or dermal route. The main objective of this study was to determine the median lethal concentration (LCt50) of paraquat through whole body exposure in adul...

The objective of the aforementioned study was to evaluate the anti-psoriatic effect of a newly formulated combinational topical sunscreen containing US FDA approved UV filters along with pumpkin seed oil and melatonin using UV radiation induced psoriasis in rats. Melatonin and pumpkin seed oil were incorporated into the formulation for enhancement...

The objective of the aforementioned study was to evaluate the anti-psoriatic effect of a newly formulated combinational topical sunscreen containing US FDA approved UV filters along with pumpkin seed oil and melatonin using UV radiation induced psoriasis in rats. Melatonin and pumpkin seed oil were incorporated into the formulation for enhancement...

Ultraviolet (UV) radiation exposure has been known to cause irreparable damages to human skin. The daunting risk of UV radiation exposure faced by military personnel led to the development of a sunscreen formulation which has superior sun protection factor combined with the ability to counteract reactive oxygen species. The present work deals with...

Gramine is a natural indole alkaloid that has been isolated from different raw plants occurring mainly in Avena sativa, etc. The study was aimed to investigate the possible in vitro antioxidant, in vitro mutagenic, in vitro antimutagenic, and in vivo genotoxic activity of gramine using ferric reducing ability of plasma (FRAP) assay, Metal chelating...

A simple, accurate and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of ethyl 2-aminobenzoate (EAB) in a matrix type monolithic polymeric device and validated as per the International Conference on Harmonization guidelines. The analysis was performed isocratically on a ZORBAX...

Compromised stability of pharmaceutical formulations loaded with volatiles is a serious problem associated with devices designed to deliver volatile compounds. The present study has been focused to evaluate the stability potential of matrix-type polymeric patches composed of volatile ethyl anthranilate for prophylaxis against vector-borne diseases....

Paraquat(PQ) is one of the most widely used non-selective herbicides in the world, marketed globally under the brand name Gramoxone by Syngenta (Ahmed, A.A. 2009). Spraying PQ lets millions of farmers grow better crops more easily but it’s highly toxic nature affects human as well as animals through inhalation route (Kumar, Harish, et al. 2016). Th...

Up to 40% of new chemical entities discovered by the pharmaceutical industry today are poorly soluble or lipophilic compounds. The solubility issues complicating the delivery of these new drugs also affect the delivery of many existing drugs. Oral bioavailability of a drug depends on its solubility and/or dissolution rate, & dissolution may be the...