Sangwook Lee

The University of Tokyo | Todai · Department of Chemistry

Vitamin D insufficiency has been linked to unfavourable outcomes in diverse malignancies. However, the prognostic significance of vitamin D levels in peripheral T-cell lymphoma (PTCL) remains unclear. In this study, we thus aimed to assess the prognostic relevance of 25-hydroxyvitamin D [25(OH)D] levels in patients newly diagnosed with PTCL. The an...

Abstract Weak interlayer couplings at 2D van der Waals (vdW) interfaces fundamentally distinguish out‐of‐plane charge flow, the information carrier in vdW‐assembled vertical electronic and optical devices, from the in‐plane band transport processes. Here, the out‐of‐plane charge transport behavior in 2D vdW semiconducting transition metal dichalcog...

Purpose: To create a nomogram that can predict the probability of prostate cancer using prostate health index (PHI) and clinical parameters of patients. And the optimal cut-off value of PHI for prostate cancer was also assessed. Materials and methods: A prospective, multi-center study was conducted. PHI was evaluated prior to biopsy in patients...

Moisture in industrial gas affects the quality of products, and thus, studies on the water desorption behaviours of the components are necessary for industries to keep their gas distribution system extremely dry. In this study, the water desorption characteristics of a gas filter was evaluated, when it was newly installed in a setup operating in th...

The inherent properties of 2D materials—light mass, high out-of-plane flexibility, and large surface area—promise great potential for precise and accurate nanomechanical mass sensing, but their application is often hampered by surface contamination. Here we demonstrate a tri-layer graphene nanomechanical resonant mass sensor with sub-attogram resol...

Higher order modulations are the key elements to the throughput and spectral efficiency increase, especially important for the limited bandwidth scenarios. In this paper, we present a detailed analysis of the 256-QAM signal demodulation performance for the novel sidelink (SL) mode of the 5G NR communication systems. The performance is frequency off...

In this study, we investigated the impacts of different riblet types of submarine surfaces on the drag force, which is directly related to the operating efficiency of submarine. We examined four cases of submarine surface: smooth surface as the reference case and three cases of sawtooth riblet with the same ratio between the height and spacing (h/s...

Nanomechanical resonator devices are widely used as ultrasensitive mass detectors for fundamental studies and practical applications. The resonance frequency of the resonators shifts when a mass is loaded, which is used to estimate the mass. However, the shift signal is often blurred by the thermal noise, which interferes with accurate mass detecti...

The uncertainties of four-dimensional computed tomography (4DCT), also called as residual motion artefacts (RMA), induced from irregular respiratory patterns can degrade the quality of overall radiotherapy. This study aims to quantify and reduce those uncertainties. A comparative study on quantitative indicators for RMA was performed, and based on...

Objective: To compare the therapeutic efficacy after suburethral adjustable sling (Remeex system) for female stress urinary incontinence (SUI) between pure intrinsic s phincter deficiency (ISD) and ISD with overactive bladder (OAB) group. Methods: The study subjects were 86 female patients with ISD who underwent Remeex system to treat female SUI an...

Background: It is rare for urothelial and renal cell carcinomas to coexist in the same patient, and even rarer for them to be detected simultaneously. Because of this rarity, a standard treatment has not been established and studies about overall survival are scarce. Therefore, physicians must modify treatments according to the individual's situat...

We fabricated hybrid nanostructures consisting of MoS2 monolayers and Au nanopillar (Au-NP) arrays. The surface morphology and Raman spectra showed that the MoS2 flakes transferred onto the Au-NPs were very flat and nonstrained. The Raman and photoluminescence intensities of MoS2/Au-NP were 3- and 20-fold larger than those of MoS2 flakes on a flat...

A dual thermistor radiosonde (DTR) comprising two (aluminium-coated and black) sensors with different emissivities was developed to correct the effects of solar radiation on temperature probes based on in situ radiation measurements. Herein, the DTR performance is characterised in terms of the uncertainty via a series of ground-based facilities and...

