Sanjeev Handa

Sanjeev Handa
Postgraduate Institute of Medical Education and Research | PGIMER · Department of Dermatology, Venereology and Leprosy

MD, FAMS, FAAD, FRCP(Edin)

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336
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Publications

Publications (336)
Article
BACKGROUND Information on bullous pemphigoid in an Indian context is scarce. AIM To report clinico-demographic profile, associated comorbidities and prescription pattern of bullous pemphigoid patients in India. METHODS This was a retrospective study, where past records of all bullous pemphigoid patients diagnosed and treated between November 2013...
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Background: Subcutaneous (SC) methotrexate(MTX) is considered to be associated with a higher and predictable linear bioavailability as compared to oral MTX. Although various studies have reported SC MTX to be safe and effective in psoriasis, prospective head-to-head comparative trials on oral vs SC MTX are limited. Objective: To compare the effi...
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Background: There is a paucity of literature on pediatric autoimmune bullous disorders (AIBD) in the Indian population. We aimed to retrospectively evaluate the clinico-demographic profile of pediatric AIBDs in our patients and their response to various therapeutic modalities. Materials and methods: This was a retrospective chart review of patie...
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Background: The literature suggests a beneficial role of cholinomimetic agents in the treatment of pemphigus. In the present open-label, prospective pilot study, we assessed the effectiveness of topical pilocarpine 2% eye-drops in the treatment of recalcitrant oral lesions of pemphigus. Methods: Twenty patients with recalcitrant oral lesions of...
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Glucocorticoids are the mainstay of treatment for pemphigus vulgaris (PV). However, the requirement of high doses for long durations often leads to serious adverse events. Methotrexate as an adjuvant has shown potential in retrospective studies but randomized trials are lacking. The objective of the study was to assess the adjuvant potential of met...
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Background: Various dosing protocols of rituximab have been used in pemphigus. B-cell repopulation post-rituximab can be considered a forerunner of clinical relapse. Immunologically-guided dosing may obviate the need of fixed timepoint maintenance dosing, hence proving more cost-effective and perhaps safer. Objective: Comparison of overall effic...
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Introduction: Ectodermal dysplasias (EDs) affect structures derived from the ectoderm such as skin, its appendages, nail, and teeth. In this series, we describe four patients presenting with a clinical phenotype of dysplasia of one or more ectodermal structures who underwent next-generation sequencing for mutational analysis. Case series: The cl...
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Primary immunodeficiencies with eczema can be easily misdiagnosed as atopic eczema, and thus require a high degree of awareness for diagnosis. Wiskott–Aldrich syndrome (WAS) is a rare disease and the fact that WAS without microthrombocytopenia has not been reported to date makes this case more interesting. As the patient's predominant problem was e...
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Hintergrund: Vitamin D hat sich als vielversprechende Behandlung für die kongenitale Ichthyose herausgestellt. Bisher liegen keine Vergleichsstudien vor. Methodik: In dieser randomisierten Doppelblindstudie erhielten Patienten mit kongenitaler Ichthyose für 24 Wochen entweder Vitamin D 2000 IU/Tag (Gruppe A) oder Acitretin 0,5 mg/kg/Tag (Gruppe B)....
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Background: Vitamin D has emerged as a promising treatment for congenital ichthyosis for which no comparative studies exist. Methodology: In this randomized, double-blinded study, patients with congenital ichthyosis received either Vitamin D 2000 IU/day (group A) or acitretin 0.5 mg/kg/day (group B) for 24 weeks. The primary outcome was improvem...
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Background: The mutational analysis along with immunofluorescence antigen mapping (IFM) are recommended as the laboratory tools of choice for diagnosing EB. In the past, transmission electron microscopy (TEM) was considered the gold standard, and more recently, clinical diagnostic matrix (CDM) has shown good concordance with next-generation sequen...
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Zusammenfassung Hintergrund und Ziele Bei Patienten mit aktivem Pemphigus liegt ein erhebliches Ausmaß an psychischer Morbidität vor. Da Pemphigus eine chronische Krankheit ist, kann psychische Morbidität auch bei Pemphigus-Patienten in Remission auftreten. Die Ziele dieser Studie waren die Beurteilung der psychischen Morbidität bei Pemphigus-Pati...
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Background and objectives Significant psychological morbidity exists in patients with active pemphigus. Pemphigus being a chronic disease, psychological morbidity may exist in pemphigus patients in remission as well. The objectives of the study were to assess the psychological morbidity in pemphigus patients in clinical remission and to correlate i...
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Background: Functional macrophage migration inhibitory factor (MIF) gene polymorphisms are associated with elevated serum levels of MIF and increased susceptibility to various autoimmune diseases. MIF levels in the sera of pemphigus vulgaris (PV) patients are increased; however, no definite association has been demonstrated between PV and MIF gene...
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Background Recent evidence has suggested that oral antihistamines could have a beneficial role in atopic dermatitis (AD) due to their anti-inflammatory action. Hence, we aimed to evaluate the effectiveness of adding an oral second generation, non-sedating, H1 antihistamine (Fexofenadine) to topical treatment in AD. Materials and Methods In this pr...
