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In my current job as medical advisor, my focus is on brain stimulation treatment of CNS disorders and clinical neuroscience exploring future treatment opportunities. My goal is to use my acquired skills and expertise to translate clinical neuroscience to new treatment standards that are safe and effective, for the purpose of improving the lives of people suffering from CNS disorders. As a researcher, I studied cortical network activity, with a focus on interneurons and GABA-receptor function in relation to neurovascular coupling and metabolism in the healthy and aged somatosensory cortex. I used neurophysiological techniques and two-photon imaging in vivo.
August 2016 - August 2020
January 2015 - September 2016
January 2010 - March 2014
Center for Healthy Aging, Department of Neuroscience and Pharmacology, University of Copenhagen
Field of study
September 2003 - September 2009
Faculty of Pharmaceutical Sciences, University of Copenhagen
Field of study
Cerebral blood flow (CBF) is regulated by the activity of neurons and astrocytes. Understanding how these cells control activity-dependent increases in CBF is crucial to interpreting functional neuroimaging signals. The relative importance of neurons and astrocytes is debated, as are the functional implications of fast Ca2+ changes in astrocytes ve...
Higher cognitive functions depend critically on synchronized network activity in the gamma range (30–100 Hz), which results from activity of fast-spiking parvalbumin-positive (PV) interneurons. Here, we examined synaptic activity in the gamma band in relation to PV interneuron activity, stimulation-induced calcium activity in neurons and astrocytes...
Neural activity regulates local increases in cerebral blood flow (ΔCBF) and the cortical metabolic rate of oxygen (ΔCMRO2) that constitutes the basis of BOLD functional neuroimaging signals. Glutamate signaling plays a key role in brain vascular and metabolic control; however, the modulatory effect of GABA is incompletely understood. Here we perfor...
Increased neuron and astrocyte activity triggers increased brain blood flow, but controversy exists over whether stimulation-induced changes in astrocyte activity are rapid and widespread enough to contribute to brain blood flow control. Here, we provide evidence for stimulus-evoked Ca(2+) elevations with rapid onset and short duration in a large p...
I would like to specifically express fluorescence in the parvalbumin positive interneurons/fast spiking interneurons in the cerebral cortex of mice. Does anyone have a good protocol and/or virus available for that?