Purpose: Prognostic Index for Natural Killer Lymphoma (PINK) is the most widely accepted prognostic model for patients with Extranodal natural killer/T-cell lymphoma (ENKTL) treated with non-anthracycline based therapy. We aimed to evaluate the prognostic implications of serum β-2 microglobulin (β2M) in the context of PINK and proposed a new progn...

An upper-air simulator (UAS) has been developed at the Korea Research Institute of Standards and Science (KRISS) to study the effects of solar irradiation of commercial radiosondes. In this study, the uncertainty in the radiation correction of a Vaisala RS41 temperature sensor is evaluated using the UAS at KRISS. First, the effects of environmental...

Brain metastases are not rare in patients with renal cell carcinoma. However, there have been few reports of isolated brain metastases. In patients with localized renal masses, urologists tend to evaluate only the chest and abdomen region. We report the case of a 65-year-old patient who presented with sudden left-sided weakness. He underwent brain...

Damage to normal tissue can occur over a long period after cancer radiotherapy. Free radical by radiation can initiate or accelerate chronic inflammation, which can lead to atherosclerosis. However, the underlying mechanisms remain unclear. Vascular smooth muscle cells (VSMCs) proliferate in response to JAK/STAT3 signalling. C‐reactive protein (CRP...

The thermal performance of a large-format (52.3 Ah) Li-ion pouch battery with an n-octadecane PCM was investigated. A simplified 1D model was employed to estimate the transient thermal behavior. Two design parameters, the thickness and the thermal conductivity of the PCM, were considered. A 0.5 mm thick n-octadecane PCM integrated with aluminum foa...

A dual thermistor radiosonde (DTR) comprising two (white and black) sensors with different emissivities was developed to correct the effects of solar radiation on temperature sensors based on in-situ radiation measurements. Herein, the DTR performance is characterised in terms of the uncertainty via a series of ground-based facilities and an interc...

Background Our study was conducted to investigate the effect of 5-ARI on the death rate from prostate cancer by means of an updated meta-analysis using related data. Methods We did comprehensive literature searches using the PubMed, Embase, and Cochrane databases through July 2019. We evaluated the risk of bias in such studies using the ROBINS-I t...

Objectives To evaluate the surgical effects of robotic paravaginal repair and sacrocolpopexy in patients diagnosed with lateral cystocele due to paravaginal defect. Patients and Methods Robotic paravaginal repair and sacrocolpopexy were performed contemporaneously in 43 patients with high-grade pelvic organ prolapse combined with a lateral or mixe...

Overexpression of the BCL2 protein has been reported as a poor prognostic factor for diffuse large B-cell lymphoma (DLBCL). However, there are currently no standardized criteria for evaluating BCL2 protein expression. We aimed to evaluate the prognostic value of BCL2 expression determined by immunohistochemistry (IHC), incorporating both the staini...

As urine is not sterile, inflammatory reactions caused by dysbiosis of the urinary microbiota may induce interstitial cystitis. A study was conducted to determine whether β-defensin 2 (BD-2), a specific antimicrobial peptide in the bladder, could be used as a novel diagnostic marker for ulcerative interstitial cystitis (IC). Urine samples from thre...

We aimed to investigate the prognostic value of serum β2-microglobulin in patients with peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS). A cohort study of PTCL-NOS patients (n = 147) was conducted. An elevated serum β2-microglobulin level was associated with the presence of previously identified predictors of a poor prognosis for PTCL...

An upper-air simulator (UAS) has been developed at the Korea Research Institute of Standards and Science (KRISS) to study the effects of solar irradiation of commercial radiosondes. In this study, the uncertainty of the radiation correction of a Vaisala RS41 temperature sensor is evaluated using the UAS at KRISS. First, the effects of environmental...