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As a response to the coronavirus disease (COVID‐19) pandemic, several vaccines have been developed globally and are being rolled out at a fast pace for public immunization. Drug controller general of India has approved use of CovaxinTM (BBV152, manufactured by Bharat Biotech) and CovishieldTM (Oxford–AstraZeneca COVID‐19 vaccine, manufactured by Se...
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Background: Quality of life (QoL) has not been evaluated in Indian patients having epidermolysis bullosa (EB). Aims: The aims of the study were to measure health-related QoL in Indian patients having EB using the quality of life in epidermolysis bullosa (QoLEB) questionnaire, and to find its correlation with clinically measured disease severity....
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WHO defines malnutrition as severe if the z-scores are less than − 3 Standard deviation (SD), moderate if between − 2 and − 3 SD and mild if between − 2 SD to – 1 SD. This study was aimed to assess nutritional aspects of Indian children suffering from EB and to evaluate the effect of severity of EB on the severity of malnutrition. In this study, pe...
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Autoimmune bullous diseases can be intraepidermal (pemphigus group of disorders) or subepidermal (pemphigoid group of disorders). The treatment of these disorders chiefly comprises corticosteroids and immunosuppressant adjuvants like azathioprine and mycophenolate mofetil. Autoantibodies are the main mediators of these diseases. Rituximab, a chimer...
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Background Teledermatology has evolved as a valuable option to outpatient visits during the current pandemic. We set up a smartphone-based hybrid model of teledermatology services providing direct care to patients at our center. Objective To analyze patient and physician-experience and acceptability for teledermatology over a 6-month-period, along...
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Background: Dermatology is primarily an outpatient specialty. However, dermatology consultations play an important role in care of inpatients. Data on inpatient dermatological consultations in tertiary care settings is limited. Objectives: To evaluate clinical characteristics of inpatient dermatological consultations and effect on clinical outco...
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Evidence for the effectiveness of metformin in the treatment of acne is limited. To assess its efficacy, comedones were experimentally induced in young New Zealand rabbit ear using Isopropyl Myristate (IM) followed by metformin treatment (30 mg/ kg bodyweight) for 60 days with continued IM application. In another group, to check whether metformi...
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Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disorder commonly affecting the elderly in the age group of 60‐80 years.¹ IgG autoantibodies against the hemidesmosomal proteins BP180 and BP 230 have been deemed central in pathogenesis. However, IgE also appears to be important in pathogenesis and targeting IgE autoantibodies may be...
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Background Placebo-controlled studies have reported the efficacy of apremilast in the management of palmoplantar psoriasis but studies comparing efficacy with a conventional agent are lacking.Objective The objective of this article was to compare the efficacy and safety of apremilast and methotrexate in patients with palmoplantar psoriasis.Methods...
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A 5‐year‐old boy presented with generalized cutaneous erosions, severe scarring, depigmentation and contractures affecting major joints. The lesions had initially affected his ears, nose, feet, and the genital and ocular mucosa, leading to significant depigmentation, scarring, contractures and mutilation. The whole of the trunk and limbs were invol...
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Background Topical corticosteroids are the standard therapy for the treatment of alopecia areata. Recently, topical latanoprost has been found effective in the treatment of eyelash alopecia areata. Objectives The objective of this study was to compare the efficacy of topical latanoprost ophthalmic solution (group 1) with that of topical betamethas...
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Background: Psoriasis is a chronic inflammatory dermatosis associated with psychological morbidity. Very few studies have evaluated stigma among caregivers of patients with psoriasis. Objective: This study aimed to evaluate the prevalence of stigma and its correlates among the caregivers of patients with psoriasis. Methodology: Forty-nine care...
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Zusammenfassung Hintergrund und Ziel Bei Akne wurde eine abweichende Gewebeexpression von Matrix‐Metalloproteinasen beobachtet. Ziel unserer Studie war es, die Bedeutung von Polymorphismen einzelner Nukleotide (single nucleotide polymorphisms, SNPs) in MMP‐2 (‐1306 C/T, rs243865) und TIMP‐2 (‐418 G/C, rs8179090) bei Akne und Post‐Akne‐Narben zu un...
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Syndromic congenital ichthyoses (CI) are genetically determined disorders of cornification that are characterized by generalized scaling along with systemic symptoms. Data on congenital syndromic ichthyosis from developing countries are scarce. To assess the prevalence, phenotype‐genotype correlation, and management of syndromic CI patients present...
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Background: Data on clinical and epidemiologic profile on pediatric alopecia is relatively scarce. Aims and objectives: We aimed to study the clinical, epidemiological, and dermoscopic profile of children presenting with alopecia, and assess the responsiveness to different treatment modalities in a real-life setting. Materials and methods: Thi...
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Background: Psoriasis is a chronic inflammatory dermatosis associated with psychological morbidity. Like mental illness, it is also associated with stigma. Very few studies from India have evaluated stigma experienced by patients with psoriasis. Aim of the study: To study stigma in patients with psoriasis (in the form of internalized stigma, per...
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Introduction There is scarcity of prospective studies assessing the correlation between vitamin D deficiency and atopic dermatitis (AD). Materials and methods We conducted a prospective study where in serum 25-hydroxy-vitamin D levels were measured in 35 AD patients and 35 age and sex-matched controls. AD patients deficient in vitamin D were suppl...
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Background: Many patients with pemphigus vulgaris (PV) in India present with predominant/exclusive oral mucosal lesions. Current validated scoring systems for pemphigus do not adequately represent the clinical variability of oral lesions. Objective: To develop and validate a novel scoring system exclusively for oral lesions in PV. Methods: In thi...
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Background Toxic epidermal necrolysis (TEN) is a life‐threatening severe cutaneous adverse reaction. Data on pediatric TEN is limited. Methods Case records of 44 children, 1 month–12 years with a diagnosis of TEN (>30% body surface area [%BSA] detachment) admitted to a tertiary pediatric intensive care unit (PICU) between 2009 and 2018 were analyz...
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Background: Many international guidelines on psoriasis management have emphasized upon the need to identify risk factors for liver fibrosis and that the risk may be increased after a certain total cumulative dose of methotrexate. Methods: Consecutive patients with moderate-to-severe psoriasis were assessed for liver fibrosis using transient elas...
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Dowling–Degos disease (DDD) is a late-onset genodermatosis characterized by hyperpigmented macules on the flexures along with scattered comedo-like lesions and pitted acneiform scars. Follicular Dowling–Degos is a rare type of DDD, with only two reports so far. It presents with follicular papules and comedo-like lesions predominantly on the face an...
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Seborrhoeic dermatitis/dandruff (SD/D) is a common, persistent, relapsing inflammatory condition affecting the areas rich in sebaceous glands. SD/D is widely prevalent in India but Malassezia species implicated are not well studied. To estimate the prevalence and spectrum of Malassezia species causing SD/D and understand the sociodemographic charac...
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Abstarct Pemphigus vulgaris is an autoimmune disease characterized by fluid-filled blisters over body and mucosal surfaces. Localized pemphigus is a rare presentation of the disease. There are few reports of localized pemphigus in literature presenting as esophageal involvement, recurrent paronychia, conjunctival mass, foot ulcers, discoloration of...
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Paediatric morphoea is a debilitating fibrosing disorder of uncertain aetiology, affecting the skin and subcutaneous tissues. Defining optimum management strategies in paediatric morphoea remains an ongoing challenge, owing to the varied presentations and a relative paucity of paediatric‐specific studies. We performed a literature search on PubMed,...
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Background: Pityriasis versicolor (PV) is the most common chronic superficial infection of the stratum corneum, reported in 40-60% of the tropical population. After the description of the new Malassezia species, only a few studies have been conducted from India. Aims: Molecular identification, quantification of Malassezia species implicated with...
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Introduction: Patients who receive orthopedic implants have been shown to develop sensitivity to its components and there are concerns that this sensitivity might lead to contact dermatitis or implant-related problems like loosening and/or failure. The objective of the study was to determine the sensitizing potential of orthopedic implants. Metho...
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Background: Pemphigus vulgaris is a potentially fatal autoimmune epidermal blistering disease with a chronic and relapsing course. It is difficult to predict clinical relapse. Identification of clinical and immunological factors that are associated with early clinical relapse in a prospective study design may help in planning treatment for better...
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Background: Psoralen with ultraviolet A is an effective photochemotherapeutic modality. A subtype of this, PUVAsol, uses sunlight as the natural source of ultraviolet A. The amount of sunlight received and the consequent ultraviolet A exposure vary according to the month in the year, time of the day and geographical location of a place. Aim: The ai...
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Background: Rituximab is being increasingly used for the treatment of pemphigus. Data derived from single-center studies following a uniform treatment protocol are limited. Effect of demography and disease type on treatment response is poorly characterized. Objective: Our aim was to assess the effectiveness of biosimilar rituximab in pemphigus p...
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Background: Lichen planus-like lesions on oral mucosa occasionally occur in Indian patients with pemphigus vulgaris. Its significance, both clinical and pathological, is yet to be elucidated. Aims and objectives: To study the clinical and pathological characteristics of clinically apparent oral mucosal lichen planus-like lesions in pemphigus pat...
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Dear Editor, A 1‐year‐old boy with unremarkable birth history sought treatment for multiple yellowish lesions all over his body for the past 6 months. The lesions were insidious in onset, slightly pruritic, painless and rapidly progressive. The child's past medical and family history were unremarkable, and there was no history of consanguinity in...
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Background Acquired dermal macular hyperpigmentation (ADMH) is an umbrella term including lichen planus pigmentosus, erythema dyschromicum perstans and pigmented contact/cosmetic dermatitis. Objective To establish contact sensitization to hair colours as an etiological factor for ADMH. Methods Detailed clinical examination, skin biopsies, and pat...
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Background There are no Indian studies on the association between filaggrin mutations and any dermatosis, including hand eczema. Objectives To determine the prevalence of filaggrin mutations in Indian hand eczema patients and examine associations between such mutation and any etiologic type of hand eczema. Materials and Methods A total of 163 pat...