Purpose: To investigate the safety and efficacy of hypofractionated radiation therapy (HFRT) in patients with non-small cell lung cancer who are unfit for surgery or stereotactic body radiation therapy (SBRT) at our institution. Materials and methods: From May 2007 to December 2018, HFRT was used to treat 68 lesions in 64 patients who were unsui...

Background: Tumor-derived exosomal microRNAs are key elements of the cell-cell communications response to lots of stimuli. However, various functions of the exosome in tumor suppression by radiotherapy (RT) are not clearly understood. Our study showed a previously unknown interaction of p53 and histone deacetylase 5 (HDAC5) by radiation exposure in...

Background: Renal agenesis is a congenital malformation that occurs due to the inhibition of metanephric blastema induction due to a decrease in ureteric bud activity. Although renal agenesis is not very rare, unilateral renal agenesis with ureterocele occurs rarely, and the coexistance of unilateral renal agenesis, ureterocele, and blind ended...

Abstract The upper‐air simulator (UAS) was developed at the Korea Research Institute of Standards and Science to test commercial radiosonde sensors under representative conditions. In this framework, humidity generation is performed through a two‐temperature mode in which the temperatures of the saturator and the test chamber are controlled indepen...

Despite central nervous system (CNS) relapse occurring in >10% of high-risk diffuse large B-cell lymphoma (DLBCL) patients, the role of CNS-directed prophylaxis is controversial in the absence of randomized controlled trials. In this retrospective study, we aimed to evaluate the safety and efficacy of prophylactic high-dose methotrexate (HD-MTX) on...

Background: Coronary arteriovenous fistulas (CAFs) are rare but can cause myocardial ischaemia and other complications. However, the haemodynamic and physiologic characteristics of significant CAFs requiring treatment are poorly described. We report a case of CAF causing coronary steal syndrome in which haemodynamic changes were assessed before an...

In this study, high‐performance few‐layered ReS2 field‐effect transistors (FETs), fabricated with hexagonal boron nitride (h‐BN) as top/bottom dual gate dielectrics, are presented. The performance of h‐BN dual gated ReS2 FET having a trade‐off of performance parameters is optimized using a compact model from analytical choice maps, which consists o...

The present study devised a method of representing and analyzing the mechanical behavior of fabrics in the clothing care system and examined the mechanical movement under various conditions using simulations and an image analysis program called TEMA Motion-Outline tracker. Through this, we proposed an algorithm to improve dust removal by finding co...

Semiconductors have long been perceived as a prerequisite for solid-state transistors. Although switching principles for nanometer-scale devices have emerged based on the deployment of two-dimensional (2D) van der Waals heterostructures, tunneling and ballistic currents through short channels are difficult to control, and semiconducting channel mat...

The quantitative flow ratio (QFR) is a novel angiography-based computational method assessing functional ischemia caused by coronary stenosis. This study aimed to evaluate the diagnostic performance of quantitative flow ratio (QFR) in patients with angina and acute myocardial infarction (AMI) and to identify the conditions with low diagnostic perfo...

The role of the Epstein-Barr virus (EBV) status in the blood for predicting survival in post-transplantation lymphoproliferative disorders–diffuse large B-cell lymphoma (PTLD–DLBCL) is unknown. We evaluated the prognostic values of pre-treatment EBV-encoded small RNA (EBER) detected with in situ hybridization in tissues and EBV DNA in the whole blo...

Purpose: We analyzed the long-term efficacy of simultaneous transurethral resection (TUR) and therapeutic hydrodistention in patients with ulcerative interstitial cystitis (IC) who did not experience recurrence on long-term follow-up. Methods: We studied 132 female patients (mean age = 56.45 ± 11.56 years) who underwent TUR followed by hydrodist...

Vertically stacked low-dimensional heterostructures are outstanding systems both for exploring fundamental physics and creating new devices. Due to nanometerscale building blocks, atomic scale phenomena become for them of fundamental importance, including during device operation. These can be accessed in situ in aberration-corrected scanning transm...

Mechanical resonance properties of porous graphene resonators were investigated by simulation studies. The finite element method was utilized to design the porous graphene membrane pattern and to calculate the mechanical resonance frequency and quality factor. The changes in the resonance frequency and quality factor were systematically studied by...

The purpose of this study is to evaluate the performance of a recurrent neural network (RNN)-based prediction algorithm to compensate for respiratory movement using an articulated robotic couch system. A prototype of a real-time respiratory motion compensation couch was built using an optical 3D motion tracking system and a six-degree-of-freedom-ar...

Purpose: The purpose of this study was to develop automated planning for whole-brain radiation therapy (WBRT) using a U-net-based deep-learning model for predicting the multileaf collimator (MLC) shape bypassing the contouring processes. Methods: A dataset of 55 cases, including 40 training sets, five validation sets, and 10 test sets, was used...

Purpose: We aimed to investigate the prognostic value of serum β2-microglobulin for patients with Burkitt lymphoma (BL) and to propose a risk-stratifying classification system. Materials and methods: A prospective registry-based cohort study of BL patients treated with dose-intensive or effective dose-adjusted chemotherapies (n=81) was conducted...

Background Extranodal natural killer T cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma with invariable infection of lymphoma cells with Epstein-Barr virus (EBV), and the presence of EBV-DNA in the blood is a well-known prognosticator. However, there is no consensus on which blood compartment is more optimal for predicting survival o...

Background: Ureteral reconstruction is a highly technical type of laparoscopic or open surgery. The incidence of ureteral injury is low; however, ureteral injuries tend to be overtreated. Robotic surgery for urinary reconstructive surgery is growing in popularity, which has made procedures such as pyeloplasty, ureteroureterostomy, and ureteroneocy...

We present photometric stereo algorithms robust to non-Lambertian reflection, which are based on a convolutional neural network in which surface normals of objects with complex geometry and surface reflectance are estimated from a given set of an arbitrary number of images. These images are taken from the same viewpoint under different directional...

The mucosa‐associated lymphoid tissue (MALT) International Prognostic Index (IPI) was recently proposed as a prognostic index for patients with MALT lymphoma. We aimed to investigate the prognostic value of the serum β2‐microglobulin level in the context of MALT‐IPI, and we proposed a new prognostic index. Survival outcomes were analysed with regar...

We prepared MoS2 monolayers on Au nanodot (ND) and nanohole (NH) arrays. Both these sample arrays exhibited enhanced photoluminescence intensity compared with that of a bare SiO2/Si substrate. The reflectance spectra of MoS2/ND and MoS2/NH had clear features originating from excitation of localized surface plasmon and propagating surface plasmon po...

We fabricated plasmonic hybrid nanostructures consisting of MoS2 monolayer flakes and Au nanogratings with a period of 500 nm. The angle-resolved reflectance and photoluminescence spectra of the hybrid nanostructures clearly indicated a coupling between surface plasmon polaritons (SPPs) and incoming photons. The surface photovoltage (SPV) maps coul...

Selective-area remote epitaxy (SA-REpi) is demonstrated for fabricating the mechanically releasable position-controlled ZnO microrod (MR) arrays from the donor wafer in the arrayed form. Intaglio-patterned graphene (IPG), consisting of basal single-layer graphene (SLG) overlayered with multilayer graphene (MLG) patterned with perforated holes, is t...

Purpose: This study evaluates the oncogenic role of PIBF1 in triple-negative breast cancer (TNBC). TNBC is considered to have a poorer prognosis than other types of breast cancer and is associated with high risk of recurrence and distant metastasis. Currently, there are no effective therapies for the TNBC patients with distant metastasis due to th...

A novel wide-field electron arc technique with a scatterer is implemented for widespread Kaposi’s sarcoma (KS) in the distal extremities. Monte Carlo beam modeling for electron arc beams was established to achieve <2% deviation from the measurements, and used for dose calculation. MC-based electron arc plan was performed using CT images of a foot